Role of lactoferrin and its derived peptides in metabolic syndrome treatment Article Swipe
Xicui Zong
,
Yajing Wang
,
Yuqing Chen
,
Penghua Fang
,
Yi Zhang
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/fendo.2025.1562653
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/fendo.2025.1562653
The prevalence of metabolic syndrome is increasing globally year by year, which has prompted researchers to actively seek and develop natural biotherapeutics to address this challenge. Lactoferrin (LF), as a multifunctional iron-binding natural transferrin, has garnered significant attention due to its potential role in regulating metabolism and the immune system. Recent studies show lactoferrin may influence lipid metabolism and glucose-insulin balance, and its levels are linked to body measurements. We systematically summarized the phenotypic and genotypic changes of LF in patients with metabolic syndrome, and the effect of exogenous LF on the treatment of metabolic syndrome. We also recapitulate LF can alleviate insulin resistance by inhibiting the NF-κB inflammatory pathway, activating the IRS/PI3K/Akt/Glut signaling pathway, and inhibiting the renin-angiotensin system to reduce the blood pressure, therefore improving the metabolic syndrome. This provides an important theoretical basis for the clinical application of LF in metabolic syndrome.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3389/fendo.2025.1562653
- https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2025.1562653/pdf
- OA Status
- gold
- Cited By
- 1
- References
- 51
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4409559454
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4409559454Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fendo.2025.1562653Digital Object Identifier
- Title
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Role of lactoferrin and its derived peptides in metabolic syndrome treatmentWork title
- Type
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reviewOpenAlex work type
- Language
-
enPrimary language
- Publication year
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2025Year of publication
- Publication date
-
2025-04-17Full publication date if available
- Authors
-
Xicui Zong, Yajing Wang, Yuqing Chen, Penghua Fang, Yi ZhangList of authors in order
- Landing page
-
https://doi.org/10.3389/fendo.2025.1562653Publisher landing page
- PDF URL
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https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2025.1562653/pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
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-
goldOpen access status per OpenAlex
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https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2025.1562653/pdfDirect OA link when available
- Concepts
-
Lactoferrin, Metabolic syndrome, Insulin resistance, Medicine, PI3K/AKT/mTOR pathway, Immune system, Endocrinology, Transferrin, Insulin, Carbohydrate metabolism, Biology, Internal medicine, Signal transduction, Bioinformatics, Diabetes mellitus, Immunology, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
1Total citation count in OpenAlex
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2025: 1Per-year citation counts (last 5 years)
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51Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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