Role of Radiation Therapy in Modulation of the Tumor Stroma and Microenvironment Article Swipe
Hari Menon
,
Rishab Ramapriyan
,
Taylor R. Cushman
,
Vivek Verma
,
Hans H. Kim
,
Jonathan E. Schoenhals
,
Semra Cemre Atalar
,
Uğur Selek
,
Stephen G. Chun
,
Joe Y. Chang
,
Hampartsoum B. Barsoumian
,
Quynh-Nhu Nguyen
,
Mehmet Altan
,
María Angélica Cortez
,
Stephen M. Hahn
,
James W. Welsh
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.3389/fimmu.2019.00193
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.3389/fimmu.2019.00193
In recent decades, there has been substantial growth in our understanding of the immune system and its role in tumor growth and overall survival. A central finding has been the cross-talk between tumor cells and the surrounding environment or stroma. This tumor stroma, comprised of various cells, and extracellular matrix (ECM), has been shown to aid in suppressing host immune responses against tumor cells. Through immunosuppressive cytokine secretion, metabolic alterations, and other mechanisms, the tumor stroma provides a complex network of safeguards for tumor proliferation. With recent advances in more effective, localized treatment, radiation therapy (XRT) has allowed for strategies that can effectively alter and ablate tumor stromal tissue. This includes promoting immunogenic cell death through tumor antigen release to increasing immune cell trafficking, XRT has a unique advantage against the tumoral immune evasion mechanisms that are orchestrated by stromal cells. Current studies are underway to elucidate pathways within the tumor stroma as potential targets for immunotherapy and chemoradiation. This review summarizes the effects of tumor stroma in tumor immune evasion, explains how XRT may help overcome these effects, with potential combinatorial approaches for future treatment modalities.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3389/fimmu.2019.00193
- https://www.frontiersin.org/articles/10.3389/fimmu.2019.00193/pdf
- OA Status
- gold
- Cited By
- 144
- References
- 143
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2914382008
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2914382008Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3389/fimmu.2019.00193Digital Object Identifier
- Title
-
Role of Radiation Therapy in Modulation of the Tumor Stroma and MicroenvironmentWork title
- Type
-
reviewOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2019Year of publication
- Publication date
-
2019-02-15Full publication date if available
- Authors
-
Hari Menon, Rishab Ramapriyan, Taylor R. Cushman, Vivek Verma, Hans H. Kim, Jonathan E. Schoenhals, Semra Cemre Atalar, Uğur Selek, Stephen G. Chun, Joe Y. Chang, Hampartsoum B. Barsoumian, Quynh-Nhu Nguyen, Mehmet Altan, María Angélica Cortez, Stephen M. Hahn, James W. WelshList of authors in order
- Landing page
-
https://doi.org/10.3389/fimmu.2019.00193Publisher landing page
- PDF URL
-
https://www.frontiersin.org/articles/10.3389/fimmu.2019.00193/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://www.frontiersin.org/articles/10.3389/fimmu.2019.00193/pdfDirect OA link when available
- Concepts
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Tumor microenvironment, Stroma, Radiation therapy, Cancer research, Medicine, Chemistry, Pathology, Tumor cells, Internal medicine, ImmunohistochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
144Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 9, 2024: 25, 2023: 22, 2022: 23, 2021: 31Per-year citation counts (last 5 years)
- References (count)
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143Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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