Role of Dual-Staining p16/Ki-67 in the Management of Patients under 30 Years with ASC-US/L-SIL Article Swipe
Cristina Secoșan
,
Andrea Pasquini
,
Delia Elena Zăhoi
,
Andrei Gheorghe Marius Motoc
,
Diana Lungeanu
,
Oana Balint
,
Aurora Ilian
,
Ligia Bălulescu
,
Dorin Grigoraş
,
Laurențiu Pirtea
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/diagnostics12020403
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/diagnostics12020403
Patients diagnosed with low-grade squamous intraepithelial lesion ((L-SIL) or atypical squamous cells of undetermined significance (ASC-US) are subjected to additional investigations, such as colposcopy and biopsy, to rule out cervical intraepithelial neoplasia 2+ (CIN 2+). Especially in young patients, lesions tend to regress spontaneously, and many human papilloma virus (HPV) infections are transient. Dual-staining p16/Ki-67 has been proposed for the triage of patients with ASC-US or L-SIL, but no prospective study addressing only this subgroup of patients has been conducted so far. We performed a prospective study including all eligible patients referred for a loop electrosurgical excision procedure (LEEP) in the Department of Obstetrics and Gynecology of Timișoara University City Hospital. HPV genotyping and dual-staining for p16/Ki-67 were performed prior to LEEP, at 6 and 12 months after LEEP. A total of 60 patients were included in the study and completed the follow-up evaluation. We analyzed the sensitivity and specificity for biopsy-confirmed CIN2+ using the 95% confidence interval (CI) of high-risk human papilloma virus (HR-HPV), dual-staining p16/Ki-67, colposcopy, and combinations of the tests on all patients and separately for the ASC-US and L-SIL groups. Dual-staining p16/Ki-67 alone or in combination with HR-HPV and/or colposcopy showed a higher specificity that HR-HPV and/or colposcopy for the diagnosis of biopsy confirmed CIN2+ in patients under 30 years. Colposcopy + p16/Ki-67 and HR-HPV + colposcopy + p16/Ki-67 showed the highest specificity in our study.
Related Topics
Concepts
Colposcopy
Medicine
Squamous intraepithelial lesion
Biopsy
Cervical intraepithelial neoplasia
Prospective cohort study
Gynecology
Internal medicine
Gastroenterology
Cervical cancer
Cancer
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/diagnostics12020403
- https://www.mdpi.com/2075-4418/12/2/403/pdf?version=1644554690
- OA Status
- gold
- Cited By
- 6
- References
- 65
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4210418052
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4210418052Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/diagnostics12020403Digital Object Identifier
- Title
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Role of Dual-Staining p16/Ki-67 in the Management of Patients under 30 Years with ASC-US/L-SILWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-02-04Full publication date if available
- Authors
-
Cristina Secoșan, Andrea Pasquini, Delia Elena Zăhoi, Andrei Gheorghe Marius Motoc, Diana Lungeanu, Oana Balint, Aurora Ilian, Ligia Bălulescu, Dorin Grigoraş, Laurențiu PirteaList of authors in order
- Landing page
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https://doi.org/10.3390/diagnostics12020403Publisher landing page
- PDF URL
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https://www.mdpi.com/2075-4418/12/2/403/pdf?version=1644554690Direct link to full text PDF
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://www.mdpi.com/2075-4418/12/2/403/pdf?version=1644554690Direct OA link when available
- Concepts
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Colposcopy, Medicine, Squamous intraepithelial lesion, Biopsy, Cervical intraepithelial neoplasia, Prospective cohort study, Gynecology, Internal medicine, Gastroenterology, Cervical cancer, CancerTop concepts (fields/topics) attached by OpenAlex
- Cited by
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6Total citation count in OpenAlex
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2025: 3, 2024: 3Per-year citation counts (last 5 years)
- References (count)
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65Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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