Risk factors of venous thromboembolic events among diffuse large B-cell lymphoma patients receiving first-line treatment Article Swipe
Anna Jokimäki
,
Susanna Tokola
,
Minna Harmanen
,
Hanne Kuitunen
,
Anni Sillanpää
,
Aino Rönkä
,
Tuomas Selander
,
Arja Jukkola
,
Päivi Auvinen
,
Outi Kuittinen
,
Milla E.L. Kuusisto
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-1478845/v2
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-1478845/v2
Venous thromboembolic events (VTEs) remain a major cause of mortality and morbidity among lymphoma patients. In this retrospective study, we analyzed the risk factors for VTEs in DLBCL (diffuse large B-cell lymphoma) patients treated with first-line (1L) chemoimmunotherapy in Kuopio and Oulu University Hospitals (2010–2019).VTE occurred in 17.2% (n = 59) in the whole population, and seven VTEs occurred during anticoagulant therapy. Statistically significant risk factors for VTE included age > 65 years, ECOG (Eastern Cooperative Oncology Group) > 1, thrombophilia, bulky disease, LDH > ULN (lactate dehydrogenase; upper limit of normal) and IPI (International Prognostic Index) 4–5. In a multivariate Cox regression model, history of thrombophilia and bulky disease were independent risk factors for VTE (p = 0.000 and p = 0.032, respectively). VTE at 1L had no significant effect on survival at 2 or 5 years of follow-up. Two different VTE risk scores were tested in DLBCL patients treated in 1L. A risk score 2 (age > 65/LDH > ULN/ ECOG > 1/thrombophilia = 1 p., bulky disease 2 p.) received a higher ROC value (0.680) than risk score 1. In the “high risk” group (5 p., according to risk score 2), VTE risk was increased, at 35.3%.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.21203/rs.3.rs-1478845/v2
- https://www.researchsquare.com/article/rs-1478845/latest.pdf
- OA Status
- gold
- References
- 28
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4224236906
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4224236906Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.21203/rs.3.rs-1478845/v2Digital Object Identifier
- Title
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Risk factors of venous thromboembolic events among diffuse large B-cell lymphoma patients receiving first-line treatmentWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-04-20Full publication date if available
- Authors
-
Anna Jokimäki, Susanna Tokola, Minna Harmanen, Hanne Kuitunen, Anni Sillanpää, Aino Rönkä, Tuomas Selander, Arja Jukkola, Päivi Auvinen, Outi Kuittinen, Milla E.L. KuusistoList of authors in order
- Landing page
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https://doi.org/10.21203/rs.3.rs-1478845/v2Publisher landing page
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https://www.researchsquare.com/article/rs-1478845/latest.pdfDirect link to full text PDF
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://www.researchsquare.com/article/rs-1478845/latest.pdfDirect OA link when available
- Concepts
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Medicine, Internal medicine, International Prognostic Index, Thrombophilia, Diffuse large B-cell lymphoma, Lymphoma, Gastroenterology, Proportional hazards model, Retrospective cohort study, Surgery, Oncology, ThrombosisTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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28Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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