Role of Lipoprotein (A) in aortic valve stenosis: Novel disease mechanisms and emerging pharmacotherapeutic approaches Article Swipe
Mohammad Ishrak Khan
,
Raisa Subaita Zahir
,
Abel Casso Dominguez
,
Francisco José Romeo
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.ijcha.2024.101543
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.ijcha.2024.101543
Lipoprotein(a) (Lp(a)) has garnered increasing attention as a significant contributor to the pathogenesis of aortic stenosis (AS), prompting a focused investigation into innovative pharmacological strategies to target this lipoprotein and its associated risks. Despite its recognized role in AS progression, Lp(a) often remains overlooked in clinical assessments, mirroring the broader challenges observed in holistic disease management. This review delves into the mechanistic intricacies of Lp(a) involvement in AS pathophysiology and its potential as a therapeutic target. Drawing parallels with the imperative for healthcare providers to proactively engage with patients regarding treatment regimens, this review underscores the essential role of cardiologists and physicians in recognizing and addressing Lp(a) as a modifiable risk factor in AS management. Furthermore, it explores promising avenues of novel drug approaches, including emerging pharmacotherapies and targeted interventions, aimed at modulating Lp(a) levels and attenuating AS progression. By navigating the complexities of Lp(a) modulation and its implications for AS management, this review aims to bridge critical gaps in understanding and clinical practice, ultimately optimizing treatment strategies and improving patient outcomes in the realm of AS therapeutics.
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- Language
- en
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- https://doi.org/10.1016/j.ijcha.2024.101543
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All OpenAlex metadata
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https://doi.org/10.1016/j.ijcha.2024.101543Digital Object Identifier
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Role of Lipoprotein (A) in aortic valve stenosis: Novel disease mechanisms and emerging pharmacotherapeutic approachesWork title
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reviewOpenAlex work type
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enPrimary language
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2024Year of publication
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2024-10-31Full publication date if available
- Authors
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Mohammad Ishrak Khan, Raisa Subaita Zahir, Abel Casso Dominguez, Francisco José RomeoList of authors in order
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https://doi.org/10.1016/j.ijcha.2024.101543Publisher landing page
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goldOpen access status per OpenAlex
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https://doi.org/10.1016/j.ijcha.2024.101543Direct OA link when available
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Medicine, Cardiology, Stenosis, Aortic valve stenosis, Internal medicine, Disease, Intensive care medicineTop concepts (fields/topics) attached by OpenAlex
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4Total citation count in OpenAlex
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2025: 4Per-year citation counts (last 5 years)
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