Safety and efficacy of autologous bone marrow clot as a multifunctional bioscaffold for instrumental posterior lumbar fusion: a 1-year follow-up pilot study Article Swipe
Francesca Salamanna
,
Giuseppe Tedesco
,
Maria Sartori
,
Cristiana Griffoni
,
Paolo Spinnato
,
P. Roméo
,
Riccardo Ghermandi
,
Milena Fini
,
Gianluca Giavaresi
,
Alessandro Gasbarrini
,
Giovanni Barbanti Bròdano
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3389/fendo.2023.1245344
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3389/fendo.2023.1245344
Background Bone marrow aspirate (BMA), when combined with graft substitutes, has long been introduced as a promising alternative to iliac crest bone graft in spinal fusion. However, the use of BMA is limited by the absence of a standardized procedure, a structural texture, and the potential for diffusion away from the implant site. Recently, the potential use of a new formulation of BMA, named BMA clot, has been preclinically described. In this report, we present the results of a prospective pilot clinical study aimed at evaluating the safety and efficacy of autologous vertebral BMA (vBMA) clot as a three-dimensional and multifunctional bioscaffold in instrumented posterior lumbar fusion. Methods Ten consecutive patients with an indication of multilevel (≤5) posterior spinal fusion due to lumbar spine degenerative diseases were included in the study and treated with vBMA. Clinical outcomes were assessed using the Visual Analog Scale (VAS), Oswestry Disability Index (ODI), and EuroQoL-5L (EQ-5L) preoperatively and at 3 months and 12 months after spinal fusion. Bone fusion quality was evaluated at the 12-month follow-up using the Brantigan classification on radiography (XR) imaging. Bone density was measured on computed tomography (CT) scans at 6 and 12 months of follow-up visits at the intervertebral arches and intervertebral joint areas and expressed in Hounsfield unit (HU). Results The results indicate a successful posterolateral fusion rate of approximately 100% (considering levels with C, D, and E grades according to the Brantigan classification) at the 12-month follow-up, along with an increase in bone density from 6 to 12 months of follow-up. An improvement in the quality of life and health status following surgery, as assessed by clinical scores (ODI, VAS, and EQ-5L), was also observed as early as 3 months postsurgery. No adverse events related to the vBMA clot were reported. Conclusion This prospective pilot study demonstrates the effectiveness and safety profile of vBMA clot as an advanced bioscaffold capable of achieving posterior lumbar fusion in the treatment of degenerative spine diseases. This lays the groundwork for a larger randomized clinical study.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fendo.2023.1245344
- https://www.frontiersin.org/articles/10.3389/fendo.2023.1245344/pdf?isPublishedV2=False
- OA Status
- gold
- Cited By
- 5
- References
- 40
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4390666841
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4390666841Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3389/fendo.2023.1245344Digital Object Identifier
- Title
-
Safety and efficacy of autologous bone marrow clot as a multifunctional bioscaffold for instrumental posterior lumbar fusion: a 1-year follow-up pilot studyWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-01-08Full publication date if available
- Authors
-
Francesca Salamanna, Giuseppe Tedesco, Maria Sartori, Cristiana Griffoni, Paolo Spinnato, P. Roméo, Riccardo Ghermandi, Milena Fini, Gianluca Giavaresi, Alessandro Gasbarrini, Giovanni Barbanti BròdanoList of authors in order
- Landing page
-
https://doi.org/10.3389/fendo.2023.1245344Publisher landing page
- PDF URL
-
https://www.frontiersin.org/articles/10.3389/fendo.2023.1245344/pdf?isPublishedV2=FalseDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.frontiersin.org/articles/10.3389/fendo.2023.1245344/pdf?isPublishedV2=FalseDirect OA link when available
- Concepts
-
Medicine, Oswestry Disability Index, Iliac crest, Spinal fusion, Lumbar, Visual analogue scale, Hounsfield scale, Surgery, Lumbar vertebrae, Radiology, Low back pain, Computed tomography, Pathology, Alternative medicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
5Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2, 2024: 3Per-year citation counts (last 5 years)
- References (count)
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40Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.lays | 326 |
| abstract_inverted_index.life | 260 |
| abstract_inverted_index.long | 11 |
| abstract_inverted_index.rate | 219 |
| abstract_inverted_index.this | 71 |
| abstract_inverted_index.unit | 209 |
| abstract_inverted_index.vBMA | 290, 306 |
| abstract_inverted_index.were | 126, 137, 292 |
| abstract_inverted_index.when | 5 |
| abstract_inverted_index.with | 7, 111, 133, 225, 241 |
| abstract_inverted_index.(HU). | 210 |
| abstract_inverted_index.(ODI, | 271 |
| abstract_inverted_index.Index | 147 |
| abstract_inverted_index.Scale | 143 |
| abstract_inverted_index.after | 160 |
| abstract_inverted_index.aimed | 83 |
| abstract_inverted_index.along | 240 |
| abstract_inverted_index.areas | 204 |
| abstract_inverted_index.clot, | 65 |
| abstract_inverted_index.crest | 20 |
| abstract_inverted_index.early | 279 |
| abstract_inverted_index.graft | 8, 22 |
| abstract_inverted_index.iliac | 19 |
| abstract_inverted_index.joint | 203 |
| abstract_inverted_index.named | 63 |
| abstract_inverted_index.pilot | 80, 297 |
| abstract_inverted_index.scans | 188 |
| abstract_inverted_index.site. | 52 |
| abstract_inverted_index.spine | 123, 323 |
| abstract_inverted_index.study | 82, 130, 298 |
| abstract_inverted_index.using | 139, 172 |
| abstract_inverted_index.vBMA. | 134 |
| abstract_inverted_index.(BMA), | 4 |
| abstract_inverted_index.(ODI), | 148 |
| abstract_inverted_index.(VAS), | 144 |
| abstract_inverted_index.(vBMA) | 94 |
| abstract_inverted_index.(≤5) | 116 |
| abstract_inverted_index.Analog | 142 |
| abstract_inverted_index.Visual | 141 |
| abstract_inverted_index.arches | 200 |
| abstract_inverted_index.events | 286 |
| abstract_inverted_index.fusion | 119, 164, 218, 317 |
| abstract_inverted_index.grades | 230 |
| abstract_inverted_index.health | 262 |
| abstract_inverted_index.larger | 331 |
| abstract_inverted_index.levels | 224 |
| abstract_inverted_index.lumbar | 105, 122, 316 |
| abstract_inverted_index.marrow | 2 |
| abstract_inverted_index.months | 156, 159, 193, 251, 282 |
| abstract_inverted_index.safety | 87, 303 |
| abstract_inverted_index.scores | 270 |
| abstract_inverted_index.spinal | 24, 118, 161 |
| abstract_inverted_index.status | 263 |
| abstract_inverted_index.study. | 334 |
| abstract_inverted_index.visits | 196 |
| abstract_inverted_index.(EQ-5L) | 151 |
| abstract_inverted_index.EQ-5L), | 274 |
| abstract_inverted_index.Methods | 107 |
| abstract_inverted_index.Results | 211 |
| abstract_inverted_index.absence | 35 |
| abstract_inverted_index.adverse | 285 |
| abstract_inverted_index.capable | 312 |
| abstract_inverted_index.density | 181, 246 |
| abstract_inverted_index.fusion. | 25, 106, 162 |
| abstract_inverted_index.implant | 51 |
| abstract_inverted_index.limited | 32 |
| abstract_inverted_index.present | 74 |
| abstract_inverted_index.profile | 304 |
| abstract_inverted_index.quality | 165, 258 |
| abstract_inverted_index.related | 287 |
| abstract_inverted_index.report, | 72 |
| abstract_inverted_index.results | 76, 213 |
| abstract_inverted_index.treated | 132 |
| abstract_inverted_index.12-month | 170, 238 |
| abstract_inverted_index.Clinical | 135 |
| abstract_inverted_index.However, | 26 |
| abstract_inverted_index.Oswestry | 145 |
| abstract_inverted_index.advanced | 310 |
| abstract_inverted_index.aspirate | 3 |
| abstract_inverted_index.assessed | 138, 267 |
| abstract_inverted_index.clinical | 81, 269, 333 |
| abstract_inverted_index.combined | 6 |
| abstract_inverted_index.computed | 185 |
| abstract_inverted_index.diseases | 125 |
| abstract_inverted_index.efficacy | 89 |
| abstract_inverted_index.imaging. | 179 |
| abstract_inverted_index.included | 127 |
| abstract_inverted_index.increase | 243 |
| abstract_inverted_index.indicate | 214 |
| abstract_inverted_index.measured | 183 |
| abstract_inverted_index.observed | 277 |
| abstract_inverted_index.outcomes | 136 |
| abstract_inverted_index.patients | 110 |
| abstract_inverted_index.surgery, | 265 |
| abstract_inverted_index.texture, | 42 |
| abstract_inverted_index.Brantigan | 174, 234 |
| abstract_inverted_index.Recently, | 53 |
| abstract_inverted_index.according | 231 |
| abstract_inverted_index.achieving | 314 |
| abstract_inverted_index.diffusion | 47 |
| abstract_inverted_index.diseases. | 324 |
| abstract_inverted_index.evaluated | 167 |
| abstract_inverted_index.expressed | 206 |
| abstract_inverted_index.follow-up | 171, 195 |
| abstract_inverted_index.following | 264 |
| abstract_inverted_index.posterior | 104, 117, 315 |
| abstract_inverted_index.potential | 45, 55 |
| abstract_inverted_index.promising | 16 |
| abstract_inverted_index.reported. | 293 |
| abstract_inverted_index.treatment | 320 |
| abstract_inverted_index.vertebral | 92 |
| abstract_inverted_index.Background | 0 |
| abstract_inverted_index.Conclusion | 294 |
| abstract_inverted_index.Disability | 146 |
| abstract_inverted_index.EuroQoL-5L | 150 |
| abstract_inverted_index.Hounsfield | 208 |
| abstract_inverted_index.autologous | 91 |
| abstract_inverted_index.described. | 69 |
| abstract_inverted_index.evaluating | 85 |
| abstract_inverted_index.follow-up, | 239 |
| abstract_inverted_index.follow-up. | 253 |
| abstract_inverted_index.groundwork | 328 |
| abstract_inverted_index.indication | 113 |
| abstract_inverted_index.introduced | 13 |
| abstract_inverted_index.multilevel | 115 |
| abstract_inverted_index.procedure, | 39 |
| abstract_inverted_index.randomized | 332 |
| abstract_inverted_index.structural | 41 |
| abstract_inverted_index.successful | 216 |
| abstract_inverted_index.tomography | 186 |
| abstract_inverted_index.alternative | 17 |
| abstract_inverted_index.bioscaffold | 101, 311 |
| abstract_inverted_index.consecutive | 109 |
| abstract_inverted_index.formulation | 60 |
| abstract_inverted_index.improvement | 255 |
| abstract_inverted_index.prospective | 79, 296 |
| abstract_inverted_index.radiography | 177 |
| abstract_inverted_index.(considering | 223 |
| abstract_inverted_index.degenerative | 124, 322 |
| abstract_inverted_index.demonstrates | 299 |
| abstract_inverted_index.instrumented | 103 |
| abstract_inverted_index.postsurgery. | 283 |
| abstract_inverted_index.standardized | 38 |
| abstract_inverted_index.substitutes, | 9 |
| abstract_inverted_index.approximately | 221 |
| abstract_inverted_index.effectiveness | 301 |
| abstract_inverted_index.preclinically | 68 |
| abstract_inverted_index.classification | 175 |
| abstract_inverted_index.intervertebral | 199, 202 |
| abstract_inverted_index.posterolateral | 217 |
| abstract_inverted_index.preoperatively | 152 |
| abstract_inverted_index.classification) | 235 |
| abstract_inverted_index.multifunctional | 100 |
| abstract_inverted_index.three-dimensional | 98 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 95 |
| corresponding_author_ids | https://openalex.org/A5064691889 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 11 |
| corresponding_institution_ids | https://openalex.org/I4210121742 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.4099999964237213 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.89516317 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |