Role of α7-nicotinic acetylcholine receptor in nicotine-induced invasion and epithelial-to-mesenchymal transition in human non-small cell lung cancer cells Article Swipe
Chun Zhang
,
Xuping Ding
,
Qingnan Zhao
,
Xinjie Yang
,
Shi-Min An
,
Hao Wang
,
Lu Xu
,
Liang Zhu
,
Hongzhuan Chen
·
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.18632/oncotarget.10498
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.18632/oncotarget.10498
Nicotine via nicotinic acetylcholine receptors (nAChRs) stimulates non-small cell lung cancer (NSCLC) cell invasion and epithelial to mesenchymal transition (EMT) which underpin the cancer metastasis. However, the receptor subtype-dependent effects of nAChRs on NSCLC cell invasion and EMT, and the signaling pathway underlying the effects remain not fully defined. We identified that nicotine induced NSCLC cell invasion, migration, and EMT; the effects were suppressed by pharmacological intervention using α7-nAChR selective antagonists or by genetic intervention using α7-nAChR knockdown via RNA inference. Meanwhile, nicotine induced activation of MEK/ERK signaling in NSCLC cells; α7-nAChR antagonism or MEK/ERK signaling pathway inhibition suppressed NSCLC cell invasion and EMT marker expression. These results indicate that nicotine induces NSCLC cell invasion, migration, and EMT; the effects are mediated by α7-nAChRs and involve MEK/ERK signaling pathway. Delineating the effect of nicotine on the NSCLC cell invasion and EMT at receptor subtype level would improve the understanding of cancer biology and offer potentials for the exploitation of selective ligands for the control of the cancer metastasis.
Related Topics
Concepts
Epithelial–mesenchymal transition
Nicotine
Cancer research
MAPK/ERK pathway
Nicotinic acetylcholine receptor
Metastasis
Lung cancer
Nicotinic agonist
Signal transduction
Biology
Cancer cell
Medicine
Cancer
Chemistry
Receptor
Cell biology
Internal medicine
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.18632/oncotarget.10498
- http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=10498&path%5B%5D=34567
- OA Status
- diamond
- Cited By
- 74
- References
- 26
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2463191693
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2463191693Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.18632/oncotarget.10498Digital Object Identifier
- Title
-
Role of α7-nicotinic acetylcholine receptor in nicotine-induced invasion and epithelial-to-mesenchymal transition in human non-small cell lung cancer cellsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2016Year of publication
- Publication date
-
2016-07-08Full publication date if available
- Authors
-
Chun Zhang, Xuping Ding, Qingnan Zhao, Xinjie Yang, Shi-Min An, Hao Wang, Lu Xu, Liang Zhu, Hongzhuan ChenList of authors in order
- Landing page
-
https://doi.org/10.18632/oncotarget.10498Publisher landing page
- PDF URL
-
https://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=10498&path%5B%5D=34567Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
diamondOpen access status per OpenAlex
- OA URL
-
https://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=10498&path%5B%5D=34567Direct OA link when available
- Concepts
-
Epithelial–mesenchymal transition, Nicotine, Cancer research, MAPK/ERK pathway, Nicotinic acetylcholine receptor, Metastasis, Lung cancer, Nicotinic agonist, Signal transduction, Biology, Cancer cell, Medicine, Cancer, Chemistry, Receptor, Cell biology, Internal medicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
74Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 8, 2024: 2, 2023: 9, 2022: 5, 2021: 6Per-year citation counts (last 5 years)
- References (count)
-
26Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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