Role of Growth Hormone Therapy in Metabolic-Dysfunction-Associated Steatotic Liver Disease: A Systematic Review and Meta-Analysis Article Swipe
Deep Dutta
,
Lakshmi Nagendra
,
Ritin Mohindra
,
Saptarshi Bhattacharya
,
Ameya Joshi
,
A B Kamrul-Hasan
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.4103/ijem.ijem_488_23
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.4103/ijem.ijem_488_23
Multiple observation studies and meta-analysis have linked growth hormone (GH) deficiency with metabolic-dysfunction-associated steatotic liver disease (MASLD). No meta-analysis has analysed the efficacy and safety of GH therapy on different aspects of MASLD. We undertook this meta-analysis to address this gap in knowledge. Electronic databases were searched for RCTs involving patients with MASLD receiving GH therapy. Primary outcome was to evaluate changes in radiologic measures of MASLD (magnetic resonance spectroscopy (MRS) and ultrasonography) and liver enzymes. Secondary outcomes were to evaluate alterations in body composition parameters [dual-energy X-ray absorptiometry (DXA)], lipids, glycaemia and side effects. From initially searched 1047 articles, data from three RCTs (120 patients) which fulfilled all criteria were analysed. After 6 months of GH therapy in MASLD, the per cent reduction in intrahepatic lipid (MRS) was significantly higher with GH as compared to placebo [MD -5.85% (95%CI:-11.41– -0.30); P = 0.04; I 2 = 63%]. Visceral adipose tissue (VAT) area reduction (DXA) was significantly higher with GH [MD-9.94 cm 2 (95%CI:-19.04– -0.84); P = 0.03; I 2 = 0%]. Serum insulin-like growth factor-1 (IGF-1) was significantly raised in MASLD patients receiving GH as compared to placebo [MD +166.86 ng/ml (95%CI: 79.19–254.53); P < 0.0.001; I 2 = 90%]. High-sensitivity C-reactive protein (hsCRP) was significantly lower in patients receiving GH [MD -0.89 mg/L (95%CI:-1.40–-0.38); P = 0.0.0006; I 2 = 0%]. Patients receiving GH had similar changes in triglycerides [MD-1.06 mg/L (95%CI:-20.45–18.34); P = 0.91; I 2 = 15%] and fasting glucose [MD -0.56 mg/L (95%CI:-4.67–3.55); P = 0.79; I 2 = 39%]. Gamma-glutamyl transpeptidase was significantly lower in patients receiving GH [MD -7.86 U/L (95%CI:-12.46–-3.27); P = 0.0008; I 2 = 0%]. No increase in new-onset hypothyroidism was noted [OR 5.49 (95%CI: 0.25–121.18); P = 0.28]. Short-term 6-month GH therapy in MASLD is associated with a significant reduction in intrahepatic lipid content, visceral adiposity, GGT and hsCRP without any increased occurrence of dysglycaemia or hypothyroidism.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.4103/ijem.ijem_488_23
- OA Status
- diamond
- Cited By
- 2
- References
- 19
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4401942677
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4401942677Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.4103/ijem.ijem_488_23Digital Object Identifier
- Title
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Role of Growth Hormone Therapy in Metabolic-Dysfunction-Associated Steatotic Liver Disease: A Systematic Review and Meta-AnalysisWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-07-01Full publication date if available
- Authors
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Deep Dutta, Lakshmi Nagendra, Ritin Mohindra, Saptarshi Bhattacharya, Ameya Joshi, A B Kamrul-HasanList of authors in order
- Landing page
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https://doi.org/10.4103/ijem.ijem_488_23Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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diamondOpen access status per OpenAlex
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https://doi.org/10.4103/ijem.ijem_488_23Direct OA link when available
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Medicine, Internal medicine, Placebo, Meta-analysis, Gastroenterology, Growth hormone, Endocrinology, Lipid profile, Hormone, Cholesterol, Pathology, Alternative medicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
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2Total citation count in OpenAlex
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2025: 2Per-year citation counts (last 5 years)
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19Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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