Risk Factors for Intestinal and Extraintestinal Cancers in Inflammatory Bowel Disease: A Retrospective Single-Center Cohort Study Article Swipe
Rosa Rosania
,
Mark Nord
,
Florian G. Scurt
,
Anke Lux
,
Verena Keitel
,
Ulrike von Arnim
,
Marino Venerito
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/cancers17091396
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/cancers17091396
Background/Objectives: Patients with inflammatory bowel disease (IBD) face an increased risk of developing intestinal and extraintestinal cancers. This retrospective single-center study aimed to quantify cancer risk and identify potential risk factors associated with cancer in IBD patients. Methods: The epidemiological data, disease characteristics, treatment regimens, and occurrences of cancer following IBD diagnosis were collected between January 2021 and February 2022. Hazard ratios (HRs) and standardized incidence ratios (SIRs) were estimated. Results: 560 IBD patients were included; 37 patients developed cancer, with 5 patients developing two distinct cancers, resulting in 42 cancers overall. This translated into a twofold increased risk of developing any cancer compared to the general population (SIR 1.94, 95% CI 1.4–2.6). Colorectal (CRC, 29%), skin (19%), and breast cancer (17%) were the most common malignancies. Female patients showed an increased risk for all cancers (SIR 3.1, 95% CI 2.06–4.3), melanoma (SIR 5.6, 95% CI 1.14–16.2), and CRC (SIR 7.5, 95% CI 3–15.4). Conversely, male patients exhibited a significantly increased risk of lymphoma (SIR 26.2, 95% CI 3.2–95.7). Young age at IBD diagnosis and the use of immunomodulators, whether as monotherapy or in combination with biologics, were associated with an increased risk of cancer. Conclusions: The risk of CRC and lymphoma in IBD patients may be higher than previously reported, potentially due to the increasing use of combination therapy. Cancer risk in IBD should be regularly assessed and personalized throughout the disease course.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/cancers17091396
- https://www.mdpi.com/2072-6694/17/9/1396/pdf?version=1745388653
- OA Status
- gold
- Cited By
- 1
- References
- 29
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4409668646
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4409668646Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/cancers17091396Digital Object Identifier
- Title
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Risk Factors for Intestinal and Extraintestinal Cancers in Inflammatory Bowel Disease: A Retrospective Single-Center Cohort StudyWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2025Year of publication
- Publication date
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2025-04-22Full publication date if available
- Authors
-
Rosa Rosania, Mark Nord, Florian G. Scurt, Anke Lux, Verena Keitel, Ulrike von Arnim, Marino VeneritoList of authors in order
- Landing page
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https://doi.org/10.3390/cancers17091396Publisher landing page
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https://www.mdpi.com/2072-6694/17/9/1396/pdf?version=1745388653Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.mdpi.com/2072-6694/17/9/1396/pdf?version=1745388653Direct OA link when available
- Concepts
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Medicine, Internal medicine, Inflammatory bowel disease, Cancer, Colorectal cancer, Retrospective cohort study, Population, Ulcerative colitis, Epidemiology, Hazard ratio, Breast cancer, Incidence (geometry), Disease, Anal cancer, Oncology, Confidence interval, Physics, Environmental health, OpticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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1Total citation count in OpenAlex
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2025: 1Per-year citation counts (last 5 years)
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29Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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