Role of adiponectin as a modulator of testicular function during aging in mice Article Swipe
Mayank Choubey
,
Ashutosh Ranjan
,
Puran S. Bora
,
Fátima Baltazar
,
Luc J. Martin
,
Amitabh Krishna
·
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1016/j.bbadis.2018.11.019
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1016/j.bbadis.2018.11.019
The mechanisms by which testicular functions decline with aging remain largely speculative. Our recent finding showed the importance of adiponectin in the regulation of testicular functions, whereas its concentration declines during male infertility. Thus, the aim of present study was to explore the potential role of adiponectin during aging. The changes in adiponectin, adiponectin-receptors, and insulin receptor proteins expression in the testis were evaluated and compared with the testicular parameters, mass, and testosterone level in the mice from early post-natal to late senescence period. Further, the current study has examined the effect of exogenous adiponectin treatment on testicular functions in aged mice. The results showed a significant decline in adiponectin/adiponectin-receptors expression simultaneously with a significant decline in testicular mass, insulin receptor expression and testosterone synthesis in the testis of aged mice. Exogenous treatment of adiponectin to aged mice resulted in marked improvements in testicular mass, histological features (cells proliferation), insulin receptor expression, testicular glucose uptake, anti-oxidative enzymes activity and testosterone synthesis as compared with the control. Based on these findings, it may be concluded that a marked decline in adiponectin synthesis and action results in decreased insulin sensitivity (development of insulin resistance) and increased oxidative stress which consequently suppresses testicular functions during aging. This study further showed that treatment with adiponectin ameliorates reduced testicular functions by enhanced expression of insulin receptor in the testis of senescent mice. It is thus hypothesized that systemic adiponectin treatment could be a promising therapeutic strategy for improvement of testosterone production and sperm counts during aging.
Related Topics
Concepts
Adiponectin
Endocrinology
Internal medicine
Testosterone (patch)
Insulin
Adiponectin receptor 1
Receptor
Biology
Oxidative stress
Senescence
Insulin resistance
Medicine
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.bbadis.2018.11.019
- OA Status
- gold
- Cited By
- 61
- References
- 61
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2901680930
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2901680930Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1016/j.bbadis.2018.11.019Digital Object Identifier
- Title
-
Role of adiponectin as a modulator of testicular function during aging in miceWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2018Year of publication
- Publication date
-
2018-11-22Full publication date if available
- Authors
-
Mayank Choubey, Ashutosh Ranjan, Puran S. Bora, Fátima Baltazar, Luc J. Martin, Amitabh KrishnaList of authors in order
- Landing page
-
https://doi.org/10.1016/j.bbadis.2018.11.019Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://hdl.handle.net/1822/67193Direct OA link when available
- Concepts
-
Adiponectin, Endocrinology, Internal medicine, Testosterone (patch), Insulin, Adiponectin receptor 1, Receptor, Biology, Oxidative stress, Senescence, Insulin resistance, MedicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
61Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 5, 2024: 19, 2023: 13, 2022: 7, 2021: 6Per-year citation counts (last 5 years)
- References (count)
-
61Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W2901680930 |
|---|---|
| doi | https://doi.org/10.1016/j.bbadis.2018.11.019 |
| ids.doi | https://doi.org/10.1016/j.bbadis.2018.11.019 |
| ids.mag | 2901680930 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/30471430 |
| ids.openalex | https://openalex.org/W2901680930 |
| fwci | 3.49304696 |
| mesh[0].qualifier_ui | Q000378 |
| mesh[0].descriptor_ui | D052242 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | metabolism |
| mesh[0].descriptor_name | Adiponectin |
| mesh[1].qualifier_ui | Q000378 |
| mesh[1].descriptor_ui | D000375 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | metabolism |
| mesh[1].descriptor_name | Aging |
| mesh[2].qualifier_ui | |
| mesh[2].descriptor_ui | D000818 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | |
| mesh[2].descriptor_name | Animals |
| mesh[3].qualifier_ui | |
| mesh[3].descriptor_ui | D000831 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | |
| mesh[3].descriptor_name | Animals, Newborn |
| mesh[4].qualifier_ui | Q000378 |
| mesh[4].descriptor_ui | D000975 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | metabolism |
| mesh[4].descriptor_name | Antioxidants |
| mesh[5].qualifier_ui | |
| mesh[5].descriptor_ui | D017209 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | |
| mesh[5].descriptor_name | Apoptosis |
| mesh[6].qualifier_ui | Q000378 |
| mesh[6].descriptor_ui | D015415 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | metabolism |
| mesh[6].descriptor_name | Biomarkers |
| mesh[7].qualifier_ui | Q000378 |
| mesh[7].descriptor_ui | D001786 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | metabolism |
| mesh[7].descriptor_name | Blood Glucose |
| mesh[8].qualifier_ui | |
| mesh[8].descriptor_ui | D001835 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | |
| mesh[8].descriptor_name | Body Weight |
| mesh[9].qualifier_ui | Q000378 |
| mesh[9].descriptor_ui | D053148 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | metabolism |
| mesh[9].descriptor_name | Caspase 3 |
| mesh[10].qualifier_ui | |
| mesh[10].descriptor_ui | D049109 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | |
| mesh[10].descriptor_name | Cell Proliferation |
| mesh[11].qualifier_ui | |
| mesh[11].descriptor_ui | D002470 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | |
| mesh[11].descriptor_name | Cell Survival |
| mesh[12].qualifier_ui | Q000378 |
| mesh[12].descriptor_ui | D048049 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | metabolism |
| mesh[12].descriptor_name | Extracellular Signal-Regulated MAP Kinases |
| mesh[13].qualifier_ui | |
| mesh[13].descriptor_ui | D015227 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | |
| mesh[13].descriptor_name | Lipid Peroxidation |
| mesh[14].qualifier_ui | |
| mesh[14].descriptor_ui | D008297 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | |
| mesh[14].descriptor_name | Male |
| mesh[15].qualifier_ui | |
| mesh[15].descriptor_ui | D051379 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | |
| mesh[15].descriptor_name | Mice |
| mesh[16].qualifier_ui | |
| mesh[16].descriptor_ui | D008954 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | |
| mesh[16].descriptor_name | Models, Biological |
| mesh[17].qualifier_ui | |
| mesh[17].descriptor_ui | D009929 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | |
| mesh[17].descriptor_name | Organ Size |
| mesh[18].qualifier_ui | |
| mesh[18].descriptor_ui | D010766 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | |
| mesh[18].descriptor_name | Phosphorylation |
| mesh[19].qualifier_ui | Q000378 |
| mesh[19].descriptor_ui | D018809 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | metabolism |
| mesh[19].descriptor_name | Proliferating Cell Nuclear Antigen |
| mesh[20].qualifier_ui | Q000378 |
| mesh[20].descriptor_ui | D019253 |
| mesh[20].is_major_topic | False |
| mesh[20].qualifier_name | metabolism |
| mesh[20].descriptor_name | Proto-Oncogene Proteins c-bcl-2 |
| mesh[21].qualifier_ui | Q000378 |
| mesh[21].descriptor_ui | D011972 |
| mesh[21].is_major_topic | False |
| mesh[21].qualifier_name | metabolism |
| mesh[21].descriptor_name | Receptor, Insulin |
| mesh[22].qualifier_ui | Q000378 |
| mesh[22].descriptor_ui | D054419 |
| mesh[22].is_major_topic | False |
| mesh[22].qualifier_name | metabolism |
| mesh[22].descriptor_name | Receptors, Adiponectin |
| mesh[23].qualifier_ui | |
| mesh[23].descriptor_ui | D015398 |
| mesh[23].is_major_topic | False |
| mesh[23].qualifier_name | |
| mesh[23].descriptor_name | Signal Transduction |
| mesh[24].qualifier_ui | Q000166 |
| mesh[24].descriptor_ui | D013737 |
| mesh[24].is_major_topic | False |
| mesh[24].qualifier_name | cytology |
| mesh[24].descriptor_name | Testis |
| mesh[25].qualifier_ui | Q000378 |
| mesh[25].descriptor_ui | D013737 |
| mesh[25].is_major_topic | False |
| mesh[25].qualifier_name | metabolism |
| mesh[25].descriptor_name | Testis |
| mesh[26].qualifier_ui | Q000097 |
| mesh[26].descriptor_ui | D013739 |
| mesh[26].is_major_topic | False |
| mesh[26].qualifier_name | blood |
| mesh[26].descriptor_name | Testosterone |
| mesh[27].qualifier_ui | Q000378 |
| mesh[27].descriptor_ui | D052242 |
| mesh[27].is_major_topic | False |
| mesh[27].qualifier_name | metabolism |
| mesh[27].descriptor_name | Adiponectin |
| mesh[28].qualifier_ui | Q000378 |
| mesh[28].descriptor_ui | D000375 |
| mesh[28].is_major_topic | False |
| mesh[28].qualifier_name | metabolism |
| mesh[28].descriptor_name | Aging |
| mesh[29].qualifier_ui | |
| mesh[29].descriptor_ui | D000818 |
| mesh[29].is_major_topic | False |
| mesh[29].qualifier_name | |
| mesh[29].descriptor_name | Animals |
| mesh[30].qualifier_ui | |
| mesh[30].descriptor_ui | D000831 |
| mesh[30].is_major_topic | False |
| mesh[30].qualifier_name | |
| mesh[30].descriptor_name | Animals, Newborn |
| mesh[31].qualifier_ui | Q000378 |
| mesh[31].descriptor_ui | D000975 |
| mesh[31].is_major_topic | False |
| mesh[31].qualifier_name | metabolism |
| mesh[31].descriptor_name | Antioxidants |
| mesh[32].qualifier_ui | |
| mesh[32].descriptor_ui | D017209 |
| mesh[32].is_major_topic | False |
| mesh[32].qualifier_name | |
| mesh[32].descriptor_name | Apoptosis |
| mesh[33].qualifier_ui | Q000378 |
| mesh[33].descriptor_ui | D015415 |
| mesh[33].is_major_topic | False |
| mesh[33].qualifier_name | metabolism |
| mesh[33].descriptor_name | Biomarkers |
| mesh[34].qualifier_ui | Q000378 |
| mesh[34].descriptor_ui | D001786 |
| mesh[34].is_major_topic | False |
| mesh[34].qualifier_name | metabolism |
| mesh[34].descriptor_name | Blood Glucose |
| mesh[35].qualifier_ui | |
| mesh[35].descriptor_ui | D001835 |
| mesh[35].is_major_topic | False |
| mesh[35].qualifier_name | |
| mesh[35].descriptor_name | Body Weight |
| mesh[36].qualifier_ui | Q000378 |
| mesh[36].descriptor_ui | D053148 |
| mesh[36].is_major_topic | False |
| mesh[36].qualifier_name | metabolism |
| mesh[36].descriptor_name | Caspase 3 |
| mesh[37].qualifier_ui | |
| mesh[37].descriptor_ui | D049109 |
| mesh[37].is_major_topic | False |
| mesh[37].qualifier_name | |
| mesh[37].descriptor_name | Cell Proliferation |
| mesh[38].qualifier_ui | |
| mesh[38].descriptor_ui | D002470 |
| mesh[38].is_major_topic | False |
| mesh[38].qualifier_name | |
| mesh[38].descriptor_name | Cell Survival |
| mesh[39].qualifier_ui | Q000378 |
| mesh[39].descriptor_ui | D048049 |
| mesh[39].is_major_topic | False |
| mesh[39].qualifier_name | metabolism |
| mesh[39].descriptor_name | Extracellular Signal-Regulated MAP Kinases |
| mesh[40].qualifier_ui | |
| mesh[40].descriptor_ui | D015227 |
| mesh[40].is_major_topic | False |
| mesh[40].qualifier_name | |
| mesh[40].descriptor_name | Lipid Peroxidation |
| mesh[41].qualifier_ui | |
| mesh[41].descriptor_ui | D008297 |
| mesh[41].is_major_topic | False |
| mesh[41].qualifier_name | |
| mesh[41].descriptor_name | Male |
| mesh[42].qualifier_ui | |
| mesh[42].descriptor_ui | D051379 |
| mesh[42].is_major_topic | False |
| mesh[42].qualifier_name | |
| mesh[42].descriptor_name | Mice |
| mesh[43].qualifier_ui | |
| mesh[43].descriptor_ui | D008954 |
| mesh[43].is_major_topic | False |
| mesh[43].qualifier_name | |
| mesh[43].descriptor_name | Models, Biological |
| mesh[44].qualifier_ui | |
| mesh[44].descriptor_ui | D009929 |
| mesh[44].is_major_topic | False |
| mesh[44].qualifier_name | |
| mesh[44].descriptor_name | Organ Size |
| mesh[45].qualifier_ui | |
| mesh[45].descriptor_ui | D010766 |
| mesh[45].is_major_topic | False |
| mesh[45].qualifier_name | |
| mesh[45].descriptor_name | Phosphorylation |
| mesh[46].qualifier_ui | Q000378 |
| mesh[46].descriptor_ui | D018809 |
| mesh[46].is_major_topic | False |
| mesh[46].qualifier_name | metabolism |
| mesh[46].descriptor_name | Proliferating Cell Nuclear Antigen |
| mesh[47].qualifier_ui | Q000378 |
| mesh[47].descriptor_ui | D019253 |
| mesh[47].is_major_topic | False |
| mesh[47].qualifier_name | metabolism |
| mesh[47].descriptor_name | Proto-Oncogene Proteins c-bcl-2 |
| mesh[48].qualifier_ui | Q000378 |
| mesh[48].descriptor_ui | D011972 |
| mesh[48].is_major_topic | False |
| mesh[48].qualifier_name | metabolism |
| mesh[48].descriptor_name | Receptor, Insulin |
| mesh[49].qualifier_ui | Q000378 |
| mesh[49].descriptor_ui | D054419 |
| mesh[49].is_major_topic | False |
| mesh[49].qualifier_name | metabolism |
| mesh[49].descriptor_name | Receptors, Adiponectin |
| type | article |
| title | Role of adiponectin as a modulator of testicular function during aging in mice |
| awards[0].id | https://openalex.org/G7791527092 |
| awards[0].funder_id | https://openalex.org/F4320320720 |
| awards[0].display_name | |
| awards[0].funder_award_id | RBMH/FW/2018/1 |
| awards[0].funder_display_name | Indian Council of Medical Research |
| biblio.issue | 2 |
| biblio.volume | 1865 |
| biblio.last_page | 427 |
| biblio.first_page | 413 |
| topics[0].id | https://openalex.org/T11146 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9994000196456909 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2712 |
| topics[0].subfield.display_name | Endocrinology, Diabetes and Metabolism |
| topics[0].display_name | Hormonal and reproductive studies |
| topics[1].id | https://openalex.org/T10528 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9979000091552734 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2713 |
| topics[1].subfield.display_name | Epidemiology |
| topics[1].display_name | Adipokines, Inflammation, and Metabolic Diseases |
| topics[2].id | https://openalex.org/T10116 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.995199978351593 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2743 |
| topics[2].subfield.display_name | Reproductive Medicine |
| topics[2].display_name | Sperm and Testicular Function |
| funders[0].id | https://openalex.org/F4320320720 |
| funders[0].ror | https://ror.org/0492wrx28 |
| funders[0].display_name | Indian Council of Medical Research |
| funders[1].id | https://openalex.org/F4320321447 |
| funders[1].ror | https://ror.org/04cdn2797 |
| funders[1].display_name | Banaras Hindu University |
| is_xpac | False |
| apc_list.value | 3660 |
| apc_list.currency | USD |
| apc_list.value_usd | 3660 |
| apc_paid.value | 3660 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 3660 |
| concepts[0].id | https://openalex.org/C2776782570 |
| concepts[0].level | 4 |
| concepts[0].score | 0.9483190774917603 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q357439 |
| concepts[0].display_name | Adiponectin |
| concepts[1].id | https://openalex.org/C134018914 |
| concepts[1].level | 1 |
| concepts[1].score | 0.8546922206878662 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q162606 |
| concepts[1].display_name | Endocrinology |
| concepts[2].id | https://openalex.org/C126322002 |
| concepts[2].level | 1 |
| concepts[2].score | 0.8299002647399902 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[2].display_name | Internal medicine |
| concepts[3].id | https://openalex.org/C2779279991 |
| concepts[3].level | 2 |
| concepts[3].score | 0.603419840335846 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q6058681 |
| concepts[3].display_name | Testosterone (patch) |
| concepts[4].id | https://openalex.org/C2779306644 |
| concepts[4].level | 2 |
| concepts[4].score | 0.5375826358795166 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q2002370 |
| concepts[4].display_name | Insulin |
| concepts[5].id | https://openalex.org/C2779183219 |
| concepts[5].level | 5 |
| concepts[5].score | 0.48793455958366394 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q4651125 |
| concepts[5].display_name | Adiponectin receptor 1 |
| concepts[6].id | https://openalex.org/C170493617 |
| concepts[6].level | 2 |
| concepts[6].score | 0.4740951955318451 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q208467 |
| concepts[6].display_name | Receptor |
| concepts[7].id | https://openalex.org/C86803240 |
| concepts[7].level | 0 |
| concepts[7].score | 0.4559112787246704 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[7].display_name | Biology |
| concepts[8].id | https://openalex.org/C2776151105 |
| concepts[8].level | 2 |
| concepts[8].score | 0.4530212879180908 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q898814 |
| concepts[8].display_name | Oxidative stress |
| concepts[9].id | https://openalex.org/C522857546 |
| concepts[9].level | 2 |
| concepts[9].score | 0.43785589933395386 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q2070979 |
| concepts[9].display_name | Senescence |
| concepts[10].id | https://openalex.org/C2777391703 |
| concepts[10].level | 3 |
| concepts[10].score | 0.400016725063324 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q1053470 |
| concepts[10].display_name | Insulin resistance |
| concepts[11].id | https://openalex.org/C71924100 |
| concepts[11].level | 0 |
| concepts[11].score | 0.28661322593688965 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[11].display_name | Medicine |
| keywords[0].id | https://openalex.org/keywords/adiponectin |
| keywords[0].score | 0.9483190774917603 |
| keywords[0].display_name | Adiponectin |
| keywords[1].id | https://openalex.org/keywords/endocrinology |
| keywords[1].score | 0.8546922206878662 |
| keywords[1].display_name | Endocrinology |
| keywords[2].id | https://openalex.org/keywords/internal-medicine |
| keywords[2].score | 0.8299002647399902 |
| keywords[2].display_name | Internal medicine |
| keywords[3].id | https://openalex.org/keywords/testosterone |
| keywords[3].score | 0.603419840335846 |
| keywords[3].display_name | Testosterone (patch) |
| keywords[4].id | https://openalex.org/keywords/insulin |
| keywords[4].score | 0.5375826358795166 |
| keywords[4].display_name | Insulin |
| keywords[5].id | https://openalex.org/keywords/adiponectin-receptor-1 |
| keywords[5].score | 0.48793455958366394 |
| keywords[5].display_name | Adiponectin receptor 1 |
| keywords[6].id | https://openalex.org/keywords/receptor |
| keywords[6].score | 0.4740951955318451 |
| keywords[6].display_name | Receptor |
| keywords[7].id | https://openalex.org/keywords/biology |
| keywords[7].score | 0.4559112787246704 |
| keywords[7].display_name | Biology |
| keywords[8].id | https://openalex.org/keywords/oxidative-stress |
| keywords[8].score | 0.4530212879180908 |
| keywords[8].display_name | Oxidative stress |
| keywords[9].id | https://openalex.org/keywords/senescence |
| keywords[9].score | 0.43785589933395386 |
| keywords[9].display_name | Senescence |
| keywords[10].id | https://openalex.org/keywords/insulin-resistance |
| keywords[10].score | 0.400016725063324 |
| keywords[10].display_name | Insulin resistance |
| keywords[11].id | https://openalex.org/keywords/medicine |
| keywords[11].score | 0.28661322593688965 |
| keywords[11].display_name | Medicine |
| language | en |
| locations[0].id | doi:10.1016/j.bbadis.2018.11.019 |
| locations[0].is_oa | False |
| locations[0].source.id | https://openalex.org/S4210173099 |
| locations[0].source.issn | 0925-4439, 1879-260X |
| locations[0].source.type | journal |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | 0925-4439 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease |
| locations[0].source.host_organization | https://openalex.org/P4310320990 |
| locations[0].source.host_organization_name | Elsevier BV |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320990 |
| locations[0].source.host_organization_lineage_names | Elsevier BV |
| locations[0].license | publisher-specific-oa |
| locations[0].pdf_url | |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/publisher-specific-oa |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease |
| locations[0].landing_page_url | https://doi.org/10.1016/j.bbadis.2018.11.019 |
| locations[1].id | pmid:30471430 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Biochimica et biophysica acta. Molecular basis of disease |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/30471430 |
| locations[2].id | pmh:oai:repositorium.uminho.pt:1822/67193 |
| locations[2].is_oa | True |
| locations[2].source | |
| locations[2].license | other-oa |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | info:eu-repo/semantics/article |
| locations[2].license_id | https://openalex.org/licenses/other-oa |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | |
| locations[2].landing_page_url | https://hdl.handle.net/1822/67193 |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5079098355 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-2350-0855 |
| authorships[0].author.display_name | Mayank Choubey |
| authorships[0].countries | IN |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I91357014 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Zoology, Institute of Science, Banaras Hindu University, 221005 Varanasi, India |
| authorships[0].institutions[0].id | https://openalex.org/I91357014 |
| authorships[0].institutions[0].ror | https://ror.org/04cdn2797 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I91357014 |
| authorships[0].institutions[0].country_code | IN |
| authorships[0].institutions[0].display_name | Banaras Hindu University |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Mayank Choubey |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Department of Zoology, Institute of Science, Banaras Hindu University, 221005 Varanasi, India |
| authorships[1].author.id | https://openalex.org/A5008919130 |
| authorships[1].author.orcid | https://orcid.org/0000-0001-9107-3499 |
| authorships[1].author.display_name | Ashutosh Ranjan |
| authorships[1].countries | IN |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I91357014 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Zoology, Institute of Science, Banaras Hindu University, 221005 Varanasi, India |
| authorships[1].institutions[0].id | https://openalex.org/I91357014 |
| authorships[1].institutions[0].ror | https://ror.org/04cdn2797 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I91357014 |
| authorships[1].institutions[0].country_code | IN |
| authorships[1].institutions[0].display_name | Banaras Hindu University |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Ashutosh Ranjan |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Zoology, Institute of Science, Banaras Hindu University, 221005 Varanasi, India |
| authorships[2].author.id | https://openalex.org/A5065261686 |
| authorships[2].author.orcid | https://orcid.org/0000-0003-4781-1217 |
| authorships[2].author.display_name | Puran S. Bora |
| authorships[2].countries | US |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I79620101 |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Ophthalmology, Jones Eye Institute, Pat & Willard Walker Eye Research Center, 4301 West Markham, University of Arkansas for Medical Sciences, AR 72205, USA |
| authorships[2].institutions[0].id | https://openalex.org/I79620101 |
| authorships[2].institutions[0].ror | https://ror.org/00xcryt71 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I79620101 |
| authorships[2].institutions[0].country_code | US |
| authorships[2].institutions[0].display_name | University of Arkansas for Medical Sciences |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Puran S. Bora |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Ophthalmology, Jones Eye Institute, Pat & Willard Walker Eye Research Center, 4301 West Markham, University of Arkansas for Medical Sciences, AR 72205, USA |
| authorships[3].author.id | https://openalex.org/A5042988285 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-1770-4544 |
| authorships[3].author.display_name | Fátima Baltazar |
| authorships[3].countries | PT |
| authorships[3].affiliations[0].raw_affiliation_string | ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal |
| authorships[3].affiliations[1].institution_ids | https://openalex.org/I99682543 |
| authorships[3].affiliations[1].raw_affiliation_string | Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus Gualtar, Braga, Portugal |
| authorships[3].institutions[0].id | https://openalex.org/I99682543 |
| authorships[3].institutions[0].ror | https://ror.org/037wpkx04 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I99682543 |
| authorships[3].institutions[0].country_code | PT |
| authorships[3].institutions[0].display_name | University of Minho |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Fatima Baltazar |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal, Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus Gualtar, Braga, Portugal |
| authorships[4].author.id | https://openalex.org/A5033888044 |
| authorships[4].author.orcid | https://orcid.org/0000-0003-1919-8646 |
| authorships[4].author.display_name | Luc J. Martin |
| authorships[4].countries | CA |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I154799132 |
| authorships[4].affiliations[0].raw_affiliation_string | Département de biologie, Université de Moncton, 18, avenue Antonine Maillet, Moncton, (Nouveau-Brunswick) E1A 3E9, Canada. |
| authorships[4].institutions[0].id | https://openalex.org/I154799132 |
| authorships[4].institutions[0].ror | https://ror.org/029tnqt29 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I154799132 |
| authorships[4].institutions[0].country_code | CA |
| authorships[4].institutions[0].display_name | Université de Moncton |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Luc J. Martin |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Département de biologie, Université de Moncton, 18, avenue Antonine Maillet, Moncton, (Nouveau-Brunswick) E1A 3E9, Canada. |
| authorships[5].author.id | https://openalex.org/A5032011923 |
| authorships[5].author.orcid | https://orcid.org/0000-0003-3219-923X |
| authorships[5].author.display_name | Amitabh Krishna |
| authorships[5].countries | IN |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I91357014 |
| authorships[5].affiliations[0].raw_affiliation_string | Department of Zoology, Institute of Science, Banaras Hindu University, 221005 Varanasi, India |
| authorships[5].institutions[0].id | https://openalex.org/I91357014 |
| authorships[5].institutions[0].ror | https://ror.org/04cdn2797 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I91357014 |
| authorships[5].institutions[0].country_code | IN |
| authorships[5].institutions[0].display_name | Banaras Hindu University |
| authorships[5].author_position | last |
| authorships[5].raw_author_name | Amitabh Krishna |
| authorships[5].is_corresponding | True |
| authorships[5].raw_affiliation_strings | Department of Zoology, Institute of Science, Banaras Hindu University, 221005 Varanasi, India |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://hdl.handle.net/1822/67193 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Role of adiponectin as a modulator of testicular function during aging in mice |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T11146 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9994000196456909 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2712 |
| primary_topic.subfield.display_name | Endocrinology, Diabetes and Metabolism |
| primary_topic.display_name | Hormonal and reproductive studies |
| related_works | https://openalex.org/W2369214765, https://openalex.org/W2010062262, https://openalex.org/W159828373, https://openalex.org/W207004869, https://openalex.org/W340326529, https://openalex.org/W2415071131, https://openalex.org/W3032326234, https://openalex.org/W2388287950, https://openalex.org/W2314363746, https://openalex.org/W3141778284 |
| cited_by_count | 61 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 5 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 19 |
| counts_by_year[2].year | 2023 |
| counts_by_year[2].cited_by_count | 13 |
| counts_by_year[3].year | 2022 |
| counts_by_year[3].cited_by_count | 7 |
| counts_by_year[4].year | 2021 |
| counts_by_year[4].cited_by_count | 6 |
| counts_by_year[5].year | 2020 |
| counts_by_year[5].cited_by_count | 6 |
| counts_by_year[6].year | 2019 |
| counts_by_year[6].cited_by_count | 5 |
| locations_count | 3 |
| best_oa_location.id | pmh:oai:repositorium.uminho.pt:1822/67193 |
| best_oa_location.is_oa | True |
| best_oa_location.source | |
| best_oa_location.license | other-oa |
| best_oa_location.pdf_url | |
| best_oa_location.version | submittedVersion |
| best_oa_location.raw_type | info:eu-repo/semantics/article |
| best_oa_location.license_id | https://openalex.org/licenses/other-oa |
| best_oa_location.is_accepted | False |
| best_oa_location.is_published | False |
| best_oa_location.raw_source_name | |
| best_oa_location.landing_page_url | https://hdl.handle.net/1822/67193 |
| primary_location.id | doi:10.1016/j.bbadis.2018.11.019 |
| primary_location.is_oa | False |
| primary_location.source.id | https://openalex.org/S4210173099 |
| primary_location.source.issn | 0925-4439, 1879-260X |
| primary_location.source.type | journal |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | 0925-4439 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease |
| primary_location.source.host_organization | https://openalex.org/P4310320990 |
| primary_location.source.host_organization_name | Elsevier BV |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320990 |
| primary_location.source.host_organization_lineage_names | Elsevier BV |
| primary_location.license | publisher-specific-oa |
| primary_location.pdf_url | |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/publisher-specific-oa |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease |
| primary_location.landing_page_url | https://doi.org/10.1016/j.bbadis.2018.11.019 |
| publication_date | 2018-11-22 |
| publication_year | 2018 |
| referenced_works | https://openalex.org/W2010181168, https://openalex.org/W2019486401, https://openalex.org/W6701674363, https://openalex.org/W1974864224, https://openalex.org/W1822373976, https://openalex.org/W1978016303, https://openalex.org/W2490895295, https://openalex.org/W2262386854, https://openalex.org/W2040770361, https://openalex.org/W6752514583, https://openalex.org/W2164229548, https://openalex.org/W6752151453, https://openalex.org/W2291092290, https://openalex.org/W2253848821, https://openalex.org/W2094440311, https://openalex.org/W2138689118, https://openalex.org/W2045472079, https://openalex.org/W1587875569, https://openalex.org/W2084885557, https://openalex.org/W2122322331, https://openalex.org/W2006166466, https://openalex.org/W1994728677, https://openalex.org/W2464905538, https://openalex.org/W2158649743, https://openalex.org/W4293247451, https://openalex.org/W6723593113, https://openalex.org/W6805623860, https://openalex.org/W2009720537, https://openalex.org/W1983310681, https://openalex.org/W2884712618, https://openalex.org/W2136493937, https://openalex.org/W2030569972, https://openalex.org/W2598924229, https://openalex.org/W2094624393, https://openalex.org/W6748939149, https://openalex.org/W2275857981, https://openalex.org/W2415772362, https://openalex.org/W2063561693, https://openalex.org/W2139825622, https://openalex.org/W2049760976, https://openalex.org/W2166862228, https://openalex.org/W2038132983, https://openalex.org/W1897071795, https://openalex.org/W2124544973, https://openalex.org/W1862968028, https://openalex.org/W2050846492, https://openalex.org/W2082467000, https://openalex.org/W2170076642, https://openalex.org/W2072898133, https://openalex.org/W2350256796, https://openalex.org/W6745898396, https://openalex.org/W2044386584, https://openalex.org/W1971525389, https://openalex.org/W2128635872, https://openalex.org/W2767767370, https://openalex.org/W2807827188, https://openalex.org/W2494396193, https://openalex.org/W2326622737, https://openalex.org/W2792149265, https://openalex.org/W1566830427, https://openalex.org/W2806754931 |
| referenced_works_count | 61 |
| abstract_inverted_index.a | 105, 113, 175, 237 |
| abstract_inverted_index.It | 227 |
| abstract_inverted_index.as | 161 |
| abstract_inverted_index.be | 172, 236 |
| abstract_inverted_index.by | 2, 215 |
| abstract_inverted_index.in | 20, 51, 59, 74, 99, 108, 116, 125, 139, 142, 178, 184, 221 |
| abstract_inverted_index.is | 228 |
| abstract_inverted_index.it | 170 |
| abstract_inverted_index.of | 18, 23, 36, 45, 92, 128, 133, 189, 218, 224, 243 |
| abstract_inverted_index.on | 96, 167 |
| abstract_inverted_index.to | 40, 80, 135 |
| abstract_inverted_index.Our | 12 |
| abstract_inverted_index.The | 0, 49, 102 |
| abstract_inverted_index.aim | 35 |
| abstract_inverted_index.and | 54, 64, 71, 122, 158, 181, 192, 246 |
| abstract_inverted_index.for | 241 |
| abstract_inverted_index.has | 88 |
| abstract_inverted_index.its | 27 |
| abstract_inverted_index.may | 171 |
| abstract_inverted_index.the | 16, 21, 34, 42, 60, 67, 75, 85, 90, 126, 164, 222 |
| abstract_inverted_index.was | 39 |
| abstract_inverted_index.This | 203 |
| abstract_inverted_index.aged | 100, 129, 136 |
| abstract_inverted_index.from | 77 |
| abstract_inverted_index.late | 81 |
| abstract_inverted_index.male | 31 |
| abstract_inverted_index.mice | 76, 137 |
| abstract_inverted_index.role | 44 |
| abstract_inverted_index.that | 174, 207, 231 |
| abstract_inverted_index.thus | 229 |
| abstract_inverted_index.were | 62 |
| abstract_inverted_index.with | 7, 66, 112, 163, 209 |
| abstract_inverted_index.Based | 166 |
| abstract_inverted_index.Thus, | 33 |
| abstract_inverted_index.aging | 8 |
| abstract_inverted_index.could | 235 |
| abstract_inverted_index.early | 78 |
| abstract_inverted_index.level | 73 |
| abstract_inverted_index.mass, | 70, 118, 144 |
| abstract_inverted_index.mice. | 101, 130, 226 |
| abstract_inverted_index.sperm | 247 |
| abstract_inverted_index.study | 38, 87, 204 |
| abstract_inverted_index.these | 168 |
| abstract_inverted_index.which | 3, 196 |
| abstract_inverted_index.(cells | 147 |
| abstract_inverted_index.action | 182 |
| abstract_inverted_index.aging. | 48, 202, 250 |
| abstract_inverted_index.counts | 248 |
| abstract_inverted_index.during | 30, 47, 201, 249 |
| abstract_inverted_index.effect | 91 |
| abstract_inverted_index.marked | 140, 176 |
| abstract_inverted_index.recent | 13 |
| abstract_inverted_index.remain | 9 |
| abstract_inverted_index.showed | 15, 104, 206 |
| abstract_inverted_index.stress | 195 |
| abstract_inverted_index.testis | 61, 127, 223 |
| abstract_inverted_index.changes | 50 |
| abstract_inverted_index.current | 86 |
| abstract_inverted_index.decline | 6, 107, 115, 177 |
| abstract_inverted_index.enzymes | 156 |
| abstract_inverted_index.explore | 41 |
| abstract_inverted_index.finding | 14 |
| abstract_inverted_index.further | 205 |
| abstract_inverted_index.glucose | 153 |
| abstract_inverted_index.insulin | 55, 119, 149, 186, 190, 219 |
| abstract_inverted_index.largely | 10 |
| abstract_inverted_index.period. | 83 |
| abstract_inverted_index.present | 37 |
| abstract_inverted_index.reduced | 212 |
| abstract_inverted_index.results | 103, 183 |
| abstract_inverted_index.uptake, | 154 |
| abstract_inverted_index.whereas | 26 |
| abstract_inverted_index.Further, | 84 |
| abstract_inverted_index.activity | 157 |
| abstract_inverted_index.compared | 65, 162 |
| abstract_inverted_index.control. | 165 |
| abstract_inverted_index.declines | 29 |
| abstract_inverted_index.enhanced | 216 |
| abstract_inverted_index.examined | 89 |
| abstract_inverted_index.features | 146 |
| abstract_inverted_index.proteins | 57 |
| abstract_inverted_index.receptor | 56, 120, 150, 220 |
| abstract_inverted_index.resulted | 138 |
| abstract_inverted_index.strategy | 240 |
| abstract_inverted_index.systemic | 232 |
| abstract_inverted_index.Exogenous | 131 |
| abstract_inverted_index.concluded | 173 |
| abstract_inverted_index.decreased | 185 |
| abstract_inverted_index.evaluated | 63 |
| abstract_inverted_index.exogenous | 93 |
| abstract_inverted_index.findings, | 169 |
| abstract_inverted_index.functions | 5, 98, 200, 214 |
| abstract_inverted_index.increased | 193 |
| abstract_inverted_index.oxidative | 194 |
| abstract_inverted_index.potential | 43 |
| abstract_inverted_index.promising | 238 |
| abstract_inverted_index.senescent | 225 |
| abstract_inverted_index.synthesis | 124, 160, 180 |
| abstract_inverted_index.treatment | 95, 132, 208, 234 |
| abstract_inverted_index.expression | 58, 110, 121, 217 |
| abstract_inverted_index.functions, | 25 |
| abstract_inverted_index.importance | 17 |
| abstract_inverted_index.mechanisms | 1 |
| abstract_inverted_index.post-natal | 79 |
| abstract_inverted_index.production | 245 |
| abstract_inverted_index.regulation | 22 |
| abstract_inverted_index.senescence | 82 |
| abstract_inverted_index.suppresses | 198 |
| abstract_inverted_index.testicular | 4, 24, 68, 97, 117, 143, 152, 199, 213 |
| abstract_inverted_index.adiponectin | 19, 46, 94, 134, 179, 210, 233 |
| abstract_inverted_index.ameliorates | 211 |
| abstract_inverted_index.expression, | 151 |
| abstract_inverted_index.improvement | 242 |
| abstract_inverted_index.parameters, | 69 |
| abstract_inverted_index.resistance) | 191 |
| abstract_inverted_index.sensitivity | 187 |
| abstract_inverted_index.significant | 106, 114 |
| abstract_inverted_index.therapeutic | 239 |
| abstract_inverted_index.(development | 188 |
| abstract_inverted_index.adiponectin, | 52 |
| abstract_inverted_index.consequently | 197 |
| abstract_inverted_index.histological | 145 |
| abstract_inverted_index.hypothesized | 230 |
| abstract_inverted_index.improvements | 141 |
| abstract_inverted_index.infertility. | 32 |
| abstract_inverted_index.speculative. | 11 |
| abstract_inverted_index.testosterone | 72, 123, 159, 244 |
| abstract_inverted_index.concentration | 28 |
| abstract_inverted_index.anti-oxidative | 155 |
| abstract_inverted_index.simultaneously | 111 |
| abstract_inverted_index.proliferation), | 148 |
| abstract_inverted_index.adiponectin-receptors, | 53 |
| abstract_inverted_index.adiponectin/adiponectin-receptors | 109 |
| cited_by_percentile_year.max | 100 |
| cited_by_percentile_year.min | 98 |
| corresponding_author_ids | https://openalex.org/A5032011923 |
| countries_distinct_count | 4 |
| institutions_distinct_count | 6 |
| corresponding_institution_ids | https://openalex.org/I91357014 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.7400000095367432 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.91566071 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |