Roles of non‐coding RNAs in eye development and diseases
Article Swipe
Xinrui Shi
,
Zhengbo Xue
,
Kaicheng Ye
,
Jian Yuan
,
Yan Zhang
,
Jia Qu
,
Jianzhong Su
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1002/wrna.1785
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1002/wrna.1785
The prevalence of ocular disorders is dramatically increasing worldwide, especially those that cause visual impairment and permanent loss of vision, including cataract, glaucoma, age‐related macular degeneration, and diabetic retinopathy. Extensive evidence has shown that ncRNAs are key regulators in various biogenesis and biological functions, controlling gene expression related to histogenesis and cell differentiation in ocular tissues. Aberrant expression and function of ncRNA can lead to dysfunction of visual system and mediate progression of eye disorders. Here, we mainly offer an overview of the role of precise modulation of ncRNAs in eye development and function in patients with eye diseases. We also highlight the challenges and future perspectives in conducting ncRNA studies, focusing specifically on the role of ncRNAs that may hold expanded promise for their diagnostic and therapeutic applications in various eye diseases. This article is categorized under: Regulatory RNAs/RNAi/Riboswitches > Regulatory RNAs RNA in Disease and Development > RNA in Disease RNA in Disease and Development > RNA in Development
Related Topics
Concepts
Non-coding RNA
microRNA
Eye development
RNA
Biology
RNA interference
Disease
Macular degeneration
Computational biology
Epigenetics
Long non-coding RNA
Bioinformatics
Gene
Medicine
Genetics
Transcription factor
Pathology
Ophthalmology
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1002/wrna.1785
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/wrna.1785
- OA Status
- bronze
- Cited By
- 7
- References
- 116
- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
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https://openalex.org/W4322486852Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1002/wrna.1785Digital Object Identifier
- Title
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Roles of non‐coding
RNAs in eye development and diseasesWork title - Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-02-27Full publication date if available
- Authors
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Xinrui Shi, Zhengbo Xue, Kaicheng Ye, Jian Yuan, Yan Zhang, Jia Qu, Jianzhong SuList of authors in order
- Landing page
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https://doi.org/10.1002/wrna.1785Publisher landing page
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/wrna.1785Direct link to full text PDF
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bronzeOpen access status per OpenAlex
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/wrna.1785Direct OA link when available
- Concepts
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Non-coding RNA, microRNA, Eye development, RNA, Biology, RNA interference, Disease, Macular degeneration, Computational biology, Epigenetics, Long non-coding RNA, Bioinformatics, Gene, Medicine, Genetics, Transcription factor, Pathology, OphthalmologyTop concepts (fields/topics) attached by OpenAlex
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7Total citation count in OpenAlex
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2025: 3, 2024: 3, 2023: 1Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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