RNF20-mediated H2B monoubiquitination protects stalled forks from degradation and promotes fork restart Article Swipe
Debanjali Bhattacharya
,
Harsh Kumar Dwivedi
,
Ganesh Nagaraju
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1038/s44319-025-00497-3
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1038/s44319-025-00497-3
Chromatin modifications play an important role in transcription, DNA replication and repair. Nonetheless, whether histone modifications regulate replication stress responses remains obscure. Here, we show that RNF20 localizes to and promotes H2B monoubiquitination (H2Bub) at replicating sites. Knockdown of RNF20 leads to degradation of stalled forks by nucleolytic enzymes, which can be rescued by inhibition of MRE11/DNA2 and co-depletion of SMARCAL1/HLTF/ZRANB3 fork remodelers. RNF20 facilitates the loading of RAD51 and RAD51C at stalled fork sites and acts in the same pathway of RAD51/RAD51C-mediated fork protection and restart. Analyses with RING domain and phosphorylation-deficient mutants of RNF20 show that its catalytic activity and ATR-mediated phosphorylation are essential for its role in replication stress responses. Finally, treatment of RNF20-depleted cells with chromatin relaxing agents rescues fork protection and restart defects. Collectively, our study uncovers a role for RNF20-mediated H2Bub in regulating chromatin dynamics to safeguard replicating genomes.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1038/s44319-025-00497-3
- https://www.embopress.org/action/downloadSupplement?doi=10.1038/s44319-025-00497-3&file=44319_2025_497_MOESM3_ESM.pdf
- OA Status
- diamond
- Cited By
- 3
- References
- 81
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4411177481
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4411177481Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1038/s44319-025-00497-3Digital Object Identifier
- Title
-
RNF20-mediated H2B monoubiquitination protects stalled forks from degradation and promotes fork restartWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-06-10Full publication date if available
- Authors
-
Debanjali Bhattacharya, Harsh Kumar Dwivedi, Ganesh NagarajuList of authors in order
- Landing page
-
https://doi.org/10.1038/s44319-025-00497-3Publisher landing page
- PDF URL
-
https://www.embopress.org/action/downloadSupplement?doi=10.1038/s44319-025-00497-3&file=44319_2025_497_MOESM3_ESM.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
diamondOpen access status per OpenAlex
- OA URL
-
https://www.embopress.org/action/downloadSupplement?doi=10.1038/s44319-025-00497-3&file=44319_2025_497_MOESM3_ESM.pdfDirect OA link when available
- Concepts
-
Fork (system call), Cell biology, Degradation (telecommunications), Biology, Computer science, Telecommunications, Operating systemTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
3Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 3Per-year citation counts (last 5 years)
- References (count)
-
81Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4411177481 |
|---|---|
| doi | https://doi.org/10.1038/s44319-025-00497-3 |
| ids.doi | https://doi.org/10.1038/s44319-025-00497-3 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/40495033 |
| ids.openalex | https://openalex.org/W4411177481 |
| fwci | 6.06469722 |
| mesh[0].qualifier_ui | Q000378 |
| mesh[0].descriptor_ui | D044767 |
| mesh[0].is_major_topic | True |
| mesh[0].qualifier_name | metabolism |
| mesh[0].descriptor_name | Ubiquitin-Protein Ligases |
| mesh[1].qualifier_ui | Q000235 |
| mesh[1].descriptor_ui | D044767 |
| mesh[1].is_major_topic | True |
| mesh[1].qualifier_name | genetics |
| mesh[1].descriptor_name | Ubiquitin-Protein Ligases |
| mesh[2].qualifier_ui | |
| mesh[2].descriptor_ui | D054875 |
| mesh[2].is_major_topic | True |
| mesh[2].qualifier_name | |
| mesh[2].descriptor_name | Ubiquitination |
| mesh[3].qualifier_ui | |
| mesh[3].descriptor_ui | D006801 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | |
| mesh[3].descriptor_name | Humans |
| mesh[4].qualifier_ui | |
| mesh[4].descriptor_ui | D004261 |
| mesh[4].is_major_topic | True |
| mesh[4].qualifier_name | |
| mesh[4].descriptor_name | DNA Replication |
| mesh[5].qualifier_ui | Q000378 |
| mesh[5].descriptor_ui | D006657 |
| mesh[5].is_major_topic | True |
| mesh[5].qualifier_name | metabolism |
| mesh[5].descriptor_name | Histones |
| mesh[6].qualifier_ui | |
| mesh[6].descriptor_ui | D010766 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | |
| mesh[6].descriptor_name | Phosphorylation |
| mesh[7].qualifier_ui | Q000378 |
| mesh[7].descriptor_ui | D002843 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | metabolism |
| mesh[7].descriptor_name | Chromatin |
| mesh[8].qualifier_ui | Q000378 |
| mesh[8].descriptor_ui | D004268 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | metabolism |
| mesh[8].descriptor_name | DNA-Binding Proteins |
| mesh[9].qualifier_ui | Q000235 |
| mesh[9].descriptor_ui | D004268 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | genetics |
| mesh[9].descriptor_name | DNA-Binding Proteins |
| mesh[10].qualifier_ui | Q000378 |
| mesh[10].descriptor_ui | D051135 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | metabolism |
| mesh[10].descriptor_name | Rad51 Recombinase |
| mesh[11].qualifier_ui | Q000235 |
| mesh[11].descriptor_ui | D051135 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | genetics |
| mesh[11].descriptor_name | Rad51 Recombinase |
| mesh[12].qualifier_ui | Q000378 |
| mesh[12].descriptor_ui | D004265 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | metabolism |
| mesh[12].descriptor_name | DNA Helicases |
| mesh[13].qualifier_ui | Q000235 |
| mesh[13].descriptor_ui | D004265 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | genetics |
| mesh[13].descriptor_name | DNA Helicases |
| mesh[14].qualifier_ui | |
| mesh[14].descriptor_ui | D006367 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | |
| mesh[14].descriptor_name | HeLa Cells |
| mesh[15].qualifier_ui | Q000378 |
| mesh[15].descriptor_ui | D044767 |
| mesh[15].is_major_topic | True |
| mesh[15].qualifier_name | metabolism |
| mesh[15].descriptor_name | Ubiquitin-Protein Ligases |
| mesh[16].qualifier_ui | Q000235 |
| mesh[16].descriptor_ui | D044767 |
| mesh[16].is_major_topic | True |
| mesh[16].qualifier_name | genetics |
| mesh[16].descriptor_name | Ubiquitin-Protein Ligases |
| mesh[17].qualifier_ui | |
| mesh[17].descriptor_ui | D054875 |
| mesh[17].is_major_topic | True |
| mesh[17].qualifier_name | |
| mesh[17].descriptor_name | Ubiquitination |
| mesh[18].qualifier_ui | |
| mesh[18].descriptor_ui | D006801 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | |
| mesh[18].descriptor_name | Humans |
| mesh[19].qualifier_ui | |
| mesh[19].descriptor_ui | D004261 |
| mesh[19].is_major_topic | True |
| mesh[19].qualifier_name | |
| mesh[19].descriptor_name | DNA Replication |
| mesh[20].qualifier_ui | Q000378 |
| mesh[20].descriptor_ui | D006657 |
| mesh[20].is_major_topic | True |
| mesh[20].qualifier_name | metabolism |
| mesh[20].descriptor_name | Histones |
| mesh[21].qualifier_ui | |
| mesh[21].descriptor_ui | D010766 |
| mesh[21].is_major_topic | False |
| mesh[21].qualifier_name | |
| mesh[21].descriptor_name | Phosphorylation |
| mesh[22].qualifier_ui | Q000378 |
| mesh[22].descriptor_ui | D002843 |
| mesh[22].is_major_topic | False |
| mesh[22].qualifier_name | metabolism |
| mesh[22].descriptor_name | Chromatin |
| mesh[23].qualifier_ui | Q000378 |
| mesh[23].descriptor_ui | D004268 |
| mesh[23].is_major_topic | False |
| mesh[23].qualifier_name | metabolism |
| mesh[23].descriptor_name | DNA-Binding Proteins |
| mesh[24].qualifier_ui | Q000235 |
| mesh[24].descriptor_ui | D004268 |
| mesh[24].is_major_topic | False |
| mesh[24].qualifier_name | genetics |
| mesh[24].descriptor_name | DNA-Binding Proteins |
| mesh[25].qualifier_ui | Q000378 |
| mesh[25].descriptor_ui | D051135 |
| mesh[25].is_major_topic | False |
| mesh[25].qualifier_name | metabolism |
| mesh[25].descriptor_name | Rad51 Recombinase |
| mesh[26].qualifier_ui | Q000235 |
| mesh[26].descriptor_ui | D051135 |
| mesh[26].is_major_topic | False |
| mesh[26].qualifier_name | genetics |
| mesh[26].descriptor_name | Rad51 Recombinase |
| mesh[27].qualifier_ui | Q000378 |
| mesh[27].descriptor_ui | D004265 |
| mesh[27].is_major_topic | False |
| mesh[27].qualifier_name | metabolism |
| mesh[27].descriptor_name | DNA Helicases |
| mesh[28].qualifier_ui | Q000235 |
| mesh[28].descriptor_ui | D004265 |
| mesh[28].is_major_topic | False |
| mesh[28].qualifier_name | genetics |
| mesh[28].descriptor_name | DNA Helicases |
| mesh[29].qualifier_ui | |
| mesh[29].descriptor_ui | D006367 |
| mesh[29].is_major_topic | False |
| mesh[29].qualifier_name | |
| mesh[29].descriptor_name | HeLa Cells |
| type | article |
| title | RNF20-mediated H2B monoubiquitination protects stalled forks from degradation and promotes fork restart |
| awards[0].id | https://openalex.org/G5574340919 |
| awards[0].funder_id | https://openalex.org/F4320320768 |
| awards[0].display_name | |
| awards[0].funder_award_id | 58/14/03/2022-BRNS |
| awards[0].funder_display_name | Department of Atomic Energy, Government of India |
| awards[1].id | https://openalex.org/G3030161087 |
| awards[1].funder_id | https://openalex.org/F4320320719 |
| awards[1].display_name | |
| awards[1].funder_award_id | EMR/2015/001720; CRG/2022/003533; JCB/2021/000009 |
| awards[1].funder_display_name | Department of Science and Technology, Ministry of Science and Technology, India |
| awards[2].id | https://openalex.org/G2719867441 |
| awards[2].funder_id | https://openalex.org/F4320320717 |
| awards[2].display_name | |
| awards[2].funder_award_id | BT/PR23498/BRB/10/1590/2017; BT/PR45508/MED/30/2414/2022 |
| awards[2].funder_display_name | Department of Biotechnology, Ministry of Science and Technology, India |
| biblio.issue | 15 |
| biblio.volume | 26 |
| biblio.last_page | 3803 |
| biblio.first_page | 3773 |
| topics[0].id | https://openalex.org/T14117 |
| topics[0].field.id | https://openalex.org/fields/22 |
| topics[0].field.display_name | Engineering |
| topics[0].score | 0.9954000115394592 |
| topics[0].domain.id | https://openalex.org/domains/3 |
| topics[0].domain.display_name | Physical Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2208 |
| topics[0].subfield.display_name | Electrical and Electronic Engineering |
| topics[0].display_name | Integrated Circuits and Semiconductor Failure Analysis |
| topics[1].id | https://openalex.org/T10857 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.9832000136375427 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1315 |
| topics[1].subfield.display_name | Structural Biology |
| topics[1].display_name | Advanced Electron Microscopy Techniques and Applications |
| topics[2].id | https://openalex.org/T11970 |
| topics[2].field.id | https://openalex.org/fields/13 |
| topics[2].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[2].score | 0.9832000136375427 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1312 |
| topics[2].subfield.display_name | Molecular Biology |
| topics[2].display_name | Molecular Biology Techniques and Applications |
| funders[0].id | https://openalex.org/F4320320717 |
| funders[0].ror | https://ror.org/03tjsyq23 |
| funders[0].display_name | Department of Biotechnology, Ministry of Science and Technology, India |
| funders[1].id | https://openalex.org/F4320320719 |
| funders[1].ror | https://ror.org/0101xrq71 |
| funders[1].display_name | Department of Science and Technology, Ministry of Science and Technology, India |
| funders[2].id | https://openalex.org/F4320320768 |
| funders[2].ror | https://ror.org/02m388s04 |
| funders[2].display_name | Department of Atomic Energy, Government of India |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C40523978 |
| concepts[0].level | 2 |
| concepts[0].score | 0.883169412612915 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q14675 |
| concepts[0].display_name | Fork (system call) |
| concepts[1].id | https://openalex.org/C95444343 |
| concepts[1].level | 1 |
| concepts[1].score | 0.5824441909790039 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q7141 |
| concepts[1].display_name | Cell biology |
| concepts[2].id | https://openalex.org/C2779679103 |
| concepts[2].level | 2 |
| concepts[2].score | 0.5120382905006409 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q5251805 |
| concepts[2].display_name | Degradation (telecommunications) |
| concepts[3].id | https://openalex.org/C86803240 |
| concepts[3].level | 0 |
| concepts[3].score | 0.4711417555809021 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[3].display_name | Biology |
| concepts[4].id | https://openalex.org/C41008148 |
| concepts[4].level | 0 |
| concepts[4].score | 0.20200270414352417 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q21198 |
| concepts[4].display_name | Computer science |
| concepts[5].id | https://openalex.org/C76155785 |
| concepts[5].level | 1 |
| concepts[5].score | 0.08667075634002686 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q418 |
| concepts[5].display_name | Telecommunications |
| concepts[6].id | https://openalex.org/C111919701 |
| concepts[6].level | 1 |
| concepts[6].score | 0.0 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q9135 |
| concepts[6].display_name | Operating system |
| keywords[0].id | https://openalex.org/keywords/fork |
| keywords[0].score | 0.883169412612915 |
| keywords[0].display_name | Fork (system call) |
| keywords[1].id | https://openalex.org/keywords/cell-biology |
| keywords[1].score | 0.5824441909790039 |
| keywords[1].display_name | Cell biology |
| keywords[2].id | https://openalex.org/keywords/degradation |
| keywords[2].score | 0.5120382905006409 |
| keywords[2].display_name | Degradation (telecommunications) |
| keywords[3].id | https://openalex.org/keywords/biology |
| keywords[3].score | 0.4711417555809021 |
| keywords[3].display_name | Biology |
| keywords[4].id | https://openalex.org/keywords/computer-science |
| keywords[4].score | 0.20200270414352417 |
| keywords[4].display_name | Computer science |
| keywords[5].id | https://openalex.org/keywords/telecommunications |
| keywords[5].score | 0.08667075634002686 |
| keywords[5].display_name | Telecommunications |
| language | en |
| locations[0].id | doi:10.1038/s44319-025-00497-3 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S57252141 |
| locations[0].source.issn | 1469-221X, 1469-3178 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 1469-221X |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | EMBO Reports |
| locations[0].source.host_organization | https://openalex.org/P4310319965 |
| locations[0].source.host_organization_name | Springer Nature |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310319965 |
| locations[0].source.host_organization_lineage_names | Springer Nature |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.embopress.org/action/downloadSupplement?doi=10.1038/s44319-025-00497-3&file=44319_2025_497_MOESM3_ESM.pdf |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | EMBO Reports |
| locations[0].landing_page_url | https://doi.org/10.1038/s44319-025-00497-3 |
| locations[1].id | pmid:40495033 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | EMBO reports |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/40495033 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5014650028 |
| authorships[0].author.orcid | https://orcid.org/0000-0001-7976-4705 |
| authorships[0].author.display_name | Debanjali Bhattacharya |
| authorships[0].countries | IN |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I59270414 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Biochemistry, Indian Institute of Science, Bangalore, Karnataka, 560012, India. |
| authorships[0].institutions[0].id | https://openalex.org/I59270414 |
| authorships[0].institutions[0].ror | https://ror.org/04dese585 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I59270414 |
| authorships[0].institutions[0].country_code | IN |
| authorships[0].institutions[0].display_name | Indian Institute of Science Bangalore |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Debanjali Bhattacharya |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Department of Biochemistry, Indian Institute of Science, Bangalore, Karnataka, 560012, India. |
| authorships[1].author.id | https://openalex.org/A5019583597 |
| authorships[1].author.orcid | https://orcid.org/0000-0001-9862-111X |
| authorships[1].author.display_name | Harsh Kumar Dwivedi |
| authorships[1].countries | IN |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I59270414 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Biochemistry, Indian Institute of Science, Bangalore, Karnataka, 560012, India. |
| authorships[1].institutions[0].id | https://openalex.org/I59270414 |
| authorships[1].institutions[0].ror | https://ror.org/04dese585 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I59270414 |
| authorships[1].institutions[0].country_code | IN |
| authorships[1].institutions[0].display_name | Indian Institute of Science Bangalore |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Harsh Kumar Dwivedi |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Biochemistry, Indian Institute of Science, Bangalore, Karnataka, 560012, India. |
| authorships[2].author.id | https://openalex.org/A5049222210 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-3386-7095 |
| authorships[2].author.display_name | Ganesh Nagaraju |
| authorships[2].countries | IN |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I59270414 |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Biochemistry, Indian Institute of Science, Bangalore, Karnataka, 560012, India. [email protected]. |
| authorships[2].institutions[0].id | https://openalex.org/I59270414 |
| authorships[2].institutions[0].ror | https://ror.org/04dese585 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I59270414 |
| authorships[2].institutions[0].country_code | IN |
| authorships[2].institutions[0].display_name | Indian Institute of Science Bangalore |
| authorships[2].author_position | last |
| authorships[2].raw_author_name | Ganesh Nagaraju |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Biochemistry, Indian Institute of Science, Bangalore, Karnataka, 560012, India. [email protected]. |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.embopress.org/action/downloadSupplement?doi=10.1038/s44319-025-00497-3&file=44319_2025_497_MOESM3_ESM.pdf |
| open_access.oa_status | diamond |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | RNF20-mediated H2B monoubiquitination protects stalled forks from degradation and promotes fork restart |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-23T05:10:03.516525 |
| primary_topic.id | https://openalex.org/T14117 |
| primary_topic.field.id | https://openalex.org/fields/22 |
| primary_topic.field.display_name | Engineering |
| primary_topic.score | 0.9954000115394592 |
| primary_topic.domain.id | https://openalex.org/domains/3 |
| primary_topic.domain.display_name | Physical Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2208 |
| primary_topic.subfield.display_name | Electrical and Electronic Engineering |
| primary_topic.display_name | Integrated Circuits and Semiconductor Failure Analysis |
| related_works | https://openalex.org/W4391375266, https://openalex.org/W2082860237, https://openalex.org/W2119695867, https://openalex.org/W2130076355, https://openalex.org/W1990804418, https://openalex.org/W1993764875, https://openalex.org/W2046158694, https://openalex.org/W2788277189, https://openalex.org/W2013243191, https://openalex.org/W1971568933 |
| cited_by_count | 3 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 3 |
| locations_count | 2 |
| best_oa_location.id | doi:10.1038/s44319-025-00497-3 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S57252141 |
| best_oa_location.source.issn | 1469-221X, 1469-3178 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 1469-221X |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | EMBO Reports |
| best_oa_location.source.host_organization | https://openalex.org/P4310319965 |
| best_oa_location.source.host_organization_name | Springer Nature |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310319965 |
| best_oa_location.source.host_organization_lineage_names | Springer Nature |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.embopress.org/action/downloadSupplement?doi=10.1038/s44319-025-00497-3&file=44319_2025_497_MOESM3_ESM.pdf |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | EMBO Reports |
| best_oa_location.landing_page_url | https://doi.org/10.1038/s44319-025-00497-3 |
| primary_location.id | doi:10.1038/s44319-025-00497-3 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S57252141 |
| primary_location.source.issn | 1469-221X, 1469-3178 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 1469-221X |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | EMBO Reports |
| primary_location.source.host_organization | https://openalex.org/P4310319965 |
| primary_location.source.host_organization_name | Springer Nature |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310319965 |
| primary_location.source.host_organization_lineage_names | Springer Nature |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.embopress.org/action/downloadSupplement?doi=10.1038/s44319-025-00497-3&file=44319_2025_497_MOESM3_ESM.pdf |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | EMBO Reports |
| primary_location.landing_page_url | https://doi.org/10.1038/s44319-025-00497-3 |
| publication_date | 2025-06-10 |
| publication_year | 2025 |
| referenced_works | https://openalex.org/W2142125232, https://openalex.org/W2126684428, https://openalex.org/W3039743046, https://openalex.org/W3043743907, https://openalex.org/W4308219508, https://openalex.org/W1965749659, https://openalex.org/W2126237780, https://openalex.org/W2948817675, https://openalex.org/W4379468838, https://openalex.org/W1808263692, https://openalex.org/W2162561014, https://openalex.org/W3043003922, https://openalex.org/W2050690313, https://openalex.org/W2508906617, https://openalex.org/W4383373583, https://openalex.org/W3119695715, https://openalex.org/W4387661832, https://openalex.org/W2138204634, https://openalex.org/W1516566300, https://openalex.org/W2809592012, https://openalex.org/W2417989094, https://openalex.org/W2134222853, https://openalex.org/W1972509315, https://openalex.org/W2887959853, https://openalex.org/W2093111356, https://openalex.org/W4367173662, https://openalex.org/W2110817748, https://openalex.org/W4220743473, https://openalex.org/W2769913534, https://openalex.org/W2152385412, https://openalex.org/W2134767616, https://openalex.org/W2125718353, https://openalex.org/W1993612709, https://openalex.org/W2006001474, https://openalex.org/W3014348148, https://openalex.org/W2616616891, https://openalex.org/W2014179038, https://openalex.org/W1969503475, https://openalex.org/W2771808827, https://openalex.org/W2915069273, https://openalex.org/W2789638631, https://openalex.org/W2745330422, https://openalex.org/W2980927117, https://openalex.org/W2904540327, https://openalex.org/W4283012954, https://openalex.org/W1970578083, https://openalex.org/W2096380982, https://openalex.org/W2887994615, https://openalex.org/W2955620588, https://openalex.org/W2809311691, https://openalex.org/W2122485686, https://openalex.org/W3186719482, https://openalex.org/W2038493035, https://openalex.org/W2081963533, https://openalex.org/W2168275402, https://openalex.org/W2020255741, https://openalex.org/W2268274178, https://openalex.org/W2765875601, https://openalex.org/W3160242511, https://openalex.org/W2055373932, https://openalex.org/W1993746844, https://openalex.org/W2587610309, https://openalex.org/W3041183674, https://openalex.org/W2168523417, https://openalex.org/W2976701571, https://openalex.org/W2104584181, https://openalex.org/W2923629362, https://openalex.org/W2896605468, https://openalex.org/W2039778682, https://openalex.org/W1721495752, https://openalex.org/W2491401272, https://openalex.org/W4407560575, https://openalex.org/W3130965286, https://openalex.org/W2912983106, https://openalex.org/W2077630337, https://openalex.org/W4375955929, https://openalex.org/W3102726164, https://openalex.org/W2477439447, https://openalex.org/W2592850216, https://openalex.org/W4282037453, https://openalex.org/W2121516200 |
| referenced_works_count | 81 |
| abstract_inverted_index.a | 133 |
| abstract_inverted_index.an | 4 |
| abstract_inverted_index.at | 35, 72 |
| abstract_inverted_index.be | 52 |
| abstract_inverted_index.by | 47, 54 |
| abstract_inverted_index.in | 7, 78, 110, 138 |
| abstract_inverted_index.of | 39, 44, 56, 60, 68, 82, 95, 116 |
| abstract_inverted_index.to | 29, 42, 142 |
| abstract_inverted_index.we | 24 |
| abstract_inverted_index.DNA | 9 |
| abstract_inverted_index.H2B | 32 |
| abstract_inverted_index.and | 11, 30, 58, 70, 76, 86, 92, 102, 126 |
| abstract_inverted_index.are | 105 |
| abstract_inverted_index.can | 51 |
| abstract_inverted_index.for | 107, 135 |
| abstract_inverted_index.its | 99, 108 |
| abstract_inverted_index.our | 130 |
| abstract_inverted_index.the | 66, 79 |
| abstract_inverted_index.RING | 90 |
| abstract_inverted_index.acts | 77 |
| abstract_inverted_index.fork | 62, 74, 84, 124 |
| abstract_inverted_index.play | 3 |
| abstract_inverted_index.role | 6, 109, 134 |
| abstract_inverted_index.same | 80 |
| abstract_inverted_index.show | 25, 97 |
| abstract_inverted_index.that | 26, 98 |
| abstract_inverted_index.with | 89, 119 |
| abstract_inverted_index.H2Bub | 137 |
| abstract_inverted_index.Here, | 23 |
| abstract_inverted_index.RAD51 | 69 |
| abstract_inverted_index.RNF20 | 27, 40, 64, 96 |
| abstract_inverted_index.cells | 118 |
| abstract_inverted_index.forks | 46 |
| abstract_inverted_index.leads | 41 |
| abstract_inverted_index.sites | 75 |
| abstract_inverted_index.study | 131 |
| abstract_inverted_index.which | 50 |
| abstract_inverted_index.RAD51C | 71 |
| abstract_inverted_index.agents | 122 |
| abstract_inverted_index.domain | 91 |
| abstract_inverted_index.sites. | 37 |
| abstract_inverted_index.stress | 19, 112 |
| abstract_inverted_index.(H2Bub) | 34 |
| abstract_inverted_index.histone | 15 |
| abstract_inverted_index.loading | 67 |
| abstract_inverted_index.mutants | 94 |
| abstract_inverted_index.pathway | 81 |
| abstract_inverted_index.remains | 21 |
| abstract_inverted_index.repair. | 12 |
| abstract_inverted_index.rescued | 53 |
| abstract_inverted_index.rescues | 123 |
| abstract_inverted_index.restart | 127 |
| abstract_inverted_index.stalled | 45, 73 |
| abstract_inverted_index.whether | 14 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.Analyses | 88 |
| abstract_inverted_index.Finally, | 114 |
| abstract_inverted_index.activity | 101 |
| abstract_inverted_index.defects. | 128 |
| abstract_inverted_index.dynamics | 141 |
| abstract_inverted_index.enzymes, | 49 |
| abstract_inverted_index.genomes. | 145 |
| abstract_inverted_index.obscure. | 22 |
| abstract_inverted_index.promotes | 31 |
| abstract_inverted_index.regulate | 17 |
| abstract_inverted_index.relaxing | 121 |
| abstract_inverted_index.restart. | 87 |
| abstract_inverted_index.uncovers | 132 |
| abstract_inverted_index.Chromatin | 1 |
| abstract_inverted_index.Knockdown | 38 |
| abstract_inverted_index.catalytic | 100 |
| abstract_inverted_index.chromatin | 120, 140 |
| abstract_inverted_index.essential | 106 |
| abstract_inverted_index.important | 5 |
| abstract_inverted_index.localizes | 28 |
| abstract_inverted_index.responses | 20 |
| abstract_inverted_index.safeguard | 143 |
| abstract_inverted_index.treatment | 115 |
| abstract_inverted_index.MRE11/DNA2 | 57 |
| abstract_inverted_index.inhibition | 55 |
| abstract_inverted_index.protection | 85, 125 |
| abstract_inverted_index.regulating | 139 |
| abstract_inverted_index.responses. | 113 |
| abstract_inverted_index.degradation | 43 |
| abstract_inverted_index.facilitates | 65 |
| abstract_inverted_index.nucleolytic | 48 |
| abstract_inverted_index.remodelers. | 63 |
| abstract_inverted_index.replicating | 36, 144 |
| abstract_inverted_index.replication | 10, 18, 111 |
| abstract_inverted_index.ATR-mediated | 103 |
| abstract_inverted_index.Nonetheless, | 13 |
| abstract_inverted_index.co-depletion | 59 |
| abstract_inverted_index.Collectively, | 129 |
| abstract_inverted_index.modifications | 2, 16 |
| abstract_inverted_index.RNF20-depleted | 117 |
| abstract_inverted_index.RNF20-mediated | 136 |
| abstract_inverted_index.transcription, | 8 |
| abstract_inverted_index.phosphorylation | 104 |
| abstract_inverted_index.monoubiquitination | 33 |
| abstract_inverted_index.SMARCAL1/HLTF/ZRANB3 | 61 |
| abstract_inverted_index.RAD51/RAD51C-mediated | 83 |
| abstract_inverted_index.phosphorylation-deficient | 93 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 96 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 3 |
| citation_normalized_percentile.value | 0.92899355 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |