RUTHENIUM(II) COMPLEXES WITH CYTOTOXIC ACTIVITY EMBEDDED IN HYDROXYPROPYL METHYLCELLULOSE/SODIUM ALGINATE MUCOADHESIVE HYDROGELS Article Swipe
Mirela‐Fernanda Zaltariov
,
Bianca-Iulia Ciubotaru
,
Liliana Vereștiuc
,
Dragos Peptanariu
,
Doina Macocinschi
,
Daniela Filip
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.35812/cellulosechemtechnol.2019.53.84
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.35812/cellulosechemtechnol.2019.53.84
Mucoadhesive hydrogels based on hydroxypropylmethyl cellulose/sodium alginate have been prepared and used as matrix for encapsulation and delivery of new ruthenium(II) complexes with selective cytotoxic activity on human melanoma (MEWO) cells.The structure of the hydrogels was investigated by FT-IR spectroscopy and SEM microscopy.The encapsulation and the delivery of ruthenium(II) complexes from polymeric matrices were monitored by UV-vis spectroscopy.Thermal and moisture stabilities of the composite gels were evidenced by FT-IR and Dynamic Vapor Sorption (DVS) analyses.The mucoadhesion properties of the hydrogels have been investigated on bladder mucosa, the most mucoadhesive gel being selected as a promising precursor composite for anticancer drug delivery systems.
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- Type
- article
- Language
- en
- Landing Page
- http://doi.org/10.35812/cellulosechemtechnol.2019.53.84
- https://doi.org/10.35812/cellulosechemtechnol.2019.53.84
- OA Status
- diamond
- Cited By
- 2
- References
- 10
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2990115636
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- OpenAlex ID
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https://openalex.org/W2990115636Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.35812/cellulosechemtechnol.2019.53.84Digital Object Identifier
- Title
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RUTHENIUM(II) COMPLEXES WITH CYTOTOXIC ACTIVITY EMBEDDED IN HYDROXYPROPYL METHYLCELLULOSE/SODIUM ALGINATE MUCOADHESIVE HYDROGELSWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2019Year of publication
- Publication date
-
2019-11-25Full publication date if available
- Authors
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Mirela‐Fernanda Zaltariov, Bianca-Iulia Ciubotaru, Liliana Vereștiuc, Dragos Peptanariu, Doina Macocinschi, Daniela FilipList of authors in order
- Landing page
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https://doi.org/10.35812/cellulosechemtechnol.2019.53.84Publisher landing page
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https://doi.org/10.35812/cellulosechemtechnol.2019.53.84Direct link to full text PDF
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YesWhether a free full text is available
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diamondOpen access status per OpenAlex
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https://doi.org/10.35812/cellulosechemtechnol.2019.53.84Direct OA link when available
- Concepts
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Self-healing hydrogels, Chemistry, Mucoadhesion, Polymer chemistry, Ruthenium, Drug delivery, Chemical engineering, Nuclear chemistry, Chitosan, Drug carrier, Organic chemistry, Engineering, CatalysisTop concepts (fields/topics) attached by OpenAlex
- Cited by
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2Total citation count in OpenAlex
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2021: 1, 2020: 1Per-year citation counts (last 5 years)
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10Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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