Robustness of single-isocenter multiple-metastasis stereotactic radiosurgery end-to-end testing across institutions Article Swipe
Daniel Saenz
,
Niko Papanikolaou
,
E. Zoros
,
E. Pappas
,
Michael Reiner
,
Lip Teck Chew
,
Hooi Yin Lim
,
Sam Hancock
,
Alex Nevelsky
,
Christopher F. Njeh
,
Georgios C. Anagnostopoulos
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-15983/v1
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-15983/v1
Background The accuracy of stereotactic radiosurgery to multiple brain metastases with a single isocenter using high definition dynamic radiosurgery (HDRS) was evaluated to assess robustness, repeatability, and possibility of inter-institutional quality assurance amongst multiple institutions. Methods A CT simulation scan obtained from a previously treated patient was used as the data set for targeting seven brain lesions. A VMAT treatment plan was generated using Monaco and was replicated at six HDRS-capable institutions using a plan template. All institutions subsequently irradiated 3D-printed head anthropomorphic phantoms mimicking the patient’s anatomy. Three different phantoms with a point dosimeter insert, film insert, and a gel dosimeter were used. Absolute dosimetry end-to-end dosimetric accuracy as well as gamma analysis for relative dose distribution agreement analysis was used to evaluate measurement agreement with calculation. Results Point measurements averaged across all institutions using six-degree-of-freedom treatment positioning correction were within 1.2±0.5%. The average gamma passing rate in the film plane using 3D global 3D gamma analysis was 96.6±2.2% (3%/2 mm). For all targets within 4 cm of the isocenter, the 3D dosimetric gel gamma passing rate averaged across institutions was >90% (3%/2 mm). 88.0% average gamma passing rate was found for targets beyond 4 cm. The targeting accuracy of high definition dynamic radiosurgery assessed by geometrical offset of the center of dose distributions was established across multiple institutions in this study to be within 1 mm for targets within 4 cm of isocenter. Conclusions Across variations in clinical practice, comparable dosimetry and localization is possible with this treatment planning and delivery technique.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.21203/rs.3.rs-15983/v1
- https://www.researchsquare.com/article/rs-15983/v1.pdf?c=1631845791000
- OA Status
- green
- Cited By
- 7
- References
- 21
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3157126304
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3157126304Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.21203/rs.3.rs-15983/v1Digital Object Identifier
- Title
-
Robustness of single-isocenter multiple-metastasis stereotactic radiosurgery end-to-end testing across institutionsWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-03-04Full publication date if available
- Authors
-
Daniel Saenz, Niko Papanikolaou, E. Zoros, E. Pappas, Michael Reiner, Lip Teck Chew, Hooi Yin Lim, Sam Hancock, Alex Nevelsky, Christopher F. Njeh, Georgios C. AnagnostopoulosList of authors in order
- Landing page
-
https://doi.org/10.21203/rs.3.rs-15983/v1Publisher landing page
- PDF URL
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https://www.researchsquare.com/article/rs-15983/v1.pdf?c=1631845791000Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
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https://www.researchsquare.com/article/rs-15983/v1.pdf?c=1631845791000Direct OA link when available
- Concepts
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Radiosurgery, Isocenter, Robustness (evolution), End-to-end principle, Medicine, Medical physics, Computer science, Radiology, Artificial intelligence, Radiation therapy, Chemistry, Gene, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
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7Total citation count in OpenAlex
- Citations by year (recent)
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2025: 3, 2024: 3, 2022: 1Per-year citation counts (last 5 years)
- References (count)
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21Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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