Safety and efficacy of a novel robotic, fractional micro-coring device in a swine model Article Swipe

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Yuval Ramot , Udi Vazana , Orna Cacical , Abraham Nyska ·

YOU? · · 2022 · Open Access · · DOI: https://doi.org/10.1293/tox.2022-0079

Laser resurfacing may be accompanied by unwanted side effects. The micro coring technology, designed to remove small skin columns, was developed to avoid the thermal injury associated with lasers. However, very limited data are available on its pre-clinical efficacy and safety. The novel robotic, fractional micro-coring device, Aime^TM, was tested on four pigs, each treated in 12 sites, at 6 time-points, over the course of 28 days. Macroscopic and microscopic evaluation was performed at each of the 6 time-points during the 28-day follow-up. Macroscopically, treatment resulted in erythema and mild edema that quickly resolved. Microscopically, there was progressive re-coverage of the tested sites with complete, well differentiated, newly formed epidermis, associated with efficient elimination of the underlying excised dermis, which was replaced by maturing fibroplasia. Some of the sites demonstrated complete healing already after 7 days. No significant adverse events were noted with the use of the device. The use of the micro-coring device Aime^TM in a porcine model for skin fractional micro-excision and resurfacing was effective and safe. The comprehensive gradual healing process shown in this study with detailed histopathological images can also serve as a basis for future pre-clinical studies of fractional ablative devices.

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Common Vulnerability Scoring System

Biomedical Engineering

Concepts

Coring Erythema Ablative case Edema Dermis Medicine Biomedical engineering Surgery Dermatology Materials science Pathology Drilling Radiation therapy Metallurgy

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Type: article
Language: en
Landing Page: https://doi.org/10.1293/tox.2022-0079
PDF: https://www.jstage.jst.go.jp/article/tox/36/1/36_2022-0079/_pdf
OA Status: diamond
Cited By: 4
References: 23
Related Works: 10
OpenAlex ID: https://openalex.org/W4313063447

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OpenAlex ID: https://openalex.org/W4313063447

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DOI: https://doi.org/10.1293/tox.2022-0079

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Title: Safety and efficacy of a novel robotic, fractional micro-coring device in a swine model

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Type: article

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Language: en

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Publication year: 2022

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Publication date: 2022-10-30

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Authors: Yuval Ramot, Udi Vazana, Orna Cacical, Abraham Nyska

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Landing page: https://doi.org/10.1293/tox.2022-0079

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PDF URL: https://www.jstage.jst.go.jp/article/tox/36/1/36_2022-0079/_pdf

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Concepts: Coring, Erythema, Ablative case, Edema, Dermis, Medicine, Biomedical engineering, Surgery, Dermatology, Materials science, Pathology, Drilling, Radiation therapy, Metallurgy

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Cited by: 4

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