Safety and Neuroprotective Efficacy of Palm Oil and Tocotrienol-Rich Fraction from Palm Oil: A Systematic Review Article Swipe
Maznah Ismail
,
Abdulsamad Alsalahi
,
Mustapha Umar Imam
,
Der Jiun Ooi
,
Huzwah Khaza’ai
,
Musheer A. Aljaberi
,
Mad Nasir Shamsudin
,
I. Zulkifli
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3390/nu12020521
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3390/nu12020521
Background: Several natural products have been reported to elicit beneficial effects against neurodegenerative disorders due to their vitamin E contents. However, the neuroprotective efficacy of palm oil or its tocotrienol-rich fraction (TRF) from the pre-clinical cell and animal studies have not been systematically reviewed. Methods: The protocol for this systematic review was registered in “PROSPERO” (CRD42019150408). This review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. The Medical Subject Heading (MeSH) descriptors of PubMed with Boolean operators were used to construct keywords, including (“Palm Oil”[Mesh]) AND “Nervous System”[Mesh], (“Palm Oil”[Mesh]) AND “Neurodegenerative Diseases”[Mesh], (“Palm Oil”[Mesh]) AND “Brain”[Mesh], and (“Palm Oil”[Mesh]) AND “Cognition”[Mesh], to retrieve the pertinent records from PubMed, Scopus, Web of Science and ScienceDirect from 1990 to 2019, while bibliographies, ProQuest and Google Scholar were searched to ensure a comprehensive identification of relevant articles. Two independent investigators were involved at every stage of the systematic review, while discrepancies were resolved through discussion with a third investigator. Results: All of the 18 included studies in this review (10 animal and eight cell studies) showed that palm oil and TRF enhanced the cognitive performance of healthy animals. In diabetes-induced rats, TRF and α-tocotrienol enhanced cognitive function and exerted antioxidant, anti-apoptotic and anti-inflammatory activities, while in a transgenic Alzheimer’s disease (AD) animal model, TRF enhanced the cognitive function and reduced the deposition of β-amyloid by altering the expression of several genes related to AD and neuroprotection. In cell studies, simultaneous treatment with α-tocotrienols and neurotoxins improved the redox status in neuronal cells better than γ- and δ-tocotrienols. Both pre-treatment and post-treatment with α-tocotrienol relative to oxidative insults were able to enhance the survival of neuronal cells via increased antioxidant responses. Conclusions: Palm oil and its TRF enhanced the cognitive functions of healthy animals, while TRF and α-tocotrienol enhanced the cognitive performance with attenuation of oxidative stress, neuroinflammation and apoptosis in diabetes-induced or transgenic AD animal models. In cell studies, TRF and α-tocotrienol exerted prophylactic neuroprotective effects, while α-tocotrienol exerted therapeutic neuroprotective effects that were superior to those of γ- and δ-tocotrienol isomers.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3390/nu12020521
- https://www.mdpi.com/2072-6643/12/2/521/pdf?version=1582701753
- OA Status
- gold
- Cited By
- 42
- References
- 68
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2994107128
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2994107128Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/nu12020521Digital Object Identifier
- Title
-
Safety and Neuroprotective Efficacy of Palm Oil and Tocotrienol-Rich Fraction from Palm Oil: A Systematic ReviewWork title
- Type
-
reviewOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-02-18Full publication date if available
- Authors
-
Maznah Ismail, Abdulsamad Alsalahi, Mustapha Umar Imam, Der Jiun Ooi, Huzwah Khaza’ai, Musheer A. Aljaberi, Mad Nasir Shamsudin, I. ZulkifliList of authors in order
- Landing page
-
https://doi.org/10.3390/nu12020521Publisher landing page
- PDF URL
-
https://www.mdpi.com/2072-6643/12/2/521/pdf?version=1582701753Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/2072-6643/12/2/521/pdf?version=1582701753Direct OA link when available
- Concepts
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Neuroprotection, Medicine, Tocotrienol, Animal studies, Cognition, Bioinformatics, Traditional medicine, Pharmacology, Tocopherol, Vitamin E, Biology, Internal medicine, Antioxidant, Biochemistry, PsychiatryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
42Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 5, 2024: 10, 2023: 8, 2022: 12, 2021: 6Per-year citation counts (last 5 years)
- References (count)
-
68Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.ProQuest | 125 |
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| abstract_inverted_index.animals. | 189 |
| abstract_inverted_index.effects, | 327 |
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| abstract_inverted_index.involved | 143 |
| abstract_inverted_index.isomers. | 343 |
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| abstract_inverted_index.protocol | 46 |
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| abstract_inverted_index.oxidative | 267, 306 |
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| abstract_inverted_index.deposition | 223 |
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