RP-HPLC Method for Determination of Salbutamol and Bromhexine in Syrup:Modelling and Optimization by Response Surface Methodology Article Swipe
Dương Đình Chung
,
Yen Nguyen Ngoc Thi
,
Khanh Quan Nguyen Huu
,
Duy Chinh Nguyen
,
Ung Thanh Dat
,
Thuy Ca Thi
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.14233/ajchem.2020.22635
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.14233/ajchem.2020.22635
In present work, the RP-HPLC method was established for the determination of bromhexine and salbutamol in syrup by using a design of experiment approach. The Plackett-Burman design was applied to screen the influence of independent variables (ratio of organic solvent and pH in mobile phase, flow rate, column temperature, sample injection volume and detection wavelength) on the output data of chromatographic signals (peak area, tailing factor, theoretical plates, resolution) of bromhexine and salbutamol. The Pareto diagram shows that the selected variables affect mainly target function. A central composite design has been used to optimize the values of main factors and Design expert® software predicts the interaction and quadratic model to evaluate the impact of input parameters on output. The optimal conditions were determined with the support of response surface methodology for flow rate 0.9 mL/min, temperature 25 °C and 60% methanol in water with 0.06% orthophosphoric acid as the mobile phase. Good linearity was observed in the concentration range of 8-48 μg/mL for bromhexine and 4-24 μg/mL for salbutamol with a significantly high correlation coefficient (R > 0.999). The limit of detection and limit of quantitation were 0.32 and 0.96 μg/mL, respectively for bromhexine and 0.08 and 0.25 μg/mL, respectively for salbutamol. This method was validated according to ICH guidelines.
Related Topics
Concepts
Chemistry
Chromatography
Central composite design
Salbutamol
Response surface methodology
Detection limit
High-performance liquid chromatography
Correlation coefficient
Volumetric flow rate
Capacity factor
Analytical Chemistry (journal)
Mathematics
Thermodynamics
Statistics
Internal medicine
Physics
Asthma
Medicine
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.14233/ajchem.2020.22635
- OA Status
- diamond
- References
- 25
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3113002617
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3113002617Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.14233/ajchem.2020.22635Digital Object Identifier
- Title
-
RP-HPLC Method for Determination of Salbutamol and Bromhexine in Syrup:Modelling and Optimization by Response Surface MethodologyWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-01-01Full publication date if available
- Authors
-
Dương Đình Chung, Yen Nguyen Ngoc Thi, Khanh Quan Nguyen Huu, Duy Chinh Nguyen, Ung Thanh Dat, Thuy Ca ThiList of authors in order
- Landing page
-
https://doi.org/10.14233/ajchem.2020.22635Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
diamondOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.14233/ajchem.2020.22635Direct OA link when available
- Concepts
-
Chemistry, Chromatography, Central composite design, Salbutamol, Response surface methodology, Detection limit, High-performance liquid chromatography, Correlation coefficient, Volumetric flow rate, Capacity factor, Analytical Chemistry (journal), Mathematics, Thermodynamics, Statistics, Internal medicine, Physics, Asthma, MedicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
25Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W3113002617 |
|---|---|
| doi | https://doi.org/10.14233/ajchem.2020.22635 |
| ids.doi | https://doi.org/10.14233/ajchem.2020.22635 |
| ids.mag | 3113002617 |
| ids.openalex | https://openalex.org/W3113002617 |
| fwci | 0.0 |
| type | article |
| title | RP-HPLC Method for Determination of Salbutamol and Bromhexine in Syrup:Modelling and Optimization by Response Surface Methodology |
| biblio.issue | 12 |
| biblio.volume | 32 |
| biblio.last_page | 3143 |
| biblio.first_page | 3135 |
| topics[0].id | https://openalex.org/T13338 |
| topics[0].field.id | https://openalex.org/fields/11 |
| topics[0].field.display_name | Agricultural and Biological Sciences |
| topics[0].score | 0.9998999834060669 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1103 |
| topics[0].subfield.display_name | Animal Science and Zoology |
| topics[0].display_name | Pharmacological Effects and Assays |
| topics[1].id | https://openalex.org/T11460 |
| topics[1].field.id | https://openalex.org/fields/16 |
| topics[1].field.display_name | Chemistry |
| topics[1].score | 0.9994000196456909 |
| topics[1].domain.id | https://openalex.org/domains/3 |
| topics[1].domain.display_name | Physical Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1602 |
| topics[1].subfield.display_name | Analytical Chemistry |
| topics[1].display_name | Analytical Methods in Pharmaceuticals |
| topics[2].id | https://openalex.org/T10908 |
| topics[2].field.id | https://openalex.org/fields/16 |
| topics[2].field.display_name | Chemistry |
| topics[2].score | 0.9986000061035156 |
| topics[2].domain.id | https://openalex.org/domains/3 |
| topics[2].domain.display_name | Physical Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1607 |
| topics[2].subfield.display_name | Spectroscopy |
| topics[2].display_name | Analytical Chemistry and Chromatography |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C185592680 |
| concepts[0].level | 0 |
| concepts[0].score | 0.7897685766220093 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[0].display_name | Chemistry |
| concepts[1].id | https://openalex.org/C43617362 |
| concepts[1].level | 1 |
| concepts[1].score | 0.7223761081695557 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q170050 |
| concepts[1].display_name | Chromatography |
| concepts[2].id | https://openalex.org/C92397422 |
| concepts[2].level | 3 |
| concepts[2].score | 0.7121753096580505 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q5062082 |
| concepts[2].display_name | Central composite design |
| concepts[3].id | https://openalex.org/C2777394947 |
| concepts[3].level | 3 |
| concepts[3].score | 0.6944283246994019 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q410358 |
| concepts[3].display_name | Salbutamol |
| concepts[4].id | https://openalex.org/C150077022 |
| concepts[4].level | 2 |
| concepts[4].score | 0.6545741558074951 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q3136137 |
| concepts[4].display_name | Response surface methodology |
| concepts[5].id | https://openalex.org/C119128265 |
| concepts[5].level | 2 |
| concepts[5].score | 0.531202495098114 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q900165 |
| concepts[5].display_name | Detection limit |
| concepts[6].id | https://openalex.org/C179998833 |
| concepts[6].level | 2 |
| concepts[6].score | 0.4943394660949707 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q381233 |
| concepts[6].display_name | High-performance liquid chromatography |
| concepts[7].id | https://openalex.org/C2780092901 |
| concepts[7].level | 2 |
| concepts[7].score | 0.4583034813404083 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q3433612 |
| concepts[7].display_name | Correlation coefficient |
| concepts[8].id | https://openalex.org/C172120300 |
| concepts[8].level | 2 |
| concepts[8].score | 0.41500720381736755 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q1134348 |
| concepts[8].display_name | Volumetric flow rate |
| concepts[9].id | https://openalex.org/C37415627 |
| concepts[9].level | 3 |
| concepts[9].score | 0.41072675585746765 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q1755148 |
| concepts[9].display_name | Capacity factor |
| concepts[10].id | https://openalex.org/C113196181 |
| concepts[10].level | 2 |
| concepts[10].score | 0.3660367727279663 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q485223 |
| concepts[10].display_name | Analytical Chemistry (journal) |
| concepts[11].id | https://openalex.org/C33923547 |
| concepts[11].level | 0 |
| concepts[11].score | 0.15532070398330688 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q395 |
| concepts[11].display_name | Mathematics |
| concepts[12].id | https://openalex.org/C97355855 |
| concepts[12].level | 1 |
| concepts[12].score | 0.09644126892089844 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q11473 |
| concepts[12].display_name | Thermodynamics |
| concepts[13].id | https://openalex.org/C105795698 |
| concepts[13].level | 1 |
| concepts[13].score | 0.08034834265708923 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q12483 |
| concepts[13].display_name | Statistics |
| concepts[14].id | https://openalex.org/C126322002 |
| concepts[14].level | 1 |
| concepts[14].score | 0.0 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[14].display_name | Internal medicine |
| concepts[15].id | https://openalex.org/C121332964 |
| concepts[15].level | 0 |
| concepts[15].score | 0.0 |
| concepts[15].wikidata | https://www.wikidata.org/wiki/Q413 |
| concepts[15].display_name | Physics |
| concepts[16].id | https://openalex.org/C2776042228 |
| concepts[16].level | 2 |
| concepts[16].score | 0.0 |
| concepts[16].wikidata | https://www.wikidata.org/wiki/Q35869 |
| concepts[16].display_name | Asthma |
| concepts[17].id | https://openalex.org/C71924100 |
| concepts[17].level | 0 |
| concepts[17].score | 0.0 |
| concepts[17].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[17].display_name | Medicine |
| keywords[0].id | https://openalex.org/keywords/chemistry |
| keywords[0].score | 0.7897685766220093 |
| keywords[0].display_name | Chemistry |
| keywords[1].id | https://openalex.org/keywords/chromatography |
| keywords[1].score | 0.7223761081695557 |
| keywords[1].display_name | Chromatography |
| keywords[2].id | https://openalex.org/keywords/central-composite-design |
| keywords[2].score | 0.7121753096580505 |
| keywords[2].display_name | Central composite design |
| keywords[3].id | https://openalex.org/keywords/salbutamol |
| keywords[3].score | 0.6944283246994019 |
| keywords[3].display_name | Salbutamol |
| keywords[4].id | https://openalex.org/keywords/response-surface-methodology |
| keywords[4].score | 0.6545741558074951 |
| keywords[4].display_name | Response surface methodology |
| keywords[5].id | https://openalex.org/keywords/detection-limit |
| keywords[5].score | 0.531202495098114 |
| keywords[5].display_name | Detection limit |
| keywords[6].id | https://openalex.org/keywords/high-performance-liquid-chromatography |
| keywords[6].score | 0.4943394660949707 |
| keywords[6].display_name | High-performance liquid chromatography |
| keywords[7].id | https://openalex.org/keywords/correlation-coefficient |
| keywords[7].score | 0.4583034813404083 |
| keywords[7].display_name | Correlation coefficient |
| keywords[8].id | https://openalex.org/keywords/volumetric-flow-rate |
| keywords[8].score | 0.41500720381736755 |
| keywords[8].display_name | Volumetric flow rate |
| keywords[9].id | https://openalex.org/keywords/capacity-factor |
| keywords[9].score | 0.41072675585746765 |
| keywords[9].display_name | Capacity factor |
| keywords[10].id | https://openalex.org/keywords/analytical-chemistry |
| keywords[10].score | 0.3660367727279663 |
| keywords[10].display_name | Analytical Chemistry (journal) |
| keywords[11].id | https://openalex.org/keywords/mathematics |
| keywords[11].score | 0.15532070398330688 |
| keywords[11].display_name | Mathematics |
| keywords[12].id | https://openalex.org/keywords/thermodynamics |
| keywords[12].score | 0.09644126892089844 |
| keywords[12].display_name | Thermodynamics |
| keywords[13].id | https://openalex.org/keywords/statistics |
| keywords[13].score | 0.08034834265708923 |
| keywords[13].display_name | Statistics |
| language | en |
| locations[0].id | doi:10.14233/ajchem.2020.22635 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S194824834 |
| locations[0].source.issn | 0970-7077, 0975-427X |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 0970-7077 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Asian Journal of Chemistry |
| locations[0].source.host_organization | https://openalex.org/P4322697052 |
| locations[0].source.host_organization_name | ASIAN PUBLICATION CORPORATION |
| locations[0].source.host_organization_lineage | https://openalex.org/P4322697052 |
| locations[0].source.host_organization_lineage_names | ASIAN PUBLICATION CORPORATION |
| locations[0].license | cc-by |
| locations[0].pdf_url | |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Asian Journal of Chemistry |
| locations[0].landing_page_url | https://doi.org/10.14233/ajchem.2020.22635 |
| indexed_in | crossref |
| authorships[0].author.id | https://openalex.org/A5055050814 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-2760-2031 |
| authorships[0].author.display_name | Dương Đình Chung |
| authorships[0].countries | VN |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I3020192730 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Pharmacy, Nguyen Tat Thanh University, Ho Chi Minh City, 700000, Vietnam |
| authorships[0].institutions[0].id | https://openalex.org/I3020192730 |
| authorships[0].institutions[0].ror | https://ror.org/04r9s1v23 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I3020192730 |
| authorships[0].institutions[0].country_code | VN |
| authorships[0].institutions[0].display_name | Trường ĐH Nguyễn Tất Thành |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Chung Duong Dinh |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Department of Pharmacy, Nguyen Tat Thanh University, Ho Chi Minh City, 700000, Vietnam |
| authorships[1].author.id | https://openalex.org/A5062906108 |
| authorships[1].author.orcid | |
| authorships[1].author.display_name | Yen Nguyen Ngoc Thi |
| authorships[1].countries | VN |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I3020192730 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Pharmacy, Nguyen Tat Thanh University, Ho Chi Minh City, 700000, Vietnam |
| authorships[1].institutions[0].id | https://openalex.org/I3020192730 |
| authorships[1].institutions[0].ror | https://ror.org/04r9s1v23 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I3020192730 |
| authorships[1].institutions[0].country_code | VN |
| authorships[1].institutions[0].display_name | Trường ĐH Nguyễn Tất Thành |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Yen Nguyen Ngoc Thi |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Pharmacy, Nguyen Tat Thanh University, Ho Chi Minh City, 700000, Vietnam |
| authorships[2].author.id | https://openalex.org/A5025713101 |
| authorships[2].author.orcid | |
| authorships[2].author.display_name | Khanh Quan Nguyen Huu |
| authorships[2].countries | VN |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I3020192730 |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Pharmacy, Nguyen Tat Thanh University, Ho Chi Minh City, 700000, Vietnam |
| authorships[2].institutions[0].id | https://openalex.org/I3020192730 |
| authorships[2].institutions[0].ror | https://ror.org/04r9s1v23 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I3020192730 |
| authorships[2].institutions[0].country_code | VN |
| authorships[2].institutions[0].display_name | Trường ĐH Nguyễn Tất Thành |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Khanh Quan Nguyen Huu |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Pharmacy, Nguyen Tat Thanh University, Ho Chi Minh City, 700000, Vietnam |
| authorships[3].author.id | https://openalex.org/A5044906171 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-9157-9358 |
| authorships[3].author.display_name | Duy Chinh Nguyen |
| authorships[3].countries | VN |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I3020192730 |
| authorships[3].affiliations[0].raw_affiliation_string | NTT Hi-Tech Institute, Nguyen Tat Thanh University, Ho Chi Minh City, 700000, Vietnam |
| authorships[3].institutions[0].id | https://openalex.org/I3020192730 |
| authorships[3].institutions[0].ror | https://ror.org/04r9s1v23 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I3020192730 |
| authorships[3].institutions[0].country_code | VN |
| authorships[3].institutions[0].display_name | Trường ĐH Nguyễn Tất Thành |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Duy Chinh Nguyen |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | NTT Hi-Tech Institute, Nguyen Tat Thanh University, Ho Chi Minh City, 700000, Vietnam |
| authorships[4].author.id | https://openalex.org/A5006950543 |
| authorships[4].author.orcid | |
| authorships[4].author.display_name | Ung Thanh Dat |
| authorships[4].countries | VN |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I3020192730 |
| authorships[4].affiliations[0].raw_affiliation_string | NTT Hi-Tech Institute, Nguyen Tat Thanh University, Ho Chi Minh City, 700000, Vietnam |
| authorships[4].institutions[0].id | https://openalex.org/I3020192730 |
| authorships[4].institutions[0].ror | https://ror.org/04r9s1v23 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I3020192730 |
| authorships[4].institutions[0].country_code | VN |
| authorships[4].institutions[0].display_name | Trường ĐH Nguyễn Tất Thành |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Ung Thanh Dat |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | NTT Hi-Tech Institute, Nguyen Tat Thanh University, Ho Chi Minh City, 700000, Vietnam |
| authorships[5].author.id | https://openalex.org/A5001911950 |
| authorships[5].author.orcid | |
| authorships[5].author.display_name | Thuy Ca Thi |
| authorships[5].countries | VN |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I2802508454 |
| authorships[5].affiliations[0].raw_affiliation_string | Faculty of Basic Science, University of Medicine and Pharmacy Ho Chi Minh, 217 Hong Bang, Ward 11, District 5, Ho Chi Minh City, 700000, Vietnam |
| authorships[5].institutions[0].id | https://openalex.org/I2802508454 |
| authorships[5].institutions[0].ror | https://ror.org/025kb2624 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I2802508454 |
| authorships[5].institutions[0].country_code | VN |
| authorships[5].institutions[0].display_name | Ho Chi Minh City Medicine and Pharmacy University |
| authorships[5].author_position | last |
| authorships[5].raw_author_name | Thuy Ca Thi |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Faculty of Basic Science, University of Medicine and Pharmacy Ho Chi Minh, 217 Hong Bang, Ward 11, District 5, Ho Chi Minh City, 700000, Vietnam |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://doi.org/10.14233/ajchem.2020.22635 |
| open_access.oa_status | diamond |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | RP-HPLC Method for Determination of Salbutamol and Bromhexine in Syrup:Modelling and Optimization by Response Surface Methodology |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T13338 |
| primary_topic.field.id | https://openalex.org/fields/11 |
| primary_topic.field.display_name | Agricultural and Biological Sciences |
| primary_topic.score | 0.9998999834060669 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1103 |
| primary_topic.subfield.display_name | Animal Science and Zoology |
| primary_topic.display_name | Pharmacological Effects and Assays |
| related_works | https://openalex.org/W2538875439, https://openalex.org/W4205730195, https://openalex.org/W2907978266, https://openalex.org/W2372722201, https://openalex.org/W1537948253, https://openalex.org/W2073503281, https://openalex.org/W2368764366, https://openalex.org/W2390105901, https://openalex.org/W2106098739, https://openalex.org/W2281919420 |
| cited_by_count | 0 |
| locations_count | 1 |
| best_oa_location.id | doi:10.14233/ajchem.2020.22635 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S194824834 |
| best_oa_location.source.issn | 0970-7077, 0975-427X |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 0970-7077 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | Asian Journal of Chemistry |
| best_oa_location.source.host_organization | https://openalex.org/P4322697052 |
| best_oa_location.source.host_organization_name | ASIAN PUBLICATION CORPORATION |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4322697052 |
| best_oa_location.source.host_organization_lineage_names | ASIAN PUBLICATION CORPORATION |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Asian Journal of Chemistry |
| best_oa_location.landing_page_url | https://doi.org/10.14233/ajchem.2020.22635 |
| primary_location.id | doi:10.14233/ajchem.2020.22635 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S194824834 |
| primary_location.source.issn | 0970-7077, 0975-427X |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 0970-7077 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Asian Journal of Chemistry |
| primary_location.source.host_organization | https://openalex.org/P4322697052 |
| primary_location.source.host_organization_name | ASIAN PUBLICATION CORPORATION |
| primary_location.source.host_organization_lineage | https://openalex.org/P4322697052 |
| primary_location.source.host_organization_lineage_names | ASIAN PUBLICATION CORPORATION |
| primary_location.license | cc-by |
| primary_location.pdf_url | |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Asian Journal of Chemistry |
| primary_location.landing_page_url | https://doi.org/10.14233/ajchem.2020.22635 |
| publication_date | 2020-01-01 |
| publication_year | 2020 |
| referenced_works | https://openalex.org/W2274595284, https://openalex.org/W2032223573, https://openalex.org/W1981552072, https://openalex.org/W2319189285, https://openalex.org/W1983582197, https://openalex.org/W2517051772, https://openalex.org/W2613328209, https://openalex.org/W2885086976, https://openalex.org/W2988133242, https://openalex.org/W2151498526, https://openalex.org/W2742983380, https://openalex.org/W2261955394, https://openalex.org/W2475743813, https://openalex.org/W1965905945, https://openalex.org/W2934289545, https://openalex.org/W2999967944, https://openalex.org/W2611505834, https://openalex.org/W6820456947, https://openalex.org/W2025118857, https://openalex.org/W2560201613, https://openalex.org/W2088376206, https://openalex.org/W2060332933, https://openalex.org/W2586783706, https://openalex.org/W2084568086, https://openalex.org/W2114304645 |
| referenced_works_count | 25 |
| abstract_inverted_index.A | 85 |
| abstract_inverted_index.a | 19, 170 |
| abstract_inverted_index.(R | 175 |
| abstract_inverted_index.25 | 136 |
| abstract_inverted_index.In | 0 |
| abstract_inverted_index.as | 147 |
| abstract_inverted_index.by | 17 |
| abstract_inverted_index.in | 15, 42, 141, 155 |
| abstract_inverted_index.of | 11, 21, 33, 37, 59, 69, 96, 113, 126, 159, 180, 184 |
| abstract_inverted_index.on | 55, 116 |
| abstract_inverted_index.pH | 41 |
| abstract_inverted_index.to | 29, 92, 109, 207 |
| abstract_inverted_index.0.9 | 133 |
| abstract_inverted_index.60% | 139 |
| abstract_inverted_index.ICH | 208 |
| abstract_inverted_index.The | 24, 73, 118, 178 |
| abstract_inverted_index.and | 13, 40, 52, 71, 99, 106, 138, 164, 182, 188, 194, 196 |
| abstract_inverted_index.for | 8, 130, 162, 167, 192, 200 |
| abstract_inverted_index.has | 89 |
| abstract_inverted_index.the | 3, 9, 31, 56, 78, 94, 104, 111, 124, 148, 156 |
| abstract_inverted_index.was | 6, 27, 153, 204 |
| abstract_inverted_index.°C | 137 |
| abstract_inverted_index.> | 176 |
| abstract_inverted_index.0.08 | 195 |
| abstract_inverted_index.0.25 | 197 |
| abstract_inverted_index.0.32 | 187 |
| abstract_inverted_index.0.96 | 189 |
| abstract_inverted_index.4-24 | 165 |
| abstract_inverted_index.8-48 | 160 |
| abstract_inverted_index.Good | 151 |
| abstract_inverted_index.This | 202 |
| abstract_inverted_index.acid | 146 |
| abstract_inverted_index.been | 90 |
| abstract_inverted_index.data | 58 |
| abstract_inverted_index.flow | 45, 131 |
| abstract_inverted_index.high | 172 |
| abstract_inverted_index.main | 97 |
| abstract_inverted_index.rate | 132 |
| abstract_inverted_index.that | 77 |
| abstract_inverted_index.used | 91 |
| abstract_inverted_index.were | 121, 186 |
| abstract_inverted_index.with | 123, 143, 169 |
| abstract_inverted_index.(peak | 62 |
| abstract_inverted_index.0.06% | 144 |
| abstract_inverted_index.area, | 63 |
| abstract_inverted_index.input | 114 |
| abstract_inverted_index.limit | 179, 183 |
| abstract_inverted_index.model | 108 |
| abstract_inverted_index.range | 158 |
| abstract_inverted_index.rate, | 46 |
| abstract_inverted_index.shows | 76 |
| abstract_inverted_index.syrup | 16 |
| abstract_inverted_index.using | 18 |
| abstract_inverted_index.water | 142 |
| abstract_inverted_index.work, | 2 |
| abstract_inverted_index.(ratio | 36 |
| abstract_inverted_index.Design | 100 |
| abstract_inverted_index.Pareto | 74 |
| abstract_inverted_index.affect | 81 |
| abstract_inverted_index.column | 47 |
| abstract_inverted_index.design | 20, 26, 88 |
| abstract_inverted_index.impact | 112 |
| abstract_inverted_index.mainly | 82 |
| abstract_inverted_index.method | 5, 203 |
| abstract_inverted_index.mobile | 43, 149 |
| abstract_inverted_index.output | 57 |
| abstract_inverted_index.phase, | 44 |
| abstract_inverted_index.phase. | 150 |
| abstract_inverted_index.sample | 49 |
| abstract_inverted_index.screen | 30 |
| abstract_inverted_index.target | 83 |
| abstract_inverted_index.values | 95 |
| abstract_inverted_index.volume | 51 |
| abstract_inverted_index.μg/mL | 161, 166 |
| abstract_inverted_index.0.999). | 177 |
| abstract_inverted_index.RP-HPLC | 4 |
| abstract_inverted_index.applied | 28 |
| abstract_inverted_index.central | 86 |
| abstract_inverted_index.diagram | 75 |
| abstract_inverted_index.factor, | 65 |
| abstract_inverted_index.factors | 98 |
| abstract_inverted_index.mL/min, | 134 |
| abstract_inverted_index.optimal | 119 |
| abstract_inverted_index.organic | 38 |
| abstract_inverted_index.output. | 117 |
| abstract_inverted_index.plates, | 67 |
| abstract_inverted_index.present | 1 |
| abstract_inverted_index.signals | 61 |
| abstract_inverted_index.solvent | 39 |
| abstract_inverted_index.support | 125 |
| abstract_inverted_index.surface | 128 |
| abstract_inverted_index.tailing | 64 |
| abstract_inverted_index.μg/mL, | 190, 198 |
| abstract_inverted_index.evaluate | 110 |
| abstract_inverted_index.expert® | 101 |
| abstract_inverted_index.methanol | 140 |
| abstract_inverted_index.observed | 154 |
| abstract_inverted_index.optimize | 93 |
| abstract_inverted_index.predicts | 103 |
| abstract_inverted_index.response | 127 |
| abstract_inverted_index.selected | 79 |
| abstract_inverted_index.software | 102 |
| abstract_inverted_index.according | 206 |
| abstract_inverted_index.approach. | 23 |
| abstract_inverted_index.composite | 87 |
| abstract_inverted_index.detection | 53, 181 |
| abstract_inverted_index.function. | 84 |
| abstract_inverted_index.influence | 32 |
| abstract_inverted_index.injection | 50 |
| abstract_inverted_index.linearity | 152 |
| abstract_inverted_index.quadratic | 107 |
| abstract_inverted_index.validated | 205 |
| abstract_inverted_index.variables | 35, 80 |
| abstract_inverted_index.bromhexine | 12, 70, 163, 193 |
| abstract_inverted_index.conditions | 120 |
| abstract_inverted_index.determined | 122 |
| abstract_inverted_index.experiment | 22 |
| abstract_inverted_index.parameters | 115 |
| abstract_inverted_index.salbutamol | 14, 168 |
| abstract_inverted_index.coefficient | 174 |
| abstract_inverted_index.correlation | 173 |
| abstract_inverted_index.established | 7 |
| abstract_inverted_index.guidelines. | 209 |
| abstract_inverted_index.independent | 34 |
| abstract_inverted_index.interaction | 105 |
| abstract_inverted_index.methodology | 129 |
| abstract_inverted_index.resolution) | 68 |
| abstract_inverted_index.salbutamol. | 72, 201 |
| abstract_inverted_index.temperature | 135 |
| abstract_inverted_index.theoretical | 66 |
| abstract_inverted_index.wavelength) | 54 |
| abstract_inverted_index.quantitation | 185 |
| abstract_inverted_index.respectively | 191, 199 |
| abstract_inverted_index.temperature, | 48 |
| abstract_inverted_index.concentration | 157 |
| abstract_inverted_index.determination | 10 |
| abstract_inverted_index.significantly | 171 |
| abstract_inverted_index.Plackett-Burman | 25 |
| abstract_inverted_index.chromatographic | 60 |
| abstract_inverted_index.orthophosphoric | 145 |
| cited_by_percentile_year | |
| countries_distinct_count | 1 |
| institutions_distinct_count | 6 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/6 |
| sustainable_development_goals[0].score | 0.5400000214576721 |
| sustainable_development_goals[0].display_name | Clean water and sanitation |
| citation_normalized_percentile.value | 0.16920301 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |