Review construction of traditional Chinese medicine syndrome models for cardiovascular diseases and non–alcoholic fatty liver disease Article Swipe
Tao Lin
,
Zhongwei Tian
,
Zhiqian Song
,
Feng Yang
,
Chun Wang
,
Zhangchi Ning
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1097/gscm.0000000000000072
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1097/gscm.0000000000000072
Objective: This study investigates the mechanistic interplay between cardiovascular diseases (CVDs) and non–alcoholic fatty liver disease (NAFLD), with emphasis on the holistic framework and syndrome differentiation principles of traditional Chinese medicine (TCM). It further establishes TCM syndrome-specific animal models to elucidate shared pathogenic pathways. Methods: A systematic review was conducted on literature from CNKI and PubMed databases (2000–2025) addressing CVDs, NAFLD, and TCM syndrome modeling. We analyzed the establishment of animal models across diverse etiopathogenic classifications, prioritizing the operationalization of TCM syndromes and their translational relevance in disease pathophysiology. Results: The findings demonstrate bidirectional pathophysiological crosstalk between CVDs and NAFLD. The established animal models faithfully recapitulate core pathologic features of both conditions, providing a validated experimental framework for investigating their interconnected pathomechanistic cascades. Conclusion: This review establishes a robust theoretical framework for investigating the comorbidity of CVDs and NAFLD, while providing critical insights for pharmacological formulation development and mechanistic exploration. Importantly, it highlights the distinctive value of traditional TCM in addressing the systemic interplay and therapeutic management of these interconnected metabolic disorders.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1097/gscm.0000000000000072
- OA Status
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- References
- 39
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4412646638
All OpenAlex metadata
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https://openalex.org/W4412646638Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1097/gscm.0000000000000072Digital Object Identifier
- Title
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Review construction of traditional Chinese medicine syndrome models for cardiovascular diseases and non–alcoholic fatty liver diseaseWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-07-24Full publication date if available
- Authors
-
Tao Lin, Zhongwei Tian, Zhiqian Song, Feng Yang, Chun Wang, Zhangchi NingList of authors in order
- Landing page
-
https://doi.org/10.1097/gscm.0000000000000072Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
diamondOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1097/gscm.0000000000000072Direct OA link when available
- Concepts
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Fatty liver, Disease, Traditional Chinese medicine, Medicine, Alcoholic liver disease, Metabolic syndrome, Traditional medicine, Alternative medicine, Internal medicine, Pathology, Obesity, CirrhosisTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
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39Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.holistic | 21 |
| abstract_inverted_index.insights | 142 |
| abstract_inverted_index.medicine | 30 |
| abstract_inverted_index.syndrome | 24, 63 |
| abstract_inverted_index.systemic | 162 |
| abstract_inverted_index.cascades. | 122 |
| abstract_inverted_index.conducted | 49 |
| abstract_inverted_index.crosstalk | 95 |
| abstract_inverted_index.databases | 56 |
| abstract_inverted_index.elucidate | 40 |
| abstract_inverted_index.framework | 22, 116, 130 |
| abstract_inverted_index.interplay | 6, 163 |
| abstract_inverted_index.metabolic | 170 |
| abstract_inverted_index.modeling. | 64 |
| abstract_inverted_index.pathways. | 43 |
| abstract_inverted_index.providing | 112, 140 |
| abstract_inverted_index.relevance | 85 |
| abstract_inverted_index.syndromes | 81 |
| abstract_inverted_index.validated | 114 |
| abstract_inverted_index.Objective: | 0 |
| abstract_inverted_index.addressing | 58, 160 |
| abstract_inverted_index.disorders. | 171 |
| abstract_inverted_index.faithfully | 104 |
| abstract_inverted_index.highlights | 152 |
| abstract_inverted_index.literature | 51 |
| abstract_inverted_index.management | 166 |
| abstract_inverted_index.pathogenic | 42 |
| abstract_inverted_index.pathologic | 107 |
| abstract_inverted_index.principles | 26 |
| abstract_inverted_index.systematic | 46 |
| abstract_inverted_index.Conclusion: | 123 |
| abstract_inverted_index.comorbidity | 134 |
| abstract_inverted_index.conditions, | 111 |
| abstract_inverted_index.demonstrate | 92 |
| abstract_inverted_index.development | 146 |
| abstract_inverted_index.distinctive | 154 |
| abstract_inverted_index.established | 101 |
| abstract_inverted_index.establishes | 34, 126 |
| abstract_inverted_index.formulation | 145 |
| abstract_inverted_index.mechanistic | 5, 148 |
| abstract_inverted_index.theoretical | 129 |
| abstract_inverted_index.therapeutic | 165 |
| abstract_inverted_index.traditional | 28, 157 |
| abstract_inverted_index.Importantly, | 150 |
| abstract_inverted_index.experimental | 115 |
| abstract_inverted_index.exploration. | 149 |
| abstract_inverted_index.investigates | 3 |
| abstract_inverted_index.prioritizing | 76 |
| abstract_inverted_index.recapitulate | 105 |
| abstract_inverted_index.(2000–2025) | 57 |
| abstract_inverted_index.bidirectional | 93 |
| abstract_inverted_index.establishment | 68 |
| abstract_inverted_index.investigating | 118, 132 |
| abstract_inverted_index.translational | 84 |
| abstract_inverted_index.cardiovascular | 8 |
| abstract_inverted_index.etiopathogenic | 74 |
| abstract_inverted_index.interconnected | 120, 169 |
| abstract_inverted_index.differentiation | 25 |
| abstract_inverted_index.non–alcoholic | 12 |
| abstract_inverted_index.pharmacological | 144 |
| abstract_inverted_index.classifications, | 75 |
| abstract_inverted_index.pathomechanistic | 121 |
| abstract_inverted_index.pathophysiology. | 88 |
| abstract_inverted_index.syndrome-specific | 36 |
| abstract_inverted_index.operationalization | 78 |
| abstract_inverted_index.pathophysiological | 94 |
| cited_by_percentile_year | |
| countries_distinct_count | 1 |
| institutions_distinct_count | 6 |
| citation_normalized_percentile.value | 0.42391719 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |