RNF169 limits 53BP1 deposition at DSBs to stimulate single-strand annealing repair Article Swipe
Liwei An
,
Chao Dong
,
Junshi Li
,
Jie Chen
,
Jingsong Yuan
,
Jun Huang
,
Kui Ming Chan
,
Cheng‐han Yu
,
Michael S.Y. Huen
·
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1073/pnas.1804823115
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1073/pnas.1804823115
Significance 53BP1 restrains DNA end resection, and its dosage imbalance upsets DNA double-strand break (DSB) repair pathway choice. Here, by monitoring 53BP1 distribution on DSB-flanking chromatin, we have established a dose-dependent role of the RING finger protein RNF169 in limiting 53BP1 DSB deposition. Moreover, we found that forced expression of RNF169 overcomes 53BP1 activity and stimulates mutagenic DSB repair via the single-strand annealing pathway. Our findings suggest that aberrant expression of RNF169 may represent a deleterious factor in DSB repair control and in maintenance of genome stability.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1073/pnas.1804823115
- https://www.pnas.org/content/pnas/115/35/E8286.full.pdf
- OA Status
- bronze
- Cited By
- 69
- References
- 89
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2885584690
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2885584690Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1073/pnas.1804823115Digital Object Identifier
- Title
-
RNF169 limits 53BP1 deposition at DSBs to stimulate single-strand annealing repairWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2018Year of publication
- Publication date
-
2018-08-13Full publication date if available
- Authors
-
Liwei An, Chao Dong, Junshi Li, Jie Chen, Jingsong Yuan, Jun Huang, Kui Ming Chan, Cheng‐han Yu, Michael S.Y. HuenList of authors in order
- Landing page
-
https://doi.org/10.1073/pnas.1804823115Publisher landing page
- PDF URL
-
https://www.pnas.org/content/pnas/115/35/E8286.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
-
https://www.pnas.org/content/pnas/115/35/E8286.full.pdfDirect OA link when available
- Concepts
-
Chromatin, DNA, Cell biology, DNA repair, DNA damage, Limiting, Molecular biology, Biology, Genome instability, Homologous recombination, Chemistry, Cancer research, Genetics, Mechanical engineering, EngineeringTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
69Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2024: 9, 2023: 8, 2022: 10, 2021: 14Per-year citation counts (last 5 years)
- References (count)
-
89Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W2885584690 |
|---|---|
| doi | https://doi.org/10.1073/pnas.1804823115 |
| ids.doi | https://doi.org/10.1073/pnas.1804823115 |
| ids.mag | 2885584690 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/30104380 |
| ids.openalex | https://openalex.org/W2885584690 |
| fwci | 4.49839372 |
| mesh[0].qualifier_ui | Q000235 |
| mesh[0].descriptor_ui | D002352 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | genetics |
| mesh[0].descriptor_name | Carrier Proteins |
| mesh[1].qualifier_ui | Q000378 |
| mesh[1].descriptor_ui | D002352 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | metabolism |
| mesh[1].descriptor_name | Carrier Proteins |
| mesh[2].qualifier_ui | |
| mesh[2].descriptor_ui | D045744 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | |
| mesh[2].descriptor_name | Cell Line, Tumor |
| mesh[3].qualifier_ui | Q000235 |
| mesh[3].descriptor_ui | D004247 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | genetics |
| mesh[3].descriptor_name | DNA |
| mesh[4].qualifier_ui | Q000378 |
| mesh[4].descriptor_ui | D004247 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | metabolism |
| mesh[4].descriptor_name | DNA |
| mesh[5].qualifier_ui | |
| mesh[5].descriptor_ui | D053903 |
| mesh[5].is_major_topic | True |
| mesh[5].qualifier_name | |
| mesh[5].descriptor_name | DNA Breaks, Double-Stranded |
| mesh[6].qualifier_ui | Q000502 |
| mesh[6].descriptor_ui | D004260 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | physiology |
| mesh[6].descriptor_name | DNA Repair |
| mesh[7].qualifier_ui | |
| mesh[7].descriptor_ui | D004706 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | |
| mesh[7].descriptor_name | Endodeoxyribonucleases |
| mesh[8].qualifier_ui | |
| mesh[8].descriptor_ui | D006801 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | |
| mesh[8].descriptor_name | Humans |
| mesh[9].qualifier_ui | Q000235 |
| mesh[9].descriptor_ui | D009687 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | genetics |
| mesh[9].descriptor_name | Nuclear Proteins |
| mesh[10].qualifier_ui | Q000378 |
| mesh[10].descriptor_ui | D009687 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | metabolism |
| mesh[10].descriptor_name | Nuclear Proteins |
| mesh[11].qualifier_ui | Q000235 |
| mesh[11].descriptor_ui | D000071857 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | genetics |
| mesh[11].descriptor_name | Tumor Suppressor p53-Binding Protein 1 |
| mesh[12].qualifier_ui | Q000378 |
| mesh[12].descriptor_ui | D000071857 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | metabolism |
| mesh[12].descriptor_name | Tumor Suppressor p53-Binding Protein 1 |
| mesh[13].qualifier_ui | Q000235 |
| mesh[13].descriptor_ui | D044767 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | genetics |
| mesh[13].descriptor_name | Ubiquitin-Protein Ligases |
| mesh[14].qualifier_ui | Q000378 |
| mesh[14].descriptor_ui | D044767 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | metabolism |
| mesh[14].descriptor_name | Ubiquitin-Protein Ligases |
| mesh[15].qualifier_ui | Q000235 |
| mesh[15].descriptor_ui | D002352 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | genetics |
| mesh[15].descriptor_name | Carrier Proteins |
| mesh[16].qualifier_ui | Q000378 |
| mesh[16].descriptor_ui | D002352 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | metabolism |
| mesh[16].descriptor_name | Carrier Proteins |
| mesh[17].qualifier_ui | |
| mesh[17].descriptor_ui | D045744 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | |
| mesh[17].descriptor_name | Cell Line, Tumor |
| mesh[18].qualifier_ui | Q000235 |
| mesh[18].descriptor_ui | D004247 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | genetics |
| mesh[18].descriptor_name | DNA |
| mesh[19].qualifier_ui | Q000378 |
| mesh[19].descriptor_ui | D004247 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | metabolism |
| mesh[19].descriptor_name | DNA |
| mesh[20].qualifier_ui | |
| mesh[20].descriptor_ui | D053903 |
| mesh[20].is_major_topic | True |
| mesh[20].qualifier_name | |
| mesh[20].descriptor_name | DNA Breaks, Double-Stranded |
| mesh[21].qualifier_ui | Q000502 |
| mesh[21].descriptor_ui | D004260 |
| mesh[21].is_major_topic | False |
| mesh[21].qualifier_name | physiology |
| mesh[21].descriptor_name | DNA Repair |
| mesh[22].qualifier_ui | |
| mesh[22].descriptor_ui | D004706 |
| mesh[22].is_major_topic | False |
| mesh[22].qualifier_name | |
| mesh[22].descriptor_name | Endodeoxyribonucleases |
| mesh[23].qualifier_ui | |
| mesh[23].descriptor_ui | D006801 |
| mesh[23].is_major_topic | False |
| mesh[23].qualifier_name | |
| mesh[23].descriptor_name | Humans |
| mesh[24].qualifier_ui | Q000235 |
| mesh[24].descriptor_ui | D009687 |
| mesh[24].is_major_topic | False |
| mesh[24].qualifier_name | genetics |
| mesh[24].descriptor_name | Nuclear Proteins |
| mesh[25].qualifier_ui | Q000378 |
| mesh[25].descriptor_ui | D009687 |
| mesh[25].is_major_topic | False |
| mesh[25].qualifier_name | metabolism |
| mesh[25].descriptor_name | Nuclear Proteins |
| mesh[26].qualifier_ui | Q000235 |
| mesh[26].descriptor_ui | D000071857 |
| mesh[26].is_major_topic | False |
| mesh[26].qualifier_name | genetics |
| mesh[26].descriptor_name | Tumor Suppressor p53-Binding Protein 1 |
| mesh[27].qualifier_ui | Q000378 |
| mesh[27].descriptor_ui | D000071857 |
| mesh[27].is_major_topic | False |
| mesh[27].qualifier_name | metabolism |
| mesh[27].descriptor_name | Tumor Suppressor p53-Binding Protein 1 |
| mesh[28].qualifier_ui | Q000235 |
| mesh[28].descriptor_ui | D044767 |
| mesh[28].is_major_topic | False |
| mesh[28].qualifier_name | genetics |
| mesh[28].descriptor_name | Ubiquitin-Protein Ligases |
| mesh[29].qualifier_ui | Q000378 |
| mesh[29].descriptor_ui | D044767 |
| mesh[29].is_major_topic | False |
| mesh[29].qualifier_name | metabolism |
| mesh[29].descriptor_name | Ubiquitin-Protein Ligases |
| type | article |
| title | RNF169 limits 53BP1 deposition at DSBs to stimulate single-strand annealing repair |
| biblio.issue | 35 |
| biblio.volume | 115 |
| biblio.last_page | E8295 |
| biblio.first_page | E8286 |
| grants[0].funder | https://openalex.org/F4320321592 |
| grants[0].award_id | C7007-17GF |
| grants[0].funder_display_name | Research Grants Council, University Grants Committee |
| topics[0].id | https://openalex.org/T10123 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 1.0 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1312 |
| topics[0].subfield.display_name | Molecular Biology |
| topics[0].display_name | DNA Repair Mechanisms |
| topics[1].id | https://openalex.org/T10222 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.9991000294685364 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1312 |
| topics[1].subfield.display_name | Molecular Biology |
| topics[1].display_name | Genomics and Chromatin Dynamics |
| topics[2].id | https://openalex.org/T10434 |
| topics[2].field.id | https://openalex.org/fields/11 |
| topics[2].field.display_name | Agricultural and Biological Sciences |
| topics[2].score | 0.9901999831199646 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1110 |
| topics[2].subfield.display_name | Plant Science |
| topics[2].display_name | Chromosomal and Genetic Variations |
| funders[0].id | https://openalex.org/F4320321592 |
| funders[0].ror | https://ror.org/00djwmt25 |
| funders[0].display_name | Research Grants Council, University Grants Committee |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C83640560 |
| concepts[0].level | 3 |
| concepts[0].score | 0.6963692307472229 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q180951 |
| concepts[0].display_name | Chromatin |
| concepts[1].id | https://openalex.org/C552990157 |
| concepts[1].level | 2 |
| concepts[1].score | 0.5882905721664429 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q7430 |
| concepts[1].display_name | DNA |
| concepts[2].id | https://openalex.org/C95444343 |
| concepts[2].level | 1 |
| concepts[2].score | 0.5653669238090515 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q7141 |
| concepts[2].display_name | Cell biology |
| concepts[3].id | https://openalex.org/C134935766 |
| concepts[3].level | 3 |
| concepts[3].score | 0.5566909313201904 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q210538 |
| concepts[3].display_name | DNA repair |
| concepts[4].id | https://openalex.org/C143425029 |
| concepts[4].level | 3 |
| concepts[4].score | 0.5263408422470093 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q5205747 |
| concepts[4].display_name | DNA damage |
| concepts[5].id | https://openalex.org/C188198153 |
| concepts[5].level | 2 |
| concepts[5].score | 0.5070431232452393 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q1613840 |
| concepts[5].display_name | Limiting |
| concepts[6].id | https://openalex.org/C153911025 |
| concepts[6].level | 1 |
| concepts[6].score | 0.4788401126861572 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q7202 |
| concepts[6].display_name | Molecular biology |
| concepts[7].id | https://openalex.org/C86803240 |
| concepts[7].level | 0 |
| concepts[7].score | 0.4499281346797943 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[7].display_name | Biology |
| concepts[8].id | https://openalex.org/C178169997 |
| concepts[8].level | 4 |
| concepts[8].score | 0.44149452447891235 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q2892636 |
| concepts[8].display_name | Genome instability |
| concepts[9].id | https://openalex.org/C102744134 |
| concepts[9].level | 3 |
| concepts[9].score | 0.42487195134162903 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q22280388 |
| concepts[9].display_name | Homologous recombination |
| concepts[10].id | https://openalex.org/C185592680 |
| concepts[10].level | 0 |
| concepts[10].score | 0.4064961075782776 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[10].display_name | Chemistry |
| concepts[11].id | https://openalex.org/C502942594 |
| concepts[11].level | 1 |
| concepts[11].score | 0.32775700092315674 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q3421914 |
| concepts[11].display_name | Cancer research |
| concepts[12].id | https://openalex.org/C54355233 |
| concepts[12].level | 1 |
| concepts[12].score | 0.2711968421936035 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q7162 |
| concepts[12].display_name | Genetics |
| concepts[13].id | https://openalex.org/C78519656 |
| concepts[13].level | 1 |
| concepts[13].score | 0.0 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q101333 |
| concepts[13].display_name | Mechanical engineering |
| concepts[14].id | https://openalex.org/C127413603 |
| concepts[14].level | 0 |
| concepts[14].score | 0.0 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q11023 |
| concepts[14].display_name | Engineering |
| keywords[0].id | https://openalex.org/keywords/chromatin |
| keywords[0].score | 0.6963692307472229 |
| keywords[0].display_name | Chromatin |
| keywords[1].id | https://openalex.org/keywords/dna |
| keywords[1].score | 0.5882905721664429 |
| keywords[1].display_name | DNA |
| keywords[2].id | https://openalex.org/keywords/cell-biology |
| keywords[2].score | 0.5653669238090515 |
| keywords[2].display_name | Cell biology |
| keywords[3].id | https://openalex.org/keywords/dna-repair |
| keywords[3].score | 0.5566909313201904 |
| keywords[3].display_name | DNA repair |
| keywords[4].id | https://openalex.org/keywords/dna-damage |
| keywords[4].score | 0.5263408422470093 |
| keywords[4].display_name | DNA damage |
| keywords[5].id | https://openalex.org/keywords/limiting |
| keywords[5].score | 0.5070431232452393 |
| keywords[5].display_name | Limiting |
| keywords[6].id | https://openalex.org/keywords/molecular-biology |
| keywords[6].score | 0.4788401126861572 |
| keywords[6].display_name | Molecular biology |
| keywords[7].id | https://openalex.org/keywords/biology |
| keywords[7].score | 0.4499281346797943 |
| keywords[7].display_name | Biology |
| keywords[8].id | https://openalex.org/keywords/genome-instability |
| keywords[8].score | 0.44149452447891235 |
| keywords[8].display_name | Genome instability |
| keywords[9].id | https://openalex.org/keywords/homologous-recombination |
| keywords[9].score | 0.42487195134162903 |
| keywords[9].display_name | Homologous recombination |
| keywords[10].id | https://openalex.org/keywords/chemistry |
| keywords[10].score | 0.4064961075782776 |
| keywords[10].display_name | Chemistry |
| keywords[11].id | https://openalex.org/keywords/cancer-research |
| keywords[11].score | 0.32775700092315674 |
| keywords[11].display_name | Cancer research |
| keywords[12].id | https://openalex.org/keywords/genetics |
| keywords[12].score | 0.2711968421936035 |
| keywords[12].display_name | Genetics |
| language | en |
| locations[0].id | doi:10.1073/pnas.1804823115 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S125754415 |
| locations[0].source.issn | 0027-8424, 1091-6490 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | 0027-8424 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Proceedings of the National Academy of Sciences |
| locations[0].source.host_organization | https://openalex.org/P4310320052 |
| locations[0].source.host_organization_name | National Academy of Sciences |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320052 |
| locations[0].license | |
| locations[0].pdf_url | https://www.pnas.org/content/pnas/115/35/E8286.full.pdf |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Proceedings of the National Academy of Sciences |
| locations[0].landing_page_url | https://doi.org/10.1073/pnas.1804823115 |
| locations[1].id | pmid:30104380 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Proceedings of the National Academy of Sciences of the United States of America |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/30104380 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:6126738 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Proc Natl Acad Sci U S A |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/6126738 |
| locations[3].id | pmh:oai:europepmc.org:5079640 |
| locations[3].is_oa | False |
| locations[3].source.id | https://openalex.org/S4306400806 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | Europe PMC (PubMed Central) |
| locations[3].source.host_organization | https://openalex.org/I1303153112 |
| locations[3].source.host_organization_name | European Bioinformatics Institute |
| locations[3].source.host_organization_lineage | https://openalex.org/I1303153112 |
| locations[3].license | |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | Text |
| locations[3].license_id | |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | |
| locations[3].landing_page_url | http://europepmc.org/pmc/articles/PMC6126738 |
| locations[4].id | pmh:oai:academiccommons.columbia.edu:10.7916/D81279H4 |
| locations[4].is_oa | False |
| locations[4].source.id | https://openalex.org/S4306402601 |
| locations[4].source.issn | |
| locations[4].source.type | repository |
| locations[4].source.is_oa | False |
| locations[4].source.issn_l | |
| locations[4].source.is_core | False |
| locations[4].source.is_in_doaj | False |
| locations[4].source.display_name | Columbia Academic Commons (Columbia University) |
| locations[4].source.host_organization | https://openalex.org/I78577930 |
| locations[4].source.host_organization_name | Columbia University |
| locations[4].source.host_organization_lineage | https://openalex.org/I78577930 |
| locations[4].license | |
| locations[4].pdf_url | |
| locations[4].version | submittedVersion |
| locations[4].raw_type | Articles |
| locations[4].license_id | |
| locations[4].is_accepted | False |
| locations[4].is_published | False |
| locations[4].raw_source_name | |
| locations[4].landing_page_url | https://doi.org/10.7916/D81279H4 |
| locations[5].id | doi:10.7916/d81279h4 |
| locations[5].is_oa | True |
| locations[5].source.id | https://openalex.org/S4306402601 |
| locations[5].source.issn | |
| locations[5].source.type | repository |
| locations[5].source.is_oa | False |
| locations[5].source.issn_l | |
| locations[5].source.is_core | False |
| locations[5].source.is_in_doaj | False |
| locations[5].source.display_name | Columbia Academic Commons (Columbia University) |
| locations[5].source.host_organization | https://openalex.org/I78577930 |
| locations[5].source.host_organization_name | Columbia University |
| locations[5].source.host_organization_lineage | https://openalex.org/I78577930 |
| locations[5].license | |
| locations[5].pdf_url | |
| locations[5].version | |
| locations[5].raw_type | article-journal |
| locations[5].license_id | |
| locations[5].is_accepted | False |
| locations[5].is_published | |
| locations[5].raw_source_name | |
| locations[5].landing_page_url | https://doi.org/10.7916/d81279h4 |
| indexed_in | crossref, datacite, pubmed |
| authorships[0].author.id | https://openalex.org/A5100674223 |
| authorships[0].author.orcid | https://orcid.org/0000-0003-4514-5476 |
| authorships[0].author.display_name | Liwei An |
| authorships[0].countries | CN, HK |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I19820366, https://openalex.org/I4210145761 |
| authorships[0].affiliations[0].raw_affiliation_string | Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, P.R. China; |
| authorships[0].affiliations[1].institution_ids | https://openalex.org/I889458895 |
| authorships[0].affiliations[1].raw_affiliation_string | School of Biomedical Sciences, Li Ka Shing (LKS) Faculty of Medicine, The University of Hong Kong, Hong Kong S.A.R.; |
| authorships[0].institutions[0].id | https://openalex.org/I19820366 |
| authorships[0].institutions[0].ror | https://ror.org/034t30j35 |
| authorships[0].institutions[0].type | government |
| authorships[0].institutions[0].lineage | https://openalex.org/I19820366 |
| authorships[0].institutions[0].country_code | CN |
| authorships[0].institutions[0].display_name | Chinese Academy of Sciences |
| authorships[0].institutions[1].id | https://openalex.org/I4210145761 |
| authorships[0].institutions[1].ror | https://ror.org/04gh4er46 |
| authorships[0].institutions[1].type | facility |
| authorships[0].institutions[1].lineage | https://openalex.org/I19820366, https://openalex.org/I4210145761 |
| authorships[0].institutions[1].country_code | CN |
| authorships[0].institutions[1].display_name | Shenzhen Institutes of Advanced Technology |
| authorships[0].institutions[2].id | https://openalex.org/I889458895 |
| authorships[0].institutions[2].ror | https://ror.org/02zhqgq86 |
| authorships[0].institutions[2].type | education |
| authorships[0].institutions[2].lineage | https://openalex.org/I889458895 |
| authorships[0].institutions[2].country_code | HK |
| authorships[0].institutions[2].display_name | University of Hong Kong |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Liwei An |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, P.R. China;, School of Biomedical Sciences, Li Ka Shing (LKS) Faculty of Medicine, The University of Hong Kong, Hong Kong S.A.R.; |
| authorships[1].author.id | https://openalex.org/A5102024735 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-7645-2025 |
| authorships[1].author.display_name | Chao Dong |
| authorships[1].countries | HK |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I889458895 |
| authorships[1].affiliations[0].raw_affiliation_string | School of Biomedical Sciences, Li Ka Shing (LKS) Faculty of Medicine, The University of Hong Kong, Hong Kong S.A.R.; |
| authorships[1].institutions[0].id | https://openalex.org/I889458895 |
| authorships[1].institutions[0].ror | https://ror.org/02zhqgq86 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I889458895 |
| authorships[1].institutions[0].country_code | HK |
| authorships[1].institutions[0].display_name | University of Hong Kong |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Chao Dong |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | School of Biomedical Sciences, Li Ka Shing (LKS) Faculty of Medicine, The University of Hong Kong, Hong Kong S.A.R.; |
| authorships[2].author.id | https://openalex.org/A5102932539 |
| authorships[2].author.orcid | https://orcid.org/0009-0008-3929-9616 |
| authorships[2].author.display_name | Junshi Li |
| authorships[2].countries | HK |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I889458895 |
| authorships[2].affiliations[0].raw_affiliation_string | School of Biomedical Sciences, Li Ka Shing (LKS) Faculty of Medicine, The University of Hong Kong, Hong Kong S.A.R.; |
| authorships[2].institutions[0].id | https://openalex.org/I889458895 |
| authorships[2].institutions[0].ror | https://ror.org/02zhqgq86 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I889458895 |
| authorships[2].institutions[0].country_code | HK |
| authorships[2].institutions[0].display_name | University of Hong Kong |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Junshi Li |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | School of Biomedical Sciences, Li Ka Shing (LKS) Faculty of Medicine, The University of Hong Kong, Hong Kong S.A.R.; |
| authorships[3].author.id | https://openalex.org/A5100333008 |
| authorships[3].author.orcid | https://orcid.org/0000-0003-2752-2098 |
| authorships[3].author.display_name | Jie Chen |
| authorships[3].countries | HK |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I889458895 |
| authorships[3].affiliations[0].raw_affiliation_string | School of Biomedical Sciences, Li Ka Shing (LKS) Faculty of Medicine, The University of Hong Kong, Hong Kong S.A.R.; |
| authorships[3].institutions[0].id | https://openalex.org/I889458895 |
| authorships[3].institutions[0].ror | https://ror.org/02zhqgq86 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I889458895 |
| authorships[3].institutions[0].country_code | HK |
| authorships[3].institutions[0].display_name | University of Hong Kong |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Jie Chen |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | School of Biomedical Sciences, Li Ka Shing (LKS) Faculty of Medicine, The University of Hong Kong, Hong Kong S.A.R.; |
| authorships[4].author.id | https://openalex.org/A5003634704 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-0019-1789 |
| authorships[4].author.display_name | Jingsong Yuan |
| authorships[4].countries | US |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I2799503643 |
| authorships[4].affiliations[0].raw_affiliation_string | Department of Radiation Oncology, Center for Radiological Research, Columbia University Medical Center, NY 10032; |
| authorships[4].institutions[0].id | https://openalex.org/I2799503643 |
| authorships[4].institutions[0].ror | https://ror.org/01esghr10 |
| authorships[4].institutions[0].type | healthcare |
| authorships[4].institutions[0].lineage | https://openalex.org/I2799503643 |
| authorships[4].institutions[0].country_code | US |
| authorships[4].institutions[0].display_name | Columbia University Irving Medical Center |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Jingsong Yuan |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Department of Radiation Oncology, Center for Radiological Research, Columbia University Medical Center, NY 10032; |
| authorships[5].author.id | https://openalex.org/A5052632562 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-7837-653X |
| authorships[5].author.display_name | Jun Huang |
| authorships[5].countries | CN |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I76130692 |
| authorships[5].affiliations[0].raw_affiliation_string | Life Sciences Institute and Innovation Center for Cell Signaling Network, Zhejiang University, Hangzhou, Zhejiang 310058, P.R. China; |
| authorships[5].institutions[0].id | https://openalex.org/I76130692 |
| authorships[5].institutions[0].ror | https://ror.org/00a2xv884 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I76130692 |
| authorships[5].institutions[0].country_code | CN |
| authorships[5].institutions[0].display_name | Zhejiang University |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Jun Huang |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Life Sciences Institute and Innovation Center for Cell Signaling Network, Zhejiang University, Hangzhou, Zhejiang 310058, P.R. China; |
| authorships[6].author.id | https://openalex.org/A5018282973 |
| authorships[6].author.orcid | https://orcid.org/0000-0001-6430-3340 |
| authorships[6].author.display_name | Kui Ming Chan |
| authorships[6].countries | HK |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I168719708 |
| authorships[6].affiliations[0].raw_affiliation_string | Department of Biomedical Sciences, City University of Hong Kong, Hong Kong S.A.R.; |
| authorships[6].institutions[0].id | https://openalex.org/I168719708 |
| authorships[6].institutions[0].ror | https://ror.org/03q8dnn23 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I168719708 |
| authorships[6].institutions[0].country_code | HK |
| authorships[6].institutions[0].display_name | City University of Hong Kong |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Kui Ming Chan |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Department of Biomedical Sciences, City University of Hong Kong, Hong Kong S.A.R.; |
| authorships[7].author.id | https://openalex.org/A5059881323 |
| authorships[7].author.orcid | https://orcid.org/0000-0002-8821-8877 |
| authorships[7].author.display_name | Cheng‐han Yu |
| authorships[7].countries | HK |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I889458895 |
| authorships[7].affiliations[0].raw_affiliation_string | School of Biomedical Sciences, Li Ka Shing (LKS) Faculty of Medicine, The University of Hong Kong, Hong Kong S.A.R.; |
| authorships[7].institutions[0].id | https://openalex.org/I889458895 |
| authorships[7].institutions[0].ror | https://ror.org/02zhqgq86 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I889458895 |
| authorships[7].institutions[0].country_code | HK |
| authorships[7].institutions[0].display_name | University of Hong Kong |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Cheng-han Yu |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | School of Biomedical Sciences, Li Ka Shing (LKS) Faculty of Medicine, The University of Hong Kong, Hong Kong S.A.R.; |
| authorships[8].author.id | https://openalex.org/A5030374291 |
| authorships[8].author.orcid | https://orcid.org/0000-0003-1774-2425 |
| authorships[8].author.display_name | Michael S.Y. Huen |
| authorships[8].countries | CN, HK |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I177725633, https://openalex.org/I889458895 |
| authorships[8].affiliations[0].raw_affiliation_string | State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong S.A.R. |
| authorships[8].affiliations[1].institution_ids | https://openalex.org/I19820366, https://openalex.org/I4210145761 |
| authorships[8].affiliations[1].raw_affiliation_string | Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, P.R. China; |
| authorships[8].affiliations[2].institution_ids | https://openalex.org/I889458895 |
| authorships[8].affiliations[2].raw_affiliation_string | School of Biomedical Sciences, Li Ka Shing (LKS) Faculty of Medicine, The University of Hong Kong, Hong Kong S.A.R.; |
| authorships[8].institutions[0].id | https://openalex.org/I19820366 |
| authorships[8].institutions[0].ror | https://ror.org/034t30j35 |
| authorships[8].institutions[0].type | government |
| authorships[8].institutions[0].lineage | https://openalex.org/I19820366 |
| authorships[8].institutions[0].country_code | CN |
| authorships[8].institutions[0].display_name | Chinese Academy of Sciences |
| authorships[8].institutions[1].id | https://openalex.org/I4210145761 |
| authorships[8].institutions[1].ror | https://ror.org/04gh4er46 |
| authorships[8].institutions[1].type | facility |
| authorships[8].institutions[1].lineage | https://openalex.org/I19820366, https://openalex.org/I4210145761 |
| authorships[8].institutions[1].country_code | CN |
| authorships[8].institutions[1].display_name | Shenzhen Institutes of Advanced Technology |
| authorships[8].institutions[2].id | https://openalex.org/I177725633 |
| authorships[8].institutions[2].ror | https://ror.org/00t33hh48 |
| authorships[8].institutions[2].type | education |
| authorships[8].institutions[2].lineage | https://openalex.org/I177725633 |
| authorships[8].institutions[2].country_code | HK |
| authorships[8].institutions[2].display_name | Chinese University of Hong Kong |
| authorships[8].institutions[3].id | https://openalex.org/I889458895 |
| authorships[8].institutions[3].ror | https://ror.org/02zhqgq86 |
| authorships[8].institutions[3].type | education |
| authorships[8].institutions[3].lineage | https://openalex.org/I889458895 |
| authorships[8].institutions[3].country_code | HK |
| authorships[8].institutions[3].display_name | University of Hong Kong |
| authorships[8].author_position | last |
| authorships[8].raw_author_name | Michael S. Y. Huen |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, P.R. China;, School of Biomedical Sciences, Li Ka Shing (LKS) Faculty of Medicine, The University of Hong Kong, Hong Kong S.A.R.;, State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong S.A.R. |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.pnas.org/content/pnas/115/35/E8286.full.pdf |
| open_access.oa_status | bronze |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | RNF169 limits 53BP1 deposition at DSBs to stimulate single-strand annealing repair |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10123 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 1.0 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1312 |
| primary_topic.subfield.display_name | Molecular Biology |
| primary_topic.display_name | DNA Repair Mechanisms |
| related_works | https://openalex.org/W4387765233, https://openalex.org/W2051467864, https://openalex.org/W2096764255, https://openalex.org/W2495885591, https://openalex.org/W2739146923, https://openalex.org/W1989456333, https://openalex.org/W2760815521, https://openalex.org/W2562131818, https://openalex.org/W2747101336, https://openalex.org/W1991644354 |
| cited_by_count | 69 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 1 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 9 |
| counts_by_year[2].year | 2023 |
| counts_by_year[2].cited_by_count | 8 |
| counts_by_year[3].year | 2022 |
| counts_by_year[3].cited_by_count | 10 |
| counts_by_year[4].year | 2021 |
| counts_by_year[4].cited_by_count | 14 |
| counts_by_year[5].year | 2020 |
| counts_by_year[5].cited_by_count | 11 |
| counts_by_year[6].year | 2019 |
| counts_by_year[6].cited_by_count | 12 |
| counts_by_year[7].year | 2018 |
| counts_by_year[7].cited_by_count | 4 |
| locations_count | 6 |
| best_oa_location.id | doi:10.1073/pnas.1804823115 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S125754415 |
| best_oa_location.source.issn | 0027-8424, 1091-6490 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | 0027-8424 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | Proceedings of the National Academy of Sciences |
| best_oa_location.source.host_organization | https://openalex.org/P4310320052 |
| best_oa_location.source.host_organization_name | National Academy of Sciences |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320052 |
| best_oa_location.license | |
| best_oa_location.pdf_url | https://www.pnas.org/content/pnas/115/35/E8286.full.pdf |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Proceedings of the National Academy of Sciences |
| best_oa_location.landing_page_url | https://doi.org/10.1073/pnas.1804823115 |
| primary_location.id | doi:10.1073/pnas.1804823115 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S125754415 |
| primary_location.source.issn | 0027-8424, 1091-6490 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | 0027-8424 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Proceedings of the National Academy of Sciences |
| primary_location.source.host_organization | https://openalex.org/P4310320052 |
| primary_location.source.host_organization_name | National Academy of Sciences |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320052 |
| primary_location.license | |
| primary_location.pdf_url | https://www.pnas.org/content/pnas/115/35/E8286.full.pdf |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Proceedings of the National Academy of Sciences |
| primary_location.landing_page_url | https://doi.org/10.1073/pnas.1804823115 |
| publication_date | 2018-08-13 |
| publication_year | 2018 |
| referenced_works | https://openalex.org/W2045058134, https://openalex.org/W2052142634, https://openalex.org/W2071411482, https://openalex.org/W2145200068, https://openalex.org/W2394483225, https://openalex.org/W1841331176, https://openalex.org/W1965531809, https://openalex.org/W2614952490, https://openalex.org/W1981816841, https://openalex.org/W2336105423, https://openalex.org/W1888032283, https://openalex.org/W2145780127, https://openalex.org/W2033009819, https://openalex.org/W2028138760, https://openalex.org/W2494174731, https://openalex.org/W2562446577, https://openalex.org/W2115084586, https://openalex.org/W1958856311, https://openalex.org/W2022289832, https://openalex.org/W2067427915, https://openalex.org/W1988259427, https://openalex.org/W2068973408, https://openalex.org/W2479899483, https://openalex.org/W2146204567, https://openalex.org/W2123215808, https://openalex.org/W2096391864, https://openalex.org/W2053674184, https://openalex.org/W1975548607, https://openalex.org/W2097360161, https://openalex.org/W2058957446, https://openalex.org/W2077715915, https://openalex.org/W2798183676, https://openalex.org/W2791859276, https://openalex.org/W2076248918, https://openalex.org/W2114860131, https://openalex.org/W2527471757, https://openalex.org/W2157899948, https://openalex.org/W1970266671, https://openalex.org/W2464252485, https://openalex.org/W2052289985, https://openalex.org/W2591666318, https://openalex.org/W2025588303, https://openalex.org/W2109716976, https://openalex.org/W1512395638, https://openalex.org/W2106861716, https://openalex.org/W2251444220, https://openalex.org/W2152886258, https://openalex.org/W1976678739, https://openalex.org/W2081264027, https://openalex.org/W2589286460, https://openalex.org/W2613061578, https://openalex.org/W2606254980, https://openalex.org/W2041656651, https://openalex.org/W2097027640, https://openalex.org/W1970891016, https://openalex.org/W2016529502, https://openalex.org/W2060247906, https://openalex.org/W2075477236, https://openalex.org/W2149649058, https://openalex.org/W2050164609, https://openalex.org/W2039201797, https://openalex.org/W2798187866, https://openalex.org/W1979385111, https://openalex.org/W2117602431, https://openalex.org/W2160999108, https://openalex.org/W2068668324, https://openalex.org/W2413931725, https://openalex.org/W2042763822, https://openalex.org/W2623921962, https://openalex.org/W2606336993, https://openalex.org/W2095594147, https://openalex.org/W2418918170, https://openalex.org/W2396545524, https://openalex.org/W2219799225, https://openalex.org/W1982634724, https://openalex.org/W2791106424, https://openalex.org/W2156238710, https://openalex.org/W2035827341, https://openalex.org/W2008396969, https://openalex.org/W1968943627, https://openalex.org/W1989800108, https://openalex.org/W1972769310, https://openalex.org/W2115626825, https://openalex.org/W2195034278, https://openalex.org/W2344125613, https://openalex.org/W1998499862, https://openalex.org/W1989266834, https://openalex.org/W2605140452, https://openalex.org/W2073229191 |
| referenced_works_count | 89 |
| abstract_inverted_index.a | 29, 74 |
| abstract_inverted_index.by | 19 |
| abstract_inverted_index.in | 38, 77, 82 |
| abstract_inverted_index.of | 32, 49, 70, 84 |
| abstract_inverted_index.on | 23 |
| abstract_inverted_index.we | 26, 44 |
| abstract_inverted_index.DNA | 3, 11 |
| abstract_inverted_index.DSB | 41, 57, 78 |
| abstract_inverted_index.Our | 64 |
| abstract_inverted_index.and | 6, 54, 81 |
| abstract_inverted_index.end | 4 |
| abstract_inverted_index.its | 7 |
| abstract_inverted_index.may | 72 |
| abstract_inverted_index.the | 33, 60 |
| abstract_inverted_index.via | 59 |
| abstract_inverted_index.RING | 34 |
| abstract_inverted_index.have | 27 |
| abstract_inverted_index.role | 31 |
| abstract_inverted_index.that | 46, 67 |
| abstract_inverted_index.(DSB) | 14 |
| abstract_inverted_index.53BP1 | 1, 21, 40, 52 |
| abstract_inverted_index.Here, | 18 |
| abstract_inverted_index.break | 13 |
| abstract_inverted_index.found | 45 |
| abstract_inverted_index.RNF169 | 37, 50, 71 |
| abstract_inverted_index.dosage | 8 |
| abstract_inverted_index.factor | 76 |
| abstract_inverted_index.finger | 35 |
| abstract_inverted_index.forced | 47 |
| abstract_inverted_index.genome | 85 |
| abstract_inverted_index.repair | 15, 58, 79 |
| abstract_inverted_index.upsets | 10 |
| abstract_inverted_index.choice. | 17 |
| abstract_inverted_index.control | 80 |
| abstract_inverted_index.pathway | 16 |
| abstract_inverted_index.protein | 36 |
| abstract_inverted_index.suggest | 66 |
| abstract_inverted_index.aberrant | 68 |
| abstract_inverted_index.activity | 53 |
| abstract_inverted_index.findings | 65 |
| abstract_inverted_index.limiting | 39 |
| abstract_inverted_index.pathway. | 63 |
| abstract_inverted_index.Moreover, | 43 |
| abstract_inverted_index.annealing | 62 |
| abstract_inverted_index.imbalance | 9 |
| abstract_inverted_index.mutagenic | 56 |
| abstract_inverted_index.overcomes | 51 |
| abstract_inverted_index.represent | 73 |
| abstract_inverted_index.restrains | 2 |
| abstract_inverted_index.chromatin, | 25 |
| abstract_inverted_index.expression | 48, 69 |
| abstract_inverted_index.monitoring | 20 |
| abstract_inverted_index.resection, | 5 |
| abstract_inverted_index.stability. | 86 |
| abstract_inverted_index.stimulates | 55 |
| abstract_inverted_index.deleterious | 75 |
| abstract_inverted_index.deposition. | 42 |
| abstract_inverted_index.established | 28 |
| abstract_inverted_index.maintenance | 83 |
| abstract_inverted_index.DSB-flanking | 24 |
| abstract_inverted_index.Significance | 0 |
| abstract_inverted_index.distribution | 22 |
| abstract_inverted_index.double-strand | 12 |
| abstract_inverted_index.single-strand | 61 |
| abstract_inverted_index.dose-dependent | 30 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 91 |
| countries_distinct_count | 3 |
| institutions_distinct_count | 9 |
| citation_normalized_percentile.value | 0.94821889 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |