RNA-binding protein PCBP1regulated dry eye disease via ferroptosis Article Swipe
Yang Li
,
Shengjia Hu
,
Pingping Yu
,
Muzhi Chen
,
Xinchang Wang
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-4776606/v1
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-4776606/v1
Background Dry eye disease (DED) is a medical condition which is characterized by a wide range of symptoms and clinical signs related to insufficient or poor-quality of tears. In this study, we investigated a potential protein and related mechanisms involved in DED process. Methods Bioinformatics technology was conducted to find potential protein. PCR and Elisa assay were performed to detect gene and protein level in the tear samples collected from patients. Ex vivo DED model was built by hyperosmotic stress‑induced cell model and knockdown of aimed gene was achieved by lentivirus vector-mediated shRNA. CCK8 assay and flow cytometry was conducted to detect cell viability and apoptosis. Western blot was performed to detect oxidative stress-related proteins. Then ROS and iron level within cells were also detected by assay kit. Results The expression of PolyC-RNA binding protein 1 (PCBP1) of tear samples was higher in DED patients compared with non-DED controls both in gene and protein level. In ex vivo DED model, PCBP1 could decrease corneal epithelial cell proliferation and increase cell apoptosis. Moreover, PCBP1 also decreased oxidative stress-related protein level as well as increased ROS and iron level within cells. Conclusion PCBP1 could influence dry eye disease via ferroptosis by regulating cell viability and oxidative stress process.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.21203/rs.3.rs-4776606/v1
- https://www.researchsquare.com/article/rs-4776606/latest.pdf
- OA Status
- gold
- References
- 38
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4401883994
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4401883994Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.21203/rs.3.rs-4776606/v1Digital Object Identifier
- Title
-
RNA-binding protein PCBP1regulated dry eye disease via ferroptosisWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-08-26Full publication date if available
- Authors
-
Yang Li, Shengjia Hu, Pingping Yu, Muzhi Chen, Xinchang WangList of authors in order
- Landing page
-
https://doi.org/10.21203/rs.3.rs-4776606/v1Publisher landing page
- PDF URL
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https://www.researchsquare.com/article/rs-4776606/latest.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://www.researchsquare.com/article/rs-4776606/latest.pdfDirect OA link when available
- Concepts
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Viability assay, Gene knockdown, Oxidative stress, Ex vivo, Molecular biology, Apoptosis, Flow cytometry, Western blot, Cell, Cell growth, Biology, Chemistry, Gene, In vitro, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
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38Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.CCK8 | 94 |
| abstract_inverted_index.Then | 116 |
| abstract_inverted_index.also | 124, 174 |
| abstract_inverted_index.blot | 108 |
| abstract_inverted_index.both | 150 |
| abstract_inverted_index.cell | 81, 103, 166, 170, 201 |
| abstract_inverted_index.find | 50 |
| abstract_inverted_index.flow | 97 |
| abstract_inverted_index.from | 70 |
| abstract_inverted_index.gene | 61, 87, 152 |
| abstract_inverted_index.iron | 119, 186 |
| abstract_inverted_index.kit. | 128 |
| abstract_inverted_index.tear | 67, 139 |
| abstract_inverted_index.this | 30 |
| abstract_inverted_index.vivo | 73, 158 |
| abstract_inverted_index.well | 181 |
| abstract_inverted_index.were | 57, 123 |
| abstract_inverted_index.wide | 15 |
| abstract_inverted_index.with | 147 |
| abstract_inverted_index.(DED) | 5 |
| abstract_inverted_index.Elisa | 55 |
| abstract_inverted_index.PCBP1 | 161, 173, 191 |
| abstract_inverted_index.aimed | 86 |
| abstract_inverted_index.assay | 56, 95, 127 |
| abstract_inverted_index.built | 77 |
| abstract_inverted_index.cells | 122 |
| abstract_inverted_index.could | 162, 192 |
| abstract_inverted_index.level | 64, 120, 179, 187 |
| abstract_inverted_index.model | 75, 82 |
| abstract_inverted_index.range | 16 |
| abstract_inverted_index.signs | 21 |
| abstract_inverted_index.which | 10 |
| abstract_inverted_index.cells. | 189 |
| abstract_inverted_index.detect | 60, 102, 112 |
| abstract_inverted_index.higher | 142 |
| abstract_inverted_index.level. | 155 |
| abstract_inverted_index.model, | 160 |
| abstract_inverted_index.shRNA. | 93 |
| abstract_inverted_index.stress | 205 |
| abstract_inverted_index.study, | 31 |
| abstract_inverted_index.tears. | 28 |
| abstract_inverted_index.within | 121, 188 |
| abstract_inverted_index.(PCBP1) | 137 |
| abstract_inverted_index.Methods | 44 |
| abstract_inverted_index.Results | 129 |
| abstract_inverted_index.Western | 107 |
| abstract_inverted_index.binding | 134 |
| abstract_inverted_index.corneal | 164 |
| abstract_inverted_index.disease | 4, 196 |
| abstract_inverted_index.medical | 8 |
| abstract_inverted_index.non-DED | 148 |
| abstract_inverted_index.protein | 36, 63, 135, 154, 178 |
| abstract_inverted_index.related | 22, 38 |
| abstract_inverted_index.samples | 68, 140 |
| abstract_inverted_index.achieved | 89 |
| abstract_inverted_index.clinical | 20 |
| abstract_inverted_index.compared | 146 |
| abstract_inverted_index.controls | 149 |
| abstract_inverted_index.decrease | 163 |
| abstract_inverted_index.detected | 125 |
| abstract_inverted_index.increase | 169 |
| abstract_inverted_index.involved | 40 |
| abstract_inverted_index.patients | 145 |
| abstract_inverted_index.process. | 43, 206 |
| abstract_inverted_index.protein. | 52 |
| abstract_inverted_index.symptoms | 18 |
| abstract_inverted_index.Moreover, | 172 |
| abstract_inverted_index.PolyC-RNA | 133 |
| abstract_inverted_index.collected | 69 |
| abstract_inverted_index.condition | 9 |
| abstract_inverted_index.conducted | 48, 100 |
| abstract_inverted_index.cytometry | 98 |
| abstract_inverted_index.decreased | 175 |
| abstract_inverted_index.increased | 183 |
| abstract_inverted_index.influence | 193 |
| abstract_inverted_index.knockdown | 84 |
| abstract_inverted_index.oxidative | 113, 176, 204 |
| abstract_inverted_index.patients. | 71 |
| abstract_inverted_index.performed | 58, 110 |
| abstract_inverted_index.potential | 35, 51 |
| abstract_inverted_index.proteins. | 115 |
| abstract_inverted_index.viability | 104, 202 |
| abstract_inverted_index.Background | 1 |
| abstract_inverted_index.Conclusion | 190 |
| abstract_inverted_index.apoptosis. | 106, 171 |
| abstract_inverted_index.epithelial | 165 |
| abstract_inverted_index.expression | 131 |
| abstract_inverted_index.lentivirus | 91 |
| abstract_inverted_index.mechanisms | 39 |
| abstract_inverted_index.regulating | 200 |
| abstract_inverted_index.technology | 46 |
| abstract_inverted_index.ferroptosis | 198 |
| abstract_inverted_index.hyperosmotic | 79 |
| abstract_inverted_index.insufficient | 24 |
| abstract_inverted_index.investigated | 33 |
| abstract_inverted_index.poor-quality | 26 |
| abstract_inverted_index.characterized | 12 |
| abstract_inverted_index.proliferation | 167 |
| abstract_inverted_index.Bioinformatics | 45 |
| abstract_inverted_index.stress-related | 114, 177 |
| abstract_inverted_index.vector-mediated | 92 |
| abstract_inverted_index.stress‑induced | 80 |
| abstract_inverted_index.<title>Abstract</title> | 0 |
| cited_by_percentile_year | |
| countries_distinct_count | 1 |
| institutions_distinct_count | 5 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/1 |
| sustainable_development_goals[0].score | 0.5600000023841858 |
| sustainable_development_goals[0].display_name | No poverty |
| citation_normalized_percentile.value | 0.23515464 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |