S8A-04 SESSION 8A: METOPIC SYNOSTOSIS CLOMIPHENE CITRATE AND ENCLOMIPHENE HYDROCHLORIDE EXPOSURE IS ASSOCIATED WITH INTERFRONTAL SUTURE ABNORMALITIES IN ZEBRAFISH (DANIO RERIO) Article Swipe
Tamara A. Franz‐Odendaal
,
Michael Bezuhly
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1097/01.gox.0000583216.91424.58
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1097/01.gox.0000583216.91424.58
Introduction: Craniofacial centres have observed a dramatic increase in the incidence of metopic craniosynostosis over the last two decades. The underlying reason for this rise in incidence is unknown, but some researchers have speculated that pharmacological exposure in uteromay be at play. Large population-based registries have pointed a potential link between the use of fertility drug use and the incidence of craniosynostosis. Here, we hypothesize that clomiphene citrate and/or enclomiphene hydrochloride, the active compounds in common fertility drugs in use over the last two decades, could be cause metopic craniosynostosis. Methods: Zebrafish (Danio rerio) are a valuable model to study human disease and offer a number of advantages over mammalian models. Zebrafish larvae were treated with clomiphene citrate or enclomiphene hydrochloride for five days at key points during calvariae development (6.5 mm SL and 5.5 mm SL). Larval fish were then transferred to regular rearing water and raised until adulthood. The zebrafish skeleton was analysed using a whole-mount skeletal stain. Control fish were treated with the solvent or were untreated. Results: More than half (58%) of the treated fish exhibited a delay in overall body growth compared to controls. Furthermore, this delay was more striking in the fish that were treated slightly later compared to earlier treatments. Treatments with each chemical at 5.5mm SL affected calvariae development, particularly the interfrontal suture. The overall head shape of these fish was broader caudally than control fish. Conclusion: The active components of common fertility drugs appear to affect development of the anterior region of the zebrafish skull, in particular the interfrontal suture. Further research is required to explore these findings in depth and to uncover the signaling mechanism involved.
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https://doi.org/10.1097/01.gox.0000583216.91424.58Digital Object Identifier
- Title
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S8A-04 SESSION 8A: METOPIC SYNOSTOSIS CLOMIPHENE CITRATE AND ENCLOMIPHENE HYDROCHLORIDE EXPOSURE IS ASSOCIATED WITH INTERFRONTAL SUTURE ABNORMALITIES IN ZEBRAFISH (DANIO RERIO)Work title
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articleOpenAlex work type
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enPrimary language
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2019Year of publication
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2019-08-01Full publication date if available
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Tamara A. Franz‐Odendaal, Michael BezuhlyList of authors in order
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https://doi.org/10.1097/01.gox.0000583216.91424.58Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.1097/01.gox.0000583216.91424.58Direct OA link when available
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Danio, Zebrafish, Biology, Fertility, Fibrous joint, Population, Craniofacial, Physiology, Dentistry, Anatomy, Medicine, Genetics, Gene, Environmental healthTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.earlier | 205 |
| abstract_inverted_index.explore | 264 |
| abstract_inverted_index.metopic | 12, 88 |
| abstract_inverted_index.models. | 110 |
| abstract_inverted_index.overall | 183, 222 |
| abstract_inverted_index.pointed | 46 |
| abstract_inverted_index.rearing | 144 |
| abstract_inverted_index.regular | 143 |
| abstract_inverted_index.solvent | 166 |
| abstract_inverted_index.suture. | 220, 258 |
| abstract_inverted_index.treated | 114, 163, 177, 200 |
| abstract_inverted_index.uncover | 271 |
| abstract_inverted_index.Methods: | 90 |
| abstract_inverted_index.Results: | 170 |
| abstract_inverted_index.affected | 214 |
| abstract_inverted_index.analysed | 154 |
| abstract_inverted_index.anterior | 248 |
| abstract_inverted_index.caudally | 230 |
| abstract_inverted_index.chemical | 210 |
| abstract_inverted_index.compared | 186, 203 |
| abstract_inverted_index.decades, | 84 |
| abstract_inverted_index.decades. | 18 |
| abstract_inverted_index.dramatic | 6 |
| abstract_inverted_index.exposure | 36 |
| abstract_inverted_index.findings | 266 |
| abstract_inverted_index.increase | 7 |
| abstract_inverted_index.observed | 4 |
| abstract_inverted_index.required | 262 |
| abstract_inverted_index.research | 260 |
| abstract_inverted_index.skeletal | 158 |
| abstract_inverted_index.skeleton | 152 |
| abstract_inverted_index.slightly | 201 |
| abstract_inverted_index.striking | 194 |
| abstract_inverted_index.unknown, | 28 |
| abstract_inverted_index.uteromay | 38 |
| abstract_inverted_index.valuable | 96 |
| abstract_inverted_index.Zebrafish | 91, 111 |
| abstract_inverted_index.calvariae | 128, 215 |
| abstract_inverted_index.compounds | 73 |
| abstract_inverted_index.controls. | 188 |
| abstract_inverted_index.exhibited | 179 |
| abstract_inverted_index.fertility | 54, 76, 240 |
| abstract_inverted_index.incidence | 10, 26, 59 |
| abstract_inverted_index.involved. | 275 |
| abstract_inverted_index.mammalian | 109 |
| abstract_inverted_index.mechanism | 274 |
| abstract_inverted_index.potential | 48 |
| abstract_inverted_index.signaling | 273 |
| abstract_inverted_index.zebrafish | 151, 252 |
| abstract_inverted_index.Treatments | 207 |
| abstract_inverted_index.adulthood. | 149 |
| abstract_inverted_index.advantages | 107 |
| abstract_inverted_index.clomiphene | 66, 116 |
| abstract_inverted_index.components | 237 |
| abstract_inverted_index.particular | 255 |
| abstract_inverted_index.registries | 44 |
| abstract_inverted_index.speculated | 33 |
| abstract_inverted_index.underlying | 20 |
| abstract_inverted_index.untreated. | 169 |
| abstract_inverted_index.Conclusion: | 234 |
| abstract_inverted_index.development | 129, 245 |
| abstract_inverted_index.hypothesize | 64 |
| abstract_inverted_index.researchers | 31 |
| abstract_inverted_index.transferred | 141 |
| abstract_inverted_index.treatments. | 206 |
| abstract_inverted_index.whole-mount | 157 |
| abstract_inverted_index.Craniofacial | 1 |
| abstract_inverted_index.Furthermore, | 189 |
| abstract_inverted_index.development, | 216 |
| abstract_inverted_index.enclomiphene | 69, 119 |
| abstract_inverted_index.interfrontal | 219, 257 |
| abstract_inverted_index.particularly | 217 |
| abstract_inverted_index.Introduction: | 0 |
| abstract_inverted_index.hydrochloride | 120 |
| abstract_inverted_index.hydrochloride, | 70 |
| abstract_inverted_index.pharmacological | 35 |
| abstract_inverted_index.craniosynostosis | 13 |
| abstract_inverted_index.population-based | 43 |
| abstract_inverted_index.craniosynostosis. | 61, 89 |
| cited_by_percentile_year | |
| corresponding_author_ids | https://openalex.org/A5054840359 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 2 |
| corresponding_institution_ids | https://openalex.org/I129902397 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/14 |
| sustainable_development_goals[0].score | 0.46000000834465027 |
| sustainable_development_goals[0].display_name | Life below water |
| citation_normalized_percentile.value | 0.15972247 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |