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Scientific Reports • Vol 15 • No 1
Rosa roxburghii Tratt fruit extract ameliorate free fatty acid induced steatosis in HepG2 cells through activating PI3K-Akt and PPAR pathways
July 2025 • Yihan Ling, Wenxi Wang, X. LI, Xiaomeng Wang, Shuwen Zhang, Shaolin Huang, Heting Zhou, Lijun Peng, Wenya Yin
There has been a continuous increase in the global incidence of obesity. Rosa roxburghii Tratt (RRT), a plant with medicinal and edible uses, contains active components that can alleviate obesity, indicating an anti-obesity potential. This research sought to investigate the anti-obesity effects of RRT fruit extract (RRTE) and elucidate the underlying mechanisms and components responsible for its action. RRTE was obtained by enriching the active ingredient in RRT and used to treat HepG2 cells. RRTE alleviated cellu…
Steatosis
Mtor
Protein Kinase B
Chemistry
Biochemistry
Cell Biology
Biology
Internal Medicine
Medicine
Metabolism