Reviewer #2 (Public Review): Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming Article Swipe
The energy-burning capability of beige adipose tissue is a potential therapeutic tool for reducing obesity and metabolic disease, but this capacity is decreased by aging. Here, we evaluate the impact of aging on the profile and activity of adipocyte stem and progenitor cells (ASPCs) and adipocytes during the beiging process. We found that aging increases the expression of Cd9 and other fibrogenic genes in fibroblastic ASPCs and blocks their differentiation into beige adipocytes. Fibroblastic ASPC populations from young and aged mice were equally competent for beige differentiation in vitro, suggesting that environmental factors suppress adipogenesis in vivo. Examination of adipocytes by single nucleus RNA-sequencing identified compositional and transcriptional differences in adipocyte populations with age and cold exposure. Notably, cold exposure induced an adipocyte population expressing high levels of de novo lipogenesis (DNL) genes, and this response was severely blunted in aged animals. We further identified natriuretic peptide clearance receptor Npr3, a beige fat repressor, as a marker gene for a subset of white adipocytes and an aging-upregulated gene in adipocytes. In summary, this study indicates that aging blocks beige adipogenesis and dysregulates adipocyte responses to cold exposure and provides a unique resource for identifying cold and/or aging-regulated pathways in adipose tissue.
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Metadata
- Type
- peer-review
- Language
- en
- Landing Page
- https://doi.org/10.7554/elife.87756.1.sa0
- OA Status
- gold
- References
- 62
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4378903669
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4378903669Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.7554/elife.87756.1.sa0Digital Object Identifier
- Title
-
Reviewer #2 (Public Review): Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogrammingWork title
- Type
-
peer-reviewOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-05-31Full publication date if available
- Authors
-
Michael CzechList of authors in order
- Landing page
-
https://doi.org/10.7554/elife.87756.1.sa0Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.7554/elife.87756.1.sa0Direct OA link when available
- Concepts
-
Adipogenesis, Adipocyte, Biology, Adipose tissue, White adipose tissue, Endocrinology, Senescence, Internal medicine, Downregulation and upregulation, Reprogramming, Lipogenesis, Cell biology, Population, Stem cell, Gene, Genetics, Medicine, Environmental healthTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
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62Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.Examination | 97 |
| abstract_inverted_index.adipocytes. | 72, 169 |
| abstract_inverted_index.differences | 108 |
| abstract_inverted_index.identifying | 193 |
| abstract_inverted_index.lipogenesis | 130 |
| abstract_inverted_index.natriuretic | 145 |
| abstract_inverted_index.populations | 75, 111 |
| abstract_inverted_index.therapeutic | 10 |
| abstract_inverted_index.Fibroblastic | 73 |
| abstract_inverted_index.adipogenesis | 94, 179 |
| abstract_inverted_index.dysregulates | 181 |
| abstract_inverted_index.fibroblastic | 64 |
| abstract_inverted_index.compositional | 105 |
| abstract_inverted_index.environmental | 91 |
| abstract_inverted_index.RNA-sequencing | 103 |
| abstract_inverted_index.energy-burning | 1 |
| abstract_inverted_index.aging-regulated | 196 |
| abstract_inverted_index.differentiation | 69, 86 |
| abstract_inverted_index.transcriptional | 107 |
| abstract_inverted_index.aging-upregulated | 166 |
| cited_by_percentile_year | |
| corresponding_author_ids | https://openalex.org/A5085687728 |
| countries_distinct_count | 0 |
| institutions_distinct_count | 1 |
| citation_normalized_percentile |