Risk Factors for Long-Term Contracture Recurrence after Collagenase Injection for Dupuytren Disease: A Prospective Cohort Study Article Swipe
David Eckerdal
,
Anna Lauritzson
,
Anna Åkesson
,
Isam Atroshi
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/biomedicines11030699
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/biomedicines11030699
In Dupuytren disease, little is known about the long-term outcomes of collagenase injection or risk factors for contracture recurrence. In this prospective study, 159 patients (242 fingers) with Dupuytren disease and active extension deficit (AED) ≥20° in a metacarpophalangeal (MCP) or proximal interphalangeal (PIP) joint were treated with collagenase injection during a 14-month period. At 5 years, 18 patients were deceased, 2 could not be contacted, and 13 had undergone fasciectomy. The remaining 126 patients (199 treated fingers) participated in a follow-up evaluation at 52–96 (mean 65) months after injection, with physical examination (114 patients) or telephone interview (12 patients). Recurrence was defined as subsequent treatment (surgery or repeat injection) or ≥20° AED worsening in a treated joint between the 6-week and 5-year measurements. The mean AED at baseline was 42° (SD 24) for MCP joints and 31° (SD 29) for PIP joints and at 5 years 11° (SD 17) and 17° (SD 23), respectively. Recurrence occurred in 17% of MCP joints and 25% of PIP joints. Statistically significant risk factors for PIP joint contracture recurrence were greater baseline AED (odds ratio 1.04, 95% CI 1.02–1.06) and small finger treatment (OR 4.6, 95% CI 1.5–14.3), with no significant risk factors found for MCP contracture recurrence.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/biomedicines11030699
- https://www.mdpi.com/2227-9059/11/3/699/pdf?version=1677238561
- OA Status
- gold
- Cited By
- 2
- References
- 30
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4322504645
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4322504645Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/biomedicines11030699Digital Object Identifier
- Title
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Risk Factors for Long-Term Contracture Recurrence after Collagenase Injection for Dupuytren Disease: A Prospective Cohort StudyWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
-
2023-02-24Full publication date if available
- Authors
-
David Eckerdal, Anna Lauritzson, Anna Åkesson, Isam AtroshiList of authors in order
- Landing page
-
https://doi.org/10.3390/biomedicines11030699Publisher landing page
- PDF URL
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https://www.mdpi.com/2227-9059/11/3/699/pdf?version=1677238561Direct link to full text PDF
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://www.mdpi.com/2227-9059/11/3/699/pdf?version=1677238561Direct OA link when available
- Concepts
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Medicine, Contracture, Dupuytren's contracture, Surgery, Prospective cohort study, Muscle contracture, Interphalangeal Joint, Odds ratio, Cohort study, Cohort, Joint Contracture, Internal medicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
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2Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1, 2024: 1Per-year citation counts (last 5 years)
- References (count)
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30Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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