Journal of Clinical Medicine • Vol 14 • No 2
Retrospective Analysis of R-COMP Therapy in Patients with Diffuse Large B-Cell Lymphoma (DLBCL): Assessing the Impact of Sample Selection Bias
January 2025 • Chiara Romano, Francesco Branda, Nicola Petrosillo, Annalisa Arcari, Francesco Merli, Michele Spina, Giancarlo Ceccarelli, Massimo Ciccozzi, Fabio Sc…
Background: Retrospective studies are often criticized for their susceptibility to case selection bias compared to prospective studies, which include all patients consecutively and are thus less prone to such limitations. However, the larger sample sizes typical of retrospective studies can sometimes offset this drawback. On behalf of the Fondazione Italiana Linfomi (FIL), a substantial retrospective study involving 946 patients was conducted to examine the use of non-pegylated liposomal anthracycline (Myocet). Th…