Role of Postoperative Radiotherapy in Resected Adenoid Cystic Carcinoma of the Head and Neck Article Swipe
Seo Hee Choi
,
Andrew Yang
,
Sun Och Yoon
,
Hye Ryun Kim
,
Min Hee Hong
,
Se‐Heon Kim
,
Eun Chang Choi
,
Ki Chang Keum
,
Chang Geol Lee
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-2067980/v1
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-2067980/v1
Purpose: Although postoperative radiotherapy (PORT) is demonstrably effective in local control of head and neck adenoid cystic carcinoma (HNACC), its application is controversial and the subset of patients who would benefit most from PORT is unknown. Herein, we analyzed the data of HNACC patients to clarify the role of PORT. Methods: We retrospectively reviewed 187 patients with nonmetastatic HNACC who underwent surgical resection between 2005 and 2019. The study endpoints were locoregional failure-free survival (LRFFS), progression-free survival (PFS), and overall survival (OS). Subgroup analysis and recursive partitioning analysis (RPA) were performed to identify patients most likely to benefit from PORT. Results: With a median follow-up of 84.7 months, the 5-year LRFFS, PFS, and OS were 70.0%, 52.6%, and 86.4%, respectively. Survival was significantly shorter in patients who experienced local failure than in those who did not (5-year OS: 88.1% vs. 80.5%, p=0.001). The local failure rate was significantly lower in patients who underwent PORT (16.9% vs. 31.0%, p=0.021), despite the high frequency of adverse factors. Especially, significant decreases in local failure and similar OS rates could be obtained after PORT among patients with positive margins, T2-4 stage disease, and major salivary gland tumors. The RPA model for PFS categorized patients into four groups according to three prognostic factors (T-stage, location, and sex). The RPA model for LRFFS and OS suggested three groups based on two factors (T-stage, margin for LRFFS; T-stage, grade 3 for OS). Conclusion: PORT could prevent dismal survival, while significantly reducing local failures in high-risk HNACC patients.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.21203/rs.3.rs-2067980/v1
- https://www.researchsquare.com/article/rs-2067980/latest.pdf
- OA Status
- green
- References
- 44
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4297884388
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4297884388Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.21203/rs.3.rs-2067980/v1Digital Object Identifier
- Title
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Role of Postoperative Radiotherapy in Resected Adenoid Cystic Carcinoma of the Head and NeckWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-09-20Full publication date if available
- Authors
-
Seo Hee Choi, Andrew Yang, Sun Och Yoon, Hye Ryun Kim, Min Hee Hong, Se‐Heon Kim, Eun Chang Choi, Ki Chang Keum, Chang Geol LeeList of authors in order
- Landing page
-
https://doi.org/10.21203/rs.3.rs-2067980/v1Publisher landing page
- PDF URL
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https://www.researchsquare.com/article/rs-2067980/latest.pdfDirect link to full text PDF
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
- OA URL
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https://www.researchsquare.com/article/rs-2067980/latest.pdfDirect OA link when available
- Concepts
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Medicine, Adenoid cystic carcinoma, Stage (stratigraphy), Port (circuit theory), Radiation therapy, Surgery, Overall survival, Medical record, Carcinoma, Internal medicine, Oncology, Paleontology, Electrical engineering, Engineering, BiologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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