RNA-DNA triplexes: molecular mechanisms and functional relevance Article Swipe
Matthias S. Leisegang
,
Timothy Warwick
,
Julia Stötzel
,
Ralf P. Brandes
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.tibs.2024.03.009
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.tibs.2024.03.009
Interactions of RNA with DNA are principles of gene expression control that have recently gained considerable attention. Among RNA-DNA interactions are R-loops and RNA-DNA hybrid G-quadruplexes, as well as RNA-DNA triplexes. It is proposed that RNA-DNA triplexes guide RNA-associated regulatory proteins to specific genomic locations, influencing transcription and epigenetic decision making. Although triplex formation initially was considered solely an in vitro event, recent progress in computational, biochemical, and biophysical methods support in vivo functionality with relevance for gene expression control. Here, we review the central methodology and biology of triplexes, outline paradigms required for triplex function, and provide examples of physiologically important triplex-forming long non-coding RNAs.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.tibs.2024.03.009
- http://www.cell.com/article/S0968000424000756/pdf
- OA Status
- hybrid
- Cited By
- 25
- References
- 85
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4393992286
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- OpenAlex ID
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https://openalex.org/W4393992286Canonical identifier for this work in OpenAlex
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https://doi.org/10.1016/j.tibs.2024.03.009Digital Object Identifier
- Title
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RNA-DNA triplexes: molecular mechanisms and functional relevanceWork title
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-04-05Full publication date if available
- Authors
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Matthias S. Leisegang, Timothy Warwick, Julia Stötzel, Ralf P. BrandesList of authors in order
- Landing page
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https://doi.org/10.1016/j.tibs.2024.03.009Publisher landing page
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https://www.cell.com/article/S0968000424000756/pdfDirect link to full text PDF
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://www.cell.com/article/S0968000424000756/pdfDirect OA link when available
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DNA, RNA, Computational biology, Relevance (law), Chemistry, Biology, Biophysics, Genetics, Gene, Political science, LawTop concepts (fields/topics) attached by OpenAlex
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25Total citation count in OpenAlex
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2025: 17, 2024: 8Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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