RetINal Toxicity And HydroxyChloroquine Therapy (INTACT): protocol for a prospective population-based cohort study Article Swipe
Narsis Daftarian
,
Adriana Lima
,
Shelby Marozoff
,
Dami Taiwo Ojo
,
Steve D. Levasseur
,
David Maberley
,
Alison M. Hoens
,
John M. Esdaile
,
Martin Dawes
,
J. Antonio Aviña‐Zubieta
,
Beatrice Adante
,
Ravinder Dennis Bhui
,
Suruchi B Bhui
,
Michael Butler
,
Lica Chui
,
Murray Erasmus
,
Mahyar Etminan
,
Derek Godinho
,
Elizabeth L. Hay
,
Hussein Hollands
,
Malvinder Hoonjan
,
Aaron W. Joe
,
Andrew Lukaris
,
Zaid Mammo
,
Eduardo V. Navajas
,
Kaivon Pakzad-Vaezi
,
Suren Sanmugasunderam
,
Kam Shojania
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1136/bmjopen-2021-053852
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1136/bmjopen-2021-053852
Purpose Hydroxychloroquine (HCQ) is an important medication for patients with systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and other rheumatic diseases. Although it is well-tolerated and cost-effective, the risk of HCQ retinal toxicity is of increasing concern. The aim of this study is to re-examine the HCQ retinal toxicity incidence rate, risk factors and clinical course after discontinuation. Methods We designed a prospective population-based cohort study in adult patients with SLE or RA, currently receiving HCQ for five or more years, who are residents of British Columbia (BC), Canada. Based on administrative data, we identified 5508 eligible participants (1346 SLE and 4162 RA). They will participate in annual or biannual retinal screening over 5 years in alignment with the recently revised American Academy of Ophthalmology guidelines. To standardise procedures for retinal screening, imaging, diagnostic criteria, severity staging and data transfer, a consensus meeting was convened in December 2019 with participation of BC retinal specialists and the research team. Agreement was attained on: use of spectral domain-optical coherence tomography as the primary objective screening modality; classification of images into categories of normal, equivocal or abnormal; and transferring the equivocal and abnormal images plus corresponding subjective test results via cloud-based server from each clinic to a reading centre. Confirmation of HCQ retinal toxicity diagnoses and severity staging will be performed by three independent and masked reviewers. The incidence of HCQ retinal toxicity will be calculated, accounting for the competing risk of death. Hazard ratios for each risk factor will be calculated for the risk of HCQ retinopathy, after adjusting for confounders. We will also estimate the risk of HCQ retinal toxicity progression over 5 years. Ethics and dissemination This study has received approval from the University of British Columbia Clinical Research Ethics Board (H20-00736) and the Vancouver Coastal Health Research Institute.
Related Topics
Concepts
Medicine
Hydroxychloroquine
Discontinuation
Population
Rheumatoid arthritis
Prospective cohort study
Incidence (geometry)
Cohort
Retinal
Internal medicine
Ophthalmology
Coronavirus disease 2019 (COVID-19)
Disease
Environmental health
Infectious disease (medical specialty)
Physics
Optics
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1136/bmjopen-2021-053852
- https://bmjopen.bmj.com/content/bmjopen/12/2/e053852.full.pdf
- OA Status
- gold
- Cited By
- 3
- References
- 51
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4213068641
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4213068641Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1136/bmjopen-2021-053852Digital Object Identifier
- Title
-
RetINal Toxicity And HydroxyChloroquine Therapy (INTACT): protocol for a prospective population-based cohort studyWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-02-01Full publication date if available
- Authors
-
Narsis Daftarian, Adriana Lima, Shelby Marozoff, Dami Taiwo Ojo, Steve D. Levasseur, David Maberley, Alison M. Hoens, John M. Esdaile, Martin Dawes, J. Antonio Aviña‐Zubieta, Beatrice Adante, Ravinder Dennis Bhui, Suruchi B Bhui, Michael Butler, Lica Chui, Murray Erasmus, Mahyar Etminan, Derek Godinho, Elizabeth L. Hay, Hussein Hollands, Malvinder Hoonjan, Aaron W. Joe, Andrew Lukaris, Zaid Mammo, Eduardo V. Navajas, Kaivon Pakzad-Vaezi, Suren Sanmugasunderam, Kam ShojaniaList of authors in order
- Landing page
-
https://doi.org/10.1136/bmjopen-2021-053852Publisher landing page
- PDF URL
-
https://bmjopen.bmj.com/content/bmjopen/12/2/e053852.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://bmjopen.bmj.com/content/bmjopen/12/2/e053852.full.pdfDirect OA link when available
- Concepts
-
Medicine, Hydroxychloroquine, Discontinuation, Population, Rheumatoid arthritis, Prospective cohort study, Incidence (geometry), Cohort, Retinal, Internal medicine, Ophthalmology, Coronavirus disease 2019 (COVID-19), Disease, Environmental health, Infectious disease (medical specialty), Physics, OpticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
3Total citation count in OpenAlex
- Citations by year (recent)
-
2024: 2, 2023: 1Per-year citation counts (last 5 years)
- References (count)
-
51Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4213068641 |
|---|---|
| doi | https://doi.org/10.1136/bmjopen-2021-053852 |
| ids.doi | https://doi.org/10.1136/bmjopen-2021-053852 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/35177450 |
| ids.openalex | https://openalex.org/W4213068641 |
| fwci | 0.84471231 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D000328 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Adult |
| mesh[1].qualifier_ui | Q000009 |
| mesh[1].descriptor_ui | D018501 |
| mesh[1].is_major_topic | True |
| mesh[1].qualifier_name | adverse effects |
| mesh[1].descriptor_name | Antirheumatic Agents |
| mesh[2].qualifier_ui | Q000139 |
| mesh[2].descriptor_ui | D001172 |
| mesh[2].is_major_topic | True |
| mesh[2].qualifier_name | chemically induced |
| mesh[2].descriptor_name | Arthritis, Rheumatoid |
| mesh[3].qualifier_ui | Q000188 |
| mesh[3].descriptor_ui | D001172 |
| mesh[3].is_major_topic | True |
| mesh[3].qualifier_name | drug therapy |
| mesh[3].descriptor_name | Arthritis, Rheumatoid |
| mesh[4].qualifier_ui | Q000453 |
| mesh[4].descriptor_ui | D001955 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | epidemiology |
| mesh[4].descriptor_name | British Columbia |
| mesh[5].qualifier_ui | |
| mesh[5].descriptor_ui | D015331 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | |
| mesh[5].descriptor_name | Cohort Studies |
| mesh[6].qualifier_ui | |
| mesh[6].descriptor_ui | D006801 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | |
| mesh[6].descriptor_name | Humans |
| mesh[7].qualifier_ui | Q000009 |
| mesh[7].descriptor_ui | D006886 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | adverse effects |
| mesh[7].descriptor_name | Hydroxychloroquine |
| mesh[8].qualifier_ui | Q000188 |
| mesh[8].descriptor_ui | D008180 |
| mesh[8].is_major_topic | True |
| mesh[8].qualifier_name | drug therapy |
| mesh[8].descriptor_name | Lupus Erythematosus, Systemic |
| mesh[9].qualifier_ui | |
| mesh[9].descriptor_ui | D011446 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | |
| mesh[9].descriptor_name | Prospective Studies |
| mesh[10].qualifier_ui | Q000139 |
| mesh[10].descriptor_ui | D012164 |
| mesh[10].is_major_topic | True |
| mesh[10].qualifier_name | chemically induced |
| mesh[10].descriptor_name | Retinal Diseases |
| mesh[11].qualifier_ui | Q000175 |
| mesh[11].descriptor_ui | D012164 |
| mesh[11].is_major_topic | True |
| mesh[11].qualifier_name | diagnosis |
| mesh[11].descriptor_name | Retinal Diseases |
| mesh[12].qualifier_ui | Q000453 |
| mesh[12].descriptor_ui | D012164 |
| mesh[12].is_major_topic | True |
| mesh[12].qualifier_name | epidemiology |
| mesh[12].descriptor_name | Retinal Diseases |
| mesh[13].qualifier_ui | |
| mesh[13].descriptor_ui | D041623 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | |
| mesh[13].descriptor_name | Tomography, Optical Coherence |
| mesh[14].qualifier_ui | |
| mesh[14].descriptor_ui | D000328 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | |
| mesh[14].descriptor_name | Adult |
| mesh[15].qualifier_ui | Q000009 |
| mesh[15].descriptor_ui | D018501 |
| mesh[15].is_major_topic | True |
| mesh[15].qualifier_name | adverse effects |
| mesh[15].descriptor_name | Antirheumatic Agents |
| mesh[16].qualifier_ui | Q000139 |
| mesh[16].descriptor_ui | D001172 |
| mesh[16].is_major_topic | True |
| mesh[16].qualifier_name | chemically induced |
| mesh[16].descriptor_name | Arthritis, Rheumatoid |
| mesh[17].qualifier_ui | Q000188 |
| mesh[17].descriptor_ui | D001172 |
| mesh[17].is_major_topic | True |
| mesh[17].qualifier_name | drug therapy |
| mesh[17].descriptor_name | Arthritis, Rheumatoid |
| mesh[18].qualifier_ui | Q000453 |
| mesh[18].descriptor_ui | D001955 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | epidemiology |
| mesh[18].descriptor_name | British Columbia |
| mesh[19].qualifier_ui | |
| mesh[19].descriptor_ui | D015331 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | |
| mesh[19].descriptor_name | Cohort Studies |
| mesh[20].qualifier_ui | |
| mesh[20].descriptor_ui | D006801 |
| mesh[20].is_major_topic | False |
| mesh[20].qualifier_name | |
| mesh[20].descriptor_name | Humans |
| mesh[21].qualifier_ui | Q000009 |
| mesh[21].descriptor_ui | D006886 |
| mesh[21].is_major_topic | False |
| mesh[21].qualifier_name | adverse effects |
| mesh[21].descriptor_name | Hydroxychloroquine |
| mesh[22].qualifier_ui | Q000188 |
| mesh[22].descriptor_ui | D008180 |
| mesh[22].is_major_topic | True |
| mesh[22].qualifier_name | drug therapy |
| mesh[22].descriptor_name | Lupus Erythematosus, Systemic |
| mesh[23].qualifier_ui | |
| mesh[23].descriptor_ui | D011446 |
| mesh[23].is_major_topic | False |
| mesh[23].qualifier_name | |
| mesh[23].descriptor_name | Prospective Studies |
| mesh[24].qualifier_ui | Q000139 |
| mesh[24].descriptor_ui | D012164 |
| mesh[24].is_major_topic | True |
| mesh[24].qualifier_name | chemically induced |
| mesh[24].descriptor_name | Retinal Diseases |
| mesh[25].qualifier_ui | Q000175 |
| mesh[25].descriptor_ui | D012164 |
| mesh[25].is_major_topic | True |
| mesh[25].qualifier_name | diagnosis |
| mesh[25].descriptor_name | Retinal Diseases |
| mesh[26].qualifier_ui | Q000453 |
| mesh[26].descriptor_ui | D012164 |
| mesh[26].is_major_topic | True |
| mesh[26].qualifier_name | epidemiology |
| mesh[26].descriptor_name | Retinal Diseases |
| mesh[27].qualifier_ui | |
| mesh[27].descriptor_ui | D041623 |
| mesh[27].is_major_topic | False |
| mesh[27].qualifier_name | |
| mesh[27].descriptor_name | Tomography, Optical Coherence |
| type | article |
| title | RetINal Toxicity And HydroxyChloroquine Therapy (INTACT): protocol for a prospective population-based cohort study |
| awards[0].id | https://openalex.org/G7876503138 |
| awards[0].funder_id | https://openalex.org/F4320334506 |
| awards[0].display_name | |
| awards[0].funder_award_id | PJT-162133 |
| awards[0].funder_display_name | Canadian Institutes of Health Research |
| awards[1].id | https://openalex.org/G6545489651 |
| awards[1].funder_id | https://openalex.org/F4320334506 |
| awards[1].display_name | |
| awards[1].funder_award_id | PCS-164995 |
| awards[1].funder_display_name | Canadian Institutes of Health Research |
| biblio.issue | 2 |
| biblio.volume | 12 |
| biblio.last_page | e053852 |
| biblio.first_page | e053852 |
| topics[0].id | https://openalex.org/T13467 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9998999834060669 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2731 |
| topics[0].subfield.display_name | Ophthalmology |
| topics[0].display_name | Drug-Induced Ocular Toxicity |
| topics[1].id | https://openalex.org/T10308 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9997000098228455 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2745 |
| topics[1].subfield.display_name | Rheumatology |
| topics[1].display_name | Systemic Lupus Erythematosus Research |
| topics[2].id | https://openalex.org/T11194 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9988999962806702 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2731 |
| topics[2].subfield.display_name | Ophthalmology |
| topics[2].display_name | Ocular Diseases and Behçet’s Syndrome |
| funders[0].id | https://openalex.org/F4320334506 |
| funders[0].ror | https://ror.org/01gavpb45 |
| funders[0].display_name | Canadian Institutes of Health Research |
| is_xpac | False |
| apc_list.value | 1500 |
| apc_list.currency | GBP |
| apc_list.value_usd | 1839 |
| apc_paid.value | 1500 |
| apc_paid.currency | GBP |
| apc_paid.value_usd | 1839 |
| concepts[0].id | https://openalex.org/C71924100 |
| concepts[0].level | 0 |
| concepts[0].score | 0.9510190486907959 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[0].display_name | Medicine |
| concepts[1].id | https://openalex.org/C2779123688 |
| concepts[1].level | 5 |
| concepts[1].score | 0.8412802219390869 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q421094 |
| concepts[1].display_name | Hydroxychloroquine |
| concepts[2].id | https://openalex.org/C2778715236 |
| concepts[2].level | 2 |
| concepts[2].score | 0.5901606678962708 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q55622662 |
| concepts[2].display_name | Discontinuation |
| concepts[3].id | https://openalex.org/C2908647359 |
| concepts[3].level | 2 |
| concepts[3].score | 0.5371262431144714 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q2625603 |
| concepts[3].display_name | Population |
| concepts[4].id | https://openalex.org/C2777575956 |
| concepts[4].level | 2 |
| concepts[4].score | 0.5331957340240479 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q187255 |
| concepts[4].display_name | Rheumatoid arthritis |
| concepts[5].id | https://openalex.org/C188816634 |
| concepts[5].level | 2 |
| concepts[5].score | 0.520063579082489 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q2113324 |
| concepts[5].display_name | Prospective cohort study |
| concepts[6].id | https://openalex.org/C61511704 |
| concepts[6].level | 2 |
| concepts[6].score | 0.5131703019142151 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q1671857 |
| concepts[6].display_name | Incidence (geometry) |
| concepts[7].id | https://openalex.org/C72563966 |
| concepts[7].level | 2 |
| concepts[7].score | 0.45744583010673523 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q1303415 |
| concepts[7].display_name | Cohort |
| concepts[8].id | https://openalex.org/C2780827179 |
| concepts[8].level | 2 |
| concepts[8].score | 0.43347951769828796 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q422001 |
| concepts[8].display_name | Retinal |
| concepts[9].id | https://openalex.org/C126322002 |
| concepts[9].level | 1 |
| concepts[9].score | 0.36419394612312317 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[9].display_name | Internal medicine |
| concepts[10].id | https://openalex.org/C118487528 |
| concepts[10].level | 1 |
| concepts[10].score | 0.3093639016151428 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q161437 |
| concepts[10].display_name | Ophthalmology |
| concepts[11].id | https://openalex.org/C3008058167 |
| concepts[11].level | 4 |
| concepts[11].score | 0.10450059175491333 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q84263196 |
| concepts[11].display_name | Coronavirus disease 2019 (COVID-19) |
| concepts[12].id | https://openalex.org/C2779134260 |
| concepts[12].level | 2 |
| concepts[12].score | 0.08002269268035889 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q12136 |
| concepts[12].display_name | Disease |
| concepts[13].id | https://openalex.org/C99454951 |
| concepts[13].level | 1 |
| concepts[13].score | 0.06781300902366638 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q932068 |
| concepts[13].display_name | Environmental health |
| concepts[14].id | https://openalex.org/C524204448 |
| concepts[14].level | 3 |
| concepts[14].score | 0.0 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q788926 |
| concepts[14].display_name | Infectious disease (medical specialty) |
| concepts[15].id | https://openalex.org/C121332964 |
| concepts[15].level | 0 |
| concepts[15].score | 0.0 |
| concepts[15].wikidata | https://www.wikidata.org/wiki/Q413 |
| concepts[15].display_name | Physics |
| concepts[16].id | https://openalex.org/C120665830 |
| concepts[16].level | 1 |
| concepts[16].score | 0.0 |
| concepts[16].wikidata | https://www.wikidata.org/wiki/Q14620 |
| concepts[16].display_name | Optics |
| keywords[0].id | https://openalex.org/keywords/medicine |
| keywords[0].score | 0.9510190486907959 |
| keywords[0].display_name | Medicine |
| keywords[1].id | https://openalex.org/keywords/hydroxychloroquine |
| keywords[1].score | 0.8412802219390869 |
| keywords[1].display_name | Hydroxychloroquine |
| keywords[2].id | https://openalex.org/keywords/discontinuation |
| keywords[2].score | 0.5901606678962708 |
| keywords[2].display_name | Discontinuation |
| keywords[3].id | https://openalex.org/keywords/population |
| keywords[3].score | 0.5371262431144714 |
| keywords[3].display_name | Population |
| keywords[4].id | https://openalex.org/keywords/rheumatoid-arthritis |
| keywords[4].score | 0.5331957340240479 |
| keywords[4].display_name | Rheumatoid arthritis |
| keywords[5].id | https://openalex.org/keywords/prospective-cohort-study |
| keywords[5].score | 0.520063579082489 |
| keywords[5].display_name | Prospective cohort study |
| keywords[6].id | https://openalex.org/keywords/incidence |
| keywords[6].score | 0.5131703019142151 |
| keywords[6].display_name | Incidence (geometry) |
| keywords[7].id | https://openalex.org/keywords/cohort |
| keywords[7].score | 0.45744583010673523 |
| keywords[7].display_name | Cohort |
| keywords[8].id | https://openalex.org/keywords/retinal |
| keywords[8].score | 0.43347951769828796 |
| keywords[8].display_name | Retinal |
| keywords[9].id | https://openalex.org/keywords/internal-medicine |
| keywords[9].score | 0.36419394612312317 |
| keywords[9].display_name | Internal medicine |
| keywords[10].id | https://openalex.org/keywords/ophthalmology |
| keywords[10].score | 0.3093639016151428 |
| keywords[10].display_name | Ophthalmology |
| keywords[11].id | https://openalex.org/keywords/coronavirus-disease-2019 |
| keywords[11].score | 0.10450059175491333 |
| keywords[11].display_name | Coronavirus disease 2019 (COVID-19) |
| keywords[12].id | https://openalex.org/keywords/disease |
| keywords[12].score | 0.08002269268035889 |
| keywords[12].display_name | Disease |
| keywords[13].id | https://openalex.org/keywords/environmental-health |
| keywords[13].score | 0.06781300902366638 |
| keywords[13].display_name | Environmental health |
| language | en |
| locations[0].id | doi:10.1136/bmjopen-2021-053852 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S79054089 |
| locations[0].source.issn | 2044-6055 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 2044-6055 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | BMJ Open |
| locations[0].source.host_organization | https://openalex.org/P4310319945 |
| locations[0].source.host_organization_name | BMJ |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310319945 |
| locations[0].source.host_organization_lineage_names | BMJ |
| locations[0].license | cc-by-nc |
| locations[0].pdf_url | https://bmjopen.bmj.com/content/bmjopen/12/2/e053852.full.pdf |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by-nc |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | BMJ Open |
| locations[0].landing_page_url | https://doi.org/10.1136/bmjopen-2021-053852 |
| locations[1].id | pmid:35177450 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | BMJ open |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/35177450 |
| locations[2].id | pmh:oai:doaj.org/article:0cfd61b1c57548b8a9401f00dcd3741e |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S4306401280 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[2].source.host_organization | |
| locations[2].source.host_organization_name | |
| locations[2].license | cc-by-sa |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | article |
| locations[2].license_id | https://openalex.org/licenses/cc-by-sa |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | BMJ Open, Vol 12, Iss 2 (2022) |
| locations[2].landing_page_url | https://doaj.org/article/0cfd61b1c57548b8a9401f00dcd3741e |
| locations[3].id | pmh:oai:pubmedcentral.nih.gov:8860004 |
| locations[3].is_oa | True |
| locations[3].source.id | https://openalex.org/S2764455111 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | PubMed Central |
| locations[3].source.host_organization | https://openalex.org/I1299303238 |
| locations[3].source.host_organization_name | National Institutes of Health |
| locations[3].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[3].license | other-oa |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | Text |
| locations[3].license_id | https://openalex.org/licenses/other-oa |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | BMJ Open |
| locations[3].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/8860004 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5018949560 |
| authorships[0].author.orcid | https://orcid.org/0000-0001-5846-8739 |
| authorships[0].author.display_name | Narsis Daftarian |
| authorships[0].countries | CA |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I4210099137 |
| authorships[0].affiliations[0].raw_affiliation_string | Arthritis Research Canada, Vancouver, British Columbia, Canada |
| authorships[0].affiliations[1].institution_ids | https://openalex.org/I141945490 |
| authorships[0].affiliations[1].raw_affiliation_string | Experimental Medicine, Department of Medicine, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada |
| authorships[0].institutions[0].id | https://openalex.org/I4210099137 |
| authorships[0].institutions[0].ror | https://ror.org/0103eqz62 |
| authorships[0].institutions[0].type | facility |
| authorships[0].institutions[0].lineage | https://openalex.org/I4210099137 |
| authorships[0].institutions[0].country_code | CA |
| authorships[0].institutions[0].display_name | Research Canada |
| authorships[0].institutions[1].id | https://openalex.org/I141945490 |
| authorships[0].institutions[1].ror | https://ror.org/03rmrcq20 |
| authorships[0].institutions[1].type | education |
| authorships[0].institutions[1].lineage | https://openalex.org/I141945490, https://openalex.org/I4210128534, https://openalex.org/I4210135497, https://openalex.org/I4387154919 |
| authorships[0].institutions[1].country_code | CA |
| authorships[0].institutions[1].display_name | University of British Columbia |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Narsis Daftarian |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Arthritis Research Canada, Vancouver, British Columbia, Canada, Experimental Medicine, Department of Medicine, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada |
| authorships[1].author.id | https://openalex.org/A5112415085 |
| authorships[1].author.orcid | |
| authorships[1].author.display_name | Adriana Lima |
| authorships[1].countries | CA |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I4210099137 |
| authorships[1].affiliations[0].raw_affiliation_string | Arthritis Research Canada, Vancouver, British Columbia, Canada |
| authorships[1].institutions[0].id | https://openalex.org/I4210099137 |
| authorships[1].institutions[0].ror | https://ror.org/0103eqz62 |
| authorships[1].institutions[0].type | facility |
| authorships[1].institutions[0].lineage | https://openalex.org/I4210099137 |
| authorships[1].institutions[0].country_code | CA |
| authorships[1].institutions[0].display_name | Research Canada |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Adriana Lima |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Arthritis Research Canada, Vancouver, British Columbia, Canada |
| authorships[2].author.id | https://openalex.org/A5060357580 |
| authorships[2].author.orcid | https://orcid.org/0009-0006-1164-5025 |
| authorships[2].author.display_name | Shelby Marozoff |
| authorships[2].countries | CA |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I4210099137 |
| authorships[2].affiliations[0].raw_affiliation_string | Arthritis Research Canada, Vancouver, British Columbia, Canada |
| authorships[2].institutions[0].id | https://openalex.org/I4210099137 |
| authorships[2].institutions[0].ror | https://ror.org/0103eqz62 |
| authorships[2].institutions[0].type | facility |
| authorships[2].institutions[0].lineage | https://openalex.org/I4210099137 |
| authorships[2].institutions[0].country_code | CA |
| authorships[2].institutions[0].display_name | Research Canada |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Shelby Marozoff |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Arthritis Research Canada, Vancouver, British Columbia, Canada |
| authorships[3].author.id | https://openalex.org/A5078640508 |
| authorships[3].author.orcid | |
| authorships[3].author.display_name | Dami Taiwo Ojo |
| authorships[3].countries | CA |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I4210099137 |
| authorships[3].affiliations[0].raw_affiliation_string | Arthritis Research Canada, Vancouver, British Columbia, Canada |
| authorships[3].institutions[0].id | https://openalex.org/I4210099137 |
| authorships[3].institutions[0].ror | https://ror.org/0103eqz62 |
| authorships[3].institutions[0].type | facility |
| authorships[3].institutions[0].lineage | https://openalex.org/I4210099137 |
| authorships[3].institutions[0].country_code | CA |
| authorships[3].institutions[0].display_name | Research Canada |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Dami Ojo |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Arthritis Research Canada, Vancouver, British Columbia, Canada |
| authorships[4].author.id | https://openalex.org/A5074025820 |
| authorships[4].author.orcid | |
| authorships[4].author.display_name | Steve D. Levasseur |
| authorships[4].countries | CA |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I141945490 |
| authorships[4].affiliations[0].raw_affiliation_string | Department of Ophthalmology and Visual Sciences, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada |
| authorships[4].institutions[0].id | https://openalex.org/I141945490 |
| authorships[4].institutions[0].ror | https://ror.org/03rmrcq20 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I141945490, https://openalex.org/I4210128534, https://openalex.org/I4210135497, https://openalex.org/I4387154919 |
| authorships[4].institutions[0].country_code | CA |
| authorships[4].institutions[0].display_name | University of British Columbia |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Steve D Levasseur |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Department of Ophthalmology and Visual Sciences, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada |
| authorships[5].author.id | https://openalex.org/A5040261462 |
| authorships[5].author.orcid | https://orcid.org/0000-0001-6237-1964 |
| authorships[5].author.display_name | David Maberley |
| authorships[5].countries | CA |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I141945490 |
| authorships[5].affiliations[0].raw_affiliation_string | Department of Ophthalmology and Visual Sciences, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada |
| authorships[5].institutions[0].id | https://openalex.org/I141945490 |
| authorships[5].institutions[0].ror | https://ror.org/03rmrcq20 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I141945490, https://openalex.org/I4210128534, https://openalex.org/I4210135497, https://openalex.org/I4387154919 |
| authorships[5].institutions[0].country_code | CA |
| authorships[5].institutions[0].display_name | University of British Columbia |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | David A L Maberley |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Department of Ophthalmology and Visual Sciences, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada |
| authorships[6].author.id | https://openalex.org/A5017304507 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-9533-9079 |
| authorships[6].author.display_name | Alison M. Hoens |
| authorships[6].countries | CA |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I141945490 |
| authorships[6].affiliations[0].raw_affiliation_string | Department of Physical Therapy, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada |
| authorships[6].affiliations[1].institution_ids | https://openalex.org/I141945490, https://openalex.org/I4210136948 |
| authorships[6].affiliations[1].raw_affiliation_string | Centre for Clinical Epidemiology & Evaluation, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada |
| authorships[6].institutions[0].id | https://openalex.org/I4210136948 |
| authorships[6].institutions[0].ror | https://ror.org/04g6gva85 |
| authorships[6].institutions[0].type | facility |
| authorships[6].institutions[0].lineage | https://openalex.org/I4210136948 |
| authorships[6].institutions[0].country_code | CA |
| authorships[6].institutions[0].display_name | Centre for Advancing Health Outcomes |
| authorships[6].institutions[1].id | https://openalex.org/I141945490 |
| authorships[6].institutions[1].ror | https://ror.org/03rmrcq20 |
| authorships[6].institutions[1].type | education |
| authorships[6].institutions[1].lineage | https://openalex.org/I141945490, https://openalex.org/I4210128534, https://openalex.org/I4210135497, https://openalex.org/I4387154919 |
| authorships[6].institutions[1].country_code | CA |
| authorships[6].institutions[1].display_name | University of British Columbia |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Alison Hoens |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Centre for Clinical Epidemiology & Evaluation, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada, Department of Physical Therapy, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada |
| authorships[7].author.id | https://openalex.org/A5088872913 |
| authorships[7].author.orcid | https://orcid.org/0000-0001-9465-7326 |
| authorships[7].author.display_name | John M. Esdaile |
| authorships[7].countries | CA |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I4210099137 |
| authorships[7].affiliations[0].raw_affiliation_string | Arthritis Research Canada, Vancouver, British Columbia, Canada |
| authorships[7].affiliations[1].institution_ids | https://openalex.org/I141945490 |
| authorships[7].affiliations[1].raw_affiliation_string | Division of Rheumatology, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada |
| authorships[7].institutions[0].id | https://openalex.org/I4210099137 |
| authorships[7].institutions[0].ror | https://ror.org/0103eqz62 |
| authorships[7].institutions[0].type | facility |
| authorships[7].institutions[0].lineage | https://openalex.org/I4210099137 |
| authorships[7].institutions[0].country_code | CA |
| authorships[7].institutions[0].display_name | Research Canada |
| authorships[7].institutions[1].id | https://openalex.org/I141945490 |
| authorships[7].institutions[1].ror | https://ror.org/03rmrcq20 |
| authorships[7].institutions[1].type | education |
| authorships[7].institutions[1].lineage | https://openalex.org/I141945490, https://openalex.org/I4210128534, https://openalex.org/I4210135497, https://openalex.org/I4387154919 |
| authorships[7].institutions[1].country_code | CA |
| authorships[7].institutions[1].display_name | University of British Columbia |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | John Esdaile |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Arthritis Research Canada, Vancouver, British Columbia, Canada, Division of Rheumatology, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada |
| authorships[8].author.id | https://openalex.org/A5074389536 |
| authorships[8].author.orcid | https://orcid.org/0000-0003-3624-2477 |
| authorships[8].author.display_name | Martin Dawes |
| authorships[8].countries | CA |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I141945490 |
| authorships[8].affiliations[0].raw_affiliation_string | Department of Family Practice, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada |
| authorships[8].institutions[0].id | https://openalex.org/I141945490 |
| authorships[8].institutions[0].ror | https://ror.org/03rmrcq20 |
| authorships[8].institutions[0].type | education |
| authorships[8].institutions[0].lineage | https://openalex.org/I141945490, https://openalex.org/I4210128534, https://openalex.org/I4210135497, https://openalex.org/I4387154919 |
| authorships[8].institutions[0].country_code | CA |
| authorships[8].institutions[0].display_name | University of British Columbia |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Martin Dawes |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Department of Family Practice, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada |
| authorships[9].author.id | https://openalex.org/A5008925315 |
| authorships[9].author.orcid | https://orcid.org/0000-0001-5526-663X |
| authorships[9].author.display_name | J. Antonio Aviña‐Zubieta |
| authorships[9].countries | CA |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I141945490 |
| authorships[9].affiliations[0].raw_affiliation_string | Division of Rheumatology, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada |
| authorships[9].affiliations[1].institution_ids | https://openalex.org/I4210099137 |
| authorships[9].affiliations[1].raw_affiliation_string | Arthritis Research Canada, Vancouver, British Columbia, Canada |
| authorships[9].institutions[0].id | https://openalex.org/I4210099137 |
| authorships[9].institutions[0].ror | https://ror.org/0103eqz62 |
| authorships[9].institutions[0].type | facility |
| authorships[9].institutions[0].lineage | https://openalex.org/I4210099137 |
| authorships[9].institutions[0].country_code | CA |
| authorships[9].institutions[0].display_name | Research Canada |
| authorships[9].institutions[1].id | https://openalex.org/I141945490 |
| authorships[9].institutions[1].ror | https://ror.org/03rmrcq20 |
| authorships[9].institutions[1].type | education |
| authorships[9].institutions[1].lineage | https://openalex.org/I141945490, https://openalex.org/I4210128534, https://openalex.org/I4210135497, https://openalex.org/I4387154919 |
| authorships[9].institutions[1].country_code | CA |
| authorships[9].institutions[1].display_name | University of British Columbia |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | J Antonio Aviña-Zubieta |
| authorships[9].is_corresponding | True |
| authorships[9].raw_affiliation_strings | Arthritis Research Canada, Vancouver, British Columbia, Canada, Division of Rheumatology, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada |
| authorships[10].author.id | https://openalex.org/A5005159265 |
| authorships[10].author.orcid | |
| authorships[10].author.display_name | Beatrice Adante |
| authorships[10].countries | CA |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I141945490 |
| authorships[10].affiliations[0].raw_affiliation_string | Department of Ophthalmology and Visual Sciences, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada |
| authorships[10].institutions[0].id | https://openalex.org/I141945490 |
| authorships[10].institutions[0].ror | https://ror.org/03rmrcq20 |
| authorships[10].institutions[0].type | education |
| authorships[10].institutions[0].lineage | https://openalex.org/I141945490, https://openalex.org/I4210128534, https://openalex.org/I4210135497, https://openalex.org/I4387154919 |
| authorships[10].institutions[0].country_code | CA |
| authorships[10].institutions[0].display_name | University of British Columbia |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Beatrice Adante |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Department of Ophthalmology and Visual Sciences, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada |
| authorships[11].author.id | https://openalex.org/A5064645717 |
| authorships[11].author.orcid | |
| authorships[11].author.display_name | Ravinder Dennis Bhui |
| authorships[11].countries | CA |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I141945490 |
| authorships[11].affiliations[0].raw_affiliation_string | Department of Ophthalmology and Visual Sciences, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada |
| authorships[11].institutions[0].id | https://openalex.org/I141945490 |
| authorships[11].institutions[0].ror | https://ror.org/03rmrcq20 |
| authorships[11].institutions[0].type | education |
| authorships[11].institutions[0].lineage | https://openalex.org/I141945490, https://openalex.org/I4210128534, https://openalex.org/I4210135497, https://openalex.org/I4387154919 |
| authorships[11].institutions[0].country_code | CA |
| authorships[11].institutions[0].display_name | University of British Columbia |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | Ravinder Dennis Bhui |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | Department of Ophthalmology and Visual Sciences, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada |
| authorships[12].author.id | https://openalex.org/A5079296795 |
| authorships[12].author.orcid | |
| authorships[12].author.display_name | Suruchi B Bhui |
| authorships[12].countries | CA |
| authorships[12].affiliations[0].institution_ids | https://openalex.org/I141945490 |
| authorships[12].affiliations[0].raw_affiliation_string | Department of Ophthalmology and Visual Sciences, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada |
| authorships[12].institutions[0].id | https://openalex.org/I141945490 |
| authorships[12].institutions[0].ror | https://ror.org/03rmrcq20 |
| authorships[12].institutions[0].type | education |
| authorships[12].institutions[0].lineage | https://openalex.org/I141945490, https://openalex.org/I4210128534, https://openalex.org/I4210135497, https://openalex.org/I4387154919 |
| authorships[12].institutions[0].country_code | CA |
| authorships[12].institutions[0].display_name | University of British Columbia |
| authorships[12].author_position | middle |
| authorships[12].raw_author_name | Suruchi B Bhui |
| authorships[12].is_corresponding | False |
| authorships[12].raw_affiliation_strings | Department of Ophthalmology and Visual Sciences, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada |
| authorships[13].author.id | https://openalex.org/A5089376239 |
| authorships[13].author.orcid | |
| authorships[13].author.display_name | Michael Butler |
| authorships[13].countries | CA |
| authorships[13].affiliations[0].institution_ids | https://openalex.org/I141945490 |
| authorships[13].affiliations[0].raw_affiliation_string | Department of Ophthalmology and Visual Sciences, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada |
| authorships[13].institutions[0].id | https://openalex.org/I141945490 |
| authorships[13].institutions[0].ror | https://ror.org/03rmrcq20 |
| authorships[13].institutions[0].type | education |
| authorships[13].institutions[0].lineage | https://openalex.org/I141945490, https://openalex.org/I4210128534, https://openalex.org/I4210135497, https://openalex.org/I4387154919 |
| authorships[13].institutions[0].country_code | CA |
| authorships[13].institutions[0].display_name | University of British Columbia |
| authorships[13].author_position | middle |
| authorships[13].raw_author_name | Michael Butler |
| authorships[13].is_corresponding | False |
| authorships[13].raw_affiliation_strings | Department of Ophthalmology and Visual Sciences, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada |
| authorships[14].author.id | https://openalex.org/A5071707966 |
| authorships[14].author.orcid | |
| authorships[14].author.display_name | Lica Chui |
| authorships[14].countries | CA |
| authorships[14].affiliations[0].institution_ids | https://openalex.org/I141945490 |
| authorships[14].affiliations[0].raw_affiliation_string | Department of Ophthalmology and Visual Sciences, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada |
| authorships[14].institutions[0].id | https://openalex.org/I141945490 |
| authorships[14].institutions[0].ror | https://ror.org/03rmrcq20 |
| authorships[14].institutions[0].type | education |
| authorships[14].institutions[0].lineage | https://openalex.org/I141945490, https://openalex.org/I4210128534, https://openalex.org/I4210135497, https://openalex.org/I4387154919 |
| authorships[14].institutions[0].country_code | CA |
| authorships[14].institutions[0].display_name | University of British Columbia |
| authorships[14].author_position | middle |
| authorships[14].raw_author_name | Lica Chui |
| authorships[14].is_corresponding | False |
| authorships[14].raw_affiliation_strings | Department of Ophthalmology and Visual Sciences, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada |
| authorships[15].author.id | https://openalex.org/A5112244558 |
| authorships[15].author.orcid | |
| authorships[15].author.display_name | Murray Erasmus |
| authorships[15].countries | CA |
| authorships[15].affiliations[0].institution_ids | https://openalex.org/I141945490 |
| authorships[15].affiliations[0].raw_affiliation_string | Department of Ophthalmology and Visual Sciences, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada |
| authorships[15].affiliations[1].institution_ids | https://openalex.org/I212119943 |
| authorships[15].affiliations[1].raw_affiliation_string | Faculty of Medicine, University of Victoria Island Medical Program, Victoria, British Columbia, Canada |
| authorships[15].institutions[0].id | https://openalex.org/I141945490 |
| authorships[15].institutions[0].ror | https://ror.org/03rmrcq20 |
| authorships[15].institutions[0].type | education |
| authorships[15].institutions[0].lineage | https://openalex.org/I141945490, https://openalex.org/I4210128534, https://openalex.org/I4210135497, https://openalex.org/I4387154919 |
| authorships[15].institutions[0].country_code | CA |
| authorships[15].institutions[0].display_name | University of British Columbia |
| authorships[15].institutions[1].id | https://openalex.org/I212119943 |
| authorships[15].institutions[1].ror | https://ror.org/04s5mat29 |
| authorships[15].institutions[1].type | education |
| authorships[15].institutions[1].lineage | https://openalex.org/I212119943 |
| authorships[15].institutions[1].country_code | CA |
| authorships[15].institutions[1].display_name | University of Victoria |
| authorships[15].author_position | middle |
| authorships[15].raw_author_name | Murray Erasmus |
| authorships[15].is_corresponding | False |
| authorships[15].raw_affiliation_strings | Department of Ophthalmology and Visual Sciences, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada, Faculty of Medicine, University of Victoria Island Medical Program, Victoria, British Columbia, Canada |
| authorships[16].author.id | https://openalex.org/A5028615443 |
| authorships[16].author.orcid | https://orcid.org/0000-0003-4628-6270 |
| authorships[16].author.display_name | Mahyar Etminan |
| authorships[16].countries | CA |
| authorships[16].affiliations[0].institution_ids | https://openalex.org/I141945490 |
| authorships[16].affiliations[0].raw_affiliation_string | Departments of Ophthalmology and Visual Sciences, Pharmacology and Medicine, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada |
| authorships[16].institutions[0].id | https://openalex.org/I141945490 |
| authorships[16].institutions[0].ror | https://ror.org/03rmrcq20 |
| authorships[16].institutions[0].type | education |
| authorships[16].institutions[0].lineage | https://openalex.org/I141945490, https://openalex.org/I4210128534, https://openalex.org/I4210135497, https://openalex.org/I4387154919 |
| authorships[16].institutions[0].country_code | CA |
| authorships[16].institutions[0].display_name | University of British Columbia |
| authorships[16].author_position | middle |
| authorships[16].raw_author_name | Mahyar Etminan |
| authorships[16].is_corresponding | False |
| authorships[16].raw_affiliation_strings | Departments of Ophthalmology and Visual Sciences, Pharmacology and Medicine, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada |
| authorships[17].author.id | https://openalex.org/A5058768136 |
| authorships[17].author.orcid | |
| authorships[17].author.display_name | Derek Godinho |
| authorships[17].countries | CA |
| authorships[17].affiliations[0].institution_ids | https://openalex.org/I141945490 |
| authorships[17].affiliations[0].raw_affiliation_string | Department of Ophthalmology and Visual Sciences, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada |
| authorships[17].institutions[0].id | https://openalex.org/I141945490 |
| authorships[17].institutions[0].ror | https://ror.org/03rmrcq20 |
| authorships[17].institutions[0].type | education |
| authorships[17].institutions[0].lineage | https://openalex.org/I141945490, https://openalex.org/I4210128534, https://openalex.org/I4210135497, https://openalex.org/I4387154919 |
| authorships[17].institutions[0].country_code | CA |
| authorships[17].institutions[0].display_name | University of British Columbia |
| authorships[17].author_position | middle |
| authorships[17].raw_author_name | Derek Godinho |
| authorships[17].is_corresponding | False |
| authorships[17].raw_affiliation_strings | Department of Ophthalmology and Visual Sciences, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada |
| authorships[18].author.id | https://openalex.org/A5110843909 |
| authorships[18].author.orcid | |
| authorships[18].author.display_name | Elizabeth L. Hay |
| authorships[18].countries | CA |
| authorships[18].affiliations[0].institution_ids | https://openalex.org/I28638086 |
| authorships[18].affiliations[0].raw_affiliation_string | Department of Ophthalmology and Visual Sciences, Nanaimo Regional General Hospital, Nanaimo, British Columbia, Canada |
| authorships[18].institutions[0].id | https://openalex.org/I28638086 |
| authorships[18].institutions[0].ror | https://ror.org/033wcvv61 |
| authorships[18].institutions[0].type | education |
| authorships[18].institutions[0].lineage | https://openalex.org/I28638086 |
| authorships[18].institutions[0].country_code | CA |
| authorships[18].institutions[0].display_name | Vancouver Island University |
| authorships[18].author_position | middle |
| authorships[18].raw_author_name | Elizabeth Hay |
| authorships[18].is_corresponding | False |
| authorships[18].raw_affiliation_strings | Department of Ophthalmology and Visual Sciences, Nanaimo Regional General Hospital, Nanaimo, British Columbia, Canada |
| authorships[19].author.id | https://openalex.org/A5037157716 |
| authorships[19].author.orcid | |
| authorships[19].author.display_name | Hussein Hollands |
| authorships[19].countries | CA |
| authorships[19].affiliations[0].institution_ids | https://openalex.org/I141945490 |
| authorships[19].affiliations[0].raw_affiliation_string | Department of Ophthalmology and Visual Sciences, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada |
| authorships[19].institutions[0].id | https://openalex.org/I141945490 |
| authorships[19].institutions[0].ror | https://ror.org/03rmrcq20 |
| authorships[19].institutions[0].type | education |
| authorships[19].institutions[0].lineage | https://openalex.org/I141945490, https://openalex.org/I4210128534, https://openalex.org/I4210135497, https://openalex.org/I4387154919 |
| authorships[19].institutions[0].country_code | CA |
| authorships[19].institutions[0].display_name | University of British Columbia |
| authorships[19].author_position | middle |
| authorships[19].raw_author_name | Hussein Hollands |
| authorships[19].is_corresponding | False |
| authorships[19].raw_affiliation_strings | Department of Ophthalmology and Visual Sciences, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada |
| authorships[20].author.id | https://openalex.org/A5056974378 |
| authorships[20].author.orcid | |
| authorships[20].author.display_name | Malvinder Hoonjan |
| authorships[20].countries | CA |
| authorships[20].affiliations[0].institution_ids | https://openalex.org/I141945490 |
| authorships[20].affiliations[0].raw_affiliation_string | Department of Ophthalmology and Visual Sciences, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada |
| authorships[20].institutions[0].id | https://openalex.org/I141945490 |
| authorships[20].institutions[0].ror | https://ror.org/03rmrcq20 |
| authorships[20].institutions[0].type | education |
| authorships[20].institutions[0].lineage | https://openalex.org/I141945490, https://openalex.org/I4210128534, https://openalex.org/I4210135497, https://openalex.org/I4387154919 |
| authorships[20].institutions[0].country_code | CA |
| authorships[20].institutions[0].display_name | University of British Columbia |
| authorships[20].author_position | middle |
| authorships[20].raw_author_name | Malvinder Hoonjan |
| authorships[20].is_corresponding | False |
| authorships[20].raw_affiliation_strings | Department of Ophthalmology and Visual Sciences, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada |
| authorships[21].author.id | https://openalex.org/A5055845431 |
| authorships[21].author.orcid | https://orcid.org/0000-0003-3070-3287 |
| authorships[21].author.display_name | Aaron W. Joe |
| authorships[21].countries | CA |
| authorships[21].affiliations[0].institution_ids | https://openalex.org/I2800978909 |
| authorships[21].affiliations[0].raw_affiliation_string | Kelowna General Hospital, Kelowna, British Columbia, Canada |
| authorships[21].institutions[0].id | https://openalex.org/I2800978909 |
| authorships[21].institutions[0].ror | https://ror.org/01j25h453 |
| authorships[21].institutions[0].type | healthcare |
| authorships[21].institutions[0].lineage | https://openalex.org/I104778310, https://openalex.org/I2800978909 |
| authorships[21].institutions[0].country_code | CA |
| authorships[21].institutions[0].display_name | Kelowna General Hospital |
| authorships[21].author_position | middle |
| authorships[21].raw_author_name | Aaron Joe |
| authorships[21].is_corresponding | False |
| authorships[21].raw_affiliation_strings | Kelowna General Hospital, Kelowna, British Columbia, Canada |
| authorships[22].author.id | https://openalex.org/A5060566048 |
| authorships[22].author.orcid | |
| authorships[22].author.display_name | Andrew Lukaris |
| authorships[22].countries | CA |
| authorships[22].affiliations[0].institution_ids | https://openalex.org/I141945490 |
| authorships[22].affiliations[0].raw_affiliation_string | Department of Ophthalmology and Visual Sciences, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada |
| authorships[22].institutions[0].id | https://openalex.org/I141945490 |
| authorships[22].institutions[0].ror | https://ror.org/03rmrcq20 |
| authorships[22].institutions[0].type | education |
| authorships[22].institutions[0].lineage | https://openalex.org/I141945490, https://openalex.org/I4210128534, https://openalex.org/I4210135497, https://openalex.org/I4387154919 |
| authorships[22].institutions[0].country_code | CA |
| authorships[22].institutions[0].display_name | University of British Columbia |
| authorships[22].author_position | middle |
| authorships[22].raw_author_name | Andrew Lukaris |
| authorships[22].is_corresponding | False |
| authorships[22].raw_affiliation_strings | Department of Ophthalmology and Visual Sciences, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada |
| authorships[23].author.id | https://openalex.org/A5079578016 |
| authorships[23].author.orcid | https://orcid.org/0000-0001-9230-9643 |
| authorships[23].author.display_name | Zaid Mammo |
| authorships[23].countries | CA |
| authorships[23].affiliations[0].institution_ids | https://openalex.org/I141945490 |
| authorships[23].affiliations[0].raw_affiliation_string | Department of Ophthalmology and Visual Sciences, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada |
| authorships[23].institutions[0].id | https://openalex.org/I141945490 |
| authorships[23].institutions[0].ror | https://ror.org/03rmrcq20 |
| authorships[23].institutions[0].type | education |
| authorships[23].institutions[0].lineage | https://openalex.org/I141945490, https://openalex.org/I4210128534, https://openalex.org/I4210135497, https://openalex.org/I4387154919 |
| authorships[23].institutions[0].country_code | CA |
| authorships[23].institutions[0].display_name | University of British Columbia |
| authorships[23].author_position | middle |
| authorships[23].raw_author_name | Zaid Mammo |
| authorships[23].is_corresponding | False |
| authorships[23].raw_affiliation_strings | Department of Ophthalmology and Visual Sciences, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada |
| authorships[24].author.id | https://openalex.org/A5003405703 |
| authorships[24].author.orcid | https://orcid.org/0000-0001-5525-1913 |
| authorships[24].author.display_name | Eduardo V. Navajas |
| authorships[24].countries | CA |
| authorships[24].affiliations[0].institution_ids | https://openalex.org/I141945490 |
| authorships[24].affiliations[0].raw_affiliation_string | Department of Ophthalmology and Visual Sciences, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada |
| authorships[24].institutions[0].id | https://openalex.org/I141945490 |
| authorships[24].institutions[0].ror | https://ror.org/03rmrcq20 |
| authorships[24].institutions[0].type | education |
| authorships[24].institutions[0].lineage | https://openalex.org/I141945490, https://openalex.org/I4210128534, https://openalex.org/I4210135497, https://openalex.org/I4387154919 |
| authorships[24].institutions[0].country_code | CA |
| authorships[24].institutions[0].display_name | University of British Columbia |
| authorships[24].author_position | middle |
| authorships[24].raw_author_name | Eduardo Navajas |
| authorships[24].is_corresponding | False |
| authorships[24].raw_affiliation_strings | Department of Ophthalmology and Visual Sciences, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada |
| authorships[25].author.id | https://openalex.org/A5055452214 |
| authorships[25].author.orcid | https://orcid.org/0009-0000-9723-1048 |
| authorships[25].author.display_name | Kaivon Pakzad-Vaezi |
| authorships[25].countries | CA |
| authorships[25].affiliations[0].institution_ids | https://openalex.org/I141945490 |
| authorships[25].affiliations[0].raw_affiliation_string | Department of Ophthalmology and Visual Sciences, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada |
| authorships[25].institutions[0].id | https://openalex.org/I141945490 |
| authorships[25].institutions[0].ror | https://ror.org/03rmrcq20 |
| authorships[25].institutions[0].type | education |
| authorships[25].institutions[0].lineage | https://openalex.org/I141945490, https://openalex.org/I4210128534, https://openalex.org/I4210135497, https://openalex.org/I4387154919 |
| authorships[25].institutions[0].country_code | CA |
| authorships[25].institutions[0].display_name | University of British Columbia |
| authorships[25].author_position | middle |
| authorships[25].raw_author_name | Kaivon Pakzad-Vaezi |
| authorships[25].is_corresponding | False |
| authorships[25].raw_affiliation_strings | Department of Ophthalmology and Visual Sciences, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada |
| authorships[26].author.id | https://openalex.org/A5018102984 |
| authorships[26].author.orcid | |
| authorships[26].author.display_name | Suren Sanmugasunderam |
| authorships[26].countries | CA |
| authorships[26].affiliations[0].institution_ids | https://openalex.org/I141945490 |
| authorships[26].affiliations[0].raw_affiliation_string | Department of Ophthalmology and Visual Sciences, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada |
| authorships[26].institutions[0].id | https://openalex.org/I141945490 |
| authorships[26].institutions[0].ror | https://ror.org/03rmrcq20 |
| authorships[26].institutions[0].type | education |
| authorships[26].institutions[0].lineage | https://openalex.org/I141945490, https://openalex.org/I4210128534, https://openalex.org/I4210135497, https://openalex.org/I4387154919 |
| authorships[26].institutions[0].country_code | CA |
| authorships[26].institutions[0].display_name | University of British Columbia |
| authorships[26].author_position | middle |
| authorships[26].raw_author_name | Suren Sanmugasunderam |
| authorships[26].is_corresponding | False |
| authorships[26].raw_affiliation_strings | Department of Ophthalmology and Visual Sciences, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada |
| authorships[27].author.id | https://openalex.org/A5006753445 |
| authorships[27].author.orcid | https://orcid.org/0000-0003-2525-3744 |
| authorships[27].author.display_name | Kam Shojania |
| authorships[27].countries | CA |
| authorships[27].affiliations[0].institution_ids | https://openalex.org/I4210099137 |
| authorships[27].affiliations[0].raw_affiliation_string | Arthritis Research Canada, Vancouver, British Columbia, Canada |
| authorships[27].affiliations[1].institution_ids | https://openalex.org/I141945490 |
| authorships[27].affiliations[1].raw_affiliation_string | Division of Rheumatology, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada |
| authorships[27].institutions[0].id | https://openalex.org/I4210099137 |
| authorships[27].institutions[0].ror | https://ror.org/0103eqz62 |
| authorships[27].institutions[0].type | facility |
| authorships[27].institutions[0].lineage | https://openalex.org/I4210099137 |
| authorships[27].institutions[0].country_code | CA |
| authorships[27].institutions[0].display_name | Research Canada |
| authorships[27].institutions[1].id | https://openalex.org/I141945490 |
| authorships[27].institutions[1].ror | https://ror.org/03rmrcq20 |
| authorships[27].institutions[1].type | education |
| authorships[27].institutions[1].lineage | https://openalex.org/I141945490, https://openalex.org/I4210128534, https://openalex.org/I4210135497, https://openalex.org/I4387154919 |
| authorships[27].institutions[1].country_code | CA |
| authorships[27].institutions[1].display_name | University of British Columbia |
| authorships[27].author_position | last |
| authorships[27].raw_author_name | Kam Shojania |
| authorships[27].is_corresponding | False |
| authorships[27].raw_affiliation_strings | Arthritis Research Canada, Vancouver, British Columbia, Canada, Division of Rheumatology, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://bmjopen.bmj.com/content/bmjopen/12/2/e053852.full.pdf |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | RetINal Toxicity And HydroxyChloroquine Therapy (INTACT): protocol for a prospective population-based cohort study |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T13467 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9998999834060669 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2731 |
| primary_topic.subfield.display_name | Ophthalmology |
| primary_topic.display_name | Drug-Induced Ocular Toxicity |
| related_works | https://openalex.org/W3110506613, https://openalex.org/W3027791452, https://openalex.org/W3149354770, https://openalex.org/W2520571625, https://openalex.org/W3124402827, https://openalex.org/W2162982134, https://openalex.org/W2075863146, https://openalex.org/W4381571638, https://openalex.org/W2010260295, https://openalex.org/W2320562573 |
| cited_by_count | 3 |
| counts_by_year[0].year | 2024 |
| counts_by_year[0].cited_by_count | 2 |
| counts_by_year[1].year | 2023 |
| counts_by_year[1].cited_by_count | 1 |
| locations_count | 4 |
| best_oa_location.id | doi:10.1136/bmjopen-2021-053852 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S79054089 |
| best_oa_location.source.issn | 2044-6055 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 2044-6055 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | BMJ Open |
| best_oa_location.source.host_organization | https://openalex.org/P4310319945 |
| best_oa_location.source.host_organization_name | BMJ |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310319945 |
| best_oa_location.source.host_organization_lineage_names | BMJ |
| best_oa_location.license | cc-by-nc |
| best_oa_location.pdf_url | https://bmjopen.bmj.com/content/bmjopen/12/2/e053852.full.pdf |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by-nc |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | BMJ Open |
| best_oa_location.landing_page_url | https://doi.org/10.1136/bmjopen-2021-053852 |
| primary_location.id | doi:10.1136/bmjopen-2021-053852 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S79054089 |
| primary_location.source.issn | 2044-6055 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 2044-6055 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | BMJ Open |
| primary_location.source.host_organization | https://openalex.org/P4310319945 |
| primary_location.source.host_organization_name | BMJ |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310319945 |
| primary_location.source.host_organization_lineage_names | BMJ |
| primary_location.license | cc-by-nc |
| primary_location.pdf_url | https://bmjopen.bmj.com/content/bmjopen/12/2/e053852.full.pdf |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by-nc |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | BMJ Open |
| primary_location.landing_page_url | https://doi.org/10.1136/bmjopen-2021-053852 |
| publication_date | 2022-02-01 |
| publication_year | 2022 |
| referenced_works | https://openalex.org/W2157038471, https://openalex.org/W2080370529, https://openalex.org/W4242308600, https://openalex.org/W2130077869, https://openalex.org/W1795240072, https://openalex.org/W3024357685, https://openalex.org/W3120636818, https://openalex.org/W1518483167, https://openalex.org/W2093377323, https://openalex.org/W4232603416, https://openalex.org/W3033025085, https://openalex.org/W2800286191, https://openalex.org/W2106020775, https://openalex.org/W2040657208, https://openalex.org/W1759546812, https://openalex.org/W2119483296, https://openalex.org/W1991433622, https://openalex.org/W2019151860, https://openalex.org/W2302013022, https://openalex.org/W2095161148, https://openalex.org/W2120158349, https://openalex.org/W2134233670, https://openalex.org/W2136096562, https://openalex.org/W2168030824, https://openalex.org/W2023929658, https://openalex.org/W2730737530, https://openalex.org/W2914579784, https://openalex.org/W2754167240, https://openalex.org/W2899647033, https://openalex.org/W3127530620, https://openalex.org/W2096060458, https://openalex.org/W2153700383, https://openalex.org/W2322330499, https://openalex.org/W2165401890, https://openalex.org/W2085667526, https://openalex.org/W1969141242, https://openalex.org/W2642555623, https://openalex.org/W2086401822, https://openalex.org/W2233853340, https://openalex.org/W1681984133, https://openalex.org/W2797042179, https://openalex.org/W2059338001, https://openalex.org/W2003797154, https://openalex.org/W2471379186, https://openalex.org/W2264767503, https://openalex.org/W2108513094, https://openalex.org/W2149407433, https://openalex.org/W1950940723, https://openalex.org/W2104487175, https://openalex.org/W4249492944, https://openalex.org/W2055182267 |
| referenced_works_count | 51 |
| abstract_inverted_index.5 | 113, 271 |
| abstract_inverted_index.a | 61, 140, 203 |
| abstract_inverted_index.BC | 151 |
| abstract_inverted_index.To | 126 |
| abstract_inverted_index.We | 59, 259 |
| abstract_inverted_index.an | 4 |
| abstract_inverted_index.as | 168 |
| abstract_inverted_index.be | 216, 231, 247 |
| abstract_inverted_index.by | 218 |
| abstract_inverted_index.in | 66, 106, 115, 145 |
| abstract_inverted_index.is | 3, 23, 33, 42 |
| abstract_inverted_index.it | 22 |
| abstract_inverted_index.of | 29, 34, 39, 84, 123, 150, 163, 175, 179, 207, 226, 238, 252, 265, 284 |
| abstract_inverted_index.on | 90 |
| abstract_inverted_index.or | 71, 78, 108, 182 |
| abstract_inverted_index.to | 43, 202 |
| abstract_inverted_index.we | 93 |
| abstract_inverted_index.HCQ | 30, 46, 75, 208, 227, 253, 266 |
| abstract_inverted_index.RA, | 72 |
| abstract_inverted_index.SLE | 70, 99 |
| abstract_inverted_index.The | 37, 224 |
| abstract_inverted_index.aim | 38 |
| abstract_inverted_index.and | 17, 25, 53, 100, 137, 154, 184, 188, 212, 221, 274, 292 |
| abstract_inverted_index.are | 82 |
| abstract_inverted_index.for | 7, 76, 129, 234, 242, 249, 257 |
| abstract_inverted_index.has | 278 |
| abstract_inverted_index.on: | 161 |
| abstract_inverted_index.the | 27, 45, 118, 155, 169, 186, 235, 250, 263, 282, 293 |
| abstract_inverted_index.use | 162 |
| abstract_inverted_index.via | 196 |
| abstract_inverted_index.was | 143, 159 |
| abstract_inverted_index.who | 81 |
| abstract_inverted_index.(RA) | 16 |
| abstract_inverted_index.2019 | 147 |
| abstract_inverted_index.4162 | 101 |
| abstract_inverted_index.5508 | 95 |
| abstract_inverted_index.RA). | 102 |
| abstract_inverted_index.They | 103 |
| abstract_inverted_index.This | 276 |
| abstract_inverted_index.also | 261 |
| abstract_inverted_index.data | 138 |
| abstract_inverted_index.each | 200, 243 |
| abstract_inverted_index.five | 77 |
| abstract_inverted_index.from | 199, 281 |
| abstract_inverted_index.into | 177 |
| abstract_inverted_index.more | 79 |
| abstract_inverted_index.over | 112, 270 |
| abstract_inverted_index.plus | 191 |
| abstract_inverted_index.risk | 28, 51, 237, 244, 251, 264 |
| abstract_inverted_index.test | 194 |
| abstract_inverted_index.this | 40 |
| abstract_inverted_index.will | 104, 215, 230, 246, 260 |
| abstract_inverted_index.with | 9, 69, 117, 148 |
| abstract_inverted_index.(1346 | 98 |
| abstract_inverted_index.(BC), | 87 |
| abstract_inverted_index.(HCQ) | 2 |
| abstract_inverted_index.Based | 89 |
| abstract_inverted_index.Board | 290 |
| abstract_inverted_index.adult | 67 |
| abstract_inverted_index.after | 56, 255 |
| abstract_inverted_index.data, | 92 |
| abstract_inverted_index.lupus | 11 |
| abstract_inverted_index.other | 18 |
| abstract_inverted_index.rate, | 50 |
| abstract_inverted_index.study | 41, 65, 277 |
| abstract_inverted_index.team. | 157 |
| abstract_inverted_index.three | 219 |
| abstract_inverted_index.years | 114 |
| abstract_inverted_index.(SLE), | 13 |
| abstract_inverted_index.Ethics | 273, 289 |
| abstract_inverted_index.Hazard | 240 |
| abstract_inverted_index.Health | 296 |
| abstract_inverted_index.annual | 107 |
| abstract_inverted_index.clinic | 201 |
| abstract_inverted_index.cohort | 64 |
| abstract_inverted_index.course | 55 |
| abstract_inverted_index.death. | 239 |
| abstract_inverted_index.factor | 245 |
| abstract_inverted_index.images | 176, 190 |
| abstract_inverted_index.masked | 222 |
| abstract_inverted_index.ratios | 241 |
| abstract_inverted_index.server | 198 |
| abstract_inverted_index.years, | 80 |
| abstract_inverted_index.years. | 272 |
| abstract_inverted_index.Academy | 122 |
| abstract_inverted_index.British | 85, 285 |
| abstract_inverted_index.Canada. | 88 |
| abstract_inverted_index.Coastal | 295 |
| abstract_inverted_index.Methods | 58 |
| abstract_inverted_index.Purpose | 0 |
| abstract_inverted_index.centre. | 205 |
| abstract_inverted_index.factors | 52 |
| abstract_inverted_index.meeting | 142 |
| abstract_inverted_index.normal, | 180 |
| abstract_inverted_index.primary | 170 |
| abstract_inverted_index.reading | 204 |
| abstract_inverted_index.results | 195 |
| abstract_inverted_index.retinal | 31, 47, 110, 130, 152, 209, 228, 267 |
| abstract_inverted_index.revised | 120 |
| abstract_inverted_index.staging | 136, 214 |
| abstract_inverted_index.Although | 21 |
| abstract_inverted_index.American | 121 |
| abstract_inverted_index.Clinical | 287 |
| abstract_inverted_index.Columbia | 86, 286 |
| abstract_inverted_index.December | 146 |
| abstract_inverted_index.Research | 288, 297 |
| abstract_inverted_index.abnormal | 189 |
| abstract_inverted_index.approval | 280 |
| abstract_inverted_index.attained | 160 |
| abstract_inverted_index.biannual | 109 |
| abstract_inverted_index.clinical | 54 |
| abstract_inverted_index.concern. | 36 |
| abstract_inverted_index.convened | 144 |
| abstract_inverted_index.designed | 60 |
| abstract_inverted_index.eligible | 96 |
| abstract_inverted_index.estimate | 262 |
| abstract_inverted_index.imaging, | 132 |
| abstract_inverted_index.patients | 8, 68 |
| abstract_inverted_index.received | 279 |
| abstract_inverted_index.recently | 119 |
| abstract_inverted_index.research | 156 |
| abstract_inverted_index.severity | 135, 213 |
| abstract_inverted_index.spectral | 164 |
| abstract_inverted_index.systemic | 10 |
| abstract_inverted_index.toxicity | 32, 48, 210, 229, 268 |
| abstract_inverted_index.Agreement | 158 |
| abstract_inverted_index.Vancouver | 294 |
| abstract_inverted_index.abnormal; | 183 |
| abstract_inverted_index.adjusting | 256 |
| abstract_inverted_index.alignment | 116 |
| abstract_inverted_index.arthritis | 15 |
| abstract_inverted_index.coherence | 166 |
| abstract_inverted_index.competing | 236 |
| abstract_inverted_index.consensus | 141 |
| abstract_inverted_index.criteria, | 134 |
| abstract_inverted_index.currently | 73 |
| abstract_inverted_index.diagnoses | 211 |
| abstract_inverted_index.diseases. | 20 |
| abstract_inverted_index.equivocal | 181, 187 |
| abstract_inverted_index.important | 5 |
| abstract_inverted_index.incidence | 49, 225 |
| abstract_inverted_index.modality; | 173 |
| abstract_inverted_index.objective | 171 |
| abstract_inverted_index.performed | 217 |
| abstract_inverted_index.receiving | 74 |
| abstract_inverted_index.residents | 83 |
| abstract_inverted_index.rheumatic | 19 |
| abstract_inverted_index.screening | 111, 172 |
| abstract_inverted_index.transfer, | 139 |
| abstract_inverted_index.Institute. | 298 |
| abstract_inverted_index.University | 283 |
| abstract_inverted_index.accounting | 233 |
| abstract_inverted_index.calculated | 248 |
| abstract_inverted_index.categories | 178 |
| abstract_inverted_index.diagnostic | 133 |
| abstract_inverted_index.identified | 94 |
| abstract_inverted_index.increasing | 35 |
| abstract_inverted_index.medication | 6 |
| abstract_inverted_index.procedures | 128 |
| abstract_inverted_index.re-examine | 44 |
| abstract_inverted_index.reviewers. | 223 |
| abstract_inverted_index.rheumatoid | 14 |
| abstract_inverted_index.screening, | 131 |
| abstract_inverted_index.subjective | 193 |
| abstract_inverted_index.tomography | 167 |
| abstract_inverted_index.(H20-00736) | 291 |
| abstract_inverted_index.calculated, | 232 |
| abstract_inverted_index.cloud-based | 197 |
| abstract_inverted_index.guidelines. | 125 |
| abstract_inverted_index.independent | 220 |
| abstract_inverted_index.participate | 105 |
| abstract_inverted_index.progression | 269 |
| abstract_inverted_index.prospective | 62 |
| abstract_inverted_index.specialists | 153 |
| abstract_inverted_index.standardise | 127 |
| abstract_inverted_index.Confirmation | 206 |
| abstract_inverted_index.confounders. | 258 |
| abstract_inverted_index.participants | 97 |
| abstract_inverted_index.retinopathy, | 254 |
| abstract_inverted_index.transferring | 185 |
| abstract_inverted_index.Ophthalmology | 124 |
| abstract_inverted_index.corresponding | 192 |
| abstract_inverted_index.dissemination | 275 |
| abstract_inverted_index.erythematosus | 12 |
| abstract_inverted_index.participation | 149 |
| abstract_inverted_index.administrative | 91 |
| abstract_inverted_index.classification | 174 |
| abstract_inverted_index.domain-optical | 165 |
| abstract_inverted_index.well-tolerated | 24 |
| abstract_inverted_index.cost-effective, | 26 |
| abstract_inverted_index.discontinuation. | 57 |
| abstract_inverted_index.population-based | 63 |
| abstract_inverted_index.Hydroxychloroquine | 1 |
| cited_by_percentile_year.max | 96 |
| cited_by_percentile_year.min | 89 |
| corresponding_author_ids | https://openalex.org/A5008925315 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 28 |
| corresponding_institution_ids | https://openalex.org/I141945490, https://openalex.org/I4210099137 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/14 |
| sustainable_development_goals[0].score | 0.8399999737739563 |
| sustainable_development_goals[0].display_name | Life below water |
| citation_normalized_percentile.value | 0.63149804 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |