Role of different immune cells and metabolic pathways in modulating the immune response in pancreatic cancer (Review) Article Swipe
Nnenna Elebo
,
Pascaline Fonteh
,
J. Omoshoro–Jones
,
Geoffrey Candy
,
Ekene Emmanuel Nweke
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3892/mmr.2020.11622
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3892/mmr.2020.11622
Pancreatic cancer is an aggressive cancer, making it a leading cause of cancer‑related deaths. It is characteristically resistant to treatment, which results in low survival rates. In pancreatic cancer, immune cells undergo transitions that can inhibit or promote their functions, enabling treatment resistance and tumor progression. These transitions can be fostered by metabolic pathways that are dysregulated during tumorigenesis. The present review aimed to summarize the different immune cells and their roles in pancreatic cancer. The review also highlighted the individual metabolic pathways in pancreatic cancer and how they enable transitions in immune cells. Finally, the potential of targeting metabolic pathways for effective therapeutic strategies was considered.
Related Topics
Concepts
Pancreatic cancer
Immune system
Cancer
Carcinogenesis
Oncogene
Cancer research
Cancer cell
Biology
Molecular medicine
Cell cycle
Metabolic pathway
Immunology
Endocrinology
Metabolism
Genetics
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3892/mmr.2020.11622
- https://www.spandidos-publications.com/10.3892/mmr.2020.11622/download
- OA Status
- hybrid
- Cited By
- 21
- References
- 146
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3093887577
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3093887577Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3892/mmr.2020.11622Digital Object Identifier
- Title
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Role of different immune cells and metabolic pathways in modulating the immune response in pancreatic cancer (Review)Work title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2020Year of publication
- Publication date
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2020-10-21Full publication date if available
- Authors
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Nnenna Elebo, Pascaline Fonteh, J. Omoshoro–Jones, Geoffrey Candy, Ekene Emmanuel NwekeList of authors in order
- Landing page
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https://doi.org/10.3892/mmr.2020.11622Publisher landing page
- PDF URL
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https://www.spandidos-publications.com/10.3892/mmr.2020.11622/downloadDirect link to full text PDF
- Open access
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://www.spandidos-publications.com/10.3892/mmr.2020.11622/downloadDirect OA link when available
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Pancreatic cancer, Immune system, Cancer, Carcinogenesis, Oncogene, Cancer research, Cancer cell, Biology, Molecular medicine, Cell cycle, Metabolic pathway, Immunology, Endocrinology, Metabolism, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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21Total citation count in OpenAlex
- Citations by year (recent)
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2025: 3, 2024: 7, 2023: 7, 2022: 1, 2021: 3Per-year citation counts (last 5 years)
- References (count)
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146Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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