Safety and Efficacy Analysis of Targeted and Immune Combination Therapy in Advanced Melanoma—A Systematic Review and Network Meta-Analysis Article Swipe
Anna Lengyel
,
Fanni Adél Meznerics
,
Noémi Ágnes Galajda
,
Noémi Gede
,
Tamás Kói
,
Alzahra Ahmed Mohammed
,
Petra Nikolett Péter
,
Alexandra I.T. Lakatos
,
Máté Krebs
,
Dezső Csupor
,
András Bánvölgyi
,
Péter Hegyi
,
Péter Holló
,
Lajos V. Kemény
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/ijms252312821
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/ijms252312821
The combinations of BRAF inhibitor-based targeted therapies with immune checkpoint inhibitors currently represent less common therapeutic approaches in advanced melanoma. The aim of this study was to assess the safety and efficacy of currently available melanoma treatments by conducting a systematic review and network meta-analysis. Four databases were systematically searched for randomized clinical studies that included patients with advanced/metastatic melanoma receiving chemotherapy, immune checkpoint inhibitors, BRAF/MEK inhibitor therapy, or combinations thereof. The primary endpoints were treatment-related adverse events (TRAE), serious adverse events (SAE) of grade ≥ 3 adverse events, therapy discontinuation, progression-free survival (PFS), as well as objective response rate (ORR) and complete response rate (CRR). A total of 63 articles were eligible for our systematic review; 59 of them were included in the statistical analysis. A separate subgroup analysis was conducted to evaluate the efficacy outcomes, specifically in BRAF-positive patients. Triple combination therapy or triple therapy (inhibiting BRAF, MEK and PD1/PDL1 axis) showed significantly longer progression-free survival compared to BRAF + MEK combination therapies (HR = 0.76; 95% CI 0.64–0.9), but similar objective and complete response rates in BRAF-mutated melanoma. This safety analysis suggests that triple therapy is not inferior to combined immune checkpoint inhibitors (ICI) and BRAF/MEK therapies in terms of serious adverse events and therapy discontinuation rates. However, monotherapies and BRAF/MEK combinations showed notable advantage over triple therapy in terms of treatment-related adverse events. Combination strategies including BRAF/MEK-targeted therapies with ICI therapies are effective first-line options for advanced, BRAF-mutant melanoma; however, they are associated with more frequent side effects. Therefore, future RCTs are required to evaluate and identify high-risk subpopulations where triple therapy therapies should be considered.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3390/ijms252312821
- OA Status
- gold
- Cited By
- 1
- References
- 97
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4404817765
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4404817765Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/ijms252312821Digital Object Identifier
- Title
-
Safety and Efficacy Analysis of Targeted and Immune Combination Therapy in Advanced Melanoma—A Systematic Review and Network Meta-AnalysisWork title
- Type
-
reviewOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-11-28Full publication date if available
- Authors
-
Anna Lengyel, Fanni Adél Meznerics, Noémi Ágnes Galajda, Noémi Gede, Tamás Kói, Alzahra Ahmed Mohammed, Petra Nikolett Péter, Alexandra I.T. Lakatos, Máté Krebs, Dezső Csupor, András Bánvölgyi, Péter Hegyi, Péter Holló, Lajos V. KeményList of authors in order
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https://doi.org/10.3390/ijms252312821Publisher landing page
- Open access
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.3390/ijms252312821Direct OA link when available
- Concepts
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Meta-analysis, Medicine, Targeted therapy, Oncology, Melanoma, Immune system, Bioinformatics, Internal medicine, Computational biology, Immunology, Cancer research, Cancer, BiologyTop concepts (fields/topics) attached by OpenAlex
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1Total citation count in OpenAlex
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2025: 1Per-year citation counts (last 5 years)
- References (count)
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97Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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