RNA m6A modification: a key regulator in normal and malignant processes Article Swipe

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Leying Zhang , Yidan Lou , W. Li , Hongshan Guo , Le Xuan Truong Nguyen , Zhenhua Chen ·

YOU? · · 2025 · Open Access · · DOI: https://doi.org/10.1016/j.clnves.2025.100023

The dedicated control of gene abundance is essential for both biological and pathological processes in mammals. Multiple layers of gene expression regulation, including transcriptional, post-transcriptional, translational, and post-translational regulation, collectively determine the highly dynamic equilibrium of functional protein abundance. Epigenetic modifications play indispensable roles in fine-tuning gene expression at either DNA, RNA, or protein level. To date, over 170 chemical modifications have been identified in RNA, with N ⁶-methyladenosine (m⁶A) emerging as the most abundant and functionally significant modification in messenger RNA (mRNA). Many proteins have been identified as m⁶A-related proteins such as "writer" (deposition), "eraser" (removal) and "reader" (recognition). The dynamic m⁶A abundance (controlled by writer and eraser) together with reader proteins determine mRNA fate/metabolism, including transcription, alternative splicing, nuclear export, mRNA stability, and translation. Here, we summarize the latest findings on m⁶A-associated molecular mechanisms, emerging technologies for mapping m⁶A, and the roles of m⁶A-related proteins in both normal and malignant contexts. We further discuss/review the controversial opinions and open debates, and translational/clinical potential of m⁶A/m⁶A-related proteins as therapeutic targets, highlighting remaining questions and research directions in RNA m⁶A modifications.

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Type: article
Language: en
Landing Page: https://doi.org/10.1016/j.clnves.2025.100023
OA Status: hybrid
Cited By: 2
References: 327
Related Works: 10
OpenAlex ID: https://openalex.org/W4411081034

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DOI: https://doi.org/10.1016/j.clnves.2025.100023

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Title: RNA m6A modification: a key regulator in normal and malignant processes

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Type: article

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Language: en

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Publication year: 2025

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Publication date: 2025-06-01

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Authors: Leying Zhang, Yidan Lou, W. Li, Hongshan Guo, Le Xuan Truong Nguyen, Zhenhua Chen

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Landing page: https://doi.org/10.1016/j.clnves.2025.100023

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OA URL: https://doi.org/10.1016/j.clnves.2025.100023

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Concepts: Regulator, Key (lock), Biology, Computational biology, Genetics, Gene, Ecology

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Cited by: 2

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