Role of matrix metalloproteinase-9 in neurodevelopmental disorders and experience-dependent plasticity in Xenopus tadpoles Article Swipe
Sayali V. Gore
,
Eric J. James
,
Lin-Chien Huang
,
Jenn J. Park
,
Andrea Berghella
,
Adrian Thompson
,
Hollis T. Cline
,
Carlos D. Aizenman
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1101/2020.05.29.123661
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1101/2020.05.29.123661
Matrix metalloproteinase-9 (MMP-9) is a secreted endopeptidase targeting extracellular matrix proteins, creating permissive environments for neuronal development and plasticity. Developmental dysregulation of MMP-9 is also associated with neurodevelopmental disorders (ND). Here we test the hypothesis that chronically elevated MMP-9 activity during early neurodevelopment is responsible for neural circuit hyperconnectivity observed after early exposure to valproic acid (VPA), a known teratogen associated with autism spectrum disorder in humans. In Xenopus tadpoles, VPA exposure results in excess local synaptic connectivity, disrupted social behavior and increased seizure susceptibility. We found that overexpressing MMP-9 in the brain copies effects of VPA on synaptic connectivity, and blocking MMP-9 activity pharmacologically or genetically reverses effects of VPA on physiology and behavior. We further show that during normal neurodevelopment MMP-9 levels are tightly regulated by neuronal activity and required for structural plasticity. These studies show a critical role for MMP-9 in both normal and abnormal development.
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- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2020.05.29.123661
- https://www.biorxiv.org/content/biorxiv/early/2020/08/13/2020.05.29.123661.full.pdf
- OA Status
- green
- Cited By
- 1
- References
- 72
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3031871619
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3031871619Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2020.05.29.123661Digital Object Identifier
- Title
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Role of matrix metalloproteinase-9 in neurodevelopmental disorders and experience-dependent plasticity in Xenopus tadpolesWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2020Year of publication
- Publication date
-
2020-05-31Full publication date if available
- Authors
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Sayali V. Gore, Eric J. James, Lin-Chien Huang, Jenn J. Park, Andrea Berghella, Adrian Thompson, Hollis T. Cline, Carlos D. AizenmanList of authors in order
- Landing page
-
https://doi.org/10.1101/2020.05.29.123661Publisher landing page
- PDF URL
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https://www.biorxiv.org/content/biorxiv/early/2020/08/13/2020.05.29.123661.full.pdfDirect link to full text PDF
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YesWhether a free full text is available
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-
greenOpen access status per OpenAlex
- OA URL
-
https://www.biorxiv.org/content/biorxiv/early/2020/08/13/2020.05.29.123661.full.pdfDirect OA link when available
- Concepts
-
Xenopus, Neuroscience, Valproic Acid, Matrix metalloproteinase, Synaptic plasticity, Biology, Extracellular matrix, Neuroplasticity, Long-term potentiation, Autism, Epilepsy, Endocrinology, Cell biology, Internal medicine, Medicine, Genetics, Gene, Psychiatry, ReceptorTop concepts (fields/topics) attached by OpenAlex
- Cited by
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1Total citation count in OpenAlex
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2022: 1Per-year citation counts (last 5 years)
- References (count)
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72Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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