Rutin-containing cyclodextrin nanosystems: a possible strategy for dietary supplementation in diabetics Article Swipe
Maddalena Sguizzato
,
Francesca Ferrara
,
Margherita Sisto
,
Markus Drechsler
,
Eleonora Gallerani
,
Francesco Nicoli
,
Rita Cortesi
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.jddst.2025.107065
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.jddst.2025.107065
The flavonoid rutin is an active ingredient with multiple health benefits featuring antioxidant, anti-inflammatory, cardiovascular, neuroprotective, anti-diabetic and anti-tumor activity, unfortunately characterized by physico-chemical instability and poor solubility in aqueous environment. The present study investigates the use of nanosystems for the delivery of rutin through oral administration for a possible dietary supplementation. In this view, rutin-containing cyclodextrins and rutin-in-cyclodextrin-in-liposomes (R-CL) have been studied. R-CL, obtained by the “thin film hydration” method, were initially homogeneous in size, but increased in the average diameter over time. R-CL showed greater encapsulation efficiency and stability of rutin over time compared to cyclodextrin complexes. R-CL were stable in term of rutin content and physically within 30 days of storage in a cool environment, showing no phase separation phenomena. The dialysis study through a Wistar rat small intestine fragment, demonstrated an increasing release of rutin from R-CL, reaching the plateau around the sixth hour. The use of a gastrointestinal fluid simulator within the selected biological fragment, led to a more linear and gradual release profile over time, still obtaining a complete release of the drug around the sixth hour. The in vitro experiments on HepG2 cells evidenced no cytotoxic effect for both R-CL and cyclodextrin-complex and a strong and significant increase in glucose uptake levels promoted by R-CL with respect to untreated cells, as well as to the other formulations. The data suggest that the formulation strategy based on the vesicular cyclodextrin system improves the biological effect of rutin on cells. However, further studies will be necessary to confirm the activity of rutin as food supplementation.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.jddst.2025.107065
- OA Status
- hybrid
- Cited By
- 2
- References
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All OpenAlex metadata
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https://openalex.org/W4410640789Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1016/j.jddst.2025.107065Digital Object Identifier
- Title
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Rutin-containing cyclodextrin nanosystems: a possible strategy for dietary supplementation in diabeticsWork title
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articleOpenAlex work type
- Language
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enPrimary language
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2025Year of publication
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2025-05-23Full publication date if available
- Authors
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Maddalena Sguizzato, Francesca Ferrara, Margherita Sisto, Markus Drechsler, Eleonora Gallerani, Francesco Nicoli, Rita CortesiList of authors in order
- Landing page
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https://doi.org/10.1016/j.jddst.2025.107065Publisher landing page
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hybridOpen access status per OpenAlex
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https://doi.org/10.1016/j.jddst.2025.107065Direct OA link when available
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Rutin, Cyclodextrin, Chemistry, Pharmacology, Medicine, Nanotechnology, Food science, Traditional medicine, Materials science, Biochemistry, AntioxidantTop concepts (fields/topics) attached by OpenAlex
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2Total citation count in OpenAlex
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2025: 2Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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