Role of lymphocyte-to-monocyte ratio as a predictive marker for diabetic coronary artery disease: A cross-sectional study Article Swipe
Pradeep Kumar Dabla
,
Dharmsheel Shrivastav
,
Pratishtha Mehra
,
Vimal Mehta
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.5662/wjm.v14.i3.92807
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.5662/wjm.v14.i3.92807
BACKGROUND The lymphocyte to monocyte ratio (LMR) is considered a marker of systemic inflammation in cardiovascular disease and acts as predictor of mortality in coronary artery disease. AIM To investigate the predictive role of LMR in diabetic coronary artery disease patients. METHODS This cross-sectional study was conducted at tertiary care super-specialty hospital at New Delhi, India. A total of 200 angiography-proven coronary artery disease (CAD) patients were enrolled and grouped into two categories: Group I [CAD patients with type 2 diabetes mellitus (T2DM) and glycated hemoglobin (HbA1c) levels ≥ 6.5%], and Group II (CAD patients without T2DM and HbA1c levels < 6.5%). Serum lipoproteins, HbA1c, and complete blood count of enrolled patients were analyzed using fully automatic analyzers. RESULTS The logistic regression analysis showed an odds ratio of 1.48 (95%CI: 1.28-1.72, P < 0.05) for diabetic coronary artery disease patients (Group I) in unadjusted model. After adjusting for age, gender, diet, smoking, and hypertension history, the odds ratio increased to 1.49 (95%CI: 1.29-1.74, P < 0.01) in close association with LMR. Further adjustment for high cholesterol and triglycerides yielded the same odds ratio of 1.49 (95%CI: 1.27-1.75, P < 0.01). Receiver operating characteristic curve analysis revealed 74% sensitivity, 64% specificity, and 0.74 area under the curve (95%CI: 0.67-0.80, P < 0.001), suggesting moderate predictive accuracy for diabetic CAD patients. CONCLUSION LMR showed positive association with diabetic coronary artery disease, with moderate predictive accuracy. These findings have implications for improving CAD management in diabetics, necessitating further research and targeted interventions.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.5662/wjm.v14.i3.92807
- OA Status
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- Cited By
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All OpenAlex metadata
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https://openalex.org/W4400015712Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.5662/wjm.v14.i3.92807Digital Object Identifier
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Role of lymphocyte-to-monocyte ratio as a predictive marker for diabetic coronary artery disease: A cross-sectional studyWork title
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articleOpenAlex work type
- Language
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enPrimary language
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2024Year of publication
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2024-06-25Full publication date if available
- Authors
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Pradeep Kumar Dabla, Dharmsheel Shrivastav, Pratishtha Mehra, Vimal MehtaList of authors in order
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https://doi.org/10.5662/wjm.v14.i3.92807Publisher landing page
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diamondOpen access status per OpenAlex
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https://doi.org/10.5662/wjm.v14.i3.92807Direct OA link when available
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Monocyte, Medicine, Coronary artery disease, Lymphocyte, Internal medicine, Cardiology, Diabetes mellitus, Disease, Cross-sectional study, Immunology, Pathology, EndocrinologyTop concepts (fields/topics) attached by OpenAlex
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6Total citation count in OpenAlex
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2025: 6Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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| referenced_works | https://openalex.org/W4312055778, https://openalex.org/W4382402771, https://openalex.org/W2122450058, https://openalex.org/W2118509723, https://openalex.org/W2015244718, https://openalex.org/W2111976103, https://openalex.org/W1996124300, https://openalex.org/W3007573596, https://openalex.org/W2978409600, https://openalex.org/W4284892802, https://openalex.org/W2570581545, https://openalex.org/W2898257240, https://openalex.org/W4221072883, https://openalex.org/W2028054185, https://openalex.org/W3148162787, https://openalex.org/W2034819178, https://openalex.org/W4207073986, https://openalex.org/W4206421612, https://openalex.org/W2131132715, https://openalex.org/W4323659997, https://openalex.org/W2980545203, https://openalex.org/W110542923 |
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