Rottlerin exhibits anti-cancer effect through inactivation of S phase kinase-associated protein 2 in pancreatic cancer cells. Article Swipe
Jingna Su
,
Lixia Wang
,
Xuyuan Yin
,
Zhe Zhao
,
Yingying Hou
,
Xiantao Ye
,
Xiuxia Zhou
,
Zhiwei Wang
·
YOU?
·
· 2016
· Open Access
·
YOU?
·
· 2016
· Open Access
·
Rottlerin, a natural product isolated from Mallotus philippinensis, has been characterized as an effective chemoprevention agent in inhibiting tumor cell growth. Although multiple studies have revealed the role of rottlerin in tumorigenesis, the molecular mechanism of rottlerin-mediated anti-tumor activity has not been fully elucidated. It has been reported that Skp2 (S-phase kinase associated protein 2) plays an oncogenic role in human malignancies, indicating that inactivation of Skp2 could be a promising approach for the treatment of cancers. Therefore, in this study, we aim to investigate whether rottlerin exhibits its anti-tumor activities via targeting Skp2 pathway in pancreatic cancer. We found that rottlerin inhibited cell growth, induced apoptosis, arrested cell cycle, and retarded cell invasion and migration. Notably, we observed that the expression of Skp2 was significantly decreased in rottlerin-treated pancreatic cancer cells. Importantly, overexpression of Skp2 abrogated the anti-tumor function induced by rottlerin in pancreatic cancer cells. Consistently, depletion of Skp2 promoted rottlerin-mediated inhibition of cell growth and invasion. Collectively, our study demonstrated that rottlerin could suppress Skp2 expression and subsequently exert its tumor suppressive function in pancreatic cancer cells, suggesting that rottlerin might be a potential therapeutic compound for treating pancreatic cancer.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://pubmed.ncbi.nlm.nih.gov/27822410
- OA Status
- green
- Cited By
- 35
- References
- 45
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2592461636
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2592461636Canonical identifier for this work in OpenAlex
- Title
-
Rottlerin exhibits anti-cancer effect through inactivation of S phase kinase-associated protein 2 in pancreatic cancer cells.Work title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2016Year of publication
- Publication date
-
2016-01-01Full publication date if available
- Authors
-
Jingna Su, Lixia Wang, Xuyuan Yin, Zhe Zhao, Yingying Hou, Xiantao Ye, Xiuxia Zhou, Zhiwei WangList of authors in order
- Landing page
-
https://pubmed.ncbi.nlm.nih.gov/27822410Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.ncbi.nlm.nih.gov/pmc/articles/5088284Direct OA link when available
- Concepts
-
Rottlerin, Pancreatic cancer, Cancer research, Cancer cell, Carcinogenesis, Biology, Apoptosis, Cell growth, Cancer, Kinase, Protein kinase A, Chemistry, Cell biology, Biochemistry, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
35Total citation count in OpenAlex
- Citations by year (recent)
-
2024: 2, 2023: 2, 2022: 2, 2021: 4, 2020: 5Per-year citation counts (last 5 years)
- References (count)
-
45Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W2592461636 |
|---|---|
| doi | |
| ids.mag | 2592461636 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/27822410 |
| ids.openalex | https://openalex.org/W2592461636 |
| fwci | 4.71726328 |
| type | article |
| title | Rottlerin exhibits anti-cancer effect through inactivation of S phase kinase-associated protein 2 in pancreatic cancer cells. |
| biblio.issue | 10 |
| biblio.volume | 6 |
| biblio.last_page | 2191 |
| biblio.first_page | 2178 |
| topics[0].id | https://openalex.org/T13779 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9977999925613403 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2734 |
| topics[0].subfield.display_name | Pathology and Forensic Medicine |
| topics[0].display_name | Cancer Mechanisms and Therapy |
| topics[1].id | https://openalex.org/T11041 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.996999979019165 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1312 |
| topics[1].subfield.display_name | Molecular Biology |
| topics[1].display_name | Ubiquitin and proteasome pathways |
| topics[2].id | https://openalex.org/T10492 |
| topics[2].field.id | https://openalex.org/fields/13 |
| topics[2].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[2].score | 0.9965000152587891 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1307 |
| topics[2].subfield.display_name | Cell Biology |
| topics[2].display_name | Microtubule and mitosis dynamics |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C2778769476 |
| concepts[0].level | 4 |
| concepts[0].score | 0.9985981583595276 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q7370686 |
| concepts[0].display_name | Rottlerin |
| concepts[1].id | https://openalex.org/C2780210213 |
| concepts[1].level | 3 |
| concepts[1].score | 0.6813406944274902 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q212961 |
| concepts[1].display_name | Pancreatic cancer |
| concepts[2].id | https://openalex.org/C502942594 |
| concepts[2].level | 1 |
| concepts[2].score | 0.6425520777702332 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q3421914 |
| concepts[2].display_name | Cancer research |
| concepts[3].id | https://openalex.org/C96232424 |
| concepts[3].level | 3 |
| concepts[3].score | 0.5411829352378845 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q4118072 |
| concepts[3].display_name | Cancer cell |
| concepts[4].id | https://openalex.org/C555283112 |
| concepts[4].level | 3 |
| concepts[4].score | 0.4992525577545166 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q1637543 |
| concepts[4].display_name | Carcinogenesis |
| concepts[5].id | https://openalex.org/C86803240 |
| concepts[5].level | 0 |
| concepts[5].score | 0.4979097843170166 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[5].display_name | Biology |
| concepts[6].id | https://openalex.org/C190283241 |
| concepts[6].level | 2 |
| concepts[6].score | 0.4691283404827118 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q14599311 |
| concepts[6].display_name | Apoptosis |
| concepts[7].id | https://openalex.org/C62112901 |
| concepts[7].level | 2 |
| concepts[7].score | 0.43623432517051697 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q189159 |
| concepts[7].display_name | Cell growth |
| concepts[8].id | https://openalex.org/C121608353 |
| concepts[8].level | 2 |
| concepts[8].score | 0.43468883633613586 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q12078 |
| concepts[8].display_name | Cancer |
| concepts[9].id | https://openalex.org/C184235292 |
| concepts[9].level | 2 |
| concepts[9].score | 0.4092088043689728 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q421851 |
| concepts[9].display_name | Kinase |
| concepts[10].id | https://openalex.org/C97029542 |
| concepts[10].level | 3 |
| concepts[10].score | 0.3936256170272827 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q281417 |
| concepts[10].display_name | Protein kinase A |
| concepts[11].id | https://openalex.org/C185592680 |
| concepts[11].level | 0 |
| concepts[11].score | 0.32418838143348694 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[11].display_name | Chemistry |
| concepts[12].id | https://openalex.org/C95444343 |
| concepts[12].level | 1 |
| concepts[12].score | 0.27292120456695557 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q7141 |
| concepts[12].display_name | Cell biology |
| concepts[13].id | https://openalex.org/C55493867 |
| concepts[13].level | 1 |
| concepts[13].score | 0.1953851580619812 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[13].display_name | Biochemistry |
| concepts[14].id | https://openalex.org/C54355233 |
| concepts[14].level | 1 |
| concepts[14].score | 0.0 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q7162 |
| concepts[14].display_name | Genetics |
| keywords[0].id | https://openalex.org/keywords/rottlerin |
| keywords[0].score | 0.9985981583595276 |
| keywords[0].display_name | Rottlerin |
| keywords[1].id | https://openalex.org/keywords/pancreatic-cancer |
| keywords[1].score | 0.6813406944274902 |
| keywords[1].display_name | Pancreatic cancer |
| keywords[2].id | https://openalex.org/keywords/cancer-research |
| keywords[2].score | 0.6425520777702332 |
| keywords[2].display_name | Cancer research |
| keywords[3].id | https://openalex.org/keywords/cancer-cell |
| keywords[3].score | 0.5411829352378845 |
| keywords[3].display_name | Cancer cell |
| keywords[4].id | https://openalex.org/keywords/carcinogenesis |
| keywords[4].score | 0.4992525577545166 |
| keywords[4].display_name | Carcinogenesis |
| keywords[5].id | https://openalex.org/keywords/biology |
| keywords[5].score | 0.4979097843170166 |
| keywords[5].display_name | Biology |
| keywords[6].id | https://openalex.org/keywords/apoptosis |
| keywords[6].score | 0.4691283404827118 |
| keywords[6].display_name | Apoptosis |
| keywords[7].id | https://openalex.org/keywords/cell-growth |
| keywords[7].score | 0.43623432517051697 |
| keywords[7].display_name | Cell growth |
| keywords[8].id | https://openalex.org/keywords/cancer |
| keywords[8].score | 0.43468883633613586 |
| keywords[8].display_name | Cancer |
| keywords[9].id | https://openalex.org/keywords/kinase |
| keywords[9].score | 0.4092088043689728 |
| keywords[9].display_name | Kinase |
| keywords[10].id | https://openalex.org/keywords/protein-kinase-a |
| keywords[10].score | 0.3936256170272827 |
| keywords[10].display_name | Protein kinase A |
| keywords[11].id | https://openalex.org/keywords/chemistry |
| keywords[11].score | 0.32418838143348694 |
| keywords[11].display_name | Chemistry |
| keywords[12].id | https://openalex.org/keywords/cell-biology |
| keywords[12].score | 0.27292120456695557 |
| keywords[12].display_name | Cell biology |
| keywords[13].id | https://openalex.org/keywords/biochemistry |
| keywords[13].score | 0.1953851580619812 |
| keywords[13].display_name | Biochemistry |
| language | en |
| locations[0].id | pmid:27822410 |
| locations[0].is_oa | False |
| locations[0].source.id | https://openalex.org/S4306525036 |
| locations[0].source.issn | |
| locations[0].source.type | repository |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | |
| locations[0].source.is_core | False |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | PubMed |
| locations[0].source.host_organization | https://openalex.org/I1299303238 |
| locations[0].source.host_organization_name | National Institutes of Health |
| locations[0].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[0].license | |
| locations[0].pdf_url | |
| locations[0].version | publishedVersion |
| locations[0].raw_type | |
| locations[0].license_id | |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | American journal of cancer research |
| locations[0].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/27822410 |
| locations[1].id | pmh:oai:pubmedcentral.nih.gov:5088284 |
| locations[1].is_oa | True |
| locations[1].source.id | https://openalex.org/S2764455111 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed Central |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | submittedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | False |
| locations[1].is_published | False |
| locations[1].raw_source_name | Am J Cancer Res |
| locations[1].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/5088284 |
| indexed_in | pubmed |
| authorships[0].author.id | https://openalex.org/A5011209310 |
| authorships[0].author.orcid | |
| authorships[0].author.display_name | Jingna Su |
| authorships[0].countries | CN |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I3923682, https://openalex.org/I4210153519 |
| authorships[0].affiliations[0].raw_affiliation_string | The Cyrus Tang Hematology Center and Collaborative Innovation Center of Hematology, Jiangsu Institute of Hematology, the First Affiliated Hospital, Soochow University Suzhou 215123, China. |
| authorships[0].institutions[0].id | https://openalex.org/I4210153519 |
| authorships[0].institutions[0].ror | https://ror.org/051jg5p78 |
| authorships[0].institutions[0].type | healthcare |
| authorships[0].institutions[0].lineage | https://openalex.org/I4210153519 |
| authorships[0].institutions[0].country_code | CN |
| authorships[0].institutions[0].display_name | First Affiliated Hospital of Soochow University |
| authorships[0].institutions[1].id | https://openalex.org/I3923682 |
| authorships[0].institutions[1].ror | https://ror.org/05t8y2r12 |
| authorships[0].institutions[1].type | education |
| authorships[0].institutions[1].lineage | https://openalex.org/I3923682 |
| authorships[0].institutions[1].country_code | CN |
| authorships[0].institutions[1].display_name | Soochow University |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Jingna Su |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | The Cyrus Tang Hematology Center and Collaborative Innovation Center of Hematology, Jiangsu Institute of Hematology, the First Affiliated Hospital, Soochow University Suzhou 215123, China. |
| authorships[1].author.id | https://openalex.org/A5100442914 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-2304-7536 |
| authorships[1].author.display_name | Lixia Wang |
| authorships[1].countries | CN |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I3923682, https://openalex.org/I4210153519 |
| authorships[1].affiliations[0].raw_affiliation_string | The Cyrus Tang Hematology Center and Collaborative Innovation Center of Hematology, Jiangsu Institute of Hematology, the First Affiliated Hospital, Soochow University Suzhou 215123, China. |
| authorships[1].institutions[0].id | https://openalex.org/I4210153519 |
| authorships[1].institutions[0].ror | https://ror.org/051jg5p78 |
| authorships[1].institutions[0].type | healthcare |
| authorships[1].institutions[0].lineage | https://openalex.org/I4210153519 |
| authorships[1].institutions[0].country_code | CN |
| authorships[1].institutions[0].display_name | First Affiliated Hospital of Soochow University |
| authorships[1].institutions[1].id | https://openalex.org/I3923682 |
| authorships[1].institutions[1].ror | https://ror.org/05t8y2r12 |
| authorships[1].institutions[1].type | education |
| authorships[1].institutions[1].lineage | https://openalex.org/I3923682 |
| authorships[1].institutions[1].country_code | CN |
| authorships[1].institutions[1].display_name | Soochow University |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Lixia Wang |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | The Cyrus Tang Hematology Center and Collaborative Innovation Center of Hematology, Jiangsu Institute of Hematology, the First Affiliated Hospital, Soochow University Suzhou 215123, China. |
| authorships[2].author.id | https://openalex.org/A5104173165 |
| authorships[2].author.orcid | |
| authorships[2].author.display_name | Xuyuan Yin |
| authorships[2].countries | CN |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I3923682, https://openalex.org/I4210153519 |
| authorships[2].affiliations[0].raw_affiliation_string | The Cyrus Tang Hematology Center and Collaborative Innovation Center of Hematology, Jiangsu Institute of Hematology, the First Affiliated Hospital, Soochow University Suzhou 215123, China. |
| authorships[2].institutions[0].id | https://openalex.org/I4210153519 |
| authorships[2].institutions[0].ror | https://ror.org/051jg5p78 |
| authorships[2].institutions[0].type | healthcare |
| authorships[2].institutions[0].lineage | https://openalex.org/I4210153519 |
| authorships[2].institutions[0].country_code | CN |
| authorships[2].institutions[0].display_name | First Affiliated Hospital of Soochow University |
| authorships[2].institutions[1].id | https://openalex.org/I3923682 |
| authorships[2].institutions[1].ror | https://ror.org/05t8y2r12 |
| authorships[2].institutions[1].type | education |
| authorships[2].institutions[1].lineage | https://openalex.org/I3923682 |
| authorships[2].institutions[1].country_code | CN |
| authorships[2].institutions[1].display_name | Soochow University |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Xuyuan Yin |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | The Cyrus Tang Hematology Center and Collaborative Innovation Center of Hematology, Jiangsu Institute of Hematology, the First Affiliated Hospital, Soochow University Suzhou 215123, China. |
| authorships[3].author.id | https://openalex.org/A5042015646 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-1124-791X |
| authorships[3].author.display_name | Zhe Zhao |
| authorships[3].countries | CN |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I3923682, https://openalex.org/I4210153519 |
| authorships[3].affiliations[0].raw_affiliation_string | The Cyrus Tang Hematology Center and Collaborative Innovation Center of Hematology, Jiangsu Institute of Hematology, the First Affiliated Hospital, Soochow University Suzhou 215123, China. |
| authorships[3].institutions[0].id | https://openalex.org/I4210153519 |
| authorships[3].institutions[0].ror | https://ror.org/051jg5p78 |
| authorships[3].institutions[0].type | healthcare |
| authorships[3].institutions[0].lineage | https://openalex.org/I4210153519 |
| authorships[3].institutions[0].country_code | CN |
| authorships[3].institutions[0].display_name | First Affiliated Hospital of Soochow University |
| authorships[3].institutions[1].id | https://openalex.org/I3923682 |
| authorships[3].institutions[1].ror | https://ror.org/05t8y2r12 |
| authorships[3].institutions[1].type | education |
| authorships[3].institutions[1].lineage | https://openalex.org/I3923682 |
| authorships[3].institutions[1].country_code | CN |
| authorships[3].institutions[1].display_name | Soochow University |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Zhe Zhao |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | The Cyrus Tang Hematology Center and Collaborative Innovation Center of Hematology, Jiangsu Institute of Hematology, the First Affiliated Hospital, Soochow University Suzhou 215123, China. |
| authorships[4].author.id | https://openalex.org/A5037283153 |
| authorships[4].author.orcid | https://orcid.org/0009-0001-0561-5835 |
| authorships[4].author.display_name | Yingying Hou |
| authorships[4].countries | CN |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I3923682, https://openalex.org/I4210153519 |
| authorships[4].affiliations[0].raw_affiliation_string | The Cyrus Tang Hematology Center and Collaborative Innovation Center of Hematology, Jiangsu Institute of Hematology, the First Affiliated Hospital, Soochow University Suzhou 215123, China. |
| authorships[4].institutions[0].id | https://openalex.org/I4210153519 |
| authorships[4].institutions[0].ror | https://ror.org/051jg5p78 |
| authorships[4].institutions[0].type | healthcare |
| authorships[4].institutions[0].lineage | https://openalex.org/I4210153519 |
| authorships[4].institutions[0].country_code | CN |
| authorships[4].institutions[0].display_name | First Affiliated Hospital of Soochow University |
| authorships[4].institutions[1].id | https://openalex.org/I3923682 |
| authorships[4].institutions[1].ror | https://ror.org/05t8y2r12 |
| authorships[4].institutions[1].type | education |
| authorships[4].institutions[1].lineage | https://openalex.org/I3923682 |
| authorships[4].institutions[1].country_code | CN |
| authorships[4].institutions[1].display_name | Soochow University |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Yingying Hou |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | The Cyrus Tang Hematology Center and Collaborative Innovation Center of Hematology, Jiangsu Institute of Hematology, the First Affiliated Hospital, Soochow University Suzhou 215123, China. |
| authorships[5].author.id | https://openalex.org/A5046804560 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-6370-3323 |
| authorships[5].author.display_name | Xiantao Ye |
| authorships[5].countries | CN |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I3923682, https://openalex.org/I4210153519 |
| authorships[5].affiliations[0].raw_affiliation_string | The Cyrus Tang Hematology Center and Collaborative Innovation Center of Hematology, Jiangsu Institute of Hematology, the First Affiliated Hospital, Soochow University Suzhou 215123, China. |
| authorships[5].institutions[0].id | https://openalex.org/I4210153519 |
| authorships[5].institutions[0].ror | https://ror.org/051jg5p78 |
| authorships[5].institutions[0].type | healthcare |
| authorships[5].institutions[0].lineage | https://openalex.org/I4210153519 |
| authorships[5].institutions[0].country_code | CN |
| authorships[5].institutions[0].display_name | First Affiliated Hospital of Soochow University |
| authorships[5].institutions[1].id | https://openalex.org/I3923682 |
| authorships[5].institutions[1].ror | https://ror.org/05t8y2r12 |
| authorships[5].institutions[1].type | education |
| authorships[5].institutions[1].lineage | https://openalex.org/I3923682 |
| authorships[5].institutions[1].country_code | CN |
| authorships[5].institutions[1].display_name | Soochow University |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Xiantao Ye |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | The Cyrus Tang Hematology Center and Collaborative Innovation Center of Hematology, Jiangsu Institute of Hematology, the First Affiliated Hospital, Soochow University Suzhou 215123, China. |
| authorships[6].author.id | https://openalex.org/A5021707712 |
| authorships[6].author.orcid | https://orcid.org/0000-0003-1562-103X |
| authorships[6].author.display_name | Xiuxia Zhou |
| authorships[6].countries | CN |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I3923682, https://openalex.org/I4210153519 |
| authorships[6].affiliations[0].raw_affiliation_string | The Cyrus Tang Hematology Center and Collaborative Innovation Center of Hematology, Jiangsu Institute of Hematology, the First Affiliated Hospital, Soochow University Suzhou 215123, China. |
| authorships[6].institutions[0].id | https://openalex.org/I4210153519 |
| authorships[6].institutions[0].ror | https://ror.org/051jg5p78 |
| authorships[6].institutions[0].type | healthcare |
| authorships[6].institutions[0].lineage | https://openalex.org/I4210153519 |
| authorships[6].institutions[0].country_code | CN |
| authorships[6].institutions[0].display_name | First Affiliated Hospital of Soochow University |
| authorships[6].institutions[1].id | https://openalex.org/I3923682 |
| authorships[6].institutions[1].ror | https://ror.org/05t8y2r12 |
| authorships[6].institutions[1].type | education |
| authorships[6].institutions[1].lineage | https://openalex.org/I3923682 |
| authorships[6].institutions[1].country_code | CN |
| authorships[6].institutions[1].display_name | Soochow University |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Xiuxia Zhou |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | The Cyrus Tang Hematology Center and Collaborative Innovation Center of Hematology, Jiangsu Institute of Hematology, the First Affiliated Hospital, Soochow University Suzhou 215123, China. |
| authorships[7].author.id | https://openalex.org/A5100449964 |
| authorships[7].author.orcid | https://orcid.org/0000-0002-6465-7779 |
| authorships[7].author.display_name | Zhiwei Wang |
| authorships[7].countries | CN, US |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I1316535847, https://openalex.org/I3923682 |
| authorships[7].affiliations[0].raw_affiliation_string | The Cyrus Tang Hematology Center and Collaborative Innovation Center of Hematology, Jiangsu Institute of Hematology, the First Affiliated Hospital, Soochow UniversitySuzhou 215123, China; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical SchoolMA 02215, USA. |
| authorships[7].institutions[0].id | https://openalex.org/I3923682 |
| authorships[7].institutions[0].ror | https://ror.org/05t8y2r12 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I3923682 |
| authorships[7].institutions[0].country_code | CN |
| authorships[7].institutions[0].display_name | Soochow University |
| authorships[7].institutions[1].id | https://openalex.org/I1316535847 |
| authorships[7].institutions[1].ror | https://ror.org/04drvxt59 |
| authorships[7].institutions[1].type | healthcare |
| authorships[7].institutions[1].lineage | https://openalex.org/I1316535847 |
| authorships[7].institutions[1].country_code | US |
| authorships[7].institutions[1].display_name | Beth Israel Deaconess Medical Center |
| authorships[7].author_position | last |
| authorships[7].raw_author_name | Zhiwei Wang |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | The Cyrus Tang Hematology Center and Collaborative Innovation Center of Hematology, Jiangsu Institute of Hematology, the First Affiliated Hospital, Soochow UniversitySuzhou 215123, China; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical SchoolMA 02215, USA. |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.ncbi.nlm.nih.gov/pmc/articles/5088284 |
| open_access.oa_status | green |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Rottlerin exhibits anti-cancer effect through inactivation of S phase kinase-associated protein 2 in pancreatic cancer cells. |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T04:12:42.849631 |
| primary_topic.id | https://openalex.org/T13779 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9977999925613403 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2734 |
| primary_topic.subfield.display_name | Pathology and Forensic Medicine |
| primary_topic.display_name | Cancer Mechanisms and Therapy |
| related_works | https://openalex.org/W2435549854, https://openalex.org/W2018159884, https://openalex.org/W2590426709, https://openalex.org/W2769390123, https://openalex.org/W4213249903, https://openalex.org/W2501960686, https://openalex.org/W2600717990, https://openalex.org/W2344637265, https://openalex.org/W2117059884, https://openalex.org/W2065690661 |
| cited_by_count | 35 |
| counts_by_year[0].year | 2024 |
| counts_by_year[0].cited_by_count | 2 |
| counts_by_year[1].year | 2023 |
| counts_by_year[1].cited_by_count | 2 |
| counts_by_year[2].year | 2022 |
| counts_by_year[2].cited_by_count | 2 |
| counts_by_year[3].year | 2021 |
| counts_by_year[3].cited_by_count | 4 |
| counts_by_year[4].year | 2020 |
| counts_by_year[4].cited_by_count | 5 |
| counts_by_year[5].year | 2019 |
| counts_by_year[5].cited_by_count | 6 |
| counts_by_year[6].year | 2018 |
| counts_by_year[6].cited_by_count | 5 |
| counts_by_year[7].year | 2017 |
| counts_by_year[7].cited_by_count | 8 |
| locations_count | 2 |
| best_oa_location.id | pmh:oai:pubmedcentral.nih.gov:5088284 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S2764455111 |
| best_oa_location.source.issn | |
| best_oa_location.source.type | repository |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | |
| best_oa_location.source.is_core | False |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | PubMed Central |
| best_oa_location.source.host_organization | https://openalex.org/I1299303238 |
| best_oa_location.source.host_organization_name | National Institutes of Health |
| best_oa_location.source.host_organization_lineage | https://openalex.org/I1299303238 |
| best_oa_location.license | |
| best_oa_location.pdf_url | |
| best_oa_location.version | submittedVersion |
| best_oa_location.raw_type | |
| best_oa_location.license_id | |
| best_oa_location.is_accepted | False |
| best_oa_location.is_published | False |
| best_oa_location.raw_source_name | Am J Cancer Res |
| best_oa_location.landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/5088284 |
| primary_location.id | pmid:27822410 |
| primary_location.is_oa | False |
| primary_location.source.id | https://openalex.org/S4306525036 |
| primary_location.source.issn | |
| primary_location.source.type | repository |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | |
| primary_location.source.is_core | False |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | PubMed |
| primary_location.source.host_organization | https://openalex.org/I1299303238 |
| primary_location.source.host_organization_name | National Institutes of Health |
| primary_location.source.host_organization_lineage | https://openalex.org/I1299303238 |
| primary_location.license | |
| primary_location.pdf_url | |
| primary_location.version | publishedVersion |
| primary_location.raw_type | |
| primary_location.license_id | |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | American journal of cancer research |
| primary_location.landing_page_url | https://pubmed.ncbi.nlm.nih.gov/27822410 |
| publication_date | 2016-01-01 |
| publication_year | 2016 |
| referenced_works | https://openalex.org/W1882059350, https://openalex.org/W2114806670, https://openalex.org/W1984768548, https://openalex.org/W2163493623, https://openalex.org/W2347047022, https://openalex.org/W1968979864, https://openalex.org/W1994232874, https://openalex.org/W2143451209, https://openalex.org/W799829193, https://openalex.org/W2112180434, https://openalex.org/W2075951376, https://openalex.org/W2047128695, https://openalex.org/W2147748248, https://openalex.org/W2119090238, https://openalex.org/W1884518148, https://openalex.org/W2124331048, https://openalex.org/W1875592451, https://openalex.org/W1965506737, https://openalex.org/W2271008339, https://openalex.org/W1988216251, https://openalex.org/W2178224952, https://openalex.org/W2030923410, https://openalex.org/W2235523093, https://openalex.org/W2194194822, https://openalex.org/W1591399906, https://openalex.org/W2027587678, https://openalex.org/W1994159320, https://openalex.org/W2162331245, https://openalex.org/W1965205650, https://openalex.org/W2167151455, https://openalex.org/W1545215516, https://openalex.org/W2164942973, https://openalex.org/W1999306559, https://openalex.org/W2018314777, https://openalex.org/W2020235979, https://openalex.org/W1831977902, https://openalex.org/W2043976827, https://openalex.org/W1988856936, https://openalex.org/W2058863407, https://openalex.org/W2124955356, https://openalex.org/W2099625798, https://openalex.org/W2192943385, https://openalex.org/W2088330248, https://openalex.org/W2289495433, https://openalex.org/W2124704384 |
| referenced_works_count | 45 |
| abstract_inverted_index.a | 1, 69, 185 |
| abstract_inverted_index.2) | 54 |
| abstract_inverted_index.It | 44 |
| abstract_inverted_index.We | 98 |
| abstract_inverted_index.an | 12, 56 |
| abstract_inverted_index.as | 11 |
| abstract_inverted_index.be | 68, 184 |
| abstract_inverted_index.by | 141 |
| abstract_inverted_index.in | 16, 30, 59, 78, 95, 127, 143, 176 |
| abstract_inverted_index.of | 28, 35, 65, 75, 122, 134, 149, 154 |
| abstract_inverted_index.to | 83 |
| abstract_inverted_index.we | 81, 117 |
| abstract_inverted_index.aim | 82 |
| abstract_inverted_index.and | 110, 114, 157, 169 |
| abstract_inverted_index.for | 72, 189 |
| abstract_inverted_index.has | 8, 39, 45 |
| abstract_inverted_index.its | 88, 172 |
| abstract_inverted_index.not | 40 |
| abstract_inverted_index.our | 160 |
| abstract_inverted_index.the | 26, 32, 73, 120, 137 |
| abstract_inverted_index.via | 91 |
| abstract_inverted_index.was | 124 |
| abstract_inverted_index.Skp2 | 49, 66, 93, 123, 135, 150, 167 |
| abstract_inverted_index.been | 9, 41, 46 |
| abstract_inverted_index.cell | 19, 103, 108, 112, 155 |
| abstract_inverted_index.from | 5 |
| abstract_inverted_index.have | 24 |
| abstract_inverted_index.role | 27, 58 |
| abstract_inverted_index.that | 48, 63, 100, 119, 163, 181 |
| abstract_inverted_index.this | 79 |
| abstract_inverted_index.agent | 15 |
| abstract_inverted_index.could | 67, 165 |
| abstract_inverted_index.exert | 171 |
| abstract_inverted_index.found | 99 |
| abstract_inverted_index.fully | 42 |
| abstract_inverted_index.human | 60 |
| abstract_inverted_index.might | 183 |
| abstract_inverted_index.plays | 55 |
| abstract_inverted_index.study | 161 |
| abstract_inverted_index.tumor | 18, 173 |
| abstract_inverted_index.cancer | 130, 145, 178 |
| abstract_inverted_index.cells, | 179 |
| abstract_inverted_index.cells. | 131, 146 |
| abstract_inverted_index.cycle, | 109 |
| abstract_inverted_index.growth | 156 |
| abstract_inverted_index.kinase | 51 |
| abstract_inverted_index.study, | 80 |
| abstract_inverted_index.cancer. | 97, 192 |
| abstract_inverted_index.growth, | 104 |
| abstract_inverted_index.growth. | 20 |
| abstract_inverted_index.induced | 105, 140 |
| abstract_inverted_index.natural | 2 |
| abstract_inverted_index.pathway | 94 |
| abstract_inverted_index.product | 3 |
| abstract_inverted_index.protein | 53 |
| abstract_inverted_index.studies | 23 |
| abstract_inverted_index.whether | 85 |
| abstract_inverted_index.(S-phase | 50 |
| abstract_inverted_index.Although | 21 |
| abstract_inverted_index.Mallotus | 6 |
| abstract_inverted_index.Notably, | 116 |
| abstract_inverted_index.activity | 38 |
| abstract_inverted_index.approach | 71 |
| abstract_inverted_index.arrested | 107 |
| abstract_inverted_index.cancers. | 76 |
| abstract_inverted_index.compound | 188 |
| abstract_inverted_index.exhibits | 87 |
| abstract_inverted_index.function | 139, 175 |
| abstract_inverted_index.invasion | 113 |
| abstract_inverted_index.isolated | 4 |
| abstract_inverted_index.multiple | 22 |
| abstract_inverted_index.observed | 118 |
| abstract_inverted_index.promoted | 151 |
| abstract_inverted_index.reported | 47 |
| abstract_inverted_index.retarded | 111 |
| abstract_inverted_index.revealed | 25 |
| abstract_inverted_index.suppress | 166 |
| abstract_inverted_index.treating | 190 |
| abstract_inverted_index.abrogated | 136 |
| abstract_inverted_index.decreased | 126 |
| abstract_inverted_index.depletion | 148 |
| abstract_inverted_index.effective | 13 |
| abstract_inverted_index.inhibited | 102 |
| abstract_inverted_index.invasion. | 158 |
| abstract_inverted_index.mechanism | 34 |
| abstract_inverted_index.molecular | 33 |
| abstract_inverted_index.oncogenic | 57 |
| abstract_inverted_index.potential | 186 |
| abstract_inverted_index.promising | 70 |
| abstract_inverted_index.rottlerin | 29, 86, 101, 142, 164, 182 |
| abstract_inverted_index.targeting | 92 |
| abstract_inverted_index.treatment | 74 |
| abstract_inverted_index.Rottlerin, | 0 |
| abstract_inverted_index.Therefore, | 77 |
| abstract_inverted_index.activities | 90 |
| abstract_inverted_index.anti-tumor | 37, 89, 138 |
| abstract_inverted_index.apoptosis, | 106 |
| abstract_inverted_index.associated | 52 |
| abstract_inverted_index.expression | 121, 168 |
| abstract_inverted_index.indicating | 62 |
| abstract_inverted_index.inhibiting | 17 |
| abstract_inverted_index.inhibition | 153 |
| abstract_inverted_index.migration. | 115 |
| abstract_inverted_index.pancreatic | 96, 129, 144, 177, 191 |
| abstract_inverted_index.suggesting | 180 |
| abstract_inverted_index.elucidated. | 43 |
| abstract_inverted_index.investigate | 84 |
| abstract_inverted_index.suppressive | 174 |
| abstract_inverted_index.therapeutic | 187 |
| abstract_inverted_index.Importantly, | 132 |
| abstract_inverted_index.demonstrated | 162 |
| abstract_inverted_index.inactivation | 64 |
| abstract_inverted_index.subsequently | 170 |
| abstract_inverted_index.Collectively, | 159 |
| abstract_inverted_index.Consistently, | 147 |
| abstract_inverted_index.characterized | 10 |
| abstract_inverted_index.malignancies, | 61 |
| abstract_inverted_index.significantly | 125 |
| abstract_inverted_index.overexpression | 133 |
| abstract_inverted_index.tumorigenesis, | 31 |
| abstract_inverted_index.chemoprevention | 14 |
| abstract_inverted_index.philippinensis, | 7 |
| abstract_inverted_index.rottlerin-treated | 128 |
| abstract_inverted_index.rottlerin-mediated | 36, 152 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 94 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 8 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.7799999713897705 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.95391397 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |