Retrospective Analysis of R-COMP Therapy in Patients with Diffuse Large B-Cell Lymphoma (DLBCL): Assessing the Impact of Sample Selection Bias Article Swipe
Chiara Romano
,
Francesco Branda
,
Nicola Petrosillo
,
Annalisa Arcari
,
Francesco Merli
,
Michele Spina
,
Giancarlo Ceccarelli
,
Massimo Ciccozzi
,
Fabio Scarpa
,
Luigi Rigacci
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/jcm14020639
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/jcm14020639
Background: Retrospective studies are often criticized for their susceptibility to case selection bias compared to prospective studies, which include all patients consecutively and are thus less prone to such limitations. However, the larger sample sizes typical of retrospective studies can sometimes offset this drawback. On behalf of the Fondazione Italiana Linfomi (FIL), a substantial retrospective study involving 946 patients was conducted to examine the use of non-pegylated liposomal anthracycline (Myocet). This was followed by a prospective study, the Prospective Elderly Project, which enrolled 308 patients treated with the same liposomal anthracycline regimen. Methods: The objective of this analysis was to determine whether the patient cohort from the retrospective study significantly differed from the cohort in the prospective study. Statistical hypothesis testing was applied to assess whether the samples from both studies originated from the same underlying population. The Anderson–Darling test, a non-parametric statistical method, was utilized to evaluate and compare the overall survival distributions between the two patient cohorts. Results: The statistical tests produced conflicting results, suggesting a potential selection bias in the retrospective study or the possibility that the two groups were from the same population. These discrepancies may have arisen due to the choice of statistical methods or the quality of the data analyzed. Conclusions: This study highlights the challenges of comparing retrospective and prospective cohorts and underscores the importance of selecting appropriate statistical methodologies. The findings provide valuable insights and lay the groundwork for developing innovative approaches to improve such comparisons in future research.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/jcm14020639
- https://www.mdpi.com/2077-0383/14/2/639/pdf?version=1737357587
- OA Status
- gold
- References
- 22
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4406614717
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4406614717Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/jcm14020639Digital Object Identifier
- Title
-
Retrospective Analysis of R-COMP Therapy in Patients with Diffuse Large B-Cell Lymphoma (DLBCL): Assessing the Impact of Sample Selection BiasWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-01-20Full publication date if available
- Authors
-
Chiara Romano, Francesco Branda, Nicola Petrosillo, Annalisa Arcari, Francesco Merli, Michele Spina, Giancarlo Ceccarelli, Massimo Ciccozzi, Fabio Scarpa, Luigi RigacciList of authors in order
- Landing page
-
https://doi.org/10.3390/jcm14020639Publisher landing page
- PDF URL
-
https://www.mdpi.com/2077-0383/14/2/639/pdf?version=1737357587Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/2077-0383/14/2/639/pdf?version=1737357587Direct OA link when available
- Concepts
-
Medicine, Retrospective cohort study, Prospective cohort study, Population, Sample size determination, Selection bias, Internal medicine, Statistical significance, Statistics, Pathology, Environmental health, MathematicsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
22Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4406614717 |
|---|---|
| doi | https://doi.org/10.3390/jcm14020639 |
| ids.doi | https://doi.org/10.3390/jcm14020639 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/39860645 |
| ids.openalex | https://openalex.org/W4406614717 |
| fwci | 0.0 |
| type | article |
| title | Retrospective Analysis of R-COMP Therapy in Patients with Diffuse Large B-Cell Lymphoma (DLBCL): Assessing the Impact of Sample Selection Bias |
| biblio.issue | 2 |
| biblio.volume | 14 |
| biblio.last_page | 639 |
| biblio.first_page | 639 |
| topics[0].id | https://openalex.org/T10185 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9998000264167786 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2734 |
| topics[0].subfield.display_name | Pathology and Forensic Medicine |
| topics[0].display_name | Lymphoma Diagnosis and Treatment |
| topics[1].id | https://openalex.org/T11235 |
| topics[1].field.id | https://openalex.org/fields/26 |
| topics[1].field.display_name | Mathematics |
| topics[1].score | 0.9977999925613403 |
| topics[1].domain.id | https://openalex.org/domains/3 |
| topics[1].domain.display_name | Physical Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2613 |
| topics[1].subfield.display_name | Statistics and Probability |
| topics[1].display_name | Statistical Methods in Clinical Trials |
| topics[2].id | https://openalex.org/T10950 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9854000210762024 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2739 |
| topics[2].subfield.display_name | Public Health, Environmental and Occupational Health |
| topics[2].display_name | Acute Lymphoblastic Leukemia research |
| is_xpac | False |
| apc_list.value | 2400 |
| apc_list.currency | CHF |
| apc_list.value_usd | 2598 |
| apc_paid.value | 2400 |
| apc_paid.currency | CHF |
| apc_paid.value_usd | 2598 |
| concepts[0].id | https://openalex.org/C71924100 |
| concepts[0].level | 0 |
| concepts[0].score | 0.8670170307159424 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[0].display_name | Medicine |
| concepts[1].id | https://openalex.org/C167135981 |
| concepts[1].level | 2 |
| concepts[1].score | 0.7783812284469604 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q2146302 |
| concepts[1].display_name | Retrospective cohort study |
| concepts[2].id | https://openalex.org/C188816634 |
| concepts[2].level | 2 |
| concepts[2].score | 0.550623893737793 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q2113324 |
| concepts[2].display_name | Prospective cohort study |
| concepts[3].id | https://openalex.org/C2908647359 |
| concepts[3].level | 2 |
| concepts[3].score | 0.488104909658432 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q2625603 |
| concepts[3].display_name | Population |
| concepts[4].id | https://openalex.org/C129848803 |
| concepts[4].level | 2 |
| concepts[4].score | 0.46982336044311523 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q2564360 |
| concepts[4].display_name | Sample size determination |
| concepts[5].id | https://openalex.org/C40423286 |
| concepts[5].level | 2 |
| concepts[5].score | 0.46263402700424194 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q284172 |
| concepts[5].display_name | Selection bias |
| concepts[6].id | https://openalex.org/C126322002 |
| concepts[6].level | 1 |
| concepts[6].score | 0.4190574288368225 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[6].display_name | Internal medicine |
| concepts[7].id | https://openalex.org/C65409693 |
| concepts[7].level | 2 |
| concepts[7].score | 0.4174134135246277 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q425265 |
| concepts[7].display_name | Statistical significance |
| concepts[8].id | https://openalex.org/C105795698 |
| concepts[8].level | 1 |
| concepts[8].score | 0.2176830768585205 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q12483 |
| concepts[8].display_name | Statistics |
| concepts[9].id | https://openalex.org/C142724271 |
| concepts[9].level | 1 |
| concepts[9].score | 0.11444312334060669 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q7208 |
| concepts[9].display_name | Pathology |
| concepts[10].id | https://openalex.org/C99454951 |
| concepts[10].level | 1 |
| concepts[10].score | 0.0 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q932068 |
| concepts[10].display_name | Environmental health |
| concepts[11].id | https://openalex.org/C33923547 |
| concepts[11].level | 0 |
| concepts[11].score | 0.0 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q395 |
| concepts[11].display_name | Mathematics |
| keywords[0].id | https://openalex.org/keywords/medicine |
| keywords[0].score | 0.8670170307159424 |
| keywords[0].display_name | Medicine |
| keywords[1].id | https://openalex.org/keywords/retrospective-cohort-study |
| keywords[1].score | 0.7783812284469604 |
| keywords[1].display_name | Retrospective cohort study |
| keywords[2].id | https://openalex.org/keywords/prospective-cohort-study |
| keywords[2].score | 0.550623893737793 |
| keywords[2].display_name | Prospective cohort study |
| keywords[3].id | https://openalex.org/keywords/population |
| keywords[3].score | 0.488104909658432 |
| keywords[3].display_name | Population |
| keywords[4].id | https://openalex.org/keywords/sample-size-determination |
| keywords[4].score | 0.46982336044311523 |
| keywords[4].display_name | Sample size determination |
| keywords[5].id | https://openalex.org/keywords/selection-bias |
| keywords[5].score | 0.46263402700424194 |
| keywords[5].display_name | Selection bias |
| keywords[6].id | https://openalex.org/keywords/internal-medicine |
| keywords[6].score | 0.4190574288368225 |
| keywords[6].display_name | Internal medicine |
| keywords[7].id | https://openalex.org/keywords/statistical-significance |
| keywords[7].score | 0.4174134135246277 |
| keywords[7].display_name | Statistical significance |
| keywords[8].id | https://openalex.org/keywords/statistics |
| keywords[8].score | 0.2176830768585205 |
| keywords[8].display_name | Statistics |
| keywords[9].id | https://openalex.org/keywords/pathology |
| keywords[9].score | 0.11444312334060669 |
| keywords[9].display_name | Pathology |
| language | en |
| locations[0].id | doi:10.3390/jcm14020639 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S2737969411 |
| locations[0].source.issn | 2077-0383 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 2077-0383 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Journal of Clinical Medicine |
| locations[0].source.host_organization | https://openalex.org/P4310310987 |
| locations[0].source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310310987 |
| locations[0].source.host_organization_lineage_names | Multidisciplinary Digital Publishing Institute |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.mdpi.com/2077-0383/14/2/639/pdf?version=1737357587 |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Journal of Clinical Medicine |
| locations[0].landing_page_url | https://doi.org/10.3390/jcm14020639 |
| locations[1].id | pmid:39860645 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Journal of clinical medicine |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/39860645 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:11766076 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | other-oa |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/other-oa |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | J Clin Med |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/11766076 |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5104315529 |
| authorships[0].author.orcid | |
| authorships[0].author.display_name | Chiara Romano |
| authorships[0].countries | IT |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I155125353 |
| authorships[0].affiliations[0].raw_affiliation_string | Unit of Medical Statistics and Molecular Epidemiology, Università Campus Bio-Medico di Roma, 00128 Rome, Italy |
| authorships[0].institutions[0].id | https://openalex.org/I155125353 |
| authorships[0].institutions[0].ror | https://ror.org/04gqx4x78 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I155125353 |
| authorships[0].institutions[0].country_code | IT |
| authorships[0].institutions[0].display_name | Università Campus Bio-Medico |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Chiara Romano |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Unit of Medical Statistics and Molecular Epidemiology, Università Campus Bio-Medico di Roma, 00128 Rome, Italy |
| authorships[1].author.id | https://openalex.org/A5066714548 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-9485-3877 |
| authorships[1].author.display_name | Francesco Branda |
| authorships[1].countries | IT |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I155125353 |
| authorships[1].affiliations[0].raw_affiliation_string | Unit of Medical Statistics and Molecular Epidemiology, Università Campus Bio-Medico di Roma, 00128 Rome, Italy |
| authorships[1].institutions[0].id | https://openalex.org/I155125353 |
| authorships[1].institutions[0].ror | https://ror.org/04gqx4x78 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I155125353 |
| authorships[1].institutions[0].country_code | IT |
| authorships[1].institutions[0].display_name | Università Campus Bio-Medico |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Francesco Branda |
| authorships[1].is_corresponding | True |
| authorships[1].raw_affiliation_strings | Unit of Medical Statistics and Molecular Epidemiology, Università Campus Bio-Medico di Roma, 00128 Rome, Italy |
| authorships[2].author.id | https://openalex.org/A5056262513 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-2585-7567 |
| authorships[2].author.display_name | Nicola Petrosillo |
| authorships[2].countries | IT |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I4210143387 |
| authorships[2].affiliations[0].raw_affiliation_string | Infection Prevention & Control, Infectious Disease Service, Fondazione Policlinico Universitario Campus Bio-Medico, 00128 Rome, Italy |
| authorships[2].institutions[0].id | https://openalex.org/I4210143387 |
| authorships[2].institutions[0].ror | https://ror.org/04gqbd180 |
| authorships[2].institutions[0].type | healthcare |
| authorships[2].institutions[0].lineage | https://openalex.org/I4210143387 |
| authorships[2].institutions[0].country_code | IT |
| authorships[2].institutions[0].display_name | Campus Bio Medico University Hospital |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Nicola Petrosillo |
| authorships[2].is_corresponding | True |
| authorships[2].raw_affiliation_strings | Infection Prevention & Control, Infectious Disease Service, Fondazione Policlinico Universitario Campus Bio-Medico, 00128 Rome, Italy |
| authorships[3].author.id | https://openalex.org/A5085955672 |
| authorships[3].author.orcid | https://orcid.org/0000-0001-5337-5947 |
| authorships[3].author.display_name | Annalisa Arcari |
| authorships[3].countries | IT |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I4210138324 |
| authorships[3].affiliations[0].raw_affiliation_string | Hematology Unit, Ospedale Guglielmo da Saliceto, 29122 Piacenza, Italy |
| authorships[3].institutions[0].id | https://openalex.org/I4210138324 |
| authorships[3].institutions[0].ror | https://ror.org/0403w5x31 |
| authorships[3].institutions[0].type | healthcare |
| authorships[3].institutions[0].lineage | https://openalex.org/I4210136395, https://openalex.org/I4210138324 |
| authorships[3].institutions[0].country_code | IT |
| authorships[3].institutions[0].display_name | Guglielmo da Saliceto Hospital |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Annalisa Arcari |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Hematology Unit, Ospedale Guglielmo da Saliceto, 29122 Piacenza, Italy |
| authorships[4].author.id | https://openalex.org/A5066201212 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-0979-7883 |
| authorships[4].author.display_name | Francesco Merli |
| authorships[4].countries | IT |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I4210090508 |
| authorships[4].affiliations[0].raw_affiliation_string | Hematology Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy |
| authorships[4].institutions[0].id | https://openalex.org/I4210090508 |
| authorships[4].institutions[0].ror | https://ror.org/001bbwj30 |
| authorships[4].institutions[0].type | healthcare |
| authorships[4].institutions[0].lineage | https://openalex.org/I4210090508 |
| authorships[4].institutions[0].country_code | IT |
| authorships[4].institutions[0].display_name | Azienda Sanitaria Unità Locale di Reggio Emilia |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Francesco Merli |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Hematology Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy |
| authorships[5].author.id | https://openalex.org/A5081879832 |
| authorships[5].author.orcid | https://orcid.org/0000-0001-6576-8182 |
| authorships[5].author.display_name | Michele Spina |
| authorships[5].countries | IT |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I4210128630 |
| authorships[5].affiliations[0].raw_affiliation_string | Division of Medical Oncology and Immune-Related Tumors, Centro di Riferimento Oncologico di Aviano IRCCS, 33081 Aviano, Italy |
| authorships[5].institutions[0].id | https://openalex.org/I4210128630 |
| authorships[5].institutions[0].ror | https://ror.org/03ks1vk59 |
| authorships[5].institutions[0].type | healthcare |
| authorships[5].institutions[0].lineage | https://openalex.org/I4210128630, https://openalex.org/I4210153126 |
| authorships[5].institutions[0].country_code | IT |
| authorships[5].institutions[0].display_name | Centro di Riferimento Oncologico |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Michele Spina |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Division of Medical Oncology and Immune-Related Tumors, Centro di Riferimento Oncologico di Aviano IRCCS, 33081 Aviano, Italy |
| authorships[6].author.id | https://openalex.org/A5041821046 |
| authorships[6].author.orcid | https://orcid.org/0000-0001-5921-3180 |
| authorships[6].author.display_name | Giancarlo Ceccarelli |
| authorships[6].countries | IT |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I2800330116, https://openalex.org/I861853513 |
| authorships[6].affiliations[0].raw_affiliation_string | Department of Public Health and Infectious Diseases, University Hospital Policlinico Umberto I, Sapienza University of Rome, 00185 Rome, Italy |
| authorships[6].institutions[0].id | https://openalex.org/I2800330116 |
| authorships[6].institutions[0].ror | https://ror.org/011cabk38 |
| authorships[6].institutions[0].type | healthcare |
| authorships[6].institutions[0].lineage | https://openalex.org/I2800330116 |
| authorships[6].institutions[0].country_code | IT |
| authorships[6].institutions[0].display_name | Policlinico Umberto I |
| authorships[6].institutions[1].id | https://openalex.org/I861853513 |
| authorships[6].institutions[1].ror | https://ror.org/02be6w209 |
| authorships[6].institutions[1].type | education |
| authorships[6].institutions[1].lineage | https://openalex.org/I861853513 |
| authorships[6].institutions[1].country_code | IT |
| authorships[6].institutions[1].display_name | Sapienza University of Rome |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Giancarlo Ceccarelli |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Department of Public Health and Infectious Diseases, University Hospital Policlinico Umberto I, Sapienza University of Rome, 00185 Rome, Italy |
| authorships[7].author.id | https://openalex.org/A5072223346 |
| authorships[7].author.orcid | https://orcid.org/0000-0003-3866-9239 |
| authorships[7].author.display_name | Massimo Ciccozzi |
| authorships[7].countries | IT |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I155125353 |
| authorships[7].affiliations[0].raw_affiliation_string | Unit of Medical Statistics and Molecular Epidemiology, Università Campus Bio-Medico di Roma, 00128 Rome, Italy |
| authorships[7].institutions[0].id | https://openalex.org/I155125353 |
| authorships[7].institutions[0].ror | https://ror.org/04gqx4x78 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I155125353 |
| authorships[7].institutions[0].country_code | IT |
| authorships[7].institutions[0].display_name | Università Campus Bio-Medico |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Massimo Ciccozzi |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Unit of Medical Statistics and Molecular Epidemiology, Università Campus Bio-Medico di Roma, 00128 Rome, Italy |
| authorships[8].author.id | https://openalex.org/A5022211262 |
| authorships[8].author.orcid | https://orcid.org/0000-0002-3501-714X |
| authorships[8].author.display_name | Fabio Scarpa |
| authorships[8].countries | IT |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I159650629 |
| authorships[8].affiliations[0].raw_affiliation_string | Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy |
| authorships[8].institutions[0].id | https://openalex.org/I159650629 |
| authorships[8].institutions[0].ror | https://ror.org/01bnjbv91 |
| authorships[8].institutions[0].type | education |
| authorships[8].institutions[0].lineage | https://openalex.org/I159650629 |
| authorships[8].institutions[0].country_code | IT |
| authorships[8].institutions[0].display_name | University of Sassari |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Fabio Scarpa |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy |
| authorships[9].author.id | https://openalex.org/A5089632360 |
| authorships[9].author.orcid | https://orcid.org/0000-0002-9320-9334 |
| authorships[9].author.display_name | Luigi Rigacci |
| authorships[9].countries | IT |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I4210143387 |
| authorships[9].affiliations[0].raw_affiliation_string | Research Unit of Hematology and Stem Cell Transplantation, Fondazione Policlinico Universitario Campus Bio-Medico di Roma, 00128 Rome, Italy |
| authorships[9].institutions[0].id | https://openalex.org/I4210143387 |
| authorships[9].institutions[0].ror | https://ror.org/04gqbd180 |
| authorships[9].institutions[0].type | healthcare |
| authorships[9].institutions[0].lineage | https://openalex.org/I4210143387 |
| authorships[9].institutions[0].country_code | IT |
| authorships[9].institutions[0].display_name | Campus Bio Medico University Hospital |
| authorships[9].author_position | last |
| authorships[9].raw_author_name | Luigi Rigacci |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Research Unit of Hematology and Stem Cell Transplantation, Fondazione Policlinico Universitario Campus Bio-Medico di Roma, 00128 Rome, Italy |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.mdpi.com/2077-0383/14/2/639/pdf?version=1737357587 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Retrospective Analysis of R-COMP Therapy in Patients with Diffuse Large B-Cell Lymphoma (DLBCL): Assessing the Impact of Sample Selection Bias |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10185 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9998000264167786 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2734 |
| primary_topic.subfield.display_name | Pathology and Forensic Medicine |
| primary_topic.display_name | Lymphoma Diagnosis and Treatment |
| related_works | https://openalex.org/W4293088233, https://openalex.org/W2111912746, https://openalex.org/W2339872203, https://openalex.org/W1994295934, https://openalex.org/W2288066013, https://openalex.org/W3023623073, https://openalex.org/W2062301734, https://openalex.org/W2056166643, https://openalex.org/W2006418866, https://openalex.org/W2124938485 |
| cited_by_count | 0 |
| locations_count | 3 |
| best_oa_location.id | doi:10.3390/jcm14020639 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S2737969411 |
| best_oa_location.source.issn | 2077-0383 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 2077-0383 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | Journal of Clinical Medicine |
| best_oa_location.source.host_organization | https://openalex.org/P4310310987 |
| best_oa_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| best_oa_location.source.host_organization_lineage_names | Multidisciplinary Digital Publishing Institute |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.mdpi.com/2077-0383/14/2/639/pdf?version=1737357587 |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Journal of Clinical Medicine |
| best_oa_location.landing_page_url | https://doi.org/10.3390/jcm14020639 |
| primary_location.id | doi:10.3390/jcm14020639 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S2737969411 |
| primary_location.source.issn | 2077-0383 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 2077-0383 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Journal of Clinical Medicine |
| primary_location.source.host_organization | https://openalex.org/P4310310987 |
| primary_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| primary_location.source.host_organization_lineage_names | Multidisciplinary Digital Publishing Institute |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.mdpi.com/2077-0383/14/2/639/pdf?version=1737357587 |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Journal of Clinical Medicine |
| primary_location.landing_page_url | https://doi.org/10.3390/jcm14020639 |
| publication_date | 2025-01-20 |
| publication_year | 2025 |
| referenced_works | https://openalex.org/W4393981324, https://openalex.org/W76396401, https://openalex.org/W4404262384, https://openalex.org/W4307776418, https://openalex.org/W2152913864, https://openalex.org/W2071360252, https://openalex.org/W2087824134, https://openalex.org/W1966377054, https://openalex.org/W6603079162, https://openalex.org/W3197464286, https://openalex.org/W2078729915, https://openalex.org/W2008399578, https://openalex.org/W3035045058, https://openalex.org/W3127059308, https://openalex.org/W4379471445, https://openalex.org/W6818474068, https://openalex.org/W6629016645, https://openalex.org/W3118412786, https://openalex.org/W4382654837, https://openalex.org/W4392883714, https://openalex.org/W4393026481, https://openalex.org/W4236316962 |
| referenced_works_count | 22 |
| abstract_inverted_index.a | 52, 74, 140, 167 |
| abstract_inverted_index.On | 44 |
| abstract_inverted_index.by | 73 |
| abstract_inverted_index.in | 114, 171, 244 |
| abstract_inverted_index.of | 36, 46, 65, 95, 196, 202, 212, 222 |
| abstract_inverted_index.or | 175, 199 |
| abstract_inverted_index.to | 9, 14, 27, 61, 99, 123, 146, 193, 240 |
| abstract_inverted_index.308 | 83 |
| abstract_inverted_index.946 | 57 |
| abstract_inverted_index.The | 93, 137, 160, 227 |
| abstract_inverted_index.all | 19 |
| abstract_inverted_index.and | 22, 148, 215, 218, 232 |
| abstract_inverted_index.are | 3, 23 |
| abstract_inverted_index.can | 39 |
| abstract_inverted_index.due | 192 |
| abstract_inverted_index.for | 6, 236 |
| abstract_inverted_index.lay | 233 |
| abstract_inverted_index.may | 189 |
| abstract_inverted_index.the | 31, 47, 63, 77, 87, 102, 106, 112, 115, 126, 133, 150, 155, 172, 176, 179, 184, 194, 200, 203, 210, 220, 234 |
| abstract_inverted_index.two | 156, 180 |
| abstract_inverted_index.use | 64 |
| abstract_inverted_index.was | 59, 71, 98, 121, 144 |
| abstract_inverted_index.This | 70, 207 |
| abstract_inverted_index.bias | 12, 170 |
| abstract_inverted_index.both | 129 |
| abstract_inverted_index.case | 10 |
| abstract_inverted_index.data | 204 |
| abstract_inverted_index.from | 105, 111, 128, 132, 183 |
| abstract_inverted_index.have | 190 |
| abstract_inverted_index.less | 25 |
| abstract_inverted_index.same | 88, 134, 185 |
| abstract_inverted_index.such | 28, 242 |
| abstract_inverted_index.that | 178 |
| abstract_inverted_index.this | 42, 96 |
| abstract_inverted_index.thus | 24 |
| abstract_inverted_index.were | 182 |
| abstract_inverted_index.with | 86 |
| abstract_inverted_index.These | 187 |
| abstract_inverted_index.often | 4 |
| abstract_inverted_index.prone | 26 |
| abstract_inverted_index.sizes | 34 |
| abstract_inverted_index.study | 55, 108, 174, 208 |
| abstract_inverted_index.test, | 139 |
| abstract_inverted_index.tests | 162 |
| abstract_inverted_index.their | 7 |
| abstract_inverted_index.which | 17, 81 |
| abstract_inverted_index.(FIL), | 51 |
| abstract_inverted_index.arisen | 191 |
| abstract_inverted_index.assess | 124 |
| abstract_inverted_index.behalf | 45 |
| abstract_inverted_index.choice | 195 |
| abstract_inverted_index.cohort | 104, 113 |
| abstract_inverted_index.future | 245 |
| abstract_inverted_index.groups | 181 |
| abstract_inverted_index.larger | 32 |
| abstract_inverted_index.offset | 41 |
| abstract_inverted_index.sample | 33 |
| abstract_inverted_index.study, | 76 |
| abstract_inverted_index.study. | 117 |
| abstract_inverted_index.Elderly | 79 |
| abstract_inverted_index.Linfomi | 50 |
| abstract_inverted_index.applied | 122 |
| abstract_inverted_index.between | 154 |
| abstract_inverted_index.cohorts | 217 |
| abstract_inverted_index.compare | 149 |
| abstract_inverted_index.examine | 62 |
| abstract_inverted_index.improve | 241 |
| abstract_inverted_index.include | 18 |
| abstract_inverted_index.method, | 143 |
| abstract_inverted_index.methods | 198 |
| abstract_inverted_index.overall | 151 |
| abstract_inverted_index.patient | 103, 157 |
| abstract_inverted_index.provide | 229 |
| abstract_inverted_index.quality | 201 |
| abstract_inverted_index.samples | 127 |
| abstract_inverted_index.studies | 2, 38, 130 |
| abstract_inverted_index.testing | 120 |
| abstract_inverted_index.treated | 85 |
| abstract_inverted_index.typical | 35 |
| abstract_inverted_index.whether | 101, 125 |
| abstract_inverted_index.However, | 30 |
| abstract_inverted_index.Italiana | 49 |
| abstract_inverted_index.Methods: | 92 |
| abstract_inverted_index.Project, | 80 |
| abstract_inverted_index.Results: | 159 |
| abstract_inverted_index.analysis | 97 |
| abstract_inverted_index.cohorts. | 158 |
| abstract_inverted_index.compared | 13 |
| abstract_inverted_index.differed | 110 |
| abstract_inverted_index.enrolled | 82 |
| abstract_inverted_index.evaluate | 147 |
| abstract_inverted_index.findings | 228 |
| abstract_inverted_index.followed | 72 |
| abstract_inverted_index.insights | 231 |
| abstract_inverted_index.patients | 20, 58, 84 |
| abstract_inverted_index.produced | 163 |
| abstract_inverted_index.regimen. | 91 |
| abstract_inverted_index.results, | 165 |
| abstract_inverted_index.studies, | 16 |
| abstract_inverted_index.survival | 152 |
| abstract_inverted_index.utilized | 145 |
| abstract_inverted_index.valuable | 230 |
| abstract_inverted_index.(Myocet). | 69 |
| abstract_inverted_index.analyzed. | 205 |
| abstract_inverted_index.comparing | 213 |
| abstract_inverted_index.conducted | 60 |
| abstract_inverted_index.determine | 100 |
| abstract_inverted_index.drawback. | 43 |
| abstract_inverted_index.involving | 56 |
| abstract_inverted_index.liposomal | 67, 89 |
| abstract_inverted_index.objective | 94 |
| abstract_inverted_index.potential | 168 |
| abstract_inverted_index.research. | 246 |
| abstract_inverted_index.selecting | 223 |
| abstract_inverted_index.selection | 11, 169 |
| abstract_inverted_index.sometimes | 40 |
| abstract_inverted_index.Fondazione | 48 |
| abstract_inverted_index.approaches | 239 |
| abstract_inverted_index.challenges | 211 |
| abstract_inverted_index.criticized | 5 |
| abstract_inverted_index.developing | 237 |
| abstract_inverted_index.groundwork | 235 |
| abstract_inverted_index.highlights | 209 |
| abstract_inverted_index.hypothesis | 119 |
| abstract_inverted_index.importance | 221 |
| abstract_inverted_index.innovative | 238 |
| abstract_inverted_index.originated | 131 |
| abstract_inverted_index.suggesting | 166 |
| abstract_inverted_index.underlying | 135 |
| abstract_inverted_index.Background: | 0 |
| abstract_inverted_index.Prospective | 78 |
| abstract_inverted_index.Statistical | 118 |
| abstract_inverted_index.appropriate | 224 |
| abstract_inverted_index.comparisons | 243 |
| abstract_inverted_index.conflicting | 164 |
| abstract_inverted_index.population. | 136, 186 |
| abstract_inverted_index.possibility | 177 |
| abstract_inverted_index.prospective | 15, 75, 116, 216 |
| abstract_inverted_index.statistical | 142, 161, 197, 225 |
| abstract_inverted_index.substantial | 53 |
| abstract_inverted_index.underscores | 219 |
| abstract_inverted_index.Conclusions: | 206 |
| abstract_inverted_index.limitations. | 29 |
| abstract_inverted_index.Retrospective | 1 |
| abstract_inverted_index.anthracycline | 68, 90 |
| abstract_inverted_index.consecutively | 21 |
| abstract_inverted_index.discrepancies | 188 |
| abstract_inverted_index.distributions | 153 |
| abstract_inverted_index.non-pegylated | 66 |
| abstract_inverted_index.retrospective | 37, 54, 107, 173, 214 |
| abstract_inverted_index.significantly | 109 |
| abstract_inverted_index.methodologies. | 226 |
| abstract_inverted_index.non-parametric | 141 |
| abstract_inverted_index.susceptibility | 8 |
| abstract_inverted_index.Anderson–Darling | 138 |
| cited_by_percentile_year | |
| corresponding_author_ids | https://openalex.org/A5066714548, https://openalex.org/A5056262513 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 10 |
| corresponding_institution_ids | https://openalex.org/I155125353, https://openalex.org/I4210143387 |
| citation_normalized_percentile.value | 0.02242713 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |