Role of LGMN in tumor development and its progression and connection with the tumor microenvironment Article Swipe
Safir Ullah Khan
,
Ibrar Muhammad Khan
,
Munir Ullah Khan
,
Muhammad Azhar Ud Din
,
Muhammad Zahoor Khan
,
Nazir Muhammad Khan
,
Yong Liu
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3389/fmolb.2023.1121964
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3389/fmolb.2023.1121964
Legumain (LGMN) has been demonstrated to be overexpressed not just in breast, prostatic, and liver tumor cells, but also in the macrophages that compose the tumor microenvironment. This supports the idea that LGMN is a pivotal protein in regulating tumor development, invasion, and dissemination. Targeting LGMN with siRNA or chemotherapeutic medicines and peptides can suppress cancer cell proliferation in culture and reduce tumor growth in vivo . Furthermore, legumain can be used as a marker for cancer detection and targeting due to its expression being significantly lower in normal cells compared to tumors or tumor-associated macrophages (TAMs). Tumor formation is influenced by aberrant expression of proteins and alterations in cellular architecture, but the tumor microenvironment is a crucial deciding factor. Legumain (LGMN) is an in vivo-active cysteine protease that catalyzes the degradation of numerous proteins. Its precise biological mechanism encompasses a number of routes, including effects on tumor-associated macrophage and neovascular endothelium in the tumor microenvironment. The purpose of this work is to establish a rationale for thoroughly investigating the function of LGMN in the tumor microenvironment and discovering novel tumor early diagnosis markers and therapeutic targets by reviewing the function of LGMN in tumor genesis and progression and its relationship with tumor milieu.
Related Topics
Concepts
Tumor microenvironment
Cancer research
Tumor progression
In vivo
Cancer
Biology
Tumor-associated macrophage
Function (biology)
Tumor cells
Cell biology
Genetics
Biotechnology
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3389/fmolb.2023.1121964
- https://www.frontiersin.org/articles/10.3389/fmolb.2023.1121964/pdf
- OA Status
- gold
- Cited By
- 38
- References
- 106
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4319346806
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://doi.org/10.3389/fmolb.2023.1121964Digital Object Identifier
- Title
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Role of LGMN in tumor development and its progression and connection with the tumor microenvironmentWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-02-07Full publication date if available
- Authors
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Safir Ullah Khan, Ibrar Muhammad Khan, Munir Ullah Khan, Muhammad Azhar Ud Din, Muhammad Zahoor Khan, Nazir Muhammad Khan, Yong LiuList of authors in order
- Landing page
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https://doi.org/10.3389/fmolb.2023.1121964Publisher landing page
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https://www.frontiersin.org/articles/10.3389/fmolb.2023.1121964/pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.frontiersin.org/articles/10.3389/fmolb.2023.1121964/pdfDirect OA link when available
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Tumor microenvironment, Cancer research, Tumor progression, In vivo, Cancer, Biology, Tumor-associated macrophage, Function (biology), Tumor cells, Cell biology, Genetics, BiotechnologyTop concepts (fields/topics) attached by OpenAlex
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38Total citation count in OpenAlex
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2025: 15, 2024: 14, 2023: 9Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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