Rutin Protects Myocardial Ischemia–Reperfusion Injury via the NF-κB/NLRP3/Pyroptosis Pathway Article Swipe
Kejun Tian
,
Lijuan Song
,
Liping Liu
,
Thomas T. Lai
,
Wenxia Liu
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1021/acsomega.5c01408
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1021/acsomega.5c01408
This study aimed to determine the protective role and mechanism of rutin on myocardial ischemia-reperfusion (I/R) injury. First, a myocardial I/R injury model was established and subjected to ischemia and hypoxia to simulate the model of I/R injury in vivo. Triphenyltetrazolium chloride was used to determine the myocardial infarct area. Immunohistochemistry, the TUNEL assay, and hematoxylin and eosin staining were performed to determine NLRP3 expression, myocardial cell apoptosis, and cardiomyocyte morphology, respectively. Western blot analysis, the CCK-8 assay, and an ELISA were used to determine pyroptosis-associated protein expression, cell viability, and inflammatory factor expression, respectively. Rutin was shown to reduce the myocardial infarct area and myocardial cell apoptosis in vivo. Furthermore, rutin reduced the CK-MB, cTnT/I, and malondialdehyde levels after I/R injury. NLRP3 expression was downregulated after treatment with rutin compared to the sham group. NF-κB, NLRP3, cleaved caspase-1, and cleaved gasdermin D protein were also downregulated after rutin treatment. Rutin treatment enhanced cell viability after hypoxia-reperfusion conditions in in vitro experiments, reduced cell apoptosis, and reduced the LDH and ROS levels. Rutin also downregulated the expression of inflammatory factors (IL-1β, TNF-α, and IL-18) and pyroptosis-related proteins (NF-κB, NLRP3, cleaved caspase-1, and cleaved gasdermin D). Moreover, the protective effect of rutin on myocardial I/R injury disappeared after the NLRP3 agonist, nigericin, combined with rutin. These findings indicated that rutin protected myocardial I/R injury via the NF-κB/NLRP3/pyroptosis pathway and suggested a new treatment approach for myocardial I/R injury.
Related Topics
Concepts
Pyroptosis
Rutin
Reperfusion injury
NF-κB
Myocardial ischemia
Ischemia
Medicine
Myocardial Reperfusion Injury
Pharmacology
Chemistry
Cardiology
Internal medicine
Inflammation
Inflammasome
Biochemistry
Antioxidant
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1021/acsomega.5c01408
- OA Status
- gold
- References
- 40
- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4410424593Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1021/acsomega.5c01408Digital Object Identifier
- Title
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Rutin Protects Myocardial Ischemia–Reperfusion Injury via the NF-κB/NLRP3/Pyroptosis PathwayWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-05-16Full publication date if available
- Authors
-
Kejun Tian, Lijuan Song, Liping Liu, Thomas T. Lai, Wenxia LiuList of authors in order
- Landing page
-
https://doi.org/10.1021/acsomega.5c01408Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1021/acsomega.5c01408Direct OA link when available
- Concepts
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Pyroptosis, Rutin, Reperfusion injury, NF-κB, Myocardial ischemia, Ischemia, Medicine, Myocardial Reperfusion Injury, Pharmacology, Chemistry, Cardiology, Internal medicine, Inflammation, Inflammasome, Biochemistry, AntioxidantTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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40Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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