Role and mechanisms of histone methylation in osteogenic/odontogenic differentiation of dental mesenchymal stem cells Article Swipe
Meijun Hu
,
Zhipeng Fan
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1038/s41368-025-00353-z
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1038/s41368-025-00353-z
Dental mesenchymal stem cells (DMSCs) are pivotal for tooth development and periodontal tissue health and play an important role in tissue engineering and regenerative medicine because of their multidirectional differentiation potential and self-renewal ability. The cellular microenvironment regulates the fate of stem cells and can be modified using various optimization techniques. These methods can influence the cellular microenvironment, activate disparate signaling pathways, and induce different biological effects. “Epigenetic regulation” refers to the process of influencing gene expression and regulating cell fate without altering DNA sequences, such as histone methylation. Histone methylation modifications regulate pivotal transcription factors governing DMSCs differentiation into osteo-/odontogenic lineages. The most important sites of histone methylation in tooth organization were found to be H3K4, H3K9, and H3K27. Histone methylation affects gene expression and regulates stem cell differentiation by maintaining a delicate balance between major trimethylation sites, generating distinct chromatin structures associated with specific downstream transcriptional states. Several crucial signaling pathways associated with osteogenic differentiation are susceptible to modulation via histone methylation modifications. A deeper understanding of the regulatory mechanisms governing histone methylation modifications in osteo-/odontogenic differentiation and immune-inflammatory responses of DMSCs will facilitate further investigation of the epigenetic regulation of histone methylation in DMSC-mediated tissue regeneration and inflammation. Here is a concise overview of the pivotal functions of epigenetic histone methylation at H3K4, H3K9, and H3K27 in the regulation of osteo-/odontogenic differentiation and renewal of DMSCs in both non-inflammatory and inflammatory microenvironments. This review summarizes the current research on these processes in the context of tissue regeneration and therapeutic interventions.
Related Topics
Concepts
Epigenetics
Histone methylation
Biology
Epigenetic regulation of neurogenesis
Histone
DNA methylation
Cell biology
Cellular differentiation
Stem cell
Chromatin remodeling
Genetics
Gene expression
Gene
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1038/s41368-025-00353-z
- https://www.nature.com/articles/s41368-025-00353-z.pdf
- OA Status
- gold
- Cited By
- 4
- References
- 172
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4408822189
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4408822189Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1038/s41368-025-00353-zDigital Object Identifier
- Title
-
Role and mechanisms of histone methylation in osteogenic/odontogenic differentiation of dental mesenchymal stem cellsWork title
- Type
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reviewOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-03-26Full publication date if available
- Authors
-
Meijun Hu, Zhipeng FanList of authors in order
- Landing page
-
https://doi.org/10.1038/s41368-025-00353-zPublisher landing page
- PDF URL
-
https://www.nature.com/articles/s41368-025-00353-z.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://www.nature.com/articles/s41368-025-00353-z.pdfDirect OA link when available
- Concepts
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Epigenetics, Histone methylation, Biology, Epigenetic regulation of neurogenesis, Histone, DNA methylation, Cell biology, Cellular differentiation, Stem cell, Chromatin remodeling, Genetics, Gene expression, GeneTop concepts (fields/topics) attached by OpenAlex
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4Total citation count in OpenAlex
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2025: 4Per-year citation counts (last 5 years)
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172Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.interventions. | 253 |
| abstract_inverted_index.modifications. | 165 |
| abstract_inverted_index.trimethylation | 138 |
| abstract_inverted_index.differentiation | 30, 99, 130, 157, 179, 225 |
| abstract_inverted_index.transcriptional | 148 |
| abstract_inverted_index.microenvironment | 37 |
| abstract_inverted_index.multidirectional | 29 |
| abstract_inverted_index.non-inflammatory | 232 |
| abstract_inverted_index.microenvironment, | 58 |
| abstract_inverted_index.microenvironments. | 235 |
| abstract_inverted_index.osteo-/odontogenic | 101, 178, 224 |
| abstract_inverted_index.immune-inflammatory | 181 |
| cited_by_percentile_year.max | 98 |
| cited_by_percentile_year.min | 97 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 2 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.699999988079071 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.9543141 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |