Ribavirin Does Not Enhance Hepatitis B Virus Nucleotide Antiviral Activity: A Pilot Study Article Swipe

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Alexa Keeshan , Carla S. Coffin , Alicia Vachon , Nishi H. Patel , Scott Fung , Leanne Mortimer , Angela M. Crawley , Mang Ma , Carla Osiowy , Curtis Cooper ·

YOU? · · 2022 · Open Access · · DOI: https://doi.org/10.25011/cim.v45i4.39274

Purpose There is a need for effective and affordable treatments that achieve hepatitis B virus (HBV) functional cure and prevent long-term complications. The use of immune-modulators combined with HBV antivirals is a promising therapeutic strategy to achieve these goals. Based on ribavirin (RBV) monotherapy data, we hypothesized that RBV could improve virological responses when used in combination with tenofovir. Methods In this randomized, open label, controlled pilot trial, we evaluated RBV (n=4) dosed for the initial 24 weeks of treatment versus no RBV (n=4) in tenofovir recipients dosed over 48 weeks. Results Although well tolerated and safe in combination with tenofovir, RBV demonstrated no beneficial effects on virologic, biochemical or immunological markers of chronic HBV infection over 48 weeks of serial evaluation. Conclusions Our data does not suggest a HBV-specific immunomodulatory effect or an impact of RBV on HBV virological and antigen suppression.

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Medicine Ribavirin Hepatitis B virus Tenofovir Hepatitis C virus Chronic hepatitis Virus Virology Internal medicine Immunology Human immunodeficiency virus (HIV)

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Type: article
Language: en
Landing Page: https://doi.org/10.25011/cim.v45i4.39274
PDF: https://cimonline.ca/index.php/cim/article/download/39274/30505
OA Status: bronze
References: 7
Related Works: 10
OpenAlex ID: https://openalex.org/W4313335340

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DOI: https://doi.org/10.25011/cim.v45i4.39274

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Title: Ribavirin Does Not Enhance Hepatitis B Virus Nucleotide Antiviral Activity: A Pilot Study

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Language: en

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Publication year: 2022

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Publication date: 2022-12-31

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Authors: Alexa Keeshan, Carla S. Coffin, Alicia Vachon, Nishi H. Patel, Scott Fung, Leanne Mortimer, Angela M. Crawley, Mang Ma, Carla Osiowy, Curtis Cooper

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Landing page: https://doi.org/10.25011/cim.v45i4.39274

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PDF URL: https://cimonline.ca/index.php/cim/article/download/39274/30505

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OA status: bronze

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Concepts: Medicine, Ribavirin, Hepatitis B virus, Tenofovir, Hepatitis C virus, Chronic hepatitis, Virus, Virology, Internal medicine, Immunology, Human immunodeficiency virus (HIV)

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