Rosmarinic Acid Exhibits a Lipid-Lowering Effect by Modulating the Expression of Reverse Cholesterol Transporters and Lipid Metabolism in High-Fat Diet-Fed Mice Article Swipe
Jean Baptiste Nyandwi
,
Gyung Hyuck Ko
,
Hana Jin
,
Seung Pil Yun
,
Sang Won Park
,
Hye Jung Kim
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/biom11101470
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/biom11101470
Hyperlipidemia is a potent risk factor for the development of cardiovascular diseases. The reverse cholesterol transport (RCT) process has been shown to alleviate hyperlipidemia and protect against cardiovascular diseases. Recently, rosmarinic acid was reported to exhibit lipid-lowering effects. However, the underlying mechanism is still unclear. This study aims to investigate whether rosmarinic acid lowers lipids by modulating the RCT process in high-fat diet (HFD)-induced hyperlipidemic C57BL/6J mice. Our results indicated that rosmarinic acid treatment significantly decreased body weight, blood glucose, and plasma total cholesterol and triglyceride levels in HFD-fed mice. Rosmarinic acid increased the expression levels of cholesterol uptake-associated receptors in liver tissues, including scavenger receptor B type 1 (SR-B1) and low-density lipoprotein receptor (LDL-R). Furthermore, rosmarinic acid treatment notably increased the expression of cholesterol excretion molecules, ATP-binding cassette G5 (ABCG5) and G8 (ABCG8) transporters, and cholesterol 7 alpha-hydroxylase A1 (CYP7A1) as well as markedly reduced cholesterol and triglyceride levels in liver tissues. In addition, rosmarinic acid facilitated fatty acid oxidation through AMP-activated protein kinase (AMPK)-mediated carnitine palmitoyltransferase 1A (CPT1A) induction. In conclusion, rosmarinic acid exhibited a lipid-lowering effect by modulating the expression of RCT-related proteins and lipid metabolism-associated molecules, confirming its potential for the prevention or treatment of hyperlipidemia-derived diseases.
Related Topics
Concepts
Rosmarinic acid
Lipid metabolism
Internal medicine
Endocrinology
Hyperlipidemia
Cholesterol
Triglyceride
Reverse cholesterol transport
Carnitine
LDL receptor
Liver X receptor alpha
Chemistry
Pharmacology
Biology
Biochemistry
Lipoprotein
Medicine
Nuclear receptor
Transcription factor
Gene
Antioxidant
Diabetes mellitus
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/biom11101470
- https://www.mdpi.com/2218-273X/11/10/1470/pdf?version=1634200148
- OA Status
- gold
- Cited By
- 38
- References
- 69
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3206397196
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3206397196Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/biom11101470Digital Object Identifier
- Title
-
Rosmarinic Acid Exhibits a Lipid-Lowering Effect by Modulating the Expression of Reverse Cholesterol Transporters and Lipid Metabolism in High-Fat Diet-Fed MiceWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-10-06Full publication date if available
- Authors
-
Jean Baptiste Nyandwi, Gyung Hyuck Ko, Hana Jin, Seung Pil Yun, Sang Won Park, Hye Jung KimList of authors in order
- Landing page
-
https://doi.org/10.3390/biom11101470Publisher landing page
- PDF URL
-
https://www.mdpi.com/2218-273X/11/10/1470/pdf?version=1634200148Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/2218-273X/11/10/1470/pdf?version=1634200148Direct OA link when available
- Concepts
-
Rosmarinic acid, Lipid metabolism, Internal medicine, Endocrinology, Hyperlipidemia, Cholesterol, Triglyceride, Reverse cholesterol transport, Carnitine, LDL receptor, Liver X receptor alpha, Chemistry, Pharmacology, Biology, Biochemistry, Lipoprotein, Medicine, Nuclear receptor, Transcription factor, Gene, Antioxidant, Diabetes mellitusTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
38Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 18, 2024: 5, 2023: 6, 2022: 8, 2021: 1Per-year citation counts (last 5 years)
- References (count)
-
69Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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