RP-HPLC simultaneous quantification of rutin, avobenzone, and octyl methoxycinnamate in the presence of hydroxypropyl β-cyclodextrin (HPβCD) and sulfobutyl ether β-cyclodextrin (SBEβCD) Article Swipe
Tércio Elyan Azevedo Martins
,
Claudinéia Aparecida Sales de Oliveira Pinto
,
Andressa Costa de Oliveira
,
Fabiana Vieira Lima
,
Maria Valéria Robles Velasco
,
Letícia Norma Carpentieri Rodrigues
,
André Rolim Baby
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.6084/m9.figshare.21946226
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.6084/m9.figshare.21946226
Development and validation of a simple and fast method of high-performance liquid chromatography with diode array detection (HPLC-DAD) for the simultaneously analysis of rutin, avobenzone, and octyl p-methoxycinnamate is presented. These substances were separated using a Kromasil C18 (250×4.6 mm, 5 μm) column, methanol: water (88:12 v/v) as the mobile phase, and a flow rate of 0.8 mL min−1. The experiment was performed at room temperature and elution was under isocratic conditions. Quantification was performed by external calibration at the wavelength of 325 nm. The validated parameters included linearity, selectivity, precision (repeatability), intermediate precision, accuracy, limit of detection, limit of quantification and robustness. The results of validation were statistically treated using the Action Stat version 3.5.152.34. The selectivity was also evaluated in the presence of two cyclodextrins (2-hydroxypropyl-β-cyclodextrin and β-cyclodextrin sulfobutyl ether sodium). The absence of parallelism between the curves of octyl p-methoxycinnamate in the absence and presence of the β-cyclodextrin sulfobutyl ether sodium in the mobile phase revealed interference from this matrix, thereby indicating the necessity of validating the method in the presence of this, and other matrices. The proposed method was selective, linear, precise, accurate, and robust for the simultaneous determination of rutin, avobenzone, and octyl p-methoxycinnamate.
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- https://doi.org/10.6084/m9.figshare.21946226
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https://openalex.org/W4394385786Canonical identifier for this work in OpenAlex
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https://doi.org/10.6084/m9.figshare.21946226Digital Object Identifier
- Title
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RP-HPLC simultaneous quantification of rutin, avobenzone, and octyl methoxycinnamate in the presence of hydroxypropyl β-cyclodextrin (HPβCD) and sulfobutyl ether β-cyclodextrin (SBEβCD)Work title
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datasetOpenAlex work type
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enPrimary language
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2023Year of publication
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2023-01-01Full publication date if available
- Authors
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Tércio Elyan Azevedo Martins, Claudinéia Aparecida Sales de Oliveira Pinto, Andressa Costa de Oliveira, Fabiana Vieira Lima, Maria Valéria Robles Velasco, Letícia Norma Carpentieri Rodrigues, André Rolim BabyList of authors in order
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https://doi.org/10.6084/m9.figshare.21946226Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.6084/m9.figshare.21946226Direct OA link when available
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Cyclodextrin, Rutin, Chemistry, Ether, Chromatography, High-performance liquid chromatography, Organic chemistry, AntioxidantTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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