Reviewer #3 (Public Review): Short-range interactions between fibrocytes and CD8+ T cells in COPD bronchial inflammatory response Article Swipe
Eyraud Edmée
,
Maurat Elise
,
Sac-Epée Jean-Marc
,
Henrot Pauline
,
M. Zysman
,
Esteves Pauline
,
Trian Thomas
,
Dupuy Jean-William
,
Leipold Alexander
,
Saliba Antoine-Emmanuel
,
Hugues Bégueret
,
Girodet Pierre-Oliver
,
Matthieu Thumerel
,
Hustache-Castaing Romain
,
Marthan Roger
,
Florian Levet
,
Vallois Pierre
,
Cécile Contin‐Bordes
,
Patrick Berger
,
Dupin Isabelle
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.7554/elife.85875.2.sa0
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.7554/elife.85875.2.sa0
Bronchi of chronic obstructive pulmonary disease (COPD) are the site of extensive cell infiltration, allowing persistent contacts between resident cells and immune cells. Tissue fibrocytes interaction with CD8+ T cells and its consequences were investigated using a combination of in situ, in vitro experiments and mathematical modeling. We show that fibrocytes and CD8+ T cells are found in vicinity in distal airways and that potential interactions are more frequent in tissues from COPD patients compared to those of control subjects. Increased proximity and clusterization between CD8+ T cells and fibrocytes are associated with altered lung function. Tissular CD8+ T cells from COPD patients promote fibrocyte chemotaxis via the CXCL8-CXCR1/2 axis. Live imaging shows that CD8+ T cells establish short-term interactions with fibrocytes, that trigger CD8+ T cell proliferation in a CD54– and CD86-dependent manner, pro-inflammatory cytokines production, CD8+ T cell cytotoxic activity against bronchial epithelial cells and fibrocyte immunomodulatory properties. We defined a computational model describing these intercellular interactions and calibrated the parameters based on our experimental measurements. We show the model's ability to reproduce histological ex vivo characteristics, and observe an important contribution of fibrocyte-mediated CD8+ T cell proliferation in COPD development. Using the model to test therapeutic scenarios, we predict a recovery time of several years, and the failure of targeting chemotaxis or interacting processes. Altogether, our study reveals that local interactions between fibrocytes and CD8+ T cells could jeopardize the balance between protective immunity and chronic inflammation in bronchi of COPD patients.
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Metadata
- Type
- peer-review
- Language
- en
- Landing Page
- https://doi.org/10.7554/elife.85875.2.sa0
- OA Status
- gold
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4382790170
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4382790170Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.7554/elife.85875.2.sa0Digital Object Identifier
- Title
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Reviewer #3 (Public Review): Short-range interactions between fibrocytes and CD8+ T cells in COPD bronchial inflammatory responseWork title
- Type
-
peer-reviewOpenAlex work type
- Language
-
enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-06-30Full publication date if available
- Authors
-
Eyraud Edmée, Maurat Elise, Sac-Epée Jean-Marc, Henrot Pauline, M. Zysman, Esteves Pauline, Trian Thomas, Dupuy Jean-William, Leipold Alexander, Saliba Antoine-Emmanuel, Hugues Bégueret, Girodet Pierre-Oliver, Matthieu Thumerel, Hustache-Castaing Romain, Marthan Roger, Florian Levet, Vallois Pierre, Cécile Contin‐Bordes, Patrick Berger, Dupin IsabelleList of authors in order
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https://doi.org/10.7554/elife.85875.2.sa0Publisher landing page
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YesWhether a free full text is available
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-
goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.7554/elife.85875.2.sa0Direct OA link when available
- Concepts
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Fibrocyte, CD8, Cytotoxic T cell, Immunology, Immune system, COPD, Cell biology, Biology, T cell, Medicine, Pathology, In vitro, Internal medicine, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.shows | 112 |
| abstract_inverted_index.situ, | 40 |
| abstract_inverted_index.study | 219 |
| abstract_inverted_index.these | 156 |
| abstract_inverted_index.those | 76 |
| abstract_inverted_index.using | 35 |
| abstract_inverted_index.vitro | 42 |
| abstract_inverted_index.(COPD) | 6 |
| abstract_inverted_index.Tissue | 23 |
| abstract_inverted_index.cells. | 22 |
| abstract_inverted_index.distal | 60 |
| abstract_inverted_index.immune | 21 |
| abstract_inverted_index.years, | 207 |
| abstract_inverted_index.Bronchi | 0 |
| abstract_inverted_index.CD54– | 130 |
| abstract_inverted_index.ability | 172 |
| abstract_inverted_index.against | 142 |
| abstract_inverted_index.airways | 61 |
| abstract_inverted_index.altered | 93 |
| abstract_inverted_index.balance | 233 |
| abstract_inverted_index.between | 17, 84, 224, 234 |
| abstract_inverted_index.bronchi | 241 |
| abstract_inverted_index.chronic | 2, 238 |
| abstract_inverted_index.control | 78 |
| abstract_inverted_index.defined | 151 |
| abstract_inverted_index.disease | 5 |
| abstract_inverted_index.failure | 210 |
| abstract_inverted_index.imaging | 111 |
| abstract_inverted_index.manner, | 133 |
| abstract_inverted_index.model's | 171 |
| abstract_inverted_index.observe | 180 |
| abstract_inverted_index.predict | 201 |
| abstract_inverted_index.promote | 103 |
| abstract_inverted_index.reveals | 220 |
| abstract_inverted_index.several | 206 |
| abstract_inverted_index.tissues | 70 |
| abstract_inverted_index.trigger | 123 |
| abstract_inverted_index.Tissular | 96 |
| abstract_inverted_index.activity | 141 |
| abstract_inverted_index.allowing | 14 |
| abstract_inverted_index.compared | 74 |
| abstract_inverted_index.contacts | 16 |
| abstract_inverted_index.frequent | 68 |
| abstract_inverted_index.immunity | 236 |
| abstract_inverted_index.patients | 73, 102 |
| abstract_inverted_index.recovery | 203 |
| abstract_inverted_index.resident | 18 |
| abstract_inverted_index.vicinity | 58 |
| abstract_inverted_index.Increased | 80 |
| abstract_inverted_index.bronchial | 143 |
| abstract_inverted_index.cytokines | 135 |
| abstract_inverted_index.cytotoxic | 140 |
| abstract_inverted_index.establish | 117 |
| abstract_inverted_index.extensive | 11 |
| abstract_inverted_index.fibrocyte | 104, 147 |
| abstract_inverted_index.function. | 95 |
| abstract_inverted_index.important | 182 |
| abstract_inverted_index.modeling. | 46 |
| abstract_inverted_index.patients. | 244 |
| abstract_inverted_index.potential | 64 |
| abstract_inverted_index.proximity | 81 |
| abstract_inverted_index.pulmonary | 4 |
| abstract_inverted_index.reproduce | 174 |
| abstract_inverted_index.subjects. | 79 |
| abstract_inverted_index.targeting | 212 |
| abstract_inverted_index.associated | 91 |
| abstract_inverted_index.calibrated | 160 |
| abstract_inverted_index.chemotaxis | 105, 213 |
| abstract_inverted_index.describing | 155 |
| abstract_inverted_index.epithelial | 144 |
| abstract_inverted_index.fibrocytes | 24, 50, 89, 225 |
| abstract_inverted_index.jeopardize | 231 |
| abstract_inverted_index.parameters | 162 |
| abstract_inverted_index.persistent | 15 |
| abstract_inverted_index.processes. | 216 |
| abstract_inverted_index.protective | 235 |
| abstract_inverted_index.scenarios, | 199 |
| abstract_inverted_index.short-term | 118 |
| abstract_inverted_index.Altogether, | 217 |
| abstract_inverted_index.combination | 37 |
| abstract_inverted_index.experiments | 43 |
| abstract_inverted_index.fibrocytes, | 121 |
| abstract_inverted_index.interacting | 215 |
| abstract_inverted_index.interaction | 25 |
| abstract_inverted_index.obstructive | 3 |
| abstract_inverted_index.production, | 136 |
| abstract_inverted_index.properties. | 149 |
| abstract_inverted_index.therapeutic | 198 |
| abstract_inverted_index.consequences | 32 |
| abstract_inverted_index.contribution | 183 |
| abstract_inverted_index.development. | 192 |
| abstract_inverted_index.experimental | 166 |
| abstract_inverted_index.histological | 175 |
| abstract_inverted_index.inflammation | 239 |
| abstract_inverted_index.interactions | 65, 119, 158, 223 |
| abstract_inverted_index.investigated | 34 |
| abstract_inverted_index.mathematical | 45 |
| abstract_inverted_index.CXCL8-CXCR1/2 | 108 |
| abstract_inverted_index.computational | 153 |
| abstract_inverted_index.infiltration, | 13 |
| abstract_inverted_index.intercellular | 157 |
| abstract_inverted_index.measurements. | 167 |
| abstract_inverted_index.proliferation | 127, 189 |
| abstract_inverted_index.CD86-dependent | 132 |
| abstract_inverted_index.clusterization | 83 |
| abstract_inverted_index.characteristics, | 178 |
| abstract_inverted_index.immunomodulatory | 148 |
| abstract_inverted_index.pro-inflammatory | 134 |
| abstract_inverted_index.fibrocyte-mediated | 185 |
| cited_by_percentile_year | |
| countries_distinct_count | 0 |
| institutions_distinct_count | 20 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.7699999809265137 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile |