Role of Hypotaurine in Protection against UVA‐Induced Damage in Keratinocytes Article Swipe
Alessia Baseggio Conrado
,
Sergio Fanelli
,
Victoria A. McGuire
,
Sally H. Ibbotson
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1111/php.13334
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1111/php.13334
Photoageing and skin cancer are major causes of morbidity and are a high cost to society. Interest in the development of photoprotective agents for inclusion in topical cosmetic and sunscreen products is profound. Recently, amino acids with a sulfinic group, notably hypotaurine, have been included as ingredients in cosmetic preparations. However, the mechanism of action of hypotaurine as a possible anti‐aging agent is unknown, despite its use as a free radical scavenger. To address this issue, we investigated hypotaurine uptake in a human keratinocyte model and examined its effect on UVR‐induced cytotoxicity. Hypotaurine was taken up by keratinocytes in a time‐ and concentration‐dependent manner, with levels remaining significantly above baseline 48 h after washout. A cytoprotective effect of pre‐incubation with 2.5–5 m M hypotaurine was shown as indicated by increased cell viability when keratinocytes were irradiated with UVA at 5 or 10 Jcm ‐2 , with the level of hypotaurine also significantly reduced. These findings indicate a potential cytoprotective effect of hypotaurine against the deleterious effects of UVA irradiation. This provides support for further studies to evaluate the potential photoprotective benefits of hypotaurine supplementation of topical cosmetic and sunscreen products.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1111/php.13334
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/php.13334
- OA Status
- hybrid
- Cited By
- 11
- References
- 35
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3087533953
All OpenAlex metadata
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https://openalex.org/W3087533953Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1111/php.13334Digital Object Identifier
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Role of Hypotaurine in Protection against UVA‐Induced Damage in KeratinocytesWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2020Year of publication
- Publication date
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2020-09-22Full publication date if available
- Authors
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Alessia Baseggio Conrado, Sergio Fanelli, Victoria A. McGuire, Sally H. IbbotsonList of authors in order
- Landing page
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https://doi.org/10.1111/php.13334Publisher landing page
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/php.13334Direct link to full text PDF
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/php.13334Direct OA link when available
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Hypotaurine, Chemistry, Biophysics, Taurine, Biochemistry, Biology, Amino acidTop concepts (fields/topics) attached by OpenAlex
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11Total citation count in OpenAlex
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2025: 3, 2024: 3, 2023: 3, 2022: 2Per-year citation counts (last 5 years)
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35Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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