Risk of Major Congenital Malformations and Exposure to Antiseizure Medication Monotherapy

Exploring foci of: JAMA Neurology • Vol 81 • No 5 Risk of Major Congenital Malformations and Exposure to Antiseizure Medication Monotherapy March 2024 • Dina Battino, Torbjörn Tomson, Erminio Bonizzoni, John Craig, Emilio Perucca, Anne Sabers, Sanjeev V. Thomas, Silje Alvestad, Piero Perucca, Frank Va… Importance Women with epilepsy (WWE) require treatment with antiseizure medications (ASMs) during pregnancy, which may be associated with an increased risk of major congenital malformations (MCMs) in their offspring. Objective To investigate the prevalence of MCMs after prenatal exposure to 8 commonly used ASM monotherapies and changes in MCM prevalence over time. Design, Setting, and Participants This was a prospective, observational, longitudinal cohort study conducted from June 1999 to October 2022. Since 1999,… Open Article Page

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