Role of CD44 in Non-Alcoholic Steatohepatitis (NASH) Progressivity Article Swipe
Sarwanti
,
Marini Stephanie
,
Ria Kodariah
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.55816/mpi.v29i2.415
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.55816/mpi.v29i2.415
Non alcoholic Steatohepatitis (NASH) is part of a group of conditions called Non-Alcoholic Fatty Liver Diseases(NAFLD) where it is a chronic disease, which defined after elimination other causes of fatty liver, such as excessivealcohol consumption and other causes of chronic liver diseases. NASH is fatty liver disease which characterized byballooning of hepatocyte and lobular inflammation with or without fibrosis. Histopathology diagnose on NASH can bedefined by performing liver biopsy. The purpose of liver biopsy is to define level and degree of the disease. Cluster ofDifferentiation (CD) 44 is a transmembrane glycoprotein receptor which located on the surface of macrophage cells,lymphocytes and endothelial cells. In studies which conducted on mice and humans, showed that CD44 playsimportant role in the progression of NASH. CD44 regulates inflammation of adipose tissue and liver. CD44 ispresumed as a marker which increase macrophage infiltration and other inflammatory cells on liver. This processleads to ultimate increment on insulin resistance and fatty liver. Deficiency was discovered on mice which injectedwith methionine and choline deficiency diet (MCDD). CD44 is associated with preventive method to prevent livercomplication by reducing macrophage or monocyte and as well as neutrophil accumulation in liver which wasevaluated through reducing numbers of inflammatory focus, expression of inflammatory cytokines: tumor necrosisfactor α (TNFα), interleukin (IL) -1B and nitric oxide synthesis (iNOS), and pro-inflammatory types of macrophage. Inobese patients, number of CD44 is predicted to be increasing.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.55816/mpi.v29i2.415
- http://majalahpatologiindonesia.com/p/index.php/patologi/article/download/415/290
- OA Status
- diamond
- References
- 13
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4285675917
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4285675917Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.55816/mpi.v29i2.415Digital Object Identifier
- Title
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Role of CD44 in Non-Alcoholic Steatohepatitis (NASH) ProgressivityWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2020Year of publication
- Publication date
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2020-05-01Full publication date if available
- Authors
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Sarwanti, Marini Stephanie, Ria KodariahList of authors in order
- Landing page
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https://doi.org/10.55816/mpi.v29i2.415Publisher landing page
- PDF URL
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https://majalahpatologiindonesia.com/p/index.php/patologi/article/download/415/290Direct link to full text PDF
- Open access
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YesWhether a free full text is available
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diamondOpen access status per OpenAlex
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https://majalahpatologiindonesia.com/p/index.php/patologi/article/download/415/290Direct OA link when available
- Concepts
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Steatohepatitis, Fatty liver, Liver biopsy, Kupffer cell, Medicine, Inflammation, Fibrosis, Liver disease, Cirrhosis, Internal medicine, CD163, Chronic liver disease, Macrophage, Endocrinology, Pathology, Biology, Biopsy, Disease, Biochemistry, In vitroTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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13Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.This | 144 |
| abstract_inverted_index.diet | 166 |
| abstract_inverted_index.mice | 108, 159 |
| abstract_inverted_index.part | 5 |
| abstract_inverted_index.role | 115 |
| abstract_inverted_index.such | 31 |
| abstract_inverted_index.that | 112 |
| abstract_inverted_index.well | 184 |
| abstract_inverted_index.with | 55, 171 |
| abstract_inverted_index.Fatty | 13 |
| abstract_inverted_index.Liver | 14 |
| abstract_inverted_index.NASH. | 120 |
| abstract_inverted_index.after | 24 |
| abstract_inverted_index.cells | 141 |
| abstract_inverted_index.fatty | 29, 44, 153 |
| abstract_inverted_index.group | 8 |
| abstract_inverted_index.level | 77 |
| abstract_inverted_index.liver | 40, 45, 67, 72, 189 |
| abstract_inverted_index.other | 26, 36, 139 |
| abstract_inverted_index.oxide | 211 |
| abstract_inverted_index.tumor | 202 |
| abstract_inverted_index.types | 216 |
| abstract_inverted_index.where | 16 |
| abstract_inverted_index.which | 22, 47, 92, 105, 134, 160, 190 |
| abstract_inverted_index.(NASH) | 3 |
| abstract_inverted_index.biopsy | 73 |
| abstract_inverted_index.called | 11 |
| abstract_inverted_index.causes | 27, 37 |
| abstract_inverted_index.cells. | 102 |
| abstract_inverted_index.define | 76 |
| abstract_inverted_index.degree | 79 |
| abstract_inverted_index.focus, | 197 |
| abstract_inverted_index.liver, | 30 |
| abstract_inverted_index.liver. | 128, 143, 154 |
| abstract_inverted_index.marker | 133 |
| abstract_inverted_index.method | 173 |
| abstract_inverted_index.nitric | 210 |
| abstract_inverted_index.number | 221 |
| abstract_inverted_index.showed | 111 |
| abstract_inverted_index.tissue | 126 |
| abstract_inverted_index.(MCDD). | 167 |
| abstract_inverted_index.(iNOS), | 213 |
| abstract_inverted_index.Cluster | 83 |
| abstract_inverted_index.Inobese | 219 |
| abstract_inverted_index.adipose | 125 |
| abstract_inverted_index.biopsy. | 68 |
| abstract_inverted_index.choline | 164 |
| abstract_inverted_index.chronic | 20, 39 |
| abstract_inverted_index.defined | 23 |
| abstract_inverted_index.disease | 46 |
| abstract_inverted_index.humans, | 110 |
| abstract_inverted_index.insulin | 150 |
| abstract_inverted_index.lobular | 53 |
| abstract_inverted_index.located | 93 |
| abstract_inverted_index.numbers | 194 |
| abstract_inverted_index.prevent | 175 |
| abstract_inverted_index.purpose | 70 |
| abstract_inverted_index.studies | 104 |
| abstract_inverted_index.surface | 96 |
| abstract_inverted_index.through | 192 |
| abstract_inverted_index.without | 57 |
| abstract_inverted_index.(TNFα), | 205 |
| abstract_inverted_index.diagnose | 60 |
| abstract_inverted_index.disease, | 21 |
| abstract_inverted_index.disease. | 82 |
| abstract_inverted_index.increase | 135 |
| abstract_inverted_index.monocyte | 181 |
| abstract_inverted_index.receptor | 91 |
| abstract_inverted_index.reducing | 178, 193 |
| abstract_inverted_index.ultimate | 147 |
| abstract_inverted_index.alcoholic | 1 |
| abstract_inverted_index.bedefined | 64 |
| abstract_inverted_index.conducted | 106 |
| abstract_inverted_index.diseases. | 41 |
| abstract_inverted_index.fibrosis. | 58 |
| abstract_inverted_index.increment | 148 |
| abstract_inverted_index.patients, | 220 |
| abstract_inverted_index.predicted | 225 |
| abstract_inverted_index.regulates | 122 |
| abstract_inverted_index.synthesis | 212 |
| abstract_inverted_index.Deficiency | 155 |
| abstract_inverted_index.associated | 170 |
| abstract_inverted_index.conditions | 10 |
| abstract_inverted_index.cytokines: | 201 |
| abstract_inverted_index.deficiency | 165 |
| abstract_inverted_index.discovered | 157 |
| abstract_inverted_index.expression | 198 |
| abstract_inverted_index.hepatocyte | 51 |
| abstract_inverted_index.ispresumed | 130 |
| abstract_inverted_index.macrophage | 98, 136, 179 |
| abstract_inverted_index.methionine | 162 |
| abstract_inverted_index.neutrophil | 186 |
| abstract_inverted_index.performing | 66 |
| abstract_inverted_index.preventive | 172 |
| abstract_inverted_index.resistance | 151 |
| abstract_inverted_index.consumption | 34 |
| abstract_inverted_index.elimination | 25 |
| abstract_inverted_index.endothelial | 101 |
| abstract_inverted_index.increasing. | 228 |
| abstract_inverted_index.interleukin | 206 |
| abstract_inverted_index.macrophage. | 218 |
| abstract_inverted_index.progression | 118 |
| abstract_inverted_index.accumulation | 187 |
| abstract_inverted_index.byballooning | 49 |
| abstract_inverted_index.glycoprotein | 90 |
| abstract_inverted_index.infiltration | 137 |
| abstract_inverted_index.inflammation | 54, 123 |
| abstract_inverted_index.inflammatory | 140, 196, 200 |
| abstract_inverted_index.injectedwith | 161 |
| abstract_inverted_index.processleads | 145 |
| abstract_inverted_index.wasevaluated | 191 |
| abstract_inverted_index.Non-Alcoholic | 12 |
| abstract_inverted_index.characterized | 48 |
| abstract_inverted_index.transmembrane | 89 |
| abstract_inverted_index.Histopathology | 59 |
| abstract_inverted_index.necrosisfactor | 203 |
| abstract_inverted_index.playsimportant | 114 |
| abstract_inverted_index.Diseases(NAFLD) | 15 |
| abstract_inverted_index.Steatohepatitis | 2 |
| abstract_inverted_index.excessivealcohol | 33 |
| abstract_inverted_index.pro-inflammatory | 215 |
| abstract_inverted_index.cells,lymphocytes | 99 |
| abstract_inverted_index.livercomplication | 176 |
| abstract_inverted_index.ofDifferentiation | 84 |
| cited_by_percentile_year | |
| corresponding_author_ids | https://openalex.org/A5058643715 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 3 |
| corresponding_institution_ids | https://openalex.org/I29617571 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8100000023841858 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.34716546 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |