Ruthenium‐Catalyzed Dehydrogenative Decarbonylation of Primary Alcohols Article Swipe
Related Concepts
Decarbonylation
Chemistry
Ruthenium
Catalysis
Primary (astronomy)
Organic chemistry
Photochemistry
Physics
Astronomy
Andrea Mazziotta
,
Robert Madsen
·
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1002/ejoc.201701173
· OA: W2748680150
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1002/ejoc.201701173
· OA: W2748680150
Dehydrogenative decarbonylation of a primary alcohol involves the release of both dihydrogen and carbon monoxide to afford the by one carbon unit shorter product. The transformation has now been achieved with a ruthenium‐catalyzed protocol by using the complex Ru(COD)Cl 2 and the hindered monodentate ligand P( o ‐tolyl) 3 in refluxing p ‐cymene. The reaction can be applied to both benzylic and long‐chain linear aliphatic alcohols. The intermediate aldehyde can be observed during the transformation, which is therefore believed to proceed through two separate catalytic cycles involving first dehydrogenation of the alcohol and then decarbonylation of the resulting aldehyde.
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