Retrospective study of definitive therapy for head and neck mucosal melanoma: The RESUME study Article Swipe
Motoo Nomura
,
Naomi Kiyota
,
Yasushi Shimizu
,
Atsushi Motegi
,
Tetsuo Akimoto
,
Takashi Mukaigawa
,
Takashi Fujii
,
Nayuta Tsushima
,
Kiyoto Shiga
,
Taiji Koyama
,
Daisuke Kawakita
,
Akira Ohkoshi
,
Mitsuhiko Nakahira
,
Nobuhiro Hanai
,
Shigeyuki Murono
,
Tsutomu Ueda
,
Hiroki Mitani
,
Mutsukazu Kitano
,
Junichiro Ohori
,
Yuki Saito
,
Nobuhiko Oridate
,
Naoki Nishio
,
Hisayuki Kato
,
Kenji Okami
,
Takenori Ogawa
,
Yasushi Fujimoto
,
Mioko Matsuo
,
Kiyoaki Tsukahara
,
Morimasa Kitamura
,
Stephen Y. D. To
,
Shujiro Minami
,
Yosuke Ariizumi
,
Soichi Fumita
,
Akihiro Homma
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.ejcskn.2025.100736
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.ejcskn.2025.100736
Background: Head and neck mucosal melanoma (HNMM) is a rare melanoma. Surgery and radiotherapy (RT) are commonly used; however, their effectiveness remains unclear. In addition, the role of immune checkpoint inhibitors (ICIs) in improving survival in patients with locally advanced HNMM has not been fully evaluated. Patients and methods: This multi-institutional retrospective cohort study analyzed patients with locally advanced HNMM who were treated within the period October 2014 to March 2022. Patients either underwent surgery (S cohort) or received RT (RT cohort). Progression-free survival (PFS) and overall survival (OS) were compared between the S and RT cohorts and between those with and without ICI using propensity score-adjusted models. Results: A total of 304 patients were enrolled: 152 in the S cohort and 152 in the RT cohort. After matching, no significant differences in PFS and OS were observed between the S and RT cohorts. The addition of ICI was associated with significantly improved PFS (hazard ratio 0.50, 95 % confidence interval 0.32–0.80), with a favorable but nonsignificant trend in OS. Subgroup analysis showed that ICI was associated with prolonged OS in the S cohort but had no statistically significant effect in the RT cohort. Disease progression was predominantly distant, irrespective of treatment modality. Conclusion: Surgery and RT were associated with comparable survival outcomes for locally advanced HNMM. ICI was associated with improved PFS, but its relationship with OS needs further investigation. Prospective and randomized studies are needed to refine treatment approaches for this rare malignancy.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.ejcskn.2025.100736
- https://www.ejcskn.com/article/S2772-6118(25)00457-4/pdf
- OA Status
- diamond
- References
- 24
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4412627494
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4412627494Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1016/j.ejcskn.2025.100736Digital Object Identifier
- Title
-
Retrospective study of definitive therapy for head and neck mucosal melanoma: The RESUME studyWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-01-01Full publication date if available
- Authors
-
Motoo Nomura, Naomi Kiyota, Yasushi Shimizu, Atsushi Motegi, Tetsuo Akimoto, Takashi Mukaigawa, Takashi Fujii, Nayuta Tsushima, Kiyoto Shiga, Taiji Koyama, Daisuke Kawakita, Akira Ohkoshi, Mitsuhiko Nakahira, Nobuhiro Hanai, Shigeyuki Murono, Tsutomu Ueda, Hiroki Mitani, Mutsukazu Kitano, Junichiro Ohori, Yuki Saito, Nobuhiko Oridate, Naoki Nishio, Hisayuki Kato, Kenji Okami, Takenori Ogawa, Yasushi Fujimoto, Mioko Matsuo, Kiyoaki Tsukahara, Morimasa Kitamura, Stephen Y. D. To, Shujiro Minami, Yosuke Ariizumi, Soichi Fumita, Akihiro HommaList of authors in order
- Landing page
-
https://doi.org/10.1016/j.ejcskn.2025.100736Publisher landing page
- PDF URL
-
https://www.ejcskn.com/article/S2772-6118(25)00457-4/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
diamondOpen access status per OpenAlex
- OA URL
-
https://www.ejcskn.com/article/S2772-6118(25)00457-4/pdfDirect OA link when available
- Concepts
-
Mucosal melanoma, Head and neck, Medicine, Retrospective cohort study, Melanoma, Dermatology, Surgery, Cancer researchTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
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24Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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