RUNX2/miR‑31/SATB2 pathway in nickel‑induced BEAS‑2B cell transformation Article Swipe
Yusha Zhu
,
Qiao Yi Chen
,
Ashley Jordan
,
Hong Sun
,
Nirmal Roy
,
Max Costa
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3892/or.2021.8105
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3892/or.2021.8105
Nickel (Ni) compounds are classified as Group 1 carcinogens by the International Agency for Research on Cancer (IARC) and are known to be carcinogenic to the lungs. In our previous study, special AT‑rich sequence‑binding protein 2 (SATB2) was required for Ni‑induced BEAS‑2B cell transformation. In the present study, a pathway that regulates the expression of SATB2 protein was investigated in Ni‑transformed BEAS‑2B cells using western blotting and RT‑qPCR for expression, and soft agar, migration and invasion assays for cell transformation. Runt‑related transcription factor 2 (RUNX2), a master regulator of osteogenesis and an oncogene, was identified as an upstream regulator for SATB2. Ni induced RUNX2 expression and initiated BEAS‑2B transformation and metastatic potential. Previously, miRNA‑31 was identified as a negative regulator of SATB2 during arsenic‑induced cell transformation, and in the present study it was identified as a downstream target of RUNX2 during carcinogenesis. miR‑31 expression was reduced in Ni‑transformed BEAS‑2B cells, which was required to maintain cancer hallmarks. The expression level of miR‑31 was suppressed by RUNX2 in BEAS‑2B cells, and this increased the expression level of SATB2, initiating cell transformation. Ni caused the repression of miR‑31 by placing repressive marks at its promoter, which in turn increased the expression level of SATB2, leading to cell transformation.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3892/or.2021.8105
- https://www.spandidos-publications.com/10.3892/or.2021.8105/download
- OA Status
- bronze
- Cited By
- 3
- References
- 117
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3170538692
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3170538692Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3892/or.2021.8105Digital Object Identifier
- Title
-
RUNX2/miR‑31/SATB2 pathway in nickel‑induced BEAS‑2B cell transformationWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-06-07Full publication date if available
- Authors
-
Yusha Zhu, Qiao Yi Chen, Ashley Jordan, Hong Sun, Nirmal Roy, Max CostaList of authors in order
- Landing page
-
https://doi.org/10.3892/or.2021.8105Publisher landing page
- PDF URL
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https://www.spandidos-publications.com/10.3892/or.2021.8105/downloadDirect link to full text PDF
- Open access
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YesWhether a free full text is available
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bronzeOpen access status per OpenAlex
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https://www.spandidos-publications.com/10.3892/or.2021.8105/downloadDirect OA link when available
- Concepts
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Oncogene, RUNX2, Carcinogenesis, Cell cycle, Cell, Biology, Regulator, Cancer research, Transcription factor, Cell growth, Molecular biology, Cell biology, Cancer, Genetics, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
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3Total citation count in OpenAlex
- Citations by year (recent)
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2024: 1, 2023: 1, 2022: 1Per-year citation counts (last 5 years)
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117Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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