Rifabutin Resistance Associated with Double Mutations in rpoB Gene in Mycobacterium tuberculosis Isolates Article Swipe
Wei Jing
,
Yu Pang
,
Zhaojing Zong
,
Jing Wang
,
Ru Guo
,
Fengmin Huo
,
Guanglu Jiang
,
Yifeng Ma
,
Hairong Huang
,
Naihui Chu
·
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.3389/fmicb.2017.01768
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.3389/fmicb.2017.01768
The objective of this study was to investigate the cross-resistance between rifampin (RIF) and rifabutin (RFB) among clinical Mycobacterium tuberculosis (MTB) isolates, and the correlations between specific rpoB mutations and the minimum inhibitory concentrations (MICs) of RIF and RFB. A total of 256 RIF-resistant isolates were included from the National Tuberculosis Clinical Laboratory in China. The MICs of MTB isolates against RIF and RFB were determined by using a microplate alamarBlue assay. In addition, all the MTB isolates were sequenced for mutations in rpoB gene. 204 out of 256 isolates (79.7%) were resistant to RFB, whereas 52 (20.3%) were susceptible to RFB. RIF-resistant/INH-susceptible (RR) group had a significant lower proportion of RFB-resistance than MDR- (P = 0.04) and XDR-TB group (P < 0.01). DNA sequencing revealed that there were 218 isolates (85.2%) with a single mutation, 26 (10.1%) with double mutations, and 12 (4.7%) without mutation in rpoB gene. Notably, although the single substitution of Leu511Pro, Asp516Gly, and His526Asn did not result in RFB resistance, 77.8% (7/9) of the MTB isolates with these double mutations became resistant to RFB. Compared with RR group (38.9%, 7/18), MDR-TB (63.5%, 106/167) had significantly higher proportion of isolates with mutations in codon 531 of rpoB gene (P = 0.04). Our data demonstrate that various rpoB mutations are associated with differential resistance to RIF and RFB. A single specific mutation in codons 511, 516, 526, and 533 was linked to the susceptibility to RFB for MTB, while the strains with these double mutations irrelevantly conferring RFB resistance produced RFB-resistant phenotype.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fmicb.2017.01768
- https://www.frontiersin.org/articles/10.3389/fmicb.2017.01768/pdf
- OA Status
- gold
- Cited By
- 24
- References
- 41
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2756268815
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2756268815Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fmicb.2017.01768Digital Object Identifier
- Title
-
Rifabutin Resistance Associated with Double Mutations in rpoB Gene in Mycobacterium tuberculosis IsolatesWork title
- Type
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articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2017Year of publication
- Publication date
-
2017-09-14Full publication date if available
- Authors
-
Wei Jing, Yu Pang, Zhaojing Zong, Jing Wang, Ru Guo, Fengmin Huo, Guanglu Jiang, Yifeng Ma, Hairong Huang, Naihui ChuList of authors in order
- Landing page
-
https://doi.org/10.3389/fmicb.2017.01768Publisher landing page
- PDF URL
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https://www.frontiersin.org/articles/10.3389/fmicb.2017.01768/pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://www.frontiersin.org/articles/10.3389/fmicb.2017.01768/pdfDirect OA link when available
- Concepts
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rpoB, Biology, Rifabutin, Mycobacterium tuberculosis, Microbiology, Gene, Genetics, Virology, Tuberculosis, Antibiotics, Medicine, 16S ribosomal RNA, Clarithromycin, PathologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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24Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1, 2024: 2, 2023: 5, 2022: 4, 2021: 2Per-year citation counts (last 5 years)
- References (count)
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41Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.mutations, | 140 |
| abstract_inverted_index.phenotype. | 254 |
| abstract_inverted_index.proportion | 109, 191 |
| abstract_inverted_index.resistance | 216, 251 |
| abstract_inverted_index.sequencing | 124 |
| abstract_inverted_index.<i>rpoB</i> | 27, 83, 147, 200, 210 |
| abstract_inverted_index.demonstrate | 207 |
| abstract_inverted_index.investigate | 7 |
| abstract_inverted_index.resistance, | 164 |
| abstract_inverted_index.significant | 107 |
| abstract_inverted_index.susceptible | 99 |
| abstract_inverted_index.Tuberculosis | 50 |
| abstract_inverted_index.correlations | 24 |
| abstract_inverted_index.differential | 215 |
| abstract_inverted_index.irrelevantly | 248 |
| abstract_inverted_index.substitution | 153 |
| abstract_inverted_index.RFB-resistant | 253 |
| abstract_inverted_index.RIF-resistant | 43 |
| abstract_inverted_index.significantly | 189 |
| abstract_inverted_index.RFB-resistance | 111 |
| abstract_inverted_index.concentrations | 33 |
| abstract_inverted_index.susceptibility | 236 |
| abstract_inverted_index.<i>Mycobacterium | 18 |
| abstract_inverted_index.cross-resistance | 9 |
| abstract_inverted_index.tuberculosis</i> | 19 |
| abstract_inverted_index.RIF-resistant/INH-susceptible | 102 |
| cited_by_percentile_year.max | 98 |
| cited_by_percentile_year.min | 89 |
| corresponding_author_ids | https://openalex.org/A5026863467, https://openalex.org/A5073166066 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 10 |
| corresponding_institution_ids | https://openalex.org/I183519381, https://openalex.org/I4210107581 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8399999737739563 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.82366877 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |